SCIENCE@home

Mucoadhesion as a strategy to enhance the direct nose-to-brain drug delivery

Mrunal U. Patil

Published 2021 in Direct Nose-to-Brain Drug Delivery

ABSTRACT

Abstract It is well apprehended that the nose-to-brain drug delivery system enables both small and large molecules to bypass the BBB via the nerves of the nasal cavity, i.e., the olfactory and trigeminal nerves. However, mucociliary clearance greatly limits the residence time of substances administered inside the nasal cavity. As a consequence, pharmaceutical scientists have now opted for the mucoadhesion-based drug delivery system wherein one can achieve prolonged, controlled retention of the drug at the site of application. This chapter provides an overview of recent advancements made in intranasal mucoadhesive polymers and their application in formulating the nose-to-brain drug delivery system. This section sheds some light on the underlying critical aspect and surface chemistry involved in mucoadhesion and summarizes the evidence supporting the development and therapeutic outcomes of mucoadhesive nose-to-brain drug delivery systems.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 292 references · Page 1 of 3

123
Next

CITED BY

Showing 1-10 of 10 citing papers · Page 1 of 1