Role of Vitamin D in Cardiometabolic Diseases

Vitamin D deficiency is a highly prevalent condition. Low vitamin D levels have long been associated with bone diseases, such as rickets in children and osteomalacia and osteoporosis in adults. However, it has become apparent in recent years that adequate vitamin D levels are also important for optimal functioning of many organs and tissues throughout the body, including the cardiovascular system. Evolving data indicate that vitamin D deficiency is associated with an increased risk of cardiovascular disease (CVD). Studies have shown that low vitamin D levels are associated with hypertension, diabetes, metabolic syndrome, left ventricular hypertrophy, and chronic vascular inflammation, all of which are risk factors for CVD. This paper reviews the definition and pathophysiology of vitamin D deficiency, clinical evidence linking vitamin D and CVD risk, diabetes and its complications, and metabolic syndrome.

• Publication year

  2013

• Venue

  Journal of Diabetes Research

• Publication date

  2013-02-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/2013/243934PMID 23671861PMCID 3647592
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?

  2012cited by this paper
• Vitamin D and Cardiovascular Risk

  2012cited by this paper
• [Vitamin D and cardiovascular risk].

  2012cited by this paper
• Greenspan’s Basic and Clinical Endocrinology

  2012cited by this paper
• Vitamin D and diabetes.

  2012cited by this paper
• Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab).

  2012cited by this paper
• Role of vitamin D in the pathophysiology and treatment of type 2 diabetes.

  2012cited by this paper
• Vitamin D Levels Predict All-Cause and Cardiovascular Disease Mortality in Subjects With the Metabolic Syndrome

  2012cited by this paper
• New Insights About Vitamin D and Cardiovascular Disease

  2011cited by this paper
• 25‐Hydroxyvitamin D Levels and Hypertension Rates

  2011cited by this paper
• Epilepsy and bone health

  2011cited by this paper
• Vitamin D Status in Relation to Glucose Metabolism and Type 2 Diabetes in Septuagenarians

  2011cited by this paper
• Vitamin D in health and disease: Current perspectives

  2010cited by this paper
• The effect of different doses of vitamin D3 on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial

  2010cited by this paper
• Vitamin D: newly discovered actions require reconsideration of physiologic requirements.

  2010cited by this paper
• IOF position statement: vitamin D recommendations for older adults

  2010cited by this paper
• Epilepsy and bone health

  2010cited by this paper
• Systematic Review: Vitamin D and Cardiometabolic Outcomes

  2010cited by this paper
• Vitamin D and diabetes: the devil is in the D-tails

  2010cited by this paper
• Associations of Serum Concentrations of 25-Hydroxyvitamin D and Parathyroid Hormone With Surrogate Markers of Insulin Resistance Among U.S. Adults Without Physician-Diagnosed Diabetes: NHANES, 2003–2006

  2009cited by this paper
• Vitamin D, proteinuria, diabetic nephropathy, and progression of CKD.

  2009cited by this paper
• Global vitamin D status and determinants of hypovitaminosis D

  2009cited by this paper
• A double‐blind, randomized, placebo‐controlled trial of the short‐term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle‐aged, centrally obese men

  2009cited by this paper
• Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient – a randomised, placebo-controlled trial

  2009cited by this paper
• Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels

  2009cited by this paper
• Diabetes and fractures: an overshadowed association

  2009cited by this paper
• The Association of Vitamin D Deficiency and Insufficiency with Diabetic Nephropathy: Implications for Health Disparities

  2009cited by this paper
• Global vitamin D status and determinants of hypovitaminosis D

  2009cited by this paper
• Vitamin D Deficiency and Risk of Cardiovascular Disease

  2008cited by this paper
• Poor outcome in end‐stage heart failure patients with low circulating calcitriol levels

  2008cited by this paper
• Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance

  2008cited by this paper
• Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels

  2008cited by this paper
• Vitamin D - a review.

  2008cited by this paper
• Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004

  2008cited by this paper
• Glucose tolerance and vitamin D: effects of treating vitamin D deficiency.

  2008cited by this paper
• 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.

  2008cited by this paper
• Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography.

  2008cited by this paper
• Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain.

  2008cited by this paper
• Vitamin D inadequacy in postmenopausal women in Eastern Asia

  2008cited by this paper
• Renoprotective role of the vitamin D receptor in diabetic nephropathy.

  2008cited by this paper
• Vitamin D Deficiency among HIV Type 1-Infected Individuals in the Netherlands: Effects of Antiretroviral Therapy

  2008cited by this paper
• Effect of Calcium and Vitamin D Supplementation on Blood Pressure: The Women's Health Initiative Randomized Trial

  2008cited by this paper
• Vitamin D and Diabetes

  2008cited by this paper
• Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes

  2008cited by this paper
• Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey.

  2007cited by this paper
• Vitamin D deficiency.

  2007cited by this paper
• High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficiency in healthy south Indians.

  2007cited by this paper
• Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension

  2007cited by this paper
• Calcium/Vitamin D Supplementation and Cardiovascular Events

  2007cited by this paper
• Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.

  2006cited by this paper
• Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients.

  2006cited by this paper
• Secondary Hyperparathyroidism and Hypovitaminosis D in African-Americans with Decompensated Heart Failure

  2006cited by this paper
• The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation

  2006cited by this paper
• Influence of cultivation temperature on the ligninolytic activity of selected fungal strains

  2006cited by this paper
• A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report.

  2005cited by this paper
• Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women.

  2005cited by this paper
• High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India.

  2005cited by this paper
• Vitamin D status and its relationship with bone mineral density in healthy Asian Indians

  2004cited by this paper
• Epilepsy and bone health in adults.

  2004cited by this paper
• Overview of general physiologic features and functions of vitamin D.

  2004cited by this paper
• Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population.

  2004cited by this paper
• Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets.

  2004cited by this paper
• Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor

  2003cited by this paper
• Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?

  2003cited by this paper
• Geographical differences in vitamin D status, with particular reference to European countries

  2003cited by this paper
• Vitamin D: A millenium perspective

  2003cited by this paper
• THE EFFECT OF VITAMIN D3 ON INSULIN SECRETION AND PERIPHERAL INSULIN SENSITIVITY IN TYPE 2 DIABETIC PATIENTS

  2003cited by this paper
• Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study.

  2002cited by this paper
• Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III.

  2002cited by this paper
• Double Blind

  2001cited by this paper
• I and i

  2001cited by this paper
• Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.

  2001cited by this paper
• Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.

  2001cited by this paper
• Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2)-adrenoceptor agonists.

  2000cited by this paper
• Decreased bioavailability of vitamin D in obesity.

  2000cited by this paper
• Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi.

  2000cited by this paper
• Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure.

  1999cited by this paper
• A vitamin D3 derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats

  1999cited by this paper
• Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism.

  1999cited by this paper
• A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.

  1999cited by this paper
• Effect of 1,25 (OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats.

  1998cited by this paper
• Prevalence of Vitamin D Insufficiency in an Adult Normal Population

  1997cited by this paper
• Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians

  1995cited by this paper
• Serum 25-hydroxycholecalciferol concentration in newly detected hypertension.

  1995cited by this paper
• Relationship between vitamin D3 and the peripheral circulation in moderate arterial primary hypertension.

  1994cited by this paper
• Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D.

  1993cited by this paper
• Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction.

  1993cited by this paper
• Low circulating vitamin D in obesity

  1988cited by this paper
• Vitamin D3 and cardiovascular function in rats.

  1987cited by this paper
• Sunscreens suppress cutaneous vitamin D3 synthesis.

  1987cited by this paper
• Vitamin D deficiency and renal calcium transport in the rat.

  1984cited by this paper
• Increased skin pigment reduces the capacity of skin to synthesise vitamin D3.

  1982cited by this paper
• Rifampicin induced osteomalacia.

  1981cited by this paper
• Vitamin D deficiency.

  1979cited by this paper
• Vitamin D and Ischaemic Heart Disease

  1978cited by this paper
• Serum 25-hydroxycalciferol in myocardial infarction.

  1977cited by this paper
• Letter: "Menstrual toxin".

  1974cited by this paper
• Response of intestinal calcium transport and bone calcium mobilization to 1,25-dihydroxyvitamin D3 in thyroparathyroidectomized rats.

  1974cited by this paper
• Vitamin-D deficiency in Asians at home and in Britain.

  1973cited by this paper
• Parathyroid hormone.

  1967cited by this paper

• Investigating the role of Vitamin D and its targeted gene-pathway interactions involved in cardiometabolic health

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• Major risk factors underlying the development of metabolic syndrome in vitamin D-deficient rats

  2025cites this paper
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  2025cites this paper
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  2023cites this paper
• Vitamin D Status of Type 2 Diabetic Patients in Oujda North-East Morocco

  2022cites this paper
• Association of vitamin D receptor polymorphisms with cardiometabolic conditions in Pakistani population.

  2022cites this paper
• Vitamin D adjuvant effect on Angiotensin II level and other biochemical markers in hypertensive patients: A prospective study

  2022cites this paper
• 1,25-dihydroxyvitamin D and cardiometabolic risk in healthy sedentary adults: The FIT-AGEING study.

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Effects of Vitamin D Supplementation on Cardiovascular and Glycemic Biomarkers

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2014cites this paper
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