WWOX, the chromosomal fragile site FRA16D spanning gene: Its role in metabolism and contribution to cancer

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Experimental biology and medicine

• Publication date

  2015-01-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/1535370214565990PMID 25595186PMCID PMC4935231
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterizing WW Domain Interactions of Tumor Suppressor WWOX Reveals Its Association with Multiprotein Networks*

  2014cited by this paper
• The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.

  2014cited by this paper
• The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration

  2014cited by this paper
• Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people

  2014cited by this paper
• Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells

  2013cited by this paper
• A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese.

  2013cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

  2011cited by this paper
• The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype

  2011cited by this paper
• A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development

  2011cited by this paper
• WWOX Oxidoreductase – Substrate and Enzymatic Characterization

  2011cited by this paper
• Signatures of mutation and selection in the cancer genome

  2010cited by this paper
• The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.

  2010cited by this paper
• Q&A: Cancer: Clues from cell metabolism

  2010cited by this paper
• Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species

  2010influential reference
• Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.

  2009cited by this paper
• Generation and Characterization of Mice Carrying a Conditional Allele of the Wwox Tumor Suppressor Gene

  2009cited by this paper
• Association of reactive oxygen species levels and radioresistance in cancer stem cells

  2009cited by this paper
• A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy

  2009cited by this paper
• Tumor cell metabolism: cancer's Achilles' heel.

  2008cited by this paper
• Medium- and short-chain dehydrogenase/reductase gene and protein families

  2008cited by this paper
• Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.

  2007cited by this paper
• Phenotypic characterization of spontaneously mutated rats showing lethal dwarfism and epilepsy.

  2007cited by this paper
• Targeted deletion of Wwox reveals a tumor suppressor function

  2007cited by this paper
• WWOX hypomorphic mice display a higher incidence of B‐cell lymphomas and develop testicular atrophy

  2007cited by this paper
• Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

  2007cited by this paper
• Association of Wwox with ErbB4 in breast cancer.

  2007cited by this paper
• WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis.

  2006cited by this paper
• FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila

  2006cited by this paper
• WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

  2005cited by this paper
• Mechanisms of common fragile site instability.

  2005cited by this paper
• WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

  2005cited by this paper
• FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila

  2005cited by this paper
• Common chromosomal fragile site FRA16D mutation in cancer cells.

  2005cited by this paper
• Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses.

  2003cited by this paper
• Direct correlation between FRA3B expression and cigarette smoking

  2002influential reference
• Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors

  2002cited by this paper
• Hyaluronidase Induction of a WW Domain-containing Oxidoreductase That Enhances Tumor Necrosis Factor Cytotoxicity*

  2001cited by this paper
• WWOX, the FRA16D gene, behaves as a suppressor of tumor growth.

  2001cited by this paper
• Fragile and unstable chromosomes in cancer: causes and consequences.

  2001cited by this paper
• Chromosomal fragile site FRA16D and DNA instability in cancer.

  2000cited by this paper
• Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.

  2000cited by this paper
• WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.

  2000cited by this paper
• Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers.

  1987cited by this paper
• Constitutive fragile sites and cancer.

  1984cited by this paper
• THE METABOLISM OF TUMORS IN THE BODY

  1927cited by this paper

• Conformational selection and linker-dependent specificity in the MAGI-1 WW tandem.

  2026cites this paper
• The Role of WWOX in Cancer Progression: Mechanisms and Therapeutic Potential

  2025cites this paper
• Twenty-five years of WWOX insight in cancer: a treasure trove of knowledge

  2025cites this paper
• DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion

  2024cites this paper
• Unraveling Molecular Signatures in Rare Bone Tumors and Navigating the Cancer Pathway Landscapes for Targeted Therapeutics.

  2024cites this paper
• Multi-Omics Analysis of NCI-60 Cell Line Data Reveals Novel Metabolic Processes Linked with Resistance to Alkylating Anti-Cancer Agents

  2023cites this paper
• Structural insights into the role of the WW2 domain on tandem WW–PPxY motif interactions of oxidoreductase WWOX

  2022cites this paper
• Structural insights into the role of the WW2 domain on tandem WW – PPxY motif interactions of oxidoreductase

  2022cites this paper
• Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice

  2022cites this paper
• Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D

  2021cites this paper
• WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

  2021cites this paper
• Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes

  2021cites this paper
• Genomic instability and cancer: lessons from Drosophila

  2020cites this paper
• Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments

  2020cites this paper
• Virus-encoded miR-155 ortholog in Marek's disease virus promotes cell proliferation via suppressing apoptosis by targeting tumor suppressor WWOX.

  2020cites this paper
• Down-regulated HSDL2 expression suppresses cell proliferation and promotes apoptosis in papillary thyroid carcinoma

  2019cites this paper
• Decoding the link between WWOX and p53 in aggressive breast cancer

  2019cites this paper
• Immunohistochemical WWOX Expression and Association with Angiogenesis, p53 Expression, Cell Proliferation and Clinicopathological Parameters in Cervical Cancer

  2018cites this paper
• Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved

  2018cites this paper
• The FRA14B common fragile site maps to a region prone to somatic and germline rearrangements within the large GPHN gene

  2018cites this paper
• Modeling WWOX Loss of Function in vivo: What Have We Learned?

  2018cites this paper
• WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

  2018cites this paper
• Exogenous WWOX enhances apoptosis and weakens metastasis in CNE2 nasopharyngeal carcinoma cells through the intrinsic apoptotic pathway.

  2017cites this paper
• HYAL-2–WWOX–SMAD4 Signaling in Cell Death and Anticancer Response

  2016cites this paper
• Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed

  2016influential citation
• Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer

  2015cites this paper
• Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster

  2015cites this paper
• Tumor suppressor WWOX moderates the mitochondrial respiratory complex

  2015cites this paper
• Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells*

  2015influential citation
• Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function

  2015cites this paper