Chromosomal fragile site FRA16D and DNA instability in cancer.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cancer Research

• Publication date

  2000-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10749140
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D.

  2000cited by this paper
• The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control.

  1999cited by this paper
• Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression.

  1999cited by this paper
• The role of the FHIT/FRA3B locus in cancer.

  1998cited by this paper
• An FHIT tumor suppressor gene?

  1998cited by this paper
• Interstitial deletions and intrachromosomal amplification initiated from a double‐strand break targeted to a mammalian chromosome

  1998cited by this paper
• The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region.

  1998cited by this paper
• Fish mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer

  1998influential reference
• The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells.

  1998cited by this paper
• Fragile sites still breaking.

  1998cited by this paper
• FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites

  1998cited by this paper
• Direct cloning and analysis of DNA sequences from a region of the Chinese hamster genome associated with aphidicolin-sensitive fragility.

  1998cited by this paper
• Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction.

  1998cited by this paper
• Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.

  1998cited by this paper
• Targeted downregulation of caveolin‐1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

  1998cited by this paper
• Genes encoding human caveolin‐1 and ‐2 are co‐localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

  1998cited by this paper
• Protein expression and functional analysis of the FHIT gene in human tumor cells.

  1998cited by this paper
• FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis.

  1998cited by this paper
• Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site.

  1998cited by this paper
• A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication.

  1997cited by this paper
• Replacement of Fhit in cancer cells suppresses tumorigenicity.

  1997cited by this paper
• Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons.

  1997cited by this paper
• Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat.

  1997cited by this paper
• Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B.

  1997cited by this paper
• Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activators.

  1997cited by this paper
• Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.

  1997cited by this paper
• Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.

  1997cited by this paper
• Genetic heterogeneity in familial acute myelogenous leukemia: evidence for a second locus at chromosome 16q21-23.2.

  1997cited by this paper
• Loss of heterozygosity at chromosome 16q in prostate adenocarcinoma: identification of three independent regions.

  1997influential reference
• The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer

  1996cited by this paper
• Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: refining a putative tumor suppressor gene region.

  1996cited by this paper
• Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE.

  1996cited by this paper
• FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.

  1996cited by this paper
• The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

  1996influential reference
• Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2

  1995cited by this paper
• A third Wilms' tumor locus on chromosome 16q.

  1992cited by this paper
• High-resolution cytogenetic-based physical map of human chromosome 16.

  1992cited by this paper
• Human chromosome 16 physical map: mapping of somatic cell hybrids using multiplex PCR deletion analysis of sequence tagged sites.

  1991cited by this paper
• Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n

  1991cited by this paper
• Detection of 98% of DMD/BMD gene deletions by polymerase chain reaction

  1990cited by this paper
• Reassessment of two apparent deletions of chromosome 16p to an ins(11;16) and a t(1;16) by chromosome painting.

  1990cited by this paper
• Identification of a chromosome 18q gene that is altered in colorectal cancers.

  1990cited by this paper
• Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification.

  1988cited by this paper
• No statistical association between common fragile sites and nonrandom chromosome breakpoints in cancer cells.

  1988cited by this paper
• Fragile sites and cancer breakpoints--the pessimistic view.

  1988cited by this paper
• Further localization of ETS1 indicates that the chromosomal rearrangement in Ewing sarcoma does not occur at fra(11)(q23)

  1988cited by this paper
• Fragile sites at 16q22 are not at the breakpoint of the chromosomal rearrangement in AMMoL.

  1987cited by this paper
• A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

  1986cited by this paper
• Fragile sites and cancer breakpoints.

  1984cited by this paper
• Constitutive fragile sites and cancer.

  1984cited by this paper

• Fragile sites, chromosomal lesions, tandem repeats, and disease

  2022cites this paper
• WWOX and metabolic regulation in normal and pathological conditions

  2022cites this paper
• Genome Instability in Multiple Myeloma: Facts and Factors

  2021cites this paper
• Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D

  2021cites this paper
• From R-Loops to G-Quadruplexes: Emerging New Threats for the Replication Fork

  2020cites this paper
• Modeling WWOX Loss of Function in vivo: What Have We Learned?

  2018cites this paper
• The role of fork stalling and DNA structures in causing chromosome fragility

  2018cites this paper
• Somatic mutations in tumors: their detection, generation mechanisms and implications

  2017cites this paper
• Fragile sites in cancer: more than meets the eye

  2017cites this paper
• Genome‐wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma

  2017cites this paper
• HumCFS: a database of fragile sites in human chromosomes

  2017cites this paper
• Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair

  2017cites this paper
• Article title: Gene Mapping and Expression Analysis of 16q Loss of Heterozygosity Identifies

  2016cites this paper
• Defining the role(s) of non-classical tumour suppressor Wwox in cellular function using Drosophila melanogaster genetic modelling

  2015cites this paper
• Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster

  2015cites this paper
• WWOX, the chromosomal fragile site FRA16D spanning gene: Its role in metabolism and contribution to cancer

  2015cites this paper
• Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes

  2014cites this paper
• Replication fork recovery and regulation of common fragile sites stability

  2014cites this paper
• Genetic and epigenetic alterations of WWOX in the development of gastric cardia adenocarcinoma

  2013cites this paper
• Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer.

  2013cites this paper
• Human common fragile sites, identification, and analysis of breaks using saccharomyces cerevisiae

  2013influential citation
• Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability

  2013cites this paper
• Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.

  2013cites this paper
• Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

  2013cites this paper
• Hereditary Prostate Cancer and Genetic Risk

  2012cites this paper
• Etude du rôle du gène suppresseur de tumeur WWOX et de ses partenaires dans la voie de signalisation Wnt/β-caténine et dans la carcinogenèse mammaire

  2012cites this paper
• Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats

  2012influential citation
• The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.

  2011cites this paper
• WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancer.

  2010cites this paper
• The common fragile site genes CNTLN and LINGO2 are associated with increased genomic instability in different tumors

  2010cites this paper
• An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis

  2010cites this paper
• Reversing effect of exogenous WWOX gene expression on malignant phenotype of primary cultured lung carcinoma cells.

  2010cites this paper
• Replication dynamics at common fragile site FRA6E

  2010cites this paper
• WWOX: Its genomics, partners, and functions

  2009cites this paper
• Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution

  2009cites this paper
• Mechanisms of Common Fragile Site Instability and Cancer.

  2009cites this paper
• Inhibition of the Wnt/β-catenin pathway by the WWOX tumor suppressor protein

  2009cites this paper
• The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome

  2009cites this paper
• Human chromosome fragility.

  2008cites this paper
• Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX

  2008cites this paper
• Deletion and mutation of WWOX exons 6–8 in human non-small cell lung cancer

  2008cites this paper
• WWOX in biological control and tumorigenesis

  2007cites this paper
• An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae.

  2007cites this paper
• Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma.

  2007cites this paper
• WWOX Expression in Different Histologic Types and Subtypes of Non–Small Cell Lung Cancer

  2007cites this paper
• WWOX, a new potential tumor suppressor gene.

  2007cites this paper
• Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1—Relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints

  2007cites this paper
• FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD).

  2007cites this paper
• Novel aphidicolin‐inducible common fragile site FRA9G maps to 9p22.2, within the C9orf39 gene

  2007influential citation
• Chromosome fragile sites.

  2007cites this paper
• Common fragile sites.

  2006cites this paper
• FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila

  2006cites this paper
• Chromosome 16 tumor‐suppressor genes in breast cancer

  2006cites this paper
• Common fragile sites as targets for chromosome rearrangements.

  2006influential citation
• Roles of FHIT and WWOX fragile genes in cancer.

  2006cites this paper
• The molecular basis of common and rare fragile sites.

  2006cites this paper
• Low-frequency common fragile sites: link to neuropsychiatric disorders?

  2006cites this paper
• Common chromosomal fragile sites and cancer: focus on FRA16D.

  2006cites this paper
• CHAPTER 12 – Chromosomal Fragile Sites: Mechanisms of Cytogenetic Expression and Pathogenic Consequences

  2006cites this paper
• The WWOX gene : investigation of its function and its role in ovarian tumourigenesis

  2005influential citation
• Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.

  2005cites this paper
• Common Fragile Genes and Digestive Tract Cancers

  2005cites this paper
• WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear.

  2005cites this paper
• Common chromosomal fragile site FRA16D mutation in cancer cells.

  2005influential citation
• Assessing fragile sites in carcinogenic environments: Is this an alert signal?

  2005cites this paper
• The neurobeachin gene spans the common fragile site FRA13A

  2005influential citation
• Short communication Biallelic deletion and loss of expression analysis of genes at FRA2G common fragile site in tumor-derived cell lines

  2005cites this paper
• Biallelic deletion and loss of expression analysis of genes at FRA2G common fragile site in tumor-derived cell lines.

  2005cites this paper
• Mechanisms of common fragile site instability.

  2005cites this paper
• Aspekte der Zell-Zell- und Zell-Matrix-Interaktion im malignen Melanom

  2005cites this paper
• Loss of WWOX Expression in Gastric Carcinoma

  2004cites this paper
• AT islands - their nature and potential for anticancer strategies.

  2004cites this paper
• BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function

  2004cites this paper
• Parkin gene alterations in hepatocellular carcinoma

  2004cites this paper
• The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma

  2004cites this paper
• The role of late/slow replication of the FRA16D in common fragile site induction

  2004influential citation
• Evolutionary breakpoints are co-localized with fragile sites and intrachromosomal telomeric sequences in primates

  2004cites this paper
• Common Fragile Sites and Cancer: Targeted Cloning by Insertional Mutagenesis

  2004cites this paper
• Common fragile genes.

  2004cites this paper
• Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis

  2003cites this paper
• Common fragile sites

  2003cites this paper
• WWOX, the common chromosomal fragile site, FRA16D, cancer gene

  2003cites this paper
• Common fragile sites are preferential targets for HPV16 integrations in cervical tumors

  2003cites this paper
• Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer

  2003influential citation
• Alterations in the common fragile site gene Parkin in ovarian and other cancers

  2003cites this paper
• Genetic alterations in cancer as a result of breakage at fragile sites.

  2003cites this paper
• How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites

  2003cites this paper
• Fragile sites and bladder cancer.

  2003cites this paper
• Implication of fragile sites and intrachromosomal telomeric ( TTAGGG ) n sequences in Primate chromosome evolution

  2003cites this paper
• Homozygous deletions scanning in tumor cell lines detects previously unsuspected loci

  2003cites this paper
• Genome‐wide scan of brothers: Replication and fine mapping of prostate cancer susceptibility and aggressiveness loci

  2003cites this paper
• Matrix attachment region (MAR) properties and abnormal expansion of AT island minisatellites in FRA16B fragile sites in leukemic CEM cells.

  2003cites this paper
• Molecular Basis for Expression of Common and Rare Fragile Sites

  2003influential citation
• Characterization of the human common fragile site FRA2G.

  2003cites this paper
• Characterization of the common fragile site FRA9E and its potential role in ovarian cancer

  2003cites this paper
• Common fragile sites associated with the breakpoints of chromosomal aberrations in hematologic neoplasms.

  2002cites this paper
• The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic level.

  2002cites this paper
• Positional cloning of a novel heritable, rare, folate-sensitive fragile site (FRAXG) in Xp22.1 associated with short stature in a finnish kindred and cloning of an associated candidate gene (FXGAG) /

  2002cites this paper
• Genetic and epigenetic changes in nasopharyngeal carcinoma.

  2002cites this paper
• The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1

  2002cites this paper