Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Pharmacy and Science

• Publication date

  2011-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/jps.22693PMID 21721007
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial-Mediated Apoptosis in Lymphoma Cells by the Diterpenoid Lactone Andrographolide, the Active Component of Andrographis paniculata

  2010cited by this paper
• Potency of Andrographolide as an Antitumor Compound in BHC-Induced Liver Damage

  2009cited by this paper
• A simple and sensitive HPLC-ESI-MS/MS method for the determination of andrographolide in human plasma.

  2009cited by this paper
• Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down-regulation of MMP-7 expression.

  2009cited by this paper
• Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level

  2008cited by this paper
• Andrographolide Up-Regulates Cellular-Reduced Glutathione Level and Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury

  2008cited by this paper
• Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in jurkat cells

  2008cited by this paper
• HPTLC analysis of hepatoprotective diterpenoid andrographolide from Andrographis paniculata nees (kalmegh)

  2007cited by this paper
• Suppression of v-Src Transformation by Andrographolide via Degradation of the v-Src Protein and Attenuation of the Erk Signaling Pathway*

  2007cited by this paper
• HPLC determination of andrographolide in rat whole blood: study on the pharmacokinetics of andrographolide incorporated in liposomes and tablets.

  2007cited by this paper
• HPLC determination of active diterpene lactones from Andrographis paniculata Nees planted in various seasons and regions in Thailand

  2007cited by this paper
• Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages: role of mitogen-activated protein kinases.

  2006cited by this paper
• Mechanisms Responsible for Poor Oral Bioavailability of Paeoniflorin: Role of Intestinal Disposition and Interactions with Sinomenine

  2006cited by this paper
• Identifying lactone hydrolysis in pharmaceuticals. A tool for metabolite structural characterization.

  2005cited by this paper
• BCRP Transports Dipyridamole and is Inhibited by Calcium Channel Blockers

  2005cited by this paper
• Andrographolide interferes with binding of nuclear factor‐κB to DNA in HL‐60‐derived neutrophilic cells

  2005cited by this paper
• Morphological and biochemical changes of andrographolide-induced cell death in human prostatic adenocarcinoma PC-3 cells.

  2005cited by this paper
• Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.

  2004cited by this paper
• Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2)

  2004cited by this paper
• Four new andrographolide metabolites in human urine.

  2004cited by this paper
• Identification of a rare sulfonic acid metabolite of andrographolide in rats.

  2003cited by this paper
• Metabolism of Flavonoids via Enteric Recycling: Mechanistic Studies of Disposition of Apigenin in the Caco-2 Cell Culture Model

  2003cited by this paper
• Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?

  2003cited by this paper
• Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status

  2001cited by this paper
• Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human.

  2000cited by this paper
• Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model.

  1998cited by this paper
• The Caco-2 cell monolayers as an intestinal metabolism model: metabolism of dipeptide Phe-Pro.

  1994cited by this paper
• Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells.

  1991cited by this paper
• [Studies on the structure of the adduct of andrographolide with sodium hydrogen sulfite (author's transl)].

  1981cited by this paper
• [Studies on the structure of the adduct of andrographolide with sodium hydrogen sulfite (author's transl)].

  1981cited by this paper

• Liquisolid powders of Andrographis paniculata extract: physicochemical attributes, dissolution, oral bioavailability, stability, and acute toxicity

  2026cites this paper
• Dosage prediction of andrographolide capsules in children by physiologically based pharmacokinetic model

  2026cites this paper
• Natural terpenoids with therapeutic potential against pulmonary arterial hypertension

  2026cites this paper
• Comprehensively investigating pharmacokinetics and metabolic fate of andrographolide in rats by liquid chromatography/mass spectrometry-based approach.

  2026cites this paper
• Intestinal Permeation Characteristics via Non-Everted Gut Sac of Diterpene Lactones from Pure Andrographolide and Three Different Andrographis Extracts: An Investigation into Liqui-Mass with Different Solvents

  2026cites this paper
• Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of 3,14,19-Triacetyl Andrographolide in Rat Plasma: Application to Preclinical Pharmacokinetic Studies.

  2025cites this paper
• Dietary andrographolide supplementation improves growth, antioxidant capacity, and innate immunity in Procambarus clarkii by reshaping gut microbiota

  2025cites this paper
• Development of Salt-Assisted Liquid–Liquid Extraction for Simultaneous Quantification of Andrographolide and 14-Deoxy-11,12-didehydroandrographolide in Plasma Using HPLC-DAD: Method Validation and Pharmacokinetic Assessment Application

  2025cites this paper
• Design and synthesis of lactam analogs of andrographolide and discovery of their anticancer activity as dual EGFR and VEGFR2 inhibitors.

  2025cites this paper
• Pharmacological Effects and Pharmacokinetic Profiles of Dehydroandrographolide

  2025cites this paper
• From in vivo disposition to therapeutic action: Tracing the pharmacokinetic journey and unveiling the anti-UC potential of oridonin and its sulfonate-conjugate.

  2025cites this paper
• Exploring the Anticancer Properties of 1,2,3-Triazole-Substituted Andrographolide Derivatives

  2025cites this paper
• Eudragit S 100 Assisted Molecular Solid Dispersion of Andrographolide Tendered Augmented Drug Delivery and Apoptosis in Human Colon Cancer, HT-29 Cells

  2025cites this paper
• Andrographolide Sulfonates and Xiyanping: A Review of Chemical Composition, Pharmacological Activities, Clinical Applications, and Adverse Reactions

  2025cites this paper
• A review on the molecular mechanisms and pharmacology of andrographolide from Andrographis paniculata (Burm.f.) Nees in the management of the interplay between type 2 diabetes and breast cancer.

  2025cites this paper
• The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells

  2025cites this paper
• Deciphering the anti-cancer potential of Andrographis paniculata (Burm.f.) Nees (Acanthaceae) against breast Cancer: insights from network pharmacology and in-vitro studies

  2025cites this paper
• In vitro Evaluation of Mitochondrial-Targeted Andrographolide Nanoparticles Against 4T1 Breast Cancer Cells

  2025cites this paper
• Crystal engineering for poorly water-soluble drugs: From design to applications

  2025cites this paper
• Current Evidence on Molecular Mechanisms of Andrographolide in Cancer.

  2024cites this paper
• Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review

  2024cites this paper
• An Integrated in Silico-In Vitro-In Vivo Approach for Pharmacokinetic Studies of Andrographolide Using Aqueous Extract of Andrographis Paniculata (Burm.F.) Wall. Ex Nees

  2024influential citation
• Crystal structure of 14-(R)-(2′-cyano-phenoxy)-3,19-diacetyl andrographolide, C31H37NO7

  2024cites this paper
• Andrographolide: A promising therapeutic agent against organ fibrosis.

  2024cites this paper
• Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis

  2024cites this paper
• Gut microbiota-mediated C-sulfonate metabolism impairs the bioavailability and anti-cholestatic efficacy of andrographolide

  2024influential citation
• Polymer Matrix and Manufacturing Methods in Solid Dispersion System for Enhancing Andrographolide Solubility and Absorption: A Systematic Review

  2024influential citation
• Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells

  2024cites this paper
• Anti-metastatic effects of AGS-30 on breast cancer through the inhibition of M2-like macrophage polarization.

  2024cites this paper
• Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs

  2024cites this paper
• Formulation of Nanoparticulate Andrographolide-Incorporated Gel for Dermal Delivery

  2023cites this paper
• Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials

  2023cites this paper
• Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants

  2023cites this paper
• Size-Dependence of the Skin Penetration of Andrographolide Nanosuspensions: In Vitro Release-Ex Vivo Permeation Correlation and Visualization of the Delivery Pathway.

  2023cites this paper
• Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

  2023cites this paper
• Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide

  2023cites this paper
• A validated LC–MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata extract

  2023cites this paper
• ADVANCES IN AMELIORATING RHEUMATOID ARTHRITIS BY ANDROGRAPHOLIDE ETHOSOME-BASED GEL: PHARMACOKINETIC AND ACTIVITY STUDY IN RATS

  2023cites this paper
• Andrographolide: A Diterpenoid from Cymbopogon schoenanthus Identified as a New Hit Compound against Trypanosoma cruzi Using Machine Learning and Experimental Approaches

  2023cites this paper
• AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity.

  2023cites this paper
• The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling It up to Rats, Dogs and Humans.

  2022cites this paper
• Application of 2H stable isotope labelling methodology and ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry for the metabolite identification of dehydroandrographolide in rats

  2022cites this paper
• An insight into the pharmacological and analytical potential of Andrographolide

  2022influential citation
• Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27.

  2022cites this paper
• Enhancing oral bioavailability of andrographolide via sodium dodecyl sulfate and D-α-Tocopherol polyethylene glycol 1000 succinate copolymer modified nanocrystals

  2022cites this paper
• Computational and experimental therapeutic efficacy analysis of andrographolide phospholipid complex self-assembled nanoparticles against Neuro2a cells.

  2022cites this paper
• Appraisal of antiretroviral herbal medicines with proven efficacy: modulation of drug-metabolizing enzymes and permeability glycoprotein activities

  2022cites this paper
• A sensitive liquid chromatography-mass spectrometry method for determination of 14-deoxy-12(R)-sulfo andrographolide concentration in rat plasma and its application to a pharmacokinetic study.

  2022cites this paper
• Elucidating the Particle Size Effect of Andrographolide Suspensions on Their IVIVC Performance in Oral Absorption.

  2022cites this paper
• Andrographolide liquisolid using porous-starch as the adsorbent with enhanced oral bioavailability in rats.

  2022cites this paper
• Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5.

  2022cites this paper
• A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease

  2022cites this paper
• Andrographis paniculata standardized extract (ParActin) and pain

  2022cites this paper
• Current developments in Nano/Micro-formulations for enhanced delivery and bioactivity of andrographolide

  2021cites this paper
• Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.

  2021cites this paper
• [Calcium-activated chloride channels: structure, properties, role in physiological and pathological processes].

  2021cites this paper
• Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of Andrographis paniculata in Animal Models

  2021cites this paper
• Andrographis paniculata: A Review of its Anti-Cancer Potential

  2021cites this paper
• Prediction of Free Drug Absorption in Cyclodextrin Formulation by a Modified Physiologically Based Pharmacokinetic Model and Phase Solubility 3-D Surface Graph

  2021cites this paper
• Andrographis paniculata (Burm. F.) Wall. Ex Nees, Andrographolide, and Andrographolide Analogues as SARS-CoV-2 Antivirals? A Rapid Review

  2021cites this paper
• Integrated computer-aided formulation design: A case study of andrographolide/ cyclodextrin ternary formulation

  2021cites this paper
• Concomitant Medication Use With Xiyanping Injection and the Risk of Suspected Allergic Reactions: A Nested Case–Control Study Based on China’s National Medical Insurance Database

  2021cites this paper
• Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update

  2021cites this paper
• Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2

  2021cites this paper
• Andrographolide Sulfonate Is a Promising Treatment to Combat Methicillin-resistant Staphylococcus aureus and Its Biofilms

  2021cites this paper
• Co-amorphous solids of dasatinib and olanzapine by saccharin with promising physicochemical properties

  2021cites this paper
• The new andrographolide derivative AGS-30 induces apoptosis in human colon cancer cells by activating a ROS-dependent JNK signalling pathway.

  2021cites this paper
• Discovery of 14S-(2'-chloro-4'-nitrophenoxy)-8R/S,17-epoxy andrographolide as EV-A71 infection inhibitor.

  2021cites this paper
• Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability

  2021cites this paper
• Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

  2021cites this paper
• Andrographolide-loaded ethosomal gel for transdermal application: Formulation and in vitro penetration study

  2021cites this paper
• Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

  2021influential citation
• Insight into the pharmacological effects of andrographolide in musculoskeletal disorders.

  2021cites this paper
• P-glycoprotein mediated interactions between Chinese materia medica and pharmaceutical drugs

  2021cites this paper
• Opportunities and challenges in managing antibiotic resistance in bacteria using plant secondary metabolites.

  2020cites this paper
• Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid Dispersion

  2020cites this paper
• Application of Simplex Lattice Design on the Optimization of Andrographolide Self Nanoemulsifying Drug Delivery System (SNEDDS)

  2020cites this paper
• Strategic approach in hepatic delivery of andrographolide: Key challenges and new insights

  2020cites this paper
• Development of Nanoemulsion-based Hydrogel Containing Andrographolide: Physical Properties and Stability Evaluation

  2020cites this paper
• Andrographolide-loaded solid lipid nanoparticles enhance anticancer activity against head and neck cancer and precancerous cells.

  2020cites this paper
• Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

  2020cites this paper
• What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism

  2020cites this paper
• Efficacy and mechanism of actions of natural antimicrobial drugs.

  2020cites this paper
• FORMULATION OF ANDROGRAPHOLIDE TRANSFERSOMES GEL FOR TRANSDERMAL DELIVERY: A PRELIMINARY STUDY

  2020cites this paper
• Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease

  2019cites this paper
• Bioavailability of the diterpenoid 14-deoxy-11,12-didehydroandrographolide in rats and up-regulation of hepatic drug-metabolizing enzyme and drug transporter expression.

  2019cites this paper
• Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents.

  2019cites this paper
• Novel Drug Delivery Systems for Phytoconstituents

  2019cites this paper
• Development of Andrographolide‑chitosan Solid Dispersion System: Physical Characterization, Solubility, and Dissolution Testing

  2019cites this paper
• Novel nanocrystal-based solid dispersion with high drug loading, enhanced dissolution, and bioavailability of andrographolide

  2018cites this paper
• Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism

  2018cites this paper
• The Shielding Effect of Microcrystalline Cellulose on Drug Nanocrystal Particles During Compaction

  2018cites this paper
• Xenobiotic C-sulfonate derivatives; metabolites or metabonates?

  2018cites this paper
• Intestinal absorption of pallidifloside D are limited by P-glycoprotein in mice

  2018cites this paper
• The anti-cancer activity of an andrographolide analogue functions through a GSK-3β-independent Wnt/β-catenin signaling pathway in colorectal cancer cells

  2018cites this paper
• A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer.

  2018cites this paper
• Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer.

  2018cites this paper
• Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide

  2018influential citation
• Exploring the mechanisms of cytotoxic and anti-inflammatory property of andrographolide and its derivatives

  2018cites this paper
• Effects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats

  2018cites this paper