Photobacterium damselae subsp. damselae, a bacterium pathogenic for marine animals and humans

Photobacterium damselae subsp. damselae (formerly Vibrio damsela) is a pathogen of a variety of marine animals including fish, crustaceans, molluscs, and cetaceans. In humans, it can cause opportunistic infections that may evolve into necrotizing fasciitis with fatal outcome. Although the genetic basis of virulence in this bacterium is not completely elucidated, recent findings demonstrate that the phospholipase-D Dly (damselysin) and the pore-forming toxins HlyApl and HlyAch play a main role in virulence for homeotherms and poikilotherms. The acquisition of the virulence plasmid pPHDD1 that encodes Dly and HlyApl has likely constituted a main driving force in the evolution of a highly hemolytic lineage within the subspecies. Interestingly, strains that naturally lack pPHDD1 show a strong pathogenic potential for a variety of fish species, indicating the existence of yet uncharacterized virulence factors. Future and deep analysis of the complete genome sequence of Photobacterium damselae subsp. damselae will surely provide a clearer picture of the virulence factors employed by this bacterium to cause disease in such a varied range of hosts.

• Publication year

  2013

• Venue

  Frontiers in Microbiology

• Publication date

  2013-09-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3389/fmicb.2013.00283PMID 24093021PMCID 3782699
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antibiotic resistance and molecular typing of Photobacterium damselae subsp. damselae, isolated from seafood

  2013cited by this paper
• Synergistic and Additive Effects of Chromosomal and Plasmid-Encoded Hemolysins Contribute to Hemolysis and Virulence in Photobacterium damselae subsp. damselae

  2013influential reference
• The Photobacterium damselae subsp. damselae Hemolysins Damselysin and HlyA Are Encoded within a New Virulence Plasmid

  2011cited by this paper
• Photobacterium damselae subsp. damselae, an Emerging Pathogen Affecting New Cultured Marine Fish Species in Southern Spain

  2011cited by this paper
• Occurrence of both subspecies of Photobacterium damselae in mullets collected in the river Magra (Italy).

  2011cited by this paper
• Toxicity of Photobacterium damselae subsp. damselae strains isolated from new cultured marine fish.

  2010cited by this paper
• The ABC-transporter hutCD genes of Photobacterium damselae subsp. piscicida are essential for haem utilization as iron source and are expressed during infection in fish.

  2010cited by this paper
• Septicemia Progressing to Fatal Hepatic Dysfunction in an Cirrhotic Patient after Oral Ingestion of Photobacterium damsela: A Case Report

  2009cited by this paper
• Photobacterium damsela wound infection in a 14-year-old surfer.

  2009cited by this paper
• Characterization of Two Phenotypes of Photobacterium damselae subsp. damselae Isolated from Diseased Juvenile Trachinotus ovatus Reared in Cage Mariculture

  2009cited by this paper
• Molecular intraspecific characterization of Photobacterium damselae ssp. damselae strains affecting cultured marine fish

  2009cited by this paper
• Photobacterium damselae subsp. damselae, an emerging pathogen in Danish rainbow trout, Oncorhynchus mykiss (Walbaum), mariculture.

  2009cited by this paper
• Photobacterium damselae ssp. damselae associated with diseased black tiger shrimp Penaeus monodon Fabricius in India

  2007cited by this paper
• An Unusual Case of Urinary Tract Infection in a Pregnant Woman With Photobacterium damsela

  2006cited by this paper
• AEROBIC MICROORGANISMS ASSOCIATED WITH FREE-RANGING BOTTLENOSE DOLPHINS IN COASTAL GULF OF MEXICO AND ATLANTIC OCEAN WATERS

  2006cited by this paper
• First isolation of Photobacterium damselae ssp. damselae from cultured redbanded seabream, Pagrus auriga Valenciennes, in Spain.

  2006cited by this paper
• Heme uptake genes in human and fish isolates of Photobacterium damselae: existence of hutA pseudogenes

  2005cited by this paper
• Two Cases of Fatal Necrotizing Fasciitis Caused by Photobacterium damsela in Japan

  2004influential reference
• Rapidly advancing necrotizing fasciitis caused by Photobacterium (Vibrio) damsela: A hyperaggressive variant

  2004influential reference
• Occurrence of Photobacterium damselae subsp. damselae in bivavlve molluscs from Northwest Spain

  2003cited by this paper
• Amplified fragment length polymorphism (AFLP) and biochemical typing of Photobacterium damselae subsp. damselae

  2002cited by this paper
• Presence of phospholipase-D (dly) gene coding for damselysin production is not a pre-requisite for pathogenicity in Photobacterium damselae subsp. damselae.

  2000cited by this paper
• Necrotizing fasciitis due to Photobacterium damsela in a man lashed by a stingray.

  2000cited by this paper
• Evidence that water transmits the disease caused by the fish pathogen Photobacterium damselae subsp. damselae

  2000cited by this paper
• Necrotizing fasciitis caused by Vibrio damsela.

  1999cited by this paper
• Vibrio species.

  1999cited by this paper
• Internalization and cytotoxicity are important virulence mechanisms in Vibrio-fish epithelial cell interactions.

  1998cited by this paper
• Phenotypic characterization of the marine pathogen Photobacterium damselae subsp. piscicida.

  1998cited by this paper
• The acetylcholinesterase ichthyotoxin is a common component in the extracellular products of Vibrionaceae strains

  1998cited by this paper
• Survival of fish-virulent strains of Photobacterium damselae subsp. damselae in seawater under starvation conditions.

  1998cited by this paper
• Rapidly fatal infection due to Photobacterium (Vibrio) damsela.

  1997influential reference
• High affinity iron‐uptake systems in Vibrio damsela: role in the acquisition of iron from transferrin

  1997cited by this paper
• Primary Vibrio damsela septicemia.

  1996cited by this paper
• Small-subunit rRNA sequences and whole DNA relatedness concur for the reassignment of Pasteurella piscicida (Snieszko et al.) Janssen and Surgalla to the genus Photobacterium as Photobacterium damsela subsp. piscicida comb. nov.

  1995cited by this paper
• Histopathological lesions caused by Vibrio damsela in cultured turbot, Scophthalmus maximus (L.): inoculations with live cells and extracellular products

  1995influential reference
• Role of iron in the pathogenicity of Vibrio damsela for fish and mammals.

  1994influential reference
• Isolation and Characterization of Vibrio damsela Infectious for Cultured Shrimp in Taiwan

  1993cited by this paper
• Vibrio damsela. A cause of fulminant septicemia.

  1993cited by this paper
• Fatal necrotizing fasciitis due to Vibrio damsela.

  1993cited by this paper
• Toxicity of the extracellular products ofVibrio damsela isolated from diseased fish

  1993influential reference
• Phenotypic, antigenic, and molecular characterization of Pasteurella piscicida strains isolated from fish

  1992cited by this paper
• Characterization of Vibrio damsela strains isolated from turbot Scophthalmus maximus in Spain

  1992influential reference
• Deaths in captive eels (Anguila reinhardtii) due to Photobacterium (Vibrio) damsela.

  1992cited by this paper
• Bacteria associated with stranded cetaceans from the northeast USA and southwest Florida Gulf coasts

  1991cited by this paper
• Evaluation of the genus Listonella and reassignment of Listonella damsela (Love et al.) MacDonell and Colwell to the genus Photobacterium as Photobacterium damsela comb. nov. with an emended description.

  1991cited by this paper
• Cloning and expression of the damselysin gene from Vibrio damsela

  1990cited by this paper
• Vibrio damsela wound infections in Australia

  1989cited by this paper
• Vibrio damsela from wounds in bottlenose dolphins Tursiops truncates

  1988cited by this paper
• Phospholipase D activity of Vibrio damsela cytolysin and its interaction with sheep erythrocytes

  1987cited by this paper
• Vibrio damsela Infection in a Stranded Leatherback Turtle (Dermochelys coriacea)

  1987cited by this paper
• Vibrios as Autochthonous Flora of Neritic Sharks

  1985cited by this paper
• Isolation and characterization of two hemolytic phenotypes of Vibrio damsela associated with a fatal wound infection

  1985influential reference
• Purification and characterization of an extracellular cytolysin produced by Vibrio damsela

  1985cited by this paper
• Cytolytic activity and virulence of Vibrio damsela

  1984cited by this paper
• Vibrio species as agents of elasmobranch disease

  1984cited by this paper
• Fatal penetrating skin ulcers in laboratory-reared octopuses.

  1984cited by this paper
• Illness caused by Vibrio damsela and Vibrio hollisae.

  1982cited by this paper
• Vibrio damsela, a Marine Bacterium, Causes Skin Ulcers on the Damselfish Chromis punctipinnis

  1981cited by this paper
• Two Cases

  1944cited by this paper
• FIRST ISOLATION OF Vibrio damsela FROM SEABREAM ( Sparus aurata )

  year unknowncited by this paper

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• Dry-aged and dry-cured fish: a critical review of the literature and food safety aspects.

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• Characterization of Photobacterium damselae subsp. damselae isolated from a spotted seal (Phoca largha) (Pinnipedia: Phocidae) stranded in Korea

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• Plastic-associated pathogens in marine environments: a meta-analysis.

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• Fatal Hemorrhagic Septicemia in Common Guitarfish (Rhinobatos rhinobatos) Caused by Photobacterium damselae Subsp. damselae in a Controlled Environment.

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• Global analysis of protein lysine lactylation profiles in the marine bacterium Photobacterium damselae subsp. damselae

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• Detection of Photobacterium damselae Using Sandwich ELISA with Two Anti-Outer Membrane Protein Antibodies

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• Genomic overview of the N4-like TEMp-D1 phage and the efficacy of antibiotic-phage synergy for the biocontrol of Photobacterium damselae subsp. damselae

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• Unravelling the genomic secrets of bacterial fish pathogens: a roadmap to aquaculture sustainability

  2024cites this paper
• Development of a Colloidal Gold Immunochromatographic Strip for Specific Detection of Photobacterium damselae subsp. piscicida.

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  2024cites this paper
• Photobacterium damselae subsp. damselae in Stranded Cetaceans: A 6-Year Monitoring of the Ligurian Sea in Italy

  2024influential citation
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• A Novel Genomic Island Encodes Vibrioferrin Synthesis in the Marine Pathogen Photobacterium damselae subsp. damselae.

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  2023cites this paper
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  2023cites this paper
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