Differences between Human and Rodent Pancreatic Islets

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Biological Chemistry

• Publication date

  2011-03-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M111.241182PMID 21454710PMCID PMC3099655
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of insulin secretion: role of mitochondrial signalling

  2010cited by this paper
• Quantitative analysis of cell composition and purity of human pancreatic islet preparations

  2010cited by this paper
• Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.

  2010cited by this paper
• Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.

  2009cited by this paper
• Chronic Reduction of the Cytosolic or Mitochondrial NAD(P)-malic Enzyme Does Not Affect Insulin Secretion in a Rat Insulinoma Cell Line*

  2009cited by this paper
• Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

  2009cited by this paper
• Meta-analysis of gene expression in human pancreatic islets after in vitro expansion.

  2009cited by this paper
• Islet architecture: A comparative study

  2009cited by this paper
• The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

  2008cited by this paper
• Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion.

  2008cited by this paper
• The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells.

  2008cited by this paper
• Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase*

  2008cited by this paper
• Elimination of KATP Channels in Mouse Islets Results in Elevated [U-13C]Glucose Metabolism, Glutaminolysis, and Pyruvate Cycling but a Decreased γ-Aminobutyric Acid Shunt*

  2008cited by this paper
• Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion.

  2008cited by this paper
• Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

  2008cited by this paper
• Capillary LC-MS for high sensitivity metabolomic analysis of single islets of Langerhans.

  2008cited by this paper
• Feasibility of Pathways for Transfer of Acyl Groups from Mitochondria to the Cytosol to Form Short Chain Acyl-CoAs in the Pancreatic Beta Cell*

  2007cited by this paper
• Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion*

  2007cited by this paper
• Cytosolic and Mitochondrial Malic Enzyme Isoforms Differentially Control Insulin Secretion*

  2007cited by this paper
• Superiority of Small Islets in Human Islet Transplantation

  2007cited by this paper
• A Role for ATP-Citrate Lyase, Malic Enzyme, and Pyruvate/Citrate Cycling in Glucose-induced Insulin Secretion*

  2007cited by this paper
• Synergistic Potent Insulin Release by Combinations of Weak Secretagogues in Pancreatic Islets and INS-1 Cells*

  2007cited by this paper
• BMC Molecular Biology BioMed Central

  2006cited by this paper
• Anaplerotic molecules: Current and future

  2006cited by this paper
• Insights into the role of anaplerosis in insulin secretion: a 13C NMR study

  2006cited by this paper
• Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

  2006cited by this paper
• The RIN: an RNA integrity number for assigning integrity values to RNA measurements

  2006cited by this paper
• Nutrient Control of Insulin Secretion in Isolated Normal Human Islets

  2006cited by this paper
• Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.

  2005cited by this paper
• Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues.

  2005cited by this paper
• Involvement of specific proteins (Sp1/Sp3) and nuclear factor Y in basal transcription of the distal promoter of the rat pyruvate carboxylase gene in beta-cells.

  2005cited by this paper
• The export of metabolites from mitochondria and anaplerosis in insulin secretion.

  2003cited by this paper
• Export of metabolites from pancreatic islet mitochondria as a means to study anaplerosis in insulin secretion.

  2003cited by this paper
• Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.

  2003cited by this paper
• The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function*

  2002cited by this paper
• Sp/Krüppel-like transcription factors are essential for the expression of mitochondrial glycerol phosphate dehydrogenase promoter B.

  2002cited by this paper
• Critical role for cataplerosis via citrate in glucose-regulated insulin release.

  2002cited by this paper
• 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

  2002cited by this paper
• Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.

  2002cited by this paper
• Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.

  2002cited by this paper
• Survey of normal appearing mouse strain which lacks enzyme and NAD+-linked glycerol phosphate dehydrogenase: Normal pancreatic beta cell function, but abnormal metabolite pattern in skeltal muscle

  2001cited by this paper
• Functional Analysis of Two Promoters for the Human Mitochondrial Glycerol Phosphate Dehydrogenase Gene*

  2000cited by this paper
• Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

  2000cited by this paper
• The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction.

  2000cited by this paper
• Metabolic Fate of Glucose in Purified Islet Cells

  1997cited by this paper
• Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of Zucker Diabetic Fatty Rats

  1996cited by this paper
• Normalization by Insulin Treatment of Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of the GK Rat

  1996cited by this paper
• Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase.

  1996cited by this paper
• Quantifying the Carboxylation of Pyruvate in Pancreatic Islets (*)

  1996cited by this paper
• Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion.

  1995cited by this paper
• Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

  1995cited by this paper
• Enzymatic, metabolic and secretory patterns in human islets of Type 2 (non-insulin-dependent) diabetic patients

  1994cited by this paper
• Metabolism of the insulin secretagogue methyl succinate by pancreatic islets.

  1993cited by this paper
• Estimates of glycolysis, pyruvate (de)carboxylation, pentose phosphate pathway, and methyl succinate metabolism in incapacitated pancreatic islets.

  1993cited by this paper
• Glucose enters mitochondrial metabolism via both carboxylation and decarboxylation of pyruvate in pancreatic islets.

  1993cited by this paper
• Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1).

  1993cited by this paper
• Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats

  1993cited by this paper
• Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets

  1992cited by this paper
• Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells.

  1992cited by this paper
• Pyruvate dehydrogenase and pyruvate carboxylase. Sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets.

  1991cited by this paper
• Impairment of Glycerol Phosphate Shuttle in Islets From Rats With Diabetes Induced by Neonatal Streptozocin

  1991cited by this paper
• Ketone bodies and islet function: 45Ca handling, insulin synthesis, and release.

  1990cited by this paper
• High activity of mitochondrial glycerol phosphate dehydrogenase in insulinomas and carcinoid and other tumors of the amine precursor uptake decarboxylation system.

  1990cited by this paper
• Effect of β-hydroxybutyrate and acetoacetate on insulin and glucagon secretion from perfused rat pancreas

  1987cited by this paper
• Effect of beta-hydroxybutyrate and acetoacetate on insulin and glucagon secretion from perfused rat pancreas.

  1987cited by this paper
• A 14CO2 ratios method for detecting pyruvate carboxylation.

  1985cited by this paper
• Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants.

  1983cited by this paper
• Evidence for the malate aspartate shuttle in pancreatic islets.

  1982cited by this paper
• Flavin content of intracellular compartments of pancreatic islets compared with acinar tissue and liver.

  1981cited by this paper
• High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide.

  1981cited by this paper
• Nicotinamide adenine dinucleotide phosphate-converting enzymes and adenosine triphosphate citrate lyase in some tissues and organs of New Zealand obese mice with special reference to the enzyme pattern of the pancreatic islets.

  1975cited by this paper
• Controls of citrate synthase activity.

  1974cited by this paper
• Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

  1974cited by this paper
• Control of citric acid cycle activity in rat heart mitochondria.

  1970cited by this paper
• Paths of carbon in gluconeogenesis and lipogenesis. 3. The role and regulation of mitochondrial processes involved in supplying precursors of phosphoenolpyruvate.

  1966cited by this paper

• Evaluating the impact of lipids in isolated islet research

  2025cites this paper
• A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

  2025cites this paper
• Long-term storage, cryopreservation, and culture of isolated human islets: a systematic review

  2025cites this paper
• The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes

  2024cites this paper
• Secretome Analysis of Human and Rat Pancreatic Islets Co-Cultured with Adipose-Derived Stromal Cells Reveals a Signature with Enhanced Regenerative Capacities

  2024cites this paper
• Advancing Diabetes Research: A Novel Islet Isolation Method from Living Donors

  2024cites this paper
• Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells.

  2024cites this paper
• Beta-Hydroxybutyrate Promotes Basal Insulin Secretion While Decreasing Glucagon Secretion in Mouse and Human Islets

  2024influential citation
• Animal Models for Understanding the Mechanisms of Beta Cell Death during Type 2 Diabetes Pathogenesis

  2024cites this paper
• Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes

  2024cites this paper
• Characterizing the effects of Dechlorane Plus on β-cells: a comparative study across models and species

  2024cites this paper
• Do ketone supplements regulate islet hormone secretion?

  2024cites this paper
• The lipogenic enzyme acetoacetyl-CoA synthetase and ketone body utilization for denovo lipid synthesis, a review

  2023cites this paper
• Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

  2023cites this paper
• Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate

  2023cites this paper
• Mechanisms underlying the combination effect of arsenite and high‐fat diet on aggravating liver injury in mice

  2023cites this paper
• Understanding the Structural Arrangement of Islets in Chronic Pancreatitis

  2023cites this paper
• Pancreatic islet organoids-on-a-chip: how far have we gone?

  2022cites this paper
• Persistent organic pollutants and β-cell toxicity: a comprehensive review

  2022cites this paper
• Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic Development

  2022cites this paper
• Metabolism-secretion coupling in glucose-stimulated insulin secretion

  2022cites this paper
• Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation

  2022cites this paper
• Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells

  2022cites this paper
• Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals.

  2022cites this paper
• Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss.

  2021cites this paper
• Fatty acid synthesis and prostate cancer

  2021cites this paper
• Primate-specific ZNF808 is essential for pancreatic development in humans

  2021cites this paper
• Engineering islets from stem cells for advanced therapies of diabetes

  2021cites this paper
• Kinetic modelling of β‐cell metabolism reveals control points in the insulin‐regulating pyruvate cycling pathways

  2021cites this paper
• Non-glucose modulators of insulin secretion in healthy humans: (dis)similarities between islet and in vivo studies.

  2021cites this paper
• Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment.

  2021cites this paper
• Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes.

  2020cites this paper
• ReviewBeta Cell Imaging – From Pre-Clinical Validation to First in Man TestingStephane Demine 1

  2020cites this paper
• Profiles of two glycaemia modifying drugs on the expression of rat and human sulfotransferases.

  2020cites this paper
• Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing

  2020cites this paper
• Pyruvate kinase controls signal strength in the insulin secretory pathway

  2020cites this paper
• Characterization of Islet Leukocyte Populations in Human and Murine Islets by Flow Cytometry.

  2020cites this paper
• Isolation and characterization of human acetoacetyl-CoA synthetase splice variants

  2020cites this paper
• Controlled Heterotypic Pseudo-Islet Assembly of Human β-Cells and Human Umbilical Vein Endothelial Cells Using Magnetic Levitation

  2020cites this paper
• The relevance of AMP-activated protein kinase in insulin-secreting β cells: a potential target for improving β cell function?

  2019cites this paper
• Amino acid transporters in the regulation of insulin secretion and signalling.

  2019cites this paper
• Recent Insights Into Mechanisms of b -Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

  2019cites this paper
• Gluconeogenic Enzymes in β-Cells: Pharmacological Targets for Improving Insulin Secretion.

  2019cites this paper
• Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model.

  2019cites this paper
• Brain Signalling Systems: A target for treating Type I Diabetes Mellitus.

  2019cites this paper
• Engineered microenvironments and microdevices for modeling the pathophysiology of type 1 diabetes.

  2019cites this paper
• Modeling Monogenic Diabetes MODY3 Using Human Pluripotent Stem Cells

  2018cites this paper
• Establishment of the First Well-differentiated Human Pancreatic Neuroendocrine Tumor Model

  2018cites this paper
• Influence of organ donor attributes and preparation characteristics on the dynamics of insulin secretion in isolated human islets

  2018cites this paper
• Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells

  2018cites this paper
• Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range

  2018cites this paper
• Nutrient sensing in pancreatic islets: lessons from congenital hyperinsulinism and monogenic diabetes

  2018cites this paper
• Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells.

  2018cites this paper
• Design principles of the paradoxical feedback between pancreatic alpha and beta cells

  2018cites this paper
• Variability of mitochondrial respiration in relation to sepsis-induced multiple organ dysfunction.

  2018cites this paper
• Human Pluripotent Stem Cells and CRISPR-Cas9 Genome Editing to Model Diabetes

  2018cites this paper
• Sex Differences in Androgen Regulation of Metabolism in Nonhuman Primates.

  2017cites this paper
• Single-Cell Dissection of Human Pancreatic Islet Dysfunction in Diabetes

  2017cites this paper
• Stem Cell-Derived Insulin-Producing β Cells to Treat Diabetes

  2017cites this paper
• Role of Prolyl 4-Hydroxylase in Pancreatic ß-cell Insulin Secretion

  2017cites this paper
• Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.

  2017cites this paper
• Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.

  2017cites this paper
• Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

  2017cites this paper
• Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes

  2017cites this paper
• Pharmacological approach to understanding the control of insulin secretion in human islets

  2017cites this paper
• Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion.

  2017cites this paper
• The Pancreatic β-Cell: A Bioenergetic Perspective.

  2016cites this paper
• Exciting Times for Pancreatic Islets: Glutamate Signaling in Endocrine Cells.

  2016cites this paper
• Metabolic and proteomic characterization of primary hepatocytes in different in vitro cultivation conditions

  2016cites this paper
• Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.

  2016cites this paper
• Discovery of a Genetic Metabolic Cause for Mauriac Syndrome in Type 1 Diabetes

  2016cites this paper
• Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion

  2016cites this paper
• Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells

  2015cites this paper
• Structural similarities and differences between the human and the mouse pancreas

  2015cites this paper
• Regulatory role of adenosine in insulin secretion from pancreatic β-cells—Action via adenosine A1 receptor and beyond

  2015cites this paper
• Quantitative Phosphoproteomics Revealed Glucose-Stimulated Responses of Islet Associated with Insulin Secretion.

  2015cites this paper
• Fibrin supports human fetal islet-epithelial cell differentiation via p70s6k and promotes vascular formation during transplantation

  2015cites this paper
• Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation*

  2015cites this paper
• The Role of Integrins in Support of Pancreatic Function, Survival and Maturation

  2014cites this paper
• Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes

  2014cites this paper
• Metabolic regulation of insulin secretion.

  2014cites this paper
• THE EVALUATION OF DIETARY BETAINE, PRE AND PROBIOTICS, TRANSITIONAL SUBSTRATES, AND B-MERCAPTOACETATE ON PHYSIOLOGICAL, METABOLIC, HORMONAL AND PRODUCTION RESPONSES IN LACTATING HOLSTEIN COWS SUBJECTED TO THERMAL STRESS.

  2014cites this paper
• Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion*

  2014cites this paper
• Role of C-Kit Receptor Tyrosine Kinase on INS-1 Cell VEGF-A Expression in Vitro

  2014cites this paper
• Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans

  2014cites this paper
• Production of Transgenic Nonhuman Primates

  2014cites this paper
• Of rodents and men: species-specific glucose regulation and type 2 diabetes research.

  2014cites this paper
• On the Role of Mitochondria in Pancreatic Beta Cells

  2013cites this paper
• Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice*

  2013cites this paper
• Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.

  2013cites this paper
• Regulation of insulin secretion in human pancreatic islets.

  2013cites this paper
• Immortalization of MIP-GFP Neurons from the Hypothalamus and Neuronal Cell Types from Human Islet Isolates

  2013cites this paper
• Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 diabetes mellitus.

  2013cites this paper
• Metabolic signaling in fuel-induced insulin secretion.

  2013cites this paper
• Minireview: intraislet regulation of insulin secretion in humans.

  2013cites this paper
• Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

  2013cites this paper
• Étude dans la cellule bêta pancréatique de voies inhibitrices de la sécrétion d'insuline liées au métabolisme des lipides

  2013cites this paper
• High Level of ATP Citrate Lyase Expression in Human and Rat Pancreatic Islets

  2012cites this paper
• Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

  2012cites this paper
• ATP-citrate lyase: a key player in cancer metabolism.

  2012cites this paper