SCIENCE@home

The roles of GTPase-activating proteins in regulated cell death and tumor immunity

Hua He,Jingjing Huang,Sufang Wu,Shiyao Jiang,Lu Liang,Yueying Liu,Wenbing Liu,Li Xie,Y. Tao,Yiqun Jiang,Li Cong

Published 2021 in Journal of Hematology & Oncology

ABSTRACT

GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 145 references · Page 1 of 2

12
Next

CITED BY

Showing 1-39 of 39 citing papers · Page 1 of 1