Control of host mitochondria by bacterial pathogens.

Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.

• Publication year

  2021

• Venue

  Trends in Microbiology

• Publication date

  2021-10-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tim.2021.09.010PMID 34656395
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii

  2021cited by this paper
• Reverting the mode of action of the mitochondrial FOF1-ATPase by Legionella pneumophila preserves its replication niche

  2021cited by this paper
• Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy

  2021cited by this paper
• Function and regulation of the divisome for mitochondrial fission

  2021cited by this paper
• Recombinant Rv1654 protein of Mycobacterium tuberculosis induces mitochondria‐mediated apoptosis in macrophage

  2021cited by this paper
• Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice

  2021cited by this paper
• Ca2+ Fluxes and Cancer.

  2020cited by this paper
• Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis

  2020cited by this paper
• Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy.

  2020cited by this paper
• Type 3 IP3 receptors: The chameleon in cancer.

  2020cited by this paper
• The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis

  2020cited by this paper
• Mitochondrial Functions in Infection and Immunity

  2020cited by this paper
• Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy

  2020cited by this paper
• Mycobacterial origin protein Rv0674 localizes into mitochondria, interacts with D-loop and regulates OXPHOS for intracellular persistence of Mycobacterium tuberculosis.

  2020cited by this paper
• Autophagic cell death in viral infection: Do TAM receptors play a role?

  2020cited by this paper
• Regulation of Mitochondrial Ca2+ Uptake.

  2020cited by this paper
• Stenotrophomonas maltophilia outer membrane protein A induces epithelial cell apoptosis via mitochondrial pathways

  2020cited by this paper
• Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.

  2020cited by this paper
• Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

  2020cited by this paper
• Bcl-2 family proteins, beyond the veil.

  2020cited by this paper
• Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

  2020cited by this paper
• Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages

  2020cited by this paper
• Phylogenetic analyses with systematic taxon sampling show that mitochondria branch within Alphaproteobacteria

  2020cited by this paper
• Listeria monocytogenes Exploits Mitochondrial Contact Site and Cristae Organizing System Complex Subunit Mic10 To Promote Mitochondrial Fragmentation and Cellular Infection

  2020cited by this paper
• The role of mitochondria-associated membranes in cellular homeostasis and diseases.

  2020cited by this paper
• The mechanisms and cell signaling pathways of programmed cell death in the bacterial world.

  2020cited by this paper
• Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR

  2020cited by this paper
• Intracellular Staphylococcus aureus Perturbs the Host Cell Ca2+ Homeostasis To Promote Cell Death

  2020cited by this paper
• Figures and figure supplements Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

  2019cited by this paper
• Immunometabolism at the interface between macrophages and pathogens

  2019cited by this paper
• Completion of BAX recruitment correlates with mitochondrial fission during apoptosis

  2019cited by this paper
• ORP5 TRANSFERS PHOSPHATIDYLSERINE TO MITOCHONDRIA AND 1 REGULATES MITOCHONDRIAL CALCIUM UPTAKE AT ENDOPLASMIC 2 RETICULUM-MITOCHONDRIA CONTACT SITES 3 4

  2019cited by this paper
• Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery

  2019cited by this paper
• Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

  2019cited by this paper
• The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders.

  2019cited by this paper
• CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection

  2019cited by this paper
• Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction

  2019cited by this paper
• Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

  2019cited by this paper
• The Mechanisms of Disease Caused by Acinetobacter baumannii

  2019cited by this paper
• Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids.

  2018cited by this paper
• Ca2+ signals triggered by bacterial pathogens and microdomains.

  2018cited by this paper
• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  2018cited by this paper
• Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA

  2018cited by this paper
• Mycobacterium fortuitum-induced ER-Mitochondrial calcium dynamics promotes calpain/caspase-12/caspase-9 mediated apoptosis in fish macrophages

  2018cited by this paper
• Chlamydia trachomatis inclusion membrane protein MrcA interacts with the inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) to regulate extrusion formation

  2018cited by this paper
• Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

  2018cited by this paper
• Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

  2018cited by this paper
• S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

  2018cited by this paper
• Rubicon: LC3‐associated phagocytosis and beyond

  2018cited by this paper
• Decision letter: Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

  2018cited by this paper
• Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

  2018cited by this paper
• The machineries, regulation and cellular functions of mitochondrial calcium

  2018cited by this paper
• Linking cellular stress responses to systemic homeostasis

  2018cited by this paper
• Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation

  2018cited by this paper
• Metabolic Stress Drives Keratinocyte Defenses Against Staphylococcus aureus Infection

  2017cited by this paper
• The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells

  2017cited by this paper
• Mitochondrial fission facilitates the selective mitophagy of protein aggregates

  2017cited by this paper
• Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages

  2017cited by this paper
• MICU2 Restricts Spatial Crosstalk between InsP3R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU.

  2017cited by this paper
• MAMs are attractive targets for bacterial repurposing of the host cell

  2017cited by this paper
• Molecular definitions of autophagy and related processes

  2017cited by this paper
• The Origin and Diversification of Mitochondria.

  2017cited by this paper
• Chlamydia trachomatis plasmid-encoded protein pORF5 protects mitochondrial function by inducing mitophagy and increasing HMGB1 expression

  2017cited by this paper
• Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin

  2017cited by this paper
• Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17

  2017cited by this paper
• Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.

  2017cited by this paper
• Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission

  2017cited by this paper
• Brucella abortus Induces a Warburg Shift in Host Metabolism That Is Linked to Enhanced Intracellular Survival of the Pathogen

  2017cited by this paper
• AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

  2016cited by this paper
• Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

  2016cited by this paper
• Macrophage Apoptosis Triggered by IpaD from Shigella flexneri

  2016cited by this paper
• Mechanistic insights into selective autophagy pathways: lessons from yeast

  2016cited by this paper
• Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

  2016cited by this paper
• Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions.

  2016cited by this paper
• Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication

  2016cited by this paper
• The molecular era of the mitochondrial calcium uniporter

  2015cited by this paper
• Defective mitochondrial fission augments NLRP3 inflammasome activation

  2015cited by this paper
• Redox Homeostasis and Mitochondrial Dynamics.

  2015cited by this paper
• Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy

  2015cited by this paper
• PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

  2015cited by this paper
• Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

  2014cited by this paper
• Tumor suppressor p53 alters host cell metabolism to limit Chlamydia trachomatis infection.

  2014cited by this paper
• Bim is a crucial regulator of apoptosis induced by Mycobacterium tuberculosis

  2014cited by this paper
• Atypical mitochondrial fission upon bacterial infection

  2013cited by this paper
• Autophagosomes form at ER–mitochondria contact sites

  2013cited by this paper
• Induction of caspase 3 activation by multiple Legionella pneumophila Dot/Icm substrates

  2013cited by this paper
• Autophagy regulates phagocytosis by modulating the expression of scavenger receptors.

  2013cited by this paper
• Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

  2013cited by this paper
• Endoplasmic reticulum–mitochondria contacts: function of the junction

  2012cited by this paper
• Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype.

  2012cited by this paper
• Mitochondria: master regulators of danger signalling

  2012cited by this paper
• Correction: Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection

  2012cited by this paper
• Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death

  2011cited by this paper
• Helicobacter pylori VacA Reduces the Cellular Expression of STAT3 and Pro-survival Bcl-2 Family Proteins, Bcl-2 and Bcl-XL, Leading to Apoptosis in Gastric Epithelial Cells

  2011cited by this paper
• Neisserial Omp85 Protein Is Selectively Recognized and Assembled into Functional Complexes in the Outer Membrane of Human Mitochondria*

  2011cited by this paper
• Listeria monocytogenes transiently alters mitochondrial dynamics during infection

  2011cited by this paper
• Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

  2010cited by this paper
• Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1

  2010cited by this paper
• Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells.

  2009cited by this paper
• Regulation of mitochondrial dehydrogenases by calcium ions.

  2009cited by this paper

• Mitochondria as sources and targets of cellular signaling.

  2026cites this paper
• A two-step actin-mediated strategy enables Campylobacter jejuni to promote mitochondrial aggregation and iron homeostasis, for intracellular survival and persistence.

  2026cites this paper
• Complex I preserves mitochondrial polarization during infection of human macrophages by secretion-competent bacteria

  2025cites this paper
• Mitochondria-lysosome crosstalk in microbial infections

  2025cites this paper
• Oridonin mitigates bacterial pneumonia by regulating mitochondrial integrity and ferroptosis via targeting KEAP1/NRF2 signaling.

  2025cites this paper
• Mechanisms and interventions of Aeromonas hydrophila-induced hepatic injury in Megalobrama amblycephala: Focus on oxidative stress-mediated mitochondrial apoptosis

  2025cites this paper
• Endoplasmic Reticulum Stress in Tuberculosis: Molecular Bases and Pathophysiological Implications in the Immunopathogenesis of the Disease

  2025cites this paper
• Analysis of cytosolic mtDNA release during Staphylococcus aureus infection.

  2025cites this paper
• Bacterial predators and BALOs: Growth protocol and relation with mitochondria.

  2025cites this paper
• Monitoring cellular dynamics upon infection using a holotomography-based approach.

  2025cites this paper
• A screening system to determine the effect of bacterial metabolites on MAdCAM-1 expression by transformed endothelial sinusoidal cells.

  2025cites this paper
• Visualizing mitochondrial electron transport chain complexes and super-complexes during infection of human macrophages with Legionella pneumophila.

  2025cites this paper
• Quantification of mitochondrial reactive oxygen species in macrophages during sepsis.

  2025cites this paper
• Assessment of adhering and invading properties of Escherichia coli strains.

  2025cites this paper
• Monitoring the mitochondrial localization of mycobacterial proteins.

  2025cites this paper
• From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party

  2025influential citation
• Mitochondria as sensors of intracellular pathogens.

  2024cites this paper
• Extracellular niche establishment by plant pathogens

  2024cites this paper
• Avian pathogenic Escherichia coli T6SS effector protein Hcp2a causes mitochondrial dysfunction through interaction with LETM1 protein in DF-1 cells

  2024cites this paper
• Cross-regulation of Listeria monocytogenes and the host ubiquitin system in listeriosis.

  2024cites this paper
• Contribution of the Type III Secretion System (T3SS2) of Vibrio parahaemolyticus in Mitochondrial Stress in Human Intestinal Cells

  2024cites this paper
• The mitochondrial carboxylase PCCA interacts with Listeria monocytogenes phospholipase PlcB to modulate bacterial survival

  2024cites this paper
• Staphylococcus aureus Conquers Host by Hijacking Mitochondria via PFKFB3 in Epithelial Cells.

  2024cites this paper
• ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation

  2024cites this paper
• RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis

  2024cites this paper
• The MICOS Complex Subunit Mic60 is Hijacked by Intracellular Bacteria to Manipulate Mitochondrial Dynamics and Promote Bacterial Pathogenicity

  2024cites this paper
• Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages

  2024cites this paper
• Stress Granules in Infectious Disease: Cellular Principles and Dynamic Roles in Immunity and Organelles

  2024cites this paper
• Quantitative assessment of mitophagy in irradiated cancer cells.

  2023cites this paper
• Adaptive Nanoparticle-Mediated Modulation of Mitochondrial Homeostasis and Inflammation to Enhance Infected Bone Defect Healing.

  2023cites this paper
• Host cell sensing and restoration of mitochondrial function and metabolism within Helicobacter pylori VacA intoxicated cells

  2023cites this paper
• Restoration of mitochondrial structure and function within Helicobacter pylori VacA intoxicated cells.

  2023cites this paper
• Mitochondrial Dysfunction in Bacterial Infections

  2023cites this paper
• Restoration of mitochondrial structure and function within Helicobacter pylori VacA intoxicated cells

  2023cites this paper
• Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation

  2023influential citation
• Legionella and mitochondria, an intriguing relationship.

  2023cites this paper
• Role of mitochondrial outer membrane permeabilization during bacterial infection.

  2023cites this paper
• Designing Single‐Atom Active Sites on sp2‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

  2023cites this paper
• A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection

  2023cites this paper
• Induction of Endoplasmic Reticulum Stress by CdhM Mediates Apoptosis of Macrophage During Mycobacterium tuberculosis Infection

  2022cites this paper
• Chlamydia trachomatis Alters Mitochondrial Protein Composition and Secretes Effector Proteins That Target Mitochondria

  2022cites this paper
• Uropathogenic Escherichia coli subverts mitochondrial metabolism to enable intracellular bacterial pathogenesis in urinary tract infection

  2022cites this paper
• Voices from beyond the grave: The impact of apoptosis on the microenvironment.

  2022cites this paper
• Mitochondrial control of inflammation

  2022cites this paper
• Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells

  2022cites this paper