A method to determine and simulate the permeation through a gel matrix in a multi-organ-chip

Background The Multi-Organ-Chip (MOC) is a new micro size bioreactor. It offers two tissue cultivation segments (e.g. skin model, liver cells), which are connected by a dynamic micro pump system. [1,2] One future application of this system is the dermal application of substances for drug testing in vitro. In this study a method to simulate and validate the permeation of fluorescein sodium salt through a barrier in the MOC was established. Fluorescein sodium salt has a molecular weight of 376.28 g/mol which is in the range of steroid hormones like testosterone (288.4 g/mol), aldesterone (360.4 g/mol), hydrocortisone (362.5.4 g/ mol) and corticosterone (346 g/mol) [3]. Furthermore, first permeation experiments through four cell-collagen models, as reference for skin models, were carried out.

• Publication year

  2015

• Venue

  BMC Proceedings

• Publication date

  2015-12-14

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1186/1753-6561-9-S9-P77PMCID 4685434
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Generation and evaluation of input values for computational analysis of transport processes within tissue cultures

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