R. Pörtner

CHO and HepG2 Single-Cell Characterization With Planar Microchip Sensors up to 40 GHz
20230 citationsauthor #3
Design of cell expansion processes for adherent‐growing cells with mDoE‐workflow
20233 citationsauthor #2
Bioprocess intensification with model-assisted DoE-strategies for the production of biopharmaceuticals
20230 citationsauthor #3
A Capacitive Microwave Sensor With Guard Electrode for Single-Cell Characterization
20224 citationsauthor #3
New Insights from Locally Resolved Hydrodynamics in Stirred Cell Culture Reactors
202216 citationsauthor #5
Special Issue “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing”
20220 citationsauthor #1
Model-assisted DoE applied to microalgae processes
20222 citationsauthor #8
Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths
202229 citationsauthor #3
Generation and evaluation of input values for computational analysis of transport processes within tissue cultures
20221 citationsauthor #5
Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study
20215 citationsauthor #3
Computational Efforts for the Development and Scale-up of Antibody-Producing Cell Culture Processes
20210 citationsauthor #2
Digital Twins for Tissue Culture Techniques—Concepts, Expectations, and State of the Art
202137 citationsauthor #2
Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses
202118 citationsauthor #6
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
202123 citationsauthor #3
Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems
202112 citationsauthor #5
Cover Feature: Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells.
20210 citationsauthor #4
NMPC-Based Workflow for Simultaneous Process and Model Development Applied to a Fed-Batch Process for Recombinant C. glutamicum
20201 citationsauthor #9
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
20200 citationsauthor #3
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an industrial cell culture seed train
202013 citationsauthor #3
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train
20201 citationsauthor #3
Near-Physiological Cell Cycle Synchronization with Countercurrent Centrifugal Elutriation.
20201 citationsauthor #3
Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells
20209 citationsauthor #4
Estimation of Process Model Parameters.
20208 citationsauthor #7
Efficient Optimization of Process Strategies with Model-Assisted Design of Experiments.
20207 citationsauthor #2
Digital Twins and Their Role in Model-Assisted Design of Experiments.
202015 citationsauthor #2
Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes
202031 citationsauthor #9
Analytical and Bioanalytical Chemistry Electronic Supplementary Material Quantification of the dynamics of population heterogeneities in CHO cultures with stably integrated fluorescent markers
20205 citationsauthor #4
Single‐Use Bioreactors for Manufacturing of Immune Cell Therapeutics
20195 citationsauthor #1
Mass Production of Highly Active NK Cells for Cancer Immunotherapy in a GMP Conform Perfusion Bioreactor
201924 citationsauthor #5
Design and Operation of Fixed-Bed Bioreactors for Immobilized Bacterial Culture
20198 citationsauthor #1
Presentation_1_Mass Production of Highly Active NK Cells for Cancer Immunotherapy in a GMP Conform Perfusion Bioreactor.PPTX
20190 citationsauthor #5
Model-assisted Design of Experiments as a concept for knowledge-based bioprocess development
201971 citationsauthor #5
Biotechnology and Bioengineering
201921 citationsauthor #6
Model-assisted Design of Experiments for Algae Cultivation Fig. 2: Workflow of mDoE for algae
20190 citationsauthor #8
Development, Engineering and Biological Characterization of Stirred Tank Bioreactors
201815 citationsauthor #4
Model‐based identification of cell‐cycle‐dependent metabolism and putative autocrine effects in antibody producing CHO cell culture
201823 citationsauthor #3
Measurement and Simulation of Permeation and Diffusion in Native and Cultivated Tissue Constructs
20185 citationsauthor #4
Model-assisted DoE - A concept study for cell culture process development
20181 citationsauthor #3
Model-based tools for optimal experiments in bioprocess engineering
201865 citationsauthor #7
Development of a process for the manufacturing of SU-8 100 for the use in cell culture
20182 citationsauthor #4
Population Dynamics in Antibody Producing CHO Cell Cultures
20180 citationsauthor #2
Bioengineering of a Full-Thickness Skin Equivalent in a 96-Well Insert Format for Substance Permeation Studies and Organ-On-A-Chip Applications
201836 citationsauthor #7
Robust GMP manufacturing process with IL-2 and a glycoprotein antibody cocktail generates highly active human NK cell batches for cancer immunotherapy
20180 citationsauthor #3
Model-Based Design of Process Strategies for Cell Culture Bioprocesses
20180 citationsauthor #1
A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
201825 citationsauthor #8
A2.1 - BioMEMS for sensing in cell characterization, drug screening and biofilm detection
20171 citationsauthor #6
Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes
201719 citationsauthor #3
Standardized expansion of human adipose tissue-derived stromal/stem cells (hASCs) in wave-mixed single-use bioreactors with one- dimensional motion
20171 citationsauthor #6
Advanced Process and Control Strategies for Bioreactors
201732 citationsauthor #1
Modeling Suspension Cultures of Microbial and Mammalian Cells with an Adaptable Six‐Compartment Model
20178 citationsauthor #3
Landscape of Manufacturing Process of ATMP Cell Therapy Products for Unmet Clinical Needs
20177 citationsauthor #1
Standardized Qualification of Stirred Bioreactors for Microbial Biopharmaceutical Production Processes
20175 citationsauthor #9
Ringvorlesung „Tissue Engineering – Regenerative Medizin“ WiSe 16/17
20170 citationsauthor #1
Evaluation of Fixed-Bed Cultures with Immobilized Lactococcus Lactis ssp. Lactis on Different Scales
20172 citationsauthor #4
Oncolytic MV Particles : New Aspects for MV Production
20170 citationsauthor #5
Cell Culture Technology
20164 citationsauthor #1
Multi-Fixed-Bed Bioreactor System Applied for Bioprocess Development of Immobilized Lactic Acid Bacteria
201611 citationsauthor #3
Experimental Investigation and Reaction Kinetics Modeling of Biomass Formation, Substrate Consumption and Product Formation During Startup of Fixed-Bed Cultures with Immobilized Lactococcus lactis ssp. lactis
20162 citationsauthor #3
Fermentation of Lactic Acid Bacteria: State of the Art and New Perspectives
20165 citationsauthor #1
Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes
201657 citationsauthor #6
Model-based strategy for cell culture seed train layout verified at lab scale
20167 citationsauthor #3
Decision tree for selection of suitable cultivation parameters for mammalian cell culture processes
20151 citationsauthor #1
A method to determine and simulate the permeation through a gel matrix in a multi-organ-chip
20151 citationsauthor #5
Considerations for cell passaging in cell culture seed trains
20150 citationsauthor #2
Confocal Raman investigation of diffusion processes in monolithic type transdermal drug delivery systems
20159 citationsauthor #4
Synchronized mammalian cell culture: Part II—population ensemble modeling and analysis for development of reproducible processes
201524 citationsauthor #3
Model-based DoE for feed batch cultivation of a CHO cell line
20154 citationsauthor #4
Synchronized mammalian cell culture: Part I—A physical strategy for synchronized cultivation under physiological conditions
201511 citationsauthor #5
Oncolytic measles viruses produced at different scales under serum‐free conditions
201517 citationsauthor #6
Model-based strategy for cell culture seed train layout verified at lab scale
201518 citationsauthor #6
Bioreactors for Mammalian Cells
201527 citationsauthor #1
In vitro efficacy and release study with anti-inflammatory drugs incorporated in adhesive transdermal drug delivery systems.
20142 citationsauthor #5
Mammalian cell culture synchronization under physiological conditions and population dynamic simulation
20140 citationsauthor #3
Mass Production of Mesenchymal Stem Cells — Impact of Bioreactor Design and Flow Conditions on Proliferation and Differentiation
201447 citationsauthor #2
Animal Cell Biotechnology
20144 citationsauthor #1
Process analytical technology (PAT) in insect and mammalian cell culture processes: dielectric spectroscopy and focused beam reflectance measurement (FBRM).
201410 citationsauthor #6
Mammalian cell culture synchronization under physiological conditions and population dynamic simulation
201422 citationsauthor #3
In search of an effective cell disruption method to isolate intact mitochondria from Chinese hamster ovary cells
201415 citationsauthor #5
Batch‐to‐batch variability of two human designer cell lines – AGE1.HN and AGE1.HN.AAT – carried out by different laboratories under defined culture conditions using a mathematical model
20134 citationsauthor #11
A New Integrated Lab-on-a-Chip System for Fast Dynamic Study of Mammalian Cells under Physiological Conditions in Bioreactor
201315 citationsauthor #6
An integrated synchronization approach for studying cell-cycle dependent processes of mammalian cells under physiological conditions
20130 citationsauthor #4
Bioreaktoren für Knochen-Tissue-Engineering
20132 citationsauthor #1
Evaluation of process parameters in shake flasks for mammalian cell culture
20139 citationsauthor #3
A microfluidic device for immuno-affinity-based separation of mitochondria from cell culture.
201314 citationsauthor #4
A modular flow-chamber bioreactor concept as a tool for continuous 2D- and 3D-cell culture
20132 citationsauthor #10
Increase of Protein Yield in High Five Cells in a Single‐Use Perfusion Bioreactor by Medium Replacement
201310 citationsauthor #2
Electrical Stimulation of NIH-3T3 Cells with Platinum-PEDOT-Electrodes Integrated in a Bioreactor
20136 citationsauthor #4
Seed train optimization for suspension cell culture
20134 citationsauthor #2
Influence of process conditions on measles virus stability
201324 citationsauthor #7
Model-based design of the first steps of a seed train for cell culture processes
20133 citationsauthor #6
Interaction of cartilage and ceramic matrix.
20122 citationsauthor #3
Cell-surface interactions for tissue culture
20121 citationsauthor #3
The development of the collagen fibre network in tissue-engineered cartilage constructs in vivo. Engineered cartilage reorganises fibre network.
20128 citationsauthor #5
Protein-protein-interaction Network Organization of the Hypusine Modification System
201221 citationsauthor #12
Functional Characterisation of Human Hepatoma Cell Line HepG2 in 3D Culture
20120 citationsauthor #6
Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture
201241 citationsauthor #13
KEY PARAMETERS OF MEASLES VIRUS PRODUCTION FOR ONCOLYTIC VIROTHERAPY
201220 citationsauthor #5
Physical methods for synchronization of a human production cell line
20115 citationsauthor #6
Sequence analysis of CYP21A1P in a German population to aid in the molecular biological diagnosis of congenital adrenal hyperplasia.
201121 citationsauthor #5
3D-Bioreactor culture of human hepatoma cell line HepG2 as a promising tool for in vitro substance testing
20115 citationsauthor #9

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