Silk fibroin incorporated with methylcellulose as mutually functional scaffolds: Bone nucleation and biological signal attachment

Silk fibroin (SF) and methylcellulose (MC) scaffolds were fabricated in different ratios of 100% SF, SF:MC (90:10), SF:MC (80:20), and 100% MC. The morphologies were observed by scanning electron microscopy before mechanical testing and culturing with osteoblasts to evaluate cell viability and proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and protein absorption. SF/MC had interconnecting pores, network structures, low mechanical properties, spherical cells, cell proliferation at the early stage, high ALP activity, and fairly good calcium deposition along with protein absorption. SF:MC (90:10) had bone nucleation and biological signal attachment that showed promise for the bone‒cartilage interface.

• Publication year

  2021

• Venue

  MRS Communications

• Publication date

  2021-09-03

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1557/s43579-021-00081-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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