Current strategies for integrative cartilage repair

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Connective Tissue Research

• Publication date

  2017-09-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1080/03008207.2016.1231180PMID 27599801
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Microstructural changes in cartilage and bone related to repetitive overloading in an equine athlete model

  2014cited by this paper
• FTIR‐I Compositional Mapping of the Cartilage‐to‐Bone Interface as a Function of Tissue Region and Age

  2014cited by this paper
• Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation

  2014cited by this paper
• Stratified scaffolds for osteochondral tissue engineering applications: Electrospun PDLLA nanofibre coated Bioglass®-derived foams

  2013cited by this paper
• The bovine patella as a model of early osteoarthritis

  2013cited by this paper
• Applied osmotic loading for promoting development of engineered cartilage.

  2013cited by this paper
• Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration.

  2013cited by this paper
• Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

  2013cited by this paper
• Effects of bilayer gelatin/β-tricalcium phosphate sponges loaded with mesenchymal stem cells, chondrocytes, bone morphogenetic protein-2, and platelet rich plasma on osteochondral defects of the talus in horses.

  2013cited by this paper
• Clinical feasibility of a novel biphasic osteochondral composite for matrix-associated autologous chondrocyte implantation.

  2013cited by this paper
• The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold.

  2013cited by this paper
• Biomimetic biphasic 3-D nanocomposite scaffold for osteochondral regeneration

  2013cited by this paper
• Regeneration of a goat femoral head using a tissue-specific, biphasic scaffold fabricated with CAD/CAM technology.

  2013cited by this paper
• Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis

  2013cited by this paper
• Integrated Bi‐Layered Scaffold for Osteochondral Tissue Engineering

  2013cited by this paper
• Novel HA-PVA/NOCC bilayered scaffold for osteochondral tissue-engineering applications - Fabrication, characterization, in vitro and in vivo biocompatibility study

  2013cited by this paper
• The incorporation of a zone of calcified cartilage improves the interfacial shear strength between in vitro-formed cartilage and the underlying substrate.

  2012cited by this paper
• Simultaneous regeneration of articular cartilage and subchondral bone induced by spatially presented TGF-beta and BMP-4 in a bilayer affinity binding system.

  2012cited by this paper
• Graded biomimetic osteochondral scaffold prepared via CO2 foaming and micronized NaCl leaching

  2012cited by this paper
• Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals.

  2012cited by this paper
• A functional agarose-hydroxyapatite scaffold for osteochondral interface regeneration.

  2012cited by this paper
• Effects of aging on articular cartilage homeostasis.

  2012cited by this paper
• ACI and MACI

  2012cited by this paper
• Novel Nano-composite Multilayered Biomaterial for Osteochondral Regeneration

  2011cited by this paper
• A Hydrogel-Mineral Composite Scaffold for Osteochondral Interface Tissue Engineering

  2011cited by this paper
• In vitro generation of an osteochondral interface from mesenchymal stem cell-collagen microspheres.

  2011cited by this paper
• An Osteochondral Culture Model to Study Mechanisms Involved in Articular Cartilage Repair

  2011cited by this paper
• Post‐traumatic osteoarthritis: Improved understanding and opportunities for early intervention

  2011cited by this paper
• Continuous Gradients of Material Composition and Growth Factors for Effective Regeneration of the Osteochondral Interface

  2011cited by this paper
• Osteochondral Tissue Formation Through Adipose-Derived Stromal Cell Differentiation on Biomimetic Polycaprolactone Nanofibrous Scaffolds with Graded Insulin and Beta-Glycerophosphate Concentrations

  2011cited by this paper
• Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds.

  2011cited by this paper
• Chondrocyte repopulation of the zone of death induced by osteochondral harvest.

  2011influential reference
• Integration of Tissue-engineered Cartilage With Host Cartilage: An In Vitro Model

  2011cited by this paper
• Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid.

  2011cited by this paper
• Effects of introducing cultured human chondrocytes into a human articular cartilage explant model

  2010cited by this paper
• Novel nanostructured scaffold for osteochondral regeneration: pilot study in horses

  2010cited by this paper
• A novel MSC‐seeded triphasic construct for the repair of osteochondral defects

  2010cited by this paper
• Three-dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues.

  2010influential reference
• Bioactive Stratified Polymer Ceramic-Hydrogel Scaffold for Integrative Osteochondral Repair

  2010cited by this paper
• Osteochondral Interface Tissue Engineering Using Macroscopic Gradients of Bioactive Signals

  2010cited by this paper
• Osteoarthritis and You: Patient Information from the CDC

  2010cited by this paper
• Silk hydrogel for cartilage tissue engineering.

  2010cited by this paper
• Engineering human cell-based, functionally integrated osteochondral grafts by biological bonding of engineered cartilage tissues to bony scaffolds.

  2010cited by this paper
• Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors and medium perfusion.

  2010cited by this paper
• In situ measurement of transport between subchondral bone and articular cartilage

  2009cited by this paper
• Multiphasic collagen fibre–PLA composites seeded with human mesenchymal stem cells for osteochondral defect repair: an in vitro study

  2009cited by this paper
• Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces.

  2009cited by this paper
• A nanofibrous cell‐seeded hydrogel promotes integration in a cartilage gap model

  2009cited by this paper
• Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis

  2009cited by this paper
• The role of interstitial fluid pressurization in articular cartilage lubrication.

  2009cited by this paper
• The mineral phase of calcified cartilage: its molecular structure and interface with the organic matrix.

  2009cited by this paper
• Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP.

  2008cited by this paper
• Cartilage in normal and osteoarthritis conditions.

  2008cited by this paper
• Functionally graded electrospun polycaprolactone and beta-tricalcium phosphate nanocomposites for tissue engineering applications.

  2008cited by this paper
• Solute transport in the deep and calcified zones of articular cartilage.

  2008cited by this paper
• Chemotaxis of human articular chondrocytes and mesenchymal stem cells

  2008influential reference
• Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair.

  2007cited by this paper
• Formation of Biphasic Constructs Containing Cartilage with a Calcified Zone Interface

  2007cited by this paper
• Repair and regeneration of osteochondral defects in the articular joints.

  2007cited by this paper
• Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.

  2007cited by this paper
• Short-Duration Enzymatic Treatment Promotes Integration of a Cartilage Graft in a Defect

  2006influential reference
• Immunolocalization of matrix proteins in different human cartilage subtypes.

  2006cited by this paper
• Preparation of a biphasic scaffold for osteochondral tissue engineering

  2006cited by this paper
• Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model.

  2006cited by this paper
• Repair of Large Articular Osteochondral Defects Using Hybrid Scaffolds and Bone Marrow-Derived Mesenchymal Stem Cells in a Rabbit Model

  2006cited by this paper
• Two different correlations between nanoindentation modulus and mineral content in the bone-cartilage interface.

  2005influential reference
• Tissue-engineered osteochondral constructs in the shape of an articular condyle.

  2005cited by this paper
• Chondrocyte death associated with human femoral osteochondral harvest as performed for mosaicplasty.

  2005cited by this paper
• Co-culture of osteoblasts and chondrocytes modulates cellular differentiation in vitro.

  2005cited by this paper
• The cellular responses of articular cartilage to sharp and blunt trauma.

  2004cited by this paper
• The role of joint architecture in the etiology of arthritis.

  2004cited by this paper
• Motile chondrocytes from newborn calf: migration properties and synthesis of collagen II.

  2003cited by this paper
• Characteristics of mineral particles in the human bone/cartilage interface.

  2003cited by this paper
• Surgical Removal of Articular Cartilage Leads to Loss of Chondrocytes from Cartilage Bordering the Wound Edge

  2003cited by this paper
• Nanomechanical properties and mineral concentration in articular calcified cartilage and subchondral bone

  2003influential reference
• A three-dimensional osteochondral composite scaffold for articular cartilage repair.

  2002cited by this paper
• Ultrastructural localization of type VI collagen in normal adult and osteoarthritic human articular cartilage.

  2002cited by this paper
• Molecular pathology and pathobiology of osteoarthritic cartilage

  2002cited by this paper
• Specific enzymatic treatment of bovine and human articular cartilage: implications for integrative cartilage repair.

  2002influential reference
• Controlled Enzymatic Matrix Degradation for Integrative Cartilage Repair: Effects on Viable Cell Density and Proteoglycan Deposition

  2002cited by this paper
• Quantitative structural organization of normal adult human articular cartilage.

  2002cited by this paper
• Tissue-Engineered Fabrication of an Osteochondral Composite Graft Using Rat Bone Marrow-Derived Mesenchymal Stem Cells

  2001cited by this paper
• The effect of dynamic compression on the response of articular cartilage to insulin‐like growth factor‐I

  2001cited by this paper
• Microfracture techniques in the treatment of osteochondral injuries.

  2001cited by this paper
• Integration of engineered cartilage

  2001cited by this paper
• Structural Barrier Principle for Growth Factor-Based Articular Cartilage Repair

  2001cited by this paper
• A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants.

  2000cited by this paper
• Adhesive Force of Chondrocytes to Cartilage: Effects of Chondroitinase ABC

  2000cited by this paper
• In vitro generation of osteochondral composites.

  2000cited by this paper
• Immunolocalization of Collagen Types II and III in Single Fibrils of Human Articular Cartilage

  2000cited by this paper
• The reactions of articular cartilage to experimental wounding: role of apoptosis.

  2000cited by this paper
• Outgrowth of chondrocytes from human articular cartilage explants and expression of α‐smooth muscle actin

  2000cited by this paper
• Age-related accumulation of Maillard reaction products in human articular cartilage collagen.

  2000cited by this paper
• Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels.

  2000cited by this paper
• Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism.

  1999cited by this paper
• Characterization of the Mineral in Calcified Articular Cartilagenous Tissue Formed in Vitro

  1999cited by this paper
• Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue‐engineered cartilage

  1999cited by this paper
• Removal of proteoglycans from the surface of defects in articular cartilage transiently enhances coverage by repair cells.

  1998cited by this paper
• Mechanical properties of the collagen network in human articular cartilage as measured by osmotic stress technique.

  1998cited by this paper
• Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects A preliminary report

  1997cited by this paper

• 3D printing of scaffolds for articular cartilage/osteochondral regeneration: Design, performance, and applications

  2025cites this paper
• Allogenic Bioengineered Cartilage Achieves Hyaline Cartilage Repair in a Large Animal Model: A Promising Step Forward

  2025cites this paper
• Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral defects

  2025cites this paper
• Advanced 3D Bioprinting Technology for Cartilage Engineering and Regeneration.

  2025cites this paper
• Development and Application of a Novel Dynamic Loading Device for Molecular Transport in Articular Cartilage.

  2025cites this paper
• Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

  2024cites this paper
• Dextran-tryamine hydrogel maintains position and integrity under simulated loading in a human cadaver knee model

  2024cites this paper
• Continuous Low-Intensity Ultrasound Improves Cartilage Repair in Rabbit Model of Subchondral Injury

  2024cites this paper
• Fabrication of gelatin-heparin based cartilage models: enhancing spatial complexity through refinement of stiffness properties and oxygen availability

  2024cites this paper
• Hydrogel-Enhanced Autologous Chondrocyte Implantation for Cartilage Regeneration—An Update on Preclinical Studies

  2024cites this paper
• A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

  2024cites this paper
• Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo

  2024cites this paper
• Nanoengineered Endocytic Biomaterials for Stem Cell Therapy

  2024cites this paper
• 3D-printed gradient scaffolds for osteochondral defects: Current status and perspectives

  2023cites this paper
• Gradient porous structures of mycelium: a quantitative structure–mechanical property analysis

  2023cites this paper
• Articular Cartilage—From Basic Science Structural Imaging to Non-Invasive Clinical Quantitative Molecular Functional Information for AI Classification and Prediction

  2023cites this paper
• Bioinspired gradient scaffolds for osteochondral tissue engineering

  2023cites this paper
• Strategy Based on Michael Addition Reaction for the Development of Bioinspired Multilayered and Multiphasic 3D Constructs

  2023cites this paper
• 3D printed hydrogel for articular cartilage regeneration

  2022cites this paper
• The application of elastin-like peptides in cancer, tissue engineering and ocular disease

  2022cites this paper
• MV-mediated biomineralization mechanisms and treatments of biomineralized diseases

  2022cites this paper
• Perspective in Achieving Stratified Articular Cartilage Repair Using Zonal Chondrocytes

  2022cites this paper
• Locally delivered modified citrus pectin - a galectin-3 inhibitor shows expected anti-inflammatory and unexpected regeneration-promoting effects on repair of articular cartilage defect.

  2022cites this paper
• [Effect of xanthohumol-loaded anti-inflammatory scaffolds on cartilage regeneration in goats].

  2022cites this paper
• Acellular Cartilage-Bone Allografts Restore Structure, Mechanics, and Surface Properties In Vivo, but Limit Recellularization and Integrative Repair

  2022cites this paper
• 3D‐Bioassembly of VH‐Spheroids for Cartilage Regeneration: in Vitro Evaluation of Chondrogenesis, Fusion and Lateral Integration

  2022cites this paper
• Roles of the calcified cartilage layer and its tissue engineering reconstruction in osteoarthritis treatment

  2022influential citation
• Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model.

  2022cites this paper
• Particulate ECM biomaterial ink is 3D printed and naturally crosslinked to form structurally-layered and lubricated cartilage tissue mimics

  2022cites this paper
• Next-Generation Marrow Stimulation Technology for Cartilage Repair: Basic Science to Clinical Application.

  2021cites this paper
• Influence of the Mechanical Environment on the Regeneration of Osteochondral Defects

  2021cites this paper
• Studies of Articular Cartilage Repair from 2009 to 2018: A Bibliometric Analysis of Articles

  2021cites this paper
• The Complexity of Joint Regeneration: How an Advanced Implant could Fail by Its In Vivo Proven Bone Component

  2021cites this paper
• Application of bone and cartilage extracellular matrices in articular cartilage regeneration

  2021cites this paper
• Green electrospinning for biomaterials and biofabrication

  2021cites this paper
• Artificial osteochondral interface of bioactive fibrous membranes mediating calcified cartilage reconstruction.

  2021cites this paper
• Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study

  2021cites this paper
• Silk fibroin incorporated with methylcellulose as mutually functional scaffolds: Bone nucleation and biological signal attachment

  2021cites this paper
• Enzyme-Cross-linked Gelatin Hydrogel Enriched with an Articular Cartilage Extracellular Matrix and Human Adipose-Derived Stem Cells for Hyaline Cartilage Regeneration of Rabbits.

  2020cites this paper
• Comparative anatomy and morphology of the knee in translational models for articular cartilage disorders. Part II: Small animals.

  2020cites this paper
• The Challenge of Cartilage Integration: Understanding a Major Barrier to Chondral Repair

  2020cites this paper
• Chondroitinase ABC Enhances Integration of Self-Assembled Articular Cartilage, but Its Dosage Needs to Be Moderated Based on Neocartilage Maturity

  2020cites this paper
• Composite Hydrogel Model of Cartilage Predicts Its Load-Bearing Ability

  2020cites this paper
• Functionally Graded Biomaterials for Use as Model Systems and Replacement Tissues

  2020cites this paper
• OP-REGB200042 1..17

  2020cites this paper
• Osteochondral repair combining therapeutics implant with Mesenchymal stem cells spheroids.

  2020cites this paper
• Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration

  2020cites this paper
• Catechol-modified poly(oxazoline)s with tunable degradability facilitate cell invasion and lateral cartilage integration

  2019cites this paper
• Tissue Engineering: An Alternative to Repair Cartilage

  2019cites this paper
• Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications.

  2019cites this paper
• Multilayer scaffolds for cartilage tissue engineering.

  2019cites this paper
• Trends in Scientific Reports on Cartilage Bioprinting: Scoping Review

  2019influential citation
• Self-assembled monolayers of phosphonates promote primary chondrocyte adhesion to silicon dioxide and polyvinyl alcohol materials

  2019cites this paper
• [Fabrication of poly (lactic-co-glycolic acid)/decellularized articular cartilage extracellular matrix scaffold by three-dimensional printing technology and investigating its physicochemical properties].

  2019cites this paper
• Trypsin Pre‐Treatment Combined With Growth Factor Functionalized Self‐Assembling Peptide Hydrogel Improves Cartilage Repair in Rabbit Model

  2019cites this paper
• Bioprinting of Human Musculoskeletal Interface

  2019cites this paper
• Report on a large animal study with Göttingen Minipigs where regenerates and controls for articular cartilage were created in a large number. Focus on the conditions of the operated stifle joints and suggestions for standardized procedures

  2019cites this paper
• Latest Advances in Cryogel Technology for Biomedical Applications

  2019cites this paper
• Therapeutic Effects of the Addition of Platelet-Rich Plasma to Bioimplants and Early Rehabilitation Exercise on Articular Cartilage Repair

  2018cites this paper
• The Scaffold-Articular Cartilage Interface: A Combined In Vitro and In Silico Analysis Under Controlled Loading Conditions.

  2018cites this paper
• Effects of TGF-β Overexpression via rAAV Gene Transfer on the Early Repair Processes in an Osteochondral Defect Model in Minipigs

  2018cites this paper
• Bioactive scaffolds for osteochondral regeneration

  2018cites this paper
• Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation

  2018cites this paper
• [Intra-articular injection of ascorbic acid/ferric chloride relieves cartilage degradation in rats with osteoarthritis].

  2018cites this paper
• Preparation of Polymeric and Composite Scaffolds by 3D Bioprinting.

  2018cites this paper
• Injectable self-crosslinking HA-SH/Col I blend hydrogels for in vitro construction of engineered cartilage.

  2018cites this paper
• Large Animal Models for Osteochondral Regeneration.

  2018cites this paper
• StarPEG/heparin-hydrogel based in vivo engineering of stable bizonal cartilage with a calcified bottom layer

  2018cites this paper
• [Preparation and in vitro evaluation of tissue engineered osteochondral integration of multi-layered scaffold].

  2018cites this paper
• Adipose-derived stem cell sheet encapsulated construct of micro-porous decellularized cartilage debris and hydrogel for cartilage defect repair.

  2017cites this paper
• Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components – Guidance of the inflammatory response as basis for osteochondral regeneration

  2017cites this paper
• Sustained Release of Transforming Growth Factor-β1 from Platelet-Rich Chondroitin Sulfate Glycosaminoglycan Gels

  2017cites this paper
• From intricate to integrated: Biofabrication of articulating joints

  2017cites this paper
• Studies on various culture systems for chondrocytes and osteoblasts

  2017cites this paper
• Interface tissue engineering

  2012cites this paper