SCIENCE@home

Multilayer scaffolds for cartilage tissue engineering.

Yaíma Campos,A. Almirall,G. Fuentes,H. Bloem,E. Kaijzel,L. J. Cruz

Published 2019 in Tissue engineering. Part B, Reviews

ABSTRACT

Herein we review the state-of-the-art in tissue engineering for repair of articular cartilage. Firstly, we describe the molecular, cellular and histologic structure and function of endogenous cartilage, focusing on chondrocytes, collagens, extracellular matrix (ECM) and proteoglycans. We then explore in vitro cell culture on scaffolds, discussing the difficulties involved in maintaining or obtaining a chondrocytic phenotype. Next, we discuss the diverse compounds and designs used for these scaffolds, including natural and synthetic biomaterials and porous, fibrous and multilayer architectures. We then report on the mechanical properties of different cell-loaded scaffolds, and the success of these scaffolds following in vivo implantation in small animals, in terms of generating tissue that structurally and functionally resembles native tissue. Lastly, we highlight future trends in this field. We conclude that, despite major technical advances made over the past 15 years, and continually improving results in cartilage repair experiments in animals, the development of clinically useful implants for regeneration of articular cartilage remains a challenge.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 172 references · Page 1 of 2

12
Next

CITED BY

Showing 1-56 of 56 citing papers · Page 1 of 1