CONTEXT A significant proportion of the first-degree female relatives of women with polycystic ovary syndrome (PCOS) may be at risk for developing PCOS. However, it is not known at which stage of pubertal development the hormonal and metabolic abnormalities ensue in PCOS. OBJECTIVE The aim of the study was to assess the reproductive and metabolic profiles of daughters of women with PCOS (PCOSd) during the peripubertal period, a stage during which the gonadal axis is activated and PCOS may become clinically manifest. DESIGN Ninety-nine PCOSd [30 prepubertal and 69 pubertal (Tanner II-V)] and 84 daughters of control women (Cd) (20 prepubertal and 64 pubertal) were studied. An oral glucose tolerance test, a GnRH agonist test (leuprolide acetate, 10 microg/kg sc), and a transabdominal ultrasound were performed. Gonadotropins, sex steroids, SHBG, glucose, insulin, and lipids were determined. RESULTS Both groups had similar chronological ages and body mass index sd scores according to Tanner stage distribution. Ovarian volume and 2-h insulin were significantly higher in PCOSd compared to Cd at all Tanner stages. In Tanner stages IV and V, basal testosterone and poststimulated LH, testosterone, and 17-hydroxyprogesterone concentrations were significantly higher in PCOSd compared to Cd. CONCLUSIONS Hyperinsulinemia and an increased ovarian volume are present in PCOSd before the onset of puberty and persist during pubertal development. The biochemical abnormalities of PCOS appear during late puberty. Considering the early onset and the nature of the alterations, PCOSd constitute a high-risk group for metabolic and reproductive derangements.
Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome.
T. Sir-Petermann,E. Codner,Virginia Pérez,B. Echiburú,M. Maliqueo,A. Ladrón de guevara,J. Preisler,N. Crisosto,Fernando Sánchez,F. Cassorla,S. Bhasin
Published 2009 in Journal of Clinical Endocrinology and Metabolism
ABSTRACT
PUBLICATION RECORD
- Publication year
2009
- Venue
Journal of Clinical Endocrinology and Metabolism
- Publication date
2009-11-01
- Fields of study
Biology, Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- 17-hydroxyprogesterone
A steroid hormone measured in the stimulated endocrine profile reported in the abstract.
- 2-h insulin
Insulin concentration measured two hours after the oral glucose tolerance test.
Aliases: 2 hour insulin, two-hour insulin
- basal testosterone
Unstimulated testosterone concentration measured at baseline before GnRH agonist stimulation.
Aliases: baseline testosterone
- biochemical abnormalities of pcos
The endocrine laboratory pattern associated with PCOS, including androgen and gonadotropin changes.
Aliases: biochemical abnormalities
- cd
The comparison cohort of daughters born to women without PCOS used as the control group.
Aliases: daughters of control women
- hyperinsulinemia
An elevated insulin state described in the conclusions and inferred from the metabolic testing.
- late puberty
The later pubertal stages, corresponding in this study to Tanner IV-V.
- ovarian volume
Ultrasound-derived measurement of ovary size used as a reproductive marker in the cohort.
- pcosd
The exposed cohort of daughters born to women with PCOS and evaluated before and during puberty.
Aliases: daughters of women with polycystic ovary syndrome
- peripubertal period
The developmental window spanning the prepubertal and pubertal stages assessed in the cohort.
- poststimulated lh
Luteinizing hormone concentration measured after the GnRH agonist challenge.
Aliases: stimulated LH, GnRH-stimulated LH
- tanner stage
A clinical pubertal staging system used here to stratify participants by developmental stage.
Aliases: Tanner II-V, Tanner IV and V
- testosterone
Serum androgen measured as part of the endocrine profile reported in the abstract.
REFERENCES
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