Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Toxicon

• Publication date

  2007-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TOXICON.2007.01.005PMID 17368702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glycosphingolipid-facilitated Membrane Insertion and Internalization of Cobra Cardiotoxin

  2006cited by this paper
• CARDIOTOXIN III INDUCES APOPTOSIS IN K562 CELLS THROUGH A MITOCHONDRIAL‐MEDIATED PATHWAY

  2005cited by this paper
• Induction of apoptosis in human leukemia K562 cells by cardiotoxin III.

  2005cited by this paper
• Amphiphilic β‐sheet cobra cardiotoxin targets mitochondria and disrupts its network

  2005cited by this paper
• Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.

  2004cited by this paper
• Recycling the cell cycle: cyclins revisited.

  2004cited by this paper
• Cardiotoxin-III selectively enhances activation-induced apoptosis of human CD8+ T lymphocytes.

  2003cited by this paper
• Heparin Binding Stabilizes the Membrane-bound Form of Cobra Cardiotoxin*

  2002cited by this paper
• Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines.

  2002cited by this paper
• Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.

  2002cited by this paper
• Separation and Structure-Function Studies of Taiwan Cobra Cardiotoxins

  2002cited by this paper
• SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

  2001cited by this paper
• Specific Residues within the α2 Integrin Subunit Cytoplasmic Domain Regulate Migration and Cell Cycle Progression via Distinct MAPK Pathways*

  2001cited by this paper
• Signal transduction by the JNK group of MAP kinases.

  2000cited by this paper
• Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.

  2000cited by this paper
• Cell cycle checkpoints and their inactivation in human cancer

  2000cited by this paper
• Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecan-induced apoptosis.

  2000cited by this paper
• Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis.

  1999cited by this paper
• Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin.

  1999cited by this paper
• Induction of cell‐cycle arrest and apoptosis by a novel retinobenzoic‐acid derivative, TAC‐101, in human pancreatic‐cancer cells

  1999cited by this paper
• Accumulation of cyclin B1, activation of cyclin B1‐dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol

  1998cited by this paper
• Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α*

  1998cited by this paper
• Regulation and function of the JNK subgroup of MAP kinases.

  1997cited by this paper
• Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis.

  1997cited by this paper
• Toxicity of the novel animal-derived anticancer agent, VRCTC-310: acute and subchronic studies in beagle dogs.

  1995cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• The cyclin‐dependent protein kinases and the control of cell division

  1994cited by this paper
• VRCTC-310 — A novel compound of purified animal toxins separates antitumor efficacy from neurotoxicity

  1993cited by this paper
• Pharmacokinetics of cytotoxin from Chinese cobra (Naja naja atra) venom.

  1993cited by this paper
• G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.

  1993cited by this paper
• Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and modes of enzyme inhibition.

  1993cited by this paper
• Fusion of sphingomyelin vesicles induced by proteins from Taiwan cobra (Naja naja atra) venom. Interactions of zwitterionic phospholipids with cardiotoxin analogues.

  1991cited by this paper
• Driving the cell cycle: M phase kinase, its partners, and substrates

  1990cited by this paper
• Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

  1990cited by this paper
• Driving the cell cycle: M phase kinase, its partners, and substrates.

  1990cited by this paper
• Checkpoints: controls that ensure the order of cell cycle events.

  1989cited by this paper
• Structure and pharmacology of elapid cytotoxins.

  1988cited by this paper

• Sulforaphane promoted mammary epithelial cell proliferation in Xizang sheep by increasing FOXM1 and PI3K-Akt signaling

  2026cites this paper
• Combination BRAFV600E Inhibition with the Multitargeting Tyrosine Kinase Inhibitor Axitinib Shows Additive Anticancer Activity in BRAFV600E -Mutant Anaplastic Thyroid Cancer

  2023cites this paper
• The secretory phenotypes of envenomed cells: Insights into venom cytotoxicity.

  2023cites this paper
• The myth of cobra venom cytotoxin: More than just direct cytolytic actions

  2022influential citation
• Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy

  2022cites this paper
• The myth of cobra venom cytotoxin: More than just direct cytolytic actions

  2022cites this paper
• Naja atra Cardiotoxin 1 Induces the FasL/Fas Death Pathway in Human Leukemia Cells

  2021cites this paper
• [1–9-NαC]-linusorb B2 and [1–9-NαC]-linusorb B3 isolated from flaxseed induce G1 cell cycle arrest on SGC-7901 cells by modulating the AKT/JNK signaling pathway

  2019cites this paper
• Chemopreventive activity of sulforaphane

  2018influential citation
• Cardiotoxin III Inhibits Hepatocyte Growth Factor‐Induced Epithelial‐Mesenchymal Transition and Suppresses Invasion of MDA‐MB‐231 Cells

  2016cites this paper
• Cardiotoxin III suppresses the invasiveness of MDA-MB-231 cells by targeting proto-oncogene tyrosine-protein kinase Src and reversing mesenchymal-to-epithelial transition

  2016cites this paper
• NKCT1 (purified Naja kaouthia protein toxin) conjugated gold nanoparticles induced Akt/mTOR inactivation mediated autophagic and caspase 3 activated apoptotic cell death in leukemic cell.

  2016cites this paper
• Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells.

  2016cites this paper
• Antiproliferative activity of cobra venom cytotoxins.

  2015cites this paper
• Cardiotoxin III suppresses hepatocyte growth factor–stimulated migration and invasion of MDA‐MB‐231 cells

  2014cites this paper
• The anticancer effect of cytotoxin 1 from Naja atra Cantor venom is mediated by a lysosomal cell death pathway involving lysosomal membrane permeabilization and cathepsin B release

  2013cites this paper
• Metallofullerol nanoparticles with low toxicity inhibit tumor growth by induction of G0/G1 arrest.

  2013cites this paper
• Cardiotoxin III Inhibits Proliferation and Migration of Oral Cancer Cells through MAPK and MMP Signaling

  2013cites this paper
• Inhibition of Src activation with cardiotoxin III blocks migration and invasion of MDA-MB-231 cells.

  2013cites this paper
• Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells.

  2012influential citation
• Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.

  2012cites this paper
• Improved method for the isolation, characterization and examination of neuromuscular and toxic properties of selected polypeptide fractions from the crude venom of the Taiwan cobra Naja naja atra.

  2012cites this paper
• Growth inhibition of a human colon carcinoma cell, COLO 201, by a natural product, Vitex agnus-castus fruits extract, in vivo and in vivo

  2012cites this paper
• Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells.

  2011cites this paper
• Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells.

  2010cites this paper
• JNK-mediated Phosphorylation of Cdc25C Regulates Cell Cycle Entry and G2/M DNA Damage Checkpoint*

  2010cites this paper
• JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125

  2009cites this paper
• Apoptosis of human hepatocellular carcinoma cell (HepG2) induced by cardiotoxin III through S-phase arrest.

  2009cites this paper
• Cytotoxicity of calotropin is through caspase activation and downregulation of anti‐apoptotic proteins in K562 cells

  2009cites this paper
• Involvement of p38 and c-Jun N-terminal protein kinase in cardiotoxin III-induced apoptosis of K562 cells.

  2009cites this paper
• Cardiotoxin III‐induced apoptosis is mediated by Ca2+‐dependent caspase‐12 activation in K562 cells

  2008cites this paper
• Chapter 4 JNK is constitutively active in mantle cell lymphoma : cell cycle deregulation and polyploidy by JNK inhibitor SP 600125

  2008cites this paper
• Biomimetic affinity purification of cardiotoxin and its pharmacological effects on the nervous system

  2008cites this paper