Amphiphilic β‐sheet cobra cardiotoxin targets mitochondria and disrupts its network

Recent advance in understanding the role of toxin proteins in controlling cell death has revealed that pro‐apoptotic viral proteins targeting mitochondria contain amphiphilic α‐helices with pore‐forming properties. Herein, we describe that the pore‐forming amphiphilic β‐sheet cardiotoxins (or cytotoxins, CTXs) from Taiwan cobra (Naja atra) also target mitochondrial membrane after internalization and act synergistically with CTX‐induced cytosolic calcium increase to disrupt mitochondria network. It is suggested that CTX‐induced fragmentation of mitochondria play a role in controlling CTX‐induced necrosis of myocytes and cause severe tissue necrosis in the victims.

• Publication year

  2005

• Venue

  FEBS Letters

• Publication date

  2005-06-06

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.febslet.2005.05.006PMID 15922335
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Author Index

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