The reverse transcriptase of the R2 non-LTR retrotransposon: continuous synthesis of cDNA on non-continuous RNA templates.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Molecular Biology

• Publication date

  2002-02-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/JMBI.2001.5369PMID 11866511
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evolutionary analyses of the human genome

  2001cited by this paper
• Phylogenetic analysis of ribonuclease H domains suggests a late, chimeric origin of LTR retrotransposable elements and retroviruses.

  2001cited by this paper
• Nucleic Acid Chaperone Activity of the ORF1 Protein from the Mouse LINE-1 Retrotransposon

  2001cited by this paper
• Crystal structure of HIV‐1 reverse transcriptase in complex with a polypurine tract RNA:DNA

  2001cited by this paper
• Integration of Bombyx mori R2 Sequences into the 28S Ribosomal RNA Genes of Drosophila melanogaster

  2000cited by this paper
• Retrotransposition of the I factor, a non-long terminal repeat retrotransposon of Drosophila, generates tandem repeats at the 3' end

  2000cited by this paper
• The domain structure and retrotransposition mechanism of R2 elements are conserved throughout arthropods.

  1999cited by this paper
• Identification of the endonuclease domain encoded by R2 and other site-specific, non-long terminal repeat retrotransposable elements.

  1999cited by this paper
• The age and evolution of non-LTR retrotransposable elements.

  1999cited by this paper
• RNA-Induced Changes in the Activity of the Endonuclease Encoded by the R2 Retrotransposable Element

  1998cited by this paper
• The impact of L1 retrotransposons on the human genome

  1998cited by this paper
• Reversing time: origin of telomerase.

  1998cited by this paper
• Retrohoming of a bacterial group II intron: mobility via complete reverse splicing, independent of homologous DNA recombination.

  1998cited by this paper
• Secondary structure model of the RNA recognized by the reverse transcriptase from the R2 retrotransposable element.

  1997cited by this paper
• Transposable elements: how non-LTR retrotransposons do it.

  1997cited by this paper
• Telomerase catalytic subunit homologs from fission yeast and human.

  1997cited by this paper
• De novo and DNA primer-mediated initiation of cDNA synthesis by the mauriceville retroplasmid reverse transcriptase involve recognition of a 3' CCA sequence.

  1997cited by this paper
• High frequency retrotransposition in cultured mammalian cells.

  1996cited by this paper
• Analysis of the 5' junctions of R2 insertions with the 28S gene: implications for non-LTR retrotransposition.

  1996cited by this paper
• Downstream 28S gene sequences on the RNA template affect the choice of primer and the accuracy of initiation by the R2 reverse transcriptase

  1996cited by this paper
• RNA template requirements for target DNA-primed reverse transcription by the R2 retrotransposable element

  1995cited by this paper
• R4, a non-LTR retrotransposon specific to the large subunit rRNA genes of nematodes.

  1995cited by this paper
• The Mauriceville plasmid of Neurospora spp. uses novel mechanisms for initiating reverse transcription in vivo

  1994cited by this paper
• The Mauriceville plasmid reverse transcriptase can initiate cDNA synthesis de novo and may be related to reverse transcriptase and DNA polymerase progenitor.

  1993cited by this paper
• 17 Bacterial Reverse Transcriptase

  1993cited by this paper
• Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition.

  1993cited by this paper
• Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.

  1992cited by this paper
• Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

  1992cited by this paper
• Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase

  1992cited by this paper
• The Mauriceville plasmid of Neurospora crassa: characterization of a novel reverse transcriptase that begins cDNA synthesis at the 3' end of template RNA

  1992cited by this paper
• Reverse transcriptase encoded by a human transposable element.

  1991cited by this paper
• Reverse transcriptase encoded by a retrotransposon from the trypanosomatid Crithidia fasciculata.

  1991cited by this paper
• Origin and evolution of retroelements based upon their reverse transcriptase sequences.

  1990cited by this paper
• Reverse transcriptases. Retrons in bacteria.

  1989cited by this paper
• Retrons in bacteria

  1989cited by this paper
• Synthesis of small RNAs using T7 RNA polymerase.

  1989cited by this paper
• Functional expression of a sequence-specific endonuclease encoded by the retrotransposon R2Bm.

  1988cited by this paper
• The next computer revolution

  1987cited by this paper
• Reverse transcription.

  1987cited by this paper
• Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

  1970cited by this paper
• Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

  1970cited by this paper
• RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

  1970cited by this paper

• Bidirectional effect of intestinal microbiome and host in circadian rhythm disruption: Environmental factors and breast cancer development.

  2026cites this paper
• Biology and utilization of R2 retrotransposons

  2025cites this paper
• Lineage-Specific Evolution, Structural Diversity, and Activity of R2 Retrotransposons in Animals

  2025cites this paper
• Structure and sequence at an RNA template 5′ end influence insertion of transgenes by an R2 retrotransposon protein

  2024cites this paper
• All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons.

  2024cites this paper
• Improved precision, sensitivity, and adaptability of ordered two-template relay cDNA library preparation for RNA sequencing

  2024cites this paper
• Characterization and implementation of the MarathonRT template-switching reaction to expand the capabilities of RNA-seq

  2024cites this paper
• Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

  2024cites this paper
• Improved precision, sensitivity, and adaptability of Ordered Two-Template Relay cDNA library preparation for RNA sequencing

  2024cites this paper
• Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription

  2023cites this paper
• The non-LTR retrotransposons of Entamoeba histolytica: genomic organization and biology

  2022cites this paper
• Separable structural requirements for cDNA synthesis, nontemplated extension, and template jumping by a non-LTR retroelement reverse transcriptase

  2022cites this paper
• Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR

  2022cites this paper
• How to start a LINE: 5’ switching rejuvenates LINE retrotransposons in tobacco and related Nicotiana species

  2022cites this paper
• Structural basis for template switching by a group II intron–encoded non-LTR-retroelement reverse transcriptase

  2021cites this paper
• Low-bias ncRNA libraries using ordered two-template relay: Serial template jumping by a modified retroelement reverse transcriptase

  2021cites this paper
• Biological Roles of Self‐Cleaving Ribozymes

  2021cites this paper
• R2 and Non-Site-Specific R2-Like Retrotransposons of the German Cockroach, Blattella germanica

  2020cites this paper
• Silence at the End: How Drosophila Regulates Expression and Transposition of Telomeric Retroelements.

  2020cites this paper
• Prostate-specific loss of UXT promotes cancer progression

  2019cites this paper
• Template switching by a group II intron reverse transcriptase: biochemical analysis and implications for RNA-seq

  2019influential citation
• Template-switching mechanism of a group II intron-encoded reverse transcriptase and its implications for biological function and RNA-Seq

  2019cites this paper
• Novel ribozymes: discovery, catalytic mechanisms, and the quest to understand biological function

  2019cites this paper
• Completion of LINE integration involves an open ‘4-way’ branched DNA intermediate

  2019influential citation
• Evolutionary modes of emergence of short interspersed nuclear element (SINE) families in grasses

  2017cites this paper
• Evolutionary Insights into RNA trans-Splicing in Vertebrates

  2016cites this paper
• Chemistry and Biology of Self-Cleaving Ribozymes.

  2015cites this paper
• LINE-1 activity as molecular basis for genomic instability associated with light exposure at night

  2015cites this paper
• Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution

  2015cites this paper
• The Biology of Retrotransposition in Entamoeba histolytica

  2015cites this paper
• Integration, Regulation, and Long-Term Stability of R2 Retrotransposons

  2015influential citation
• Discovery and biological function of self-cleaving ribozymes

  2015cites this paper
• The aging clock and circadian control of metabolism and genome stability

  2015cites this paper
• Diversity-generating Retroelements in Phage and Bacterial Genomes

  2014cites this paper
• Preferential Occupancy of R2 Retroelements on the B Chromosomes of the Grasshopper Eyprepocnemis plorans

  2014cites this paper
• Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase

  2014cites this paper
• Reverse transcriptase and intron number evolution.

  2014cites this paper
• Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing

  2013cites this paper
• Endonuclease domain of the Drosophila melanogaster R2 non-LTR retrotransposon and related retroelements: a new model for transposition

  2013cites this paper
• 28S junctions and chimeric elements of the rDNA targeting non-LTR retrotransposon R2 in crustacean living fossils (Branchiopoda, Notostraca).

  2012cites this paper
• The Retrohoming of Linear Group II Intron RNAs in Drosophila melanogaster Occurs by Both DNA Ligase 4–Dependent and –Independent Mechanisms

  2012cites this paper
• Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon

  2012cites this paper
• Recombinant SINEs are formed at high frequency during induced retrotransposition in vivo

  2012cites this paper
• Polymerization and nucleic acid-binding properties of human L1 ORF1 protein

  2011cites this paper
• CTCF contributes to the regulation of the ribosomal DNA in Drosophila melanogaster

  2011cites this paper
• Retrotransposons that maintain chromosome ends

  2011cites this paper
• Processing and Translation Initiation of Non-long Terminal Repeat Retrotransposons by Hepatitis Delta Virus (HDV)-like Self-cleaving Ribozymes*

  2011cites this paper
• The reverse transcriptase encoded by the non-LTR retrotransposon R2 is as error-prone as that encoded by HIV-1.

  2011cites this paper
• Different integration site structures between L1 protein-mediated retrotransposition in cis and retrotransposition in trans

  2010cites this paper
• Processing of insect retrotransposons by self-cleaving ribozymes

  2010cites this paper
• Genetic identification of potential RNA-binding regions in a group II intron-encoded reverse transcriptase.

  2010cites this paper
• Evolution of diverse mechanisms for protecting chromosome ends by Drosophila TART telomere retrotransposons

  2010cites this paper
• The biology and evolution of transposable elements in parasites.

  2010cites this paper
• 5S rRNA-derived and tRNA-derived SINEs in fruit bats.

  2009influential citation
• Bead-probe complex capture a couple of SINE and LINE family from genomes of two closely related species of East Asian cyprinid directly using magnetic separation

  2009cites this paper
• Genetic Evidence That the Non-Homologous End-Joining Repair Pathway Is Involved in LINE Retrotransposition

  2009cites this paper
• Author ' s personal copy 5 S rRNA-derived and tRNA-derived SINEs in fruit bats

  2009influential citation
• The diversity of retrotransposons and the properties of their reverse transcriptases.

  2008influential citation
• Directly accessing de novo L1 retrotransposition in the human germline

  2007cites this paper
• Retroplasmids: Linear and Circular Plasmids that Replicate via Reverse Transcription

  2007cites this paper
• Progress in understanding the biology of the human mutagen LINE‐1

  2007cites this paper
• Random strand transfer recombination (RSTR) for homology-independent nucleic acid recombination.

  2007cites this paper
• DNA-directed DNA polymerase and strand displacement activity of the reverse transcriptase encoded by the R2 retrotransposon.

  2007cites this paper
• DNA polymerization by the reverse transcriptase of the human L1 retrotransposon on its own template in vitro

  2006cites this paper
• Mechanisms involved in target sequence recognition and integration of human LINE-1 retrotransposons

  2005cites this paper
• Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joining.

  2005cites this paper
• Domain structure and three-dimensional model of a group II intron-encoded reverse transcriptase.

  2005cites this paper
• Competition between R1 and R2 transposable elements in the 28S rRNA genes of insects

  2005cites this paper
• Multiple template switches on LINE-directed reverse transcription: The most probable formation mechanism for the double and triple chimeric retroelements in mammals

  2005cites this paper
• Role of the Bombyx mori R2 element N-terminal domain in the target-primed reverse transcription (TPRT) reaction

  2005cites this paper
• SINEs and LINEs: symbionts of eukaryotic genomes with a common tail

  2005influential citation
• R2 Target-Primed Reverse Transcription: Ordered Cleavage and Polymerization Steps by Protein Subunits Asymmetrically Bound to the Target DNA

  2005cites this paper
• Genome-wide experimental identification and functional analysis of human specific retroelements

  2005cites this paper
• A New Mechanism of Retrogene Formation in Mammalian Genomes: In Vivo Recombination during RNA Reverse Transcription

  2005cites this paper
• RNA/protein interactions during group II intron splicing and toward group II intron targeting in mammalian cells

  2005cites this paper
• Group II Intron Homing Endonucleases: Ribonucleoprotein Complexes with Programmable Target Specificity

  2005cites this paper
• L1 integration in a transgenic mouse model.

  2005cites this paper
• Template jumping by a LINE reverse transcriptase has created a SINE-like 5S rRNA retropseudogene in Dictyostelium

  2004cites this paper
• Secondary structure models of the 3' untranslated regions of diverse R2 RNAs.

  2004cites this paper
• A group II intron-encoded maturase functions preferentially in cis and requires both the reverse transcriptase and X domains to promote RNA splicing.

  2004cites this paper
• Ty1 Mobilizes Subtelomeric Y′ Elements in Telomerase-Negative Saccharomyces cerevisiae Survivors

  2004cites this paper
• An Entamoeba histolytica LINE/SINE Pair Inserts at Common Target Sites Cleaved by the Restriction Enzyme-Like LINE-Encoded Endonuclease

  2004cites this paper
• Retroelements and formation of chimeric retrogenes

  2004cites this paper
• Genomic analysis of Drosophila melanogaster telomeres: full-length copies of HeT-A and TART elements at telomeres.

  2004cites this paper
• End-to-End Template Jumping by the Reverse Transcriptase Encoded by the R2 Retrotransposon*

  2004cites this paper
• Characterization of reverse transcriptase activity of the L1Tc retroelement from Trypanosoma cruzi

  2003cites this paper
• The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination.

  2003cites this paper
• High Processivity of the Reverse Transcriptase from a Non-long Terminal Repeat Retrotransposon*

  2002cites this paper
• Human L1 element target‐primed reverse transcription in vitro

  2002cites this paper