Progress in understanding the biology of the human mutagen LINE‐1

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Human Mutation

• Publication date

  2007-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/HUMU.20486PMID 17309057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective inhibition of Alu retrotransposition by APOBEC3G.

  2007cited by this paper
• Requirements for polyadenylation at the 3' end of LINE-1 elements.

  2007cited by this paper
• A large genomic deletion in the PDHX gene caused by the retrotranspositional insertion of a full‐length LINE‐1 element

  2007influential reference
• Identification and characterization of novel polymorphic LINE-1 insertions through comparison of two human genome sequence assemblies.

  2007cited by this paper
• DNA polymerization by the reverse transcriptase of the human L1 retrotransposon on its own template in vitro

  2006influential reference
• The ORF1 Protein Encoded by LINE-1: Structure and Function During L1 Retrotransposition

  2006cited by this paper
• Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes.

  2006cited by this paper
• Selection of Target Sites for Mobile DNA Integration in the Human Genome

  2006cited by this paper
• Methylation of endogenous human retroelements in health and disease.

  2006cited by this paper
• The dicistronic RNA from the mouse LINE-1 retrotransposon contains an internal ribosome entry site upstream of each ORF: implications for retrotransposition

  2006cited by this paper
• A novel insertion of a rearranged L1 element in exon 44 of the dystrophin gene: further evidence for possible bias in retroposon integration.

  2006cited by this paper
• Extensive individual variation in L1 retrotransposition capability contributes to human genetic diversity.

  2006cited by this paper
• Retrotransposition and Human Disorders

  2006cited by this paper
• Small interfering RNAs to the rescue: blocking L1 retrotransposition

  2006cited by this paper
• Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.

  2006cited by this paper
• Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles

  2006cited by this paper
• Cell Divisions Are Required for L1 Retrotransposition

  2006cited by this paper
• L1 retrotransposition in nondividing and primary human somatic cells.

  2006cited by this paper
• Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells

  2006cited by this paper
• Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling.

  2006cited by this paper
• Estimating the retrotransposition rate of human Alu elements.

  2006influential reference
• L1 Antisense Promoter Drives Tissue-Specific Transcription of Human Genes

  2006influential reference
• High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition

  2006cited by this paper
• LINE-1 RNA splicing and influences on mammalian gene expression

  2006influential reference
• APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.

  2006influential reference
• The Impact of LINE-1 Retro transposition on the Human Genome

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• LINE-1 Endonuclease-Dependent Retrotranspositional Events Causing Human Genetic Disease: Mutation Detection Bias and Multiple Mechanisms of Target Gene Disruption

  2006influential reference
• The human LINE-1 retrotransposon creates DNA double-strand breaks.

  2006cited by this paper
• APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition*

  2006cited by this paper
• APOBEC3B and APOBEC3F Inhibit L1 Retrotransposition by a DNA Deamination-independent Mechanism*

  2006cited by this paper
• Active retrotransposition by a synthetic L1 element in mice

  2006influential reference
• Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons

  2006cited by this paper
• L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells

  2006cited by this paper
• Unconventional translation of mammalian LINE-1 retrotransposons.

  2006influential reference
• Multiple Fates of L1 Retrotransposition Intermediates in Cultured Human Cells

  2005influential reference
• R2 Target-Primed Reverse Transcription: Ordered Cleavage and Polymerization Steps by Protein Subunits Asymmetrically Bound to the Target DNA

  2005cited by this paper
• Meta‐Analysis of gross insertions causing human genetic disease: Novel mutational mechanisms and the role of replication slippage

  2005influential reference
• Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joining.

  2005cited by this paper
• Genome sequence, comparative analysis and haplotype structure of the domestic dog

  2005cited by this paper
• Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia

  2005cited by this paper
• LINE-1 retrotransposition requires the nucleic acid chaperone activity of the ORF1 protein.

  2005cited by this paper
• Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition

  2005influential reference
• Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition.

  2005cited by this paper
• Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution.

  2005cited by this paper
• The structures of mouse and human L1 elements reflect their insertion mechanism

  2005cited by this paper
• Eukaryotic Translational Coupling in UAAUG Stop-Start Codons for the Bicistronic RNA Translation of the Non-Long Terminal Repeat Retrotransposon SART1

  2005cited by this paper
• L1 integration in a transgenic mouse model.

  2005influential reference
• A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease

  2005influential reference
• SVA elements: a hominid-specific retroposon family.

  2005cited by this paper
• The Innate Antiretroviral Factor APOBEC3G Does Not Affect Human LINE-1 Retrotransposition in a Cell Culture Assay*

  2004cited by this paper
• A YY1-binding site is required for accurate human LINE-1 transcription initiation.

  2004cited by this paper
• Cell Type-specific Expression of LINE-1 Open Reading Frames 1 and 2 in Fetal and Adult Human Tissues*

  2004influential reference
• Mobile Elements: Drivers of Genome Evolution

  2004cited by this paper
• Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

  2004cited by this paper
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution

  2004cited by this paper
• Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes

  2004influential reference
• A potential role for the nucleolus in L1 retrotransposition.

  2004influential reference
• End-to-End Template Jumping by the Reverse Transcriptase Encoded by the R2 Retrotransposon*

  2004cited by this paper
• How did alternative splicing evolve?

  2004influential reference
• Serial segmental duplications during primate evolution result in complex human genome architecture.

  2004cited by this paper
• Evolutionary impact of human Alu repetitive elements.

  2004cited by this paper
• The human L1 promoter: variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity.

  2004cited by this paper
• High-affinity, Non-sequence-specific RNA Binding by the Open Reading Frame 1 (ORF1) Protein from Long Interspersed Nuclear Element 1 (LINE-1)*

  2003cited by this paper
• Evolution by gene duplication: an update

  2003cited by this paper
• Tn5 as a model for understanding DNA transposition

  2003cited by this paper
• Hot L1s account for the bulk of retrotransposition in the human population

  2003cited by this paper
• The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination.

  2003cited by this paper
• An Alu transposition model for the origin and expansion of human segmental duplications.

  2003cited by this paper
• An important role for RUNX3 in human L1 transcription and retrotransposition.

  2003cited by this paper
• RNA truncation by premature polyadenylation attenuates human mobile element activity

  2003influential reference
• Tracking an embryonic L1 retrotransposition event

  2003cited by this paper
• The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons

  2003influential reference
• Functional reverse transcriptase encoded by the human LINE-1 from baculovirus-infected insect cells.

  2003influential reference
• LINE-mediated retrotransposition of marked Alu sequences

  2003cited by this paper
• Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu-mediated recombination events during evolution.

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002influential reference
• Origins and Evolution of Retrotransposons

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  2002influential reference
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  2002cited by this paper
• A mouse model of human L1 retrotransposition

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  2002cited by this paper
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• Human l1 retrotransposition is associated with genetic instability in vivo.

  2002influential reference
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  2002cited by this paper
• Evidence consistent with human L1 retrotransposition in maternal meiosis I.

  2002cited by this paper
• Ylli, a non-LTR retrotransposon L1 family in the dimorphic yeast Yarrowia lipolytica.

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• Nucleic Acid Chaperone Activity of the ORF1 Protein from the Mouse LINE-1 Retrotransposon

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• Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes

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• Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription.

  2001cited by this paper
• L1-like non-LTR retrotransposons in the yeast Candida albicans

  2001cited by this paper
• Biology of mammalian L1 retrotransposons.

  2001cited by this paper
• Twin priming: a proposed mechanism for the creation of inversions in L1 retrotransposition.

  2001cited by this paper
• Recent duplication, domain accretion and the dynamic mutation of the human genome.

  2001cited by this paper
• Human L1 Retrotransposition: cisPreference versus trans Complementation

  2001influential reference
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  2001influential reference

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