SOX‐11 regulates LINE‐1 retrotransposon activity during neuronal differentiation

Activity of the human long interspersed nuclear elements‐1 (LINE‐1) retrotransposon occurs mainly in early embryonic development and during hippocampal neurogenesis. SOX‐11, a transcription factor relevant to neuronal development, has unknown functions in the control of LINE‐1 retrotransposon activity during neuronal differentiation. To study the dependence of LINE‐1 activity on SOX‐11 during neuronal differentiation, we induced differentiation of human SH‐SY5Y neuroblastoma cells and adult adipose mesenchymal stem cells (hASCs) to a neuronal fate and found increased LINE‐1 activity. We also show that SOX‐11 protein binding to the LINE‐1 promoter is higher in differentiating neuroblastoma cells, while knock‐down of SOX‐11 inhibits the induction of LINE‐1 transcription in differentiating conditions. These results suggest that activation of LINE‐1 retrotransposition during neuronal differentiation is mediated by SOX‐11.

• Publication year

  2018

• Venue

  FEBS Letters

• Publication date

  2018-10-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/1873-3468.13260PMID 30276805
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene Targeting

  2020cited by this paper
• Engineered LINE-1 retrotransposition in nondividing human neurons

  2017cited by this paper
• Explorer Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

  2017cited by this paper
• Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

  2017cited by this paper
• The Human Long Interspersed Element-1 Retrotransposon: An Emerging Biomarker of Neoplasia.

  2017cited by this paper
• Retrotransposon Capture Sequencing (RC-Seq): A Targeted, High-Throughput Approach to Resolve Somatic L1 Retrotransposition in Humans.

  2016cited by this paper
• Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

  2016cited by this paper
• LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines

  2016cited by this paper
• Ubiquitous L1 Mosaicism in Hippocampal Neurons

  2015cited by this paper
• Primate-specific ORF0 contributes to retrotransposon-mediated diversity.

  2015cited by this paper
• SOX11 expression in chronic lymphocytic leukemia correlates with adverse prognostic markers

  2015cited by this paper
• LINE-1 Hypomethylation in Blood and Tissue Samples as an Epigenetic Marker for Cancer Risk: A Systematic Review and Meta-Analysis

  2014cited by this paper
• Flow cytometric assessment of lymphocyte subsets in Gaucher type 1 patients.

  2014cited by this paper
• Long interspersed element-1 protein expression is a hallmark of many human cancers.

  2014cited by this paper
• piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells

  2014cited by this paper
• Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes.

  2013cited by this paper
• Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

  2013cited by this paper
• Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology.

  2013cited by this paper
• Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

  2013cited by this paper
• The chromatin remodeler CHD7 regulates adult neurogenesis via activation of SoxC transcription factors.

  2013cited by this paper
• LINE-1 retrotransposition in the nervous system.

  2012cited by this paper
• Reprogramming of somatic cells.

  2012cited by this paper
• Landscape of Somatic Retrotransposition in Human Cancers

  2012cited by this paper
• Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility.

  2012cited by this paper
• Neurogenic differentiation of human adipose-derived stem cells: relevance of different signaling molecules, transcription factors, and key marker genes.

  2012cited by this paper
• Transcriptional Characterization of Wnt and Notch Signaling Pathways in Neuronal Differentiation of Human Adipose Tissue-Derived Stem Cells

  2011cited by this paper
• Critical roles for SoxC transcription factors in development and cancer.

  2010cited by this paper
• L1 retrotransposition in neurons is modulated by MeCP2

  2010cited by this paper
• Evaluation of LINE-1 mobility in neuroblastoma cells by in vitro retrotransposition reporter assay: FACS analysis can detect only the tip of the iceberg of the inserted L1 elements.

  2010cited by this paper
• Small RNAs as guardians of the genome.

  2009cited by this paper
• Small RNAs as Guardians of the Genome

  2009cited by this paper
• L1 retrotransposition in human neural progenitor cells

  2009cited by this paper
• The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.

  2008cited by this paper
• Progress in understanding the biology of the human mutagen LINE‐1

  2007cited by this paper
• LINE-1 retrotransposition in human embryonic stem cells.

  2007cited by this paper
• Concise Review: Adipose Tissue‐Derived Stromal Cells—Basic and Clinical Implications for Novel Cell‐Based Therapies

  2007cited by this paper
• Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types.

  2006cited by this paper
• SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth.

  2006cited by this paper
• The establishment of neuronal properties is controlled by Sox4 and Sox11.

  2006cited by this paper
• Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition

  2005cited by this paper
• Gene Targeting Reveals a Widespread Role for the High-Mobility-Group Transcription Factor Sox11 in Tissue Remodeling

  2004cited by this paper
• A YY1-binding site is required for accurate human LINE-1 transcription initiation.

  2004cited by this paper
• RNA truncation by premature polyadenylation attenuates human mobile element activity

  2003cited by this paper
• Hot L1s account for the bulk of retrotransposition in the human population

  2003cited by this paper
• Molecular archeology of L1 insertions in the human genome

  2002cited by this paper
• Human adipose tissue is a source of multipotent stem cells.

  2002cited by this paper
• Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription.

  2001cited by this paper
• A novel active L1 retrotransposon subfamily in the mouse.

  2001cited by this paper
• Nucleic Acid Chaperone Activity of the ORF1 Protein from the Mouse LINE-1 Retrotransposon

  2001cited by this paper
• Members of the SRY family regulate the human LINE retrotransposons.

  2000cited by this paper
• Mapping DNA target sites of chromatin proteins in vivo by formaldehyde crosslinking.

  1999cited by this paper
• CDK‐5‐Mediated Neurofilament Phosphorylation in SHSY5Y Human Neuroblastoma Cells

  1999cited by this paper
• Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition.

  1996cited by this paper
• Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development.

  1995cited by this paper
• An in vivo assay for the reverse transcriptase of human retrotransposon L1 in Saccharomyces cerevisiae

  1994cited by this paper
• A discrete LINE-1 transcript in mouse blastocysts.

  1993cited by this paper
• www.cognizantcommunication.com Differential Expression of Shh and BMP Signaling in the Potential Conversion of Human Adipose Tissue Stem Cells Into Neuron-Like Cells In

  year unknowncited by this paper

• An Exploratory Application of a CNS Tumor Methylation Classifier in Ovarian Neuroectodermal Tumors.

  2025cites this paper
• Transposable element dynamics in glioblastoma stem cells: insights from locus-specific quantification

  2025influential citation
• Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and aging

  2025cites this paper
• Low‐intensity pulsed ultrasound induces proliferation of human neural stem cells

  2024cites this paper
• Effects of transcription factor SOX11 on the biological behavior of neuroblastoma cell and potential regulatory mechanism

  2024cites this paper
• Transposon control as a checkpoint for tissue regeneration.

  2022cites this paper
• TFs for TEs: the transcription factor repertoire of mammalian transposable elements

  2021cites this paper
• Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors

  2021cites this paper
• Factors Regulating the Activity of LINE1 Retrotransposons

  2021cites this paper
• SOX11, SOX10 and MITF Gene Interaction: A Possible Diagnostic Tool in Malignant Melanoma

  2021cites this paper
• Retroviral Elements in Human Evolution and Neural Development

  2021cites this paper