The significance of regulatory light chain phosphorylation in cardiac physiology.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Archives of Biochemistry and Biophysics

• Publication date

  2011-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.abb.2011.02.013PMID 21345328PMCID PMC3114105
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential roles of regulatory light chain and myosin binding protein‐C phosphorylations in the modulation of cardiac force development

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• A Novel, In-solution Separation of Endogenous Cardiac Sarcomeric Proteins and Identification of Distinct Charged Variants of Regulatory Light Chain*

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• Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function.

  2010cited by this paper
• Cardiac Myosin Is a Substrate for Zipper-interacting Protein Kinase (ZIPK)*

  2009cited by this paper
• The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation.

  2009cited by this paper
• Ablation of Ventricular Myosin Regulatory Light Chain Phosphorylation in Mice Causes Cardiac Dysfunction in Situ and Affects Neighboring Myofilament Protein Phosphorylation*

  2009cited by this paper
• Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts.

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• Identification of Cardiac-Specific Myosin Light Chain Kinase

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• The regulation of smooth muscle contractility by zipper-interacting protein kinase.

  2007cited by this paper
• ROCK1 Phosphorylates and Activates Zipper-interacting Protein Kinase*

  2007cited by this paper
• Modulation of myosin phosphatase targeting subunit and protein phosphatase 1 in the heart.

  2005cited by this paper
• ZIP kinase, a key regulator of myosin protein phosphatase 1.

  2005cited by this paper
• Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development.

  2004cited by this paper
• Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence

  2004cited by this paper
• Handbook of Physiology, Section 2: The Cardiovascular System, Volume I: The Heart

  2004cited by this paper
• Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase.

  2003cited by this paper
• Modifications of myosin-regulatory light chain correlate with function of stunned myocardium.

  2003cited by this paper
• Alpha(1)-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation.

  2002cited by this paper
• A gradient of myosin regulatory light-chain phosphorylation across the ventricular wall supports cardiac torsion.

  2002cited by this paper
• The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation.

  2001cited by this paper
• Identification, Characterization, and Functional Analysis of Heart-specific Myosin Light Chain Phosphatase Small Subunit*

  2001cited by this paper
• Familial Hypertrophic Cardiomyopathy Mutations in the Regulatory Light Chains of Myosin Affect Their Structure, Ca2+Binding, and Phosphorylation*

  2001cited by this paper
• Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro

  2000cited by this paper
• Sequence and structure-based prediction of eukaryotic protein phosphorylation sites.

  1999cited by this paper
• Abnormal Cardiac Structure and Function in Mice Expressing Nonphosphorylatable Cardiac Regulatory Myosin Light Chain 2*

  1999cited by this paper
• A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping.

  1998cited by this paper
• Fluorescence polarization transients from rhodamine isomers on the myosin regulatory light chain in skeletal muscle fibers.

  1998cited by this paper
• Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains.

  1998cited by this paper
• Changes in interfilament spacing mimic the effects of myosin regulatory light chain phosphorylation in rabbit psoas fibers.

  1998cited by this paper
• Mechanism of action of endothelin in rat cardiac muscle: cross‐bridge kinetics and myosin light chain phosphorylation

  1997cited by this paper
• Evidence for myosin-binding phosphatase in heart myofibrils.

  1997cited by this paper
• The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.

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  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper
• Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function.

  1993cited by this paper
• Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase.

  1993cited by this paper
• Protein kinase C enhances myosin light-chain kinase effects on force development and ATPase activity in rat single skinned cardiac cells.

  1992cited by this paper
• Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: implications for regulation of actin-myosin interaction.

  1990cited by this paper
• Phosphorylation of rodent cardiac myosin light chain 2: effects of exercise.

  1989cited by this paper
• Variations in cross-bridge attachment rate and tension with phosphorylation of myosin in mammalian skinned skeletal muscle fibers. Implications for twitch potentiation in intact muscle

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• Further studies on the effects of myosin P-light chain phosphorylation on contractile properties of skinned cardiac fibres

  1986cited by this paper
• Phosphorylation of myosin in permeabilized mammalian cardiac and skeletal muscle cells.

  1986cited by this paper
• The influence of P‐light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned heart fibres

  1985cited by this paper
• The Cardiovascular System

  1983cited by this paper
• The effect of adrenaline on the phosphorylation of the P light chain of myosin and troponin I in the perfused rabbit heart.

  1981cited by this paper
• Activation of skeletal muscle myosin light chain kinase by calcium(2+) and calmodulin.

  1980cited by this paper
• Phosphorylation of myosin light chains in perfused rat heart. Effect of adrenaline and increased cytoplasmic calcium ions.

  1980cited by this paper
• Phosphorylation of myosin in perfused rabbit and rat hearts.

  1980cited by this paper
• The calcium binding properties of phosphorylated and unphosphorylated cardiac and skeletal myosins.

  1979cited by this paper
• Purification and characterization of bovine cardiac calmodulin-dependent myosin light chain kinase.

  1979cited by this paper
• Isolation of cardiac myofibrils and myosin light chains with in vivo levels of light chain phosphorylation.

  1979cited by this paper
• On the location of the divalent metal binding sites and the light chain subunits of vertebrate myosin.

  1977cited by this paper
• Changes in phosphorylation of P light chain of myosin in perfused rabbit heart

  1976cited by this paper
• Phosphorylation of the light-chain components of myosin from cardiac and red skeletal muscles.

  1975cited by this paper
• Substructure of the thick filament of vertebrate striated muscle.

  1974cited by this paper
• A phosphorylated light-chain component of myosin from skeletal muscle.

  1973cited by this paper
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