Peroxisomal protein import and ERAD: variations on a common theme

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrm3008PMID 21081964
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The peroxisomal importomer constitutes a large and highly dynamic pore

  2010cited by this paper
• Peroxisomal protein translocation.

  2010cited by this paper
• The peroxisomal matrix import of Pex8p requires only PTS receptors and Pex14p.

  2009cited by this paper
• Novel ubiquitin-dependent quality control in the endoplasmic reticulum.

  2009cited by this paper
• Properties of the Ubiquitin-Pex5p Thiol Ester Conjugate*

  2009cited by this paper
• Pex2 and Pex12 Function as Protein-Ubiquitin Ligases in Peroxisomal Protein Import

  2009cited by this paper
• The ubiquitylation machinery of the endoplasmic reticulum

  2009cited by this paper
• The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

  2009cited by this paper
• Members of the E2D (UbcH5) Family Mediate the Ubiquitination of the Conserved Cysteine of Pex5p, the Peroxisomal Import Receptor*

  2008cited by this paper
• Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p.

  2008cited by this paper
• The AAA+ superfamily of functionally diverse proteins

  2008cited by this paper
• The Recognition and Retrotranslocation of Misfolded Proteins from the Endoplasmic Reticulum

  2008cited by this paper
• Shuttles and cycles: transport of proteins into the peroxisome matrix (Review)

  2008cited by this paper
• Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling

  2007cited by this paper
• Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

  2007cited by this paper
• A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

  2007cited by this paper
• Ubiquitination of Mammalian Pex5p, the Peroxisomal Import Receptor*

  2007cited by this paper
• A Conserved Cysteine Residue of Pichia pastoris Pex20p Is Essential for Its Recycling from the Peroxisome to the Cytosol*

  2007cited by this paper
• Membrane association of the cycling peroxisome import receptor Pex5p.

  2007cited by this paper
• Evolutionary relationships and structural mechanisms of AAA+ proteins.

  2006cited by this paper
• Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.

  2006cited by this paper
• Dynamics of the peroxisomal import cycle of PpPex20p

  2006cited by this paper
• Peroxisome targeting signal 1: is it really a simple tripeptide?

  2006cited by this paper
• Membrane Topology of the Yeast Endoplasmic Reticulum-localized Ubiquitin Ligase Doa10 and Comparison with Its Human Ortholog TEB4 (MARCH-VI)*

  2006cited by this paper
• Modification of proteins by ubiquitin and ubiquitin-like proteins.

  2006cited by this paper
• PTS2 co-receptors: diverse proteins with common features.

  2006cited by this paper
• A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery

  2006cited by this paper
• The Hrd1p ligase complex forms a linchpin between ER‐lumenal substrate selection and Cdc48p recruitment

  2006cited by this paper
• Ubiquitination of the Peroxisomal Targeting Signal Type 1 Receptor, Pex5p, Suggests the Presence of a Quality Control Mechanism during Peroxisomal Matrix Protein Import*

  2005cited by this paper
• Shuttling Mechanism of Peroxisome Targeting Signal Type 1 Receptor Pex5: ATP-Independent Import and ATP-Dependent Export

  2005cited by this paper
• Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

  2005cited by this paper
• Peroxisomal matrix protein import: the transient pore model

  2005cited by this paper
• AAA+ proteins: have engine, will work

  2005cited by this paper
• Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol

  2005cited by this paper
• Distinct Machinery Is Required in Saccharomyces cerevisiae for the Endoplasmic Reticulum-associated Degradation of a Multispanning Membrane Protein and a Soluble Luminal Protein*

  2004cited by this paper
• Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

  2004cited by this paper
• Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin‐dependent protein degradation

  2004cited by this paper
• X-ray structure of a protein-conducting channel

  2004cited by this paper
• Metabolic and molecular basis of peroxisomal disorders: A review

  2004cited by this paper
• A membrane protein required for dislocation of misfolded proteins from the ER

  2004cited by this paper
• Ubiquitination of the peroxisomal import receptor Pex5p.

  2004cited by this paper
• Cystic fibrosis: premature degradation of mutant proteins as a molecular disease mechanism.

  2003cited by this paper
• The pathogenic peroxin Pex26p recruits the Pex1p–Pex6p AAA ATPase complexes to peroxisomes

  2003cited by this paper
• Protein translocons: multifunctional mediators of protein translocation across membranes.

  2003cited by this paper
• Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes.

  2003cited by this paper
• Insertion of Pex5p into the Peroxisomal Membrane Is Cargo Protein-dependent*

  2003cited by this paper
• CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

  2002cited by this paper
• Membrane Topology and Function of Der3/Hrd1p as a Ubiquitin-Protein Ligase (E3) Involved in Endoplasmic Reticulum Degradation*

  2001cited by this paper
• The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol.

  2001cited by this paper
• Pex18p Is Constitutively Degraded during Peroxisome Biogenesis*

  2001cited by this paper
• Characterization of Peroxisomal Pex5p from Rat Liver

  2000cited by this paper
• Pex22p of Pichia pastoris, Essential for Peroxisomal Matrix Protein Import, Anchors the Ubiquitin-Conjugating Enzyme, Pex4p, on the Peroxisomal Membrane

  1999cited by this paper
• Role of Cue1p in ubiquitination and degradation at the ER surface.

  1997cited by this paper
• Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

  1996cited by this paper
• Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin

  1996cited by this paper
• An oligomeric protein is imported into peroxisomes in vivo

  1994cited by this paper
• Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer.

  1994cited by this paper
• A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

  1993cited by this paper

• Import mechanism of peroxisomal proteins with an N-terminal signal sequence

  2025cites this paper
• ATP-Dependent Steps in Peroxisomal Protein Import.

  2024cites this paper
• Precise subcellular targeting approaches for organelle-related disorders.

  2024cites this paper
• Towards solving the mystery of peroxisomal matrix protein import.

  2023cites this paper
• The Pex6 N1 domain is required for Pex15 binding and proper assembly with Pex1

  2023cites this paper
• Import and quality control of peroxisomal proteins.

  2023cites this paper
• The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1

  2023cites this paper
• Effects of multiple stressors on pancreatic human islets proteome reveal new insights into the pathways involved

  2023cites this paper
• Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate

  2023cites this paper
• Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate

  2022cites this paper
• Biogenesis and metabolic homeostasis of trypanosomatid glycosomes: New insights and new questions

  2022cites this paper
• Peroxisomal ATPase ATAD1 acts in quality control of the protein import machinery

  2022cites this paper
• A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel

  2022cites this paper
• Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis

  2022cites this paper
• Good things come to those who bait: the peroxisomal docking complex

  2022cites this paper
• Structure and function of the peroxisomal ubiquitin ligase complex

  2022cites this paper
• Inferred Subcellular Localization of Peroxisomal Matrix Proteins of Guillardia theta Suggests an Important Role of Peroxisomes in Cryptophytes

  2022cites this paper
• Sharing the wealth: The versatility of proteins targeted to peroxisomes and other organelles

  2022cites this paper
• Unique Endomembrane Systems and Virulence in Pathogenic Protozoa

  2021cites this paper
• Evolucija ključnih peroksisomalnih proteina

  2021cites this paper
• Peroxisome import stress impairs ribosome biogenesis and induces endoplasmic reticulum genes

  2020cites this paper
• Peroxisome import stress impairs ribosome biogenesis and induces integrative stress response through eIF2α phosphorylation

  2020cites this paper
• The Principles of Protein Targeting and Transport Across Cell Membranes

  2019cites this paper
• Current Advances in Protein Import into Peroxisomes

  2019cites this paper
• Towards the molecular architecture of the peroxisomal receptor docking complex

  2019cites this paper
• Receptor recognition by the peroxisomal AAA complex depends on the presence of the ubiquitin moiety and is mediated by Pex1p

  2018cites this paper
• Meiotic development initiation in the fungus Podospora anserina requires the peroxisome receptor export machinery.

  2018cites this paper
• ATP-driven processes of peroxisomal matrix protein import

  2017cites this paper
• The VDAC2–BAK axis regulates peroxisomal membrane permeability

  2017cites this paper
• The VDAC2–BAK axis regulates peroxisomal membrane permeability

  2017cites this paper
• Distribution and Evolution of Peroxisomes in Alveolates (Apicomplexa, Dinoflagellates, Ciliates)

  2017cites this paper
• Evolution of peroxisomes illustrates symbiogenesis

  2017cites this paper
• Peroxisome Function, Biogenesis, and Dynamics in Plants1[OPEN]

  2017cites this paper
• The VDAC2–BAK axis regulates peroxisomal membrane permeability

  2017cites this paper
• Update on Plant Peroxisomes Peroxisome Function , Biogenesis , and Dynamics in Plants 1 [ OPEN ]

  2017cites this paper
• A role for mRNA trafficking and localized translation in peroxisome biogenesis and function?

  2016cites this paper
• Einblick in den Mechanismus des Pex1p/Pex6p‐AAA\(^{+}\)‐Komplexes der peroxisomalen Matrixprotein‐Importmaschinerie mittels Struktur‐Funktionsanalysen

  2016cites this paper
• Peroxisomal protein import pores.

  2016cites this paper
• Protein–protein interactions indicate composition of a 480 kDa SELMA complex in the second outermost membrane of diatom complex plastids

  2016cites this paper
• Peroxisomes in parasitic protists.

  2016cites this paper
• Genetic Interactions between PEROXIN12 and Other Peroxisome-Associated Ubiquitination Components1[OPEN]

  2016cites this paper
• Regulation of peroxisomal matrix protein import by ubiquitination.

  2016cites this paper
• Peroxisome biogenesis disorders

  2016cites this paper
• Pex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins

  2016cites this paper
• Genetic Interactions between PEROXIN 12 and Other Peroxisome-Associated Ubiquitination Components 1 [ OPEN ]

  2016cites this paper
• Endoplasmic Reticulum-Associated Degradation and Lipid Homeostasis.

  2016cites this paper
• Role of AAA(+)-proteins in peroxisome biogenesis and function.

  2016cites this paper
• Structures of the double‐ring AAA ATPase Pex1–Pex6 involved in peroxisome biogenesis

  2016cites this paper
• Zellkompartimente und Proteinsortierung

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• Targeting and insertion of peroxisomal membrane proteins: ER trafficking versus direct delivery to peroxisomes.

  2016cites this paper
• Pexophagy and peroxisomal protein turnover in plants.

  2016cites this paper
• Peroxisome protein import: a complex journey

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• Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell

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• The evolution of eukaryotic cells from the perspective of peroxisomes

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• Multiple Pathways for Protein Transport to Peroxisomes

  2015cites this paper
• Structural and functional insights into the mechanism of the Pex1/6 complex

  2015cites this paper
• Distinct Pores for Peroxiso mal Import of PTS 1 and PTS 2 Proteins Graphical Abstract Highlights

  2015cites this paper
• Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

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• Protein import into complex plastids: Cellular organization of higher complexity.

  2015cites this paper
• Role of Pex21p for Piggyback Import of Gpd1p and Pnc1p into Peroxisomes of Saccharomyces cerevisiae*

  2015cites this paper
• Covalent Label Transfer between Peroxisomal Importomer Components Reveals Export-driven Import Interactions*

  2015cites this paper
• Distinct Pores for Peroxisomal Import of PTS1 and PTS2 Proteins.

  2015cites this paper
• Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation

  2015cites this paper
• Intracellular parcel service: current issues in intracellular membrane trafficking.

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• QUANTITATIVE MODELLING OF AUTOPHAGY-RELATED PROTEIN DYNAMICS AND CLUSTERING ON PEROXISOME SURFACES

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• A PEX7-Centered Perspective on the Peroxisomal Targeting Signal Type 2-Mediated Protein Import Pathway

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• A PEX 7-centered perspective on the peroxisomal targeting signal type 2-mediated protein 1 import pathway

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• History and Discovery of Peroxins

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• The Cytosolic Domain of Pex22p Stimulates the Pex4p-Dependent Ubiquitination of the PTS1-Receptor

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• PEX5 and Ubiquitin Dynamics on Mammalian Peroxisome Membranes

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• Chaperones of the Endoplasmic Reticulum Associated Degradation (ERAD) Pathway

  2014cites this paper
• The Peroxisomal Exportomer

  2014cites this paper
• Membrane heredity composed by symbiogenesis

  2014cites this paper
• Evolving models for peroxisome biogenesis

  2014cites this paper
• The peroxisomal receptor dislocation pathway: to the exportomer and beyond.

  2014cites this paper
• The cycling peroxisomal targeting signal type 1 - receptor Pex5p: reaching the circle’s end with ubiquitin

  2014cites this paper
• The Matrix Protein Import Complex in Yeast

  2014cites this paper
• Protein Transport In and Out of Plant Peroxisomes

  2014cites this paper
• Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features.

  2013cites this paper
• Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes

  2013cites this paper
• Pexophagy-linked degradation of the peroxisomal membrane protein Pex3p involves the ubiquitin-proteasome system.

  2013cites this paper
• A metabolic scenario for the evolutionary origin of peroxisomes from the endomembranous system

  2013cites this paper
• Peroxisomes: offshoots of the ER.

  2013cites this paper
• Peroxisome membrane proteins: multiple trafficking routes and multiple functions?

  2013cites this paper
• Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat—Store ’em Up or Burn ’em Down

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• Import of proteins into the peroxisomal matrix

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• The exportomer: the peroxisomal receptor export machinery

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• The protein translocation systems in plants – composition and variability on the example of Solanum lycopersicum

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• Peroxisomes take shape

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• The role of the endoplasmic reticulum in peroxisome biogenesis.

  2013cites this paper
• Peroxisome formation and maintenance are dependent on the endoplasmic reticulum.

  2013cites this paper
• Smart fluorescent proteins: Innovation for barrier‐free superresolution imaging in living cells

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• Protein targeting to subcellular organelles via MRNA localization.

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• Assembly of the heteromeric Pex 1 p-Pex 6 p-complex of the peroxisomal matrix protein import machinery

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• Development of Secretion System for Heterologous Recombinant Protein Expression in E.coli Bacteria and Pichia pastoris Yeast

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• ATP-dependent assembly of the heteromeric Pex1p-Pex6p-complex of the peroxisomal matrix protein import machinery.

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• The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae.

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