Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2002-07-12

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-291X(02)00667-8PMID 12150965
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isoflavones and bone: animal and human evidence of efficacy.

  2002cited by this paper
• The Effect of a Single Dose of Osteoprotegerin in Postmenopausal Women

  2001cited by this paper
• Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake.

  2000cited by this paper
• Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women.

  2000cited by this paper
• Hormonal responses to dietary soy and flax meal in F344 rats

  2000cited by this paper
• Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function.

  2000cited by this paper
• Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

  1999cited by this paper
• Why do postmenopausal women discontinue hormone replacement therapy?

  1999cited by this paper
• Effects of phyto-oestrogens on tissues

  1999cited by this paper
• Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

  1998cited by this paper
• Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content.

  1998cited by this paper
• Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.

  1998cited by this paper
• Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.

  1998cited by this paper
• Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.

  1998cited by this paper
• Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women.

  1998cited by this paper
• 1Phytoestrogens and bone

  1998cited by this paper
• Phytoestrogens and bone.

  1998cited by this paper
• Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

  1997cited by this paper
• Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats

  1996cited by this paper
• Cloning of a novel receptor expressed in rat prostate and ovary.

  1996cited by this paper
• Estrogen inhibits interleukin‐6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors

  1996cited by this paper
• Development and characterization of a conditionally immortalized human fetal osteoblastic cell line

  1995cited by this paper
• Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

  1994cited by this paper
• 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.

  1994cited by this paper
• Increased osteoclast development after estrogen loss: mediation by interleukin-6.

  1992cited by this paper
• Increased osteoclast development after estrogen loss: mediation by interleukin-6

  1992cited by this paper
• Osteoblastic cells are involved in osteoclast formation.

  1988cited by this paper
• A simple, rapid, and sensitive DNA assay procedure.

  1980cited by this paper

• Osteoprotective Effect of the Phytonutraceutical Ormona® on Ovariectomy-Induced Osteoporosis in Wistar Rats

  2024cites this paper
• Effect of Tempeh and Daidzein on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in Ovariectomized Rats

  2024cites this paper
• Association between Phytochemical Index and Osteoporosis in Women: A Prospective Cohort Study in Korea

  2023cites this paper
• Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma

  2023cites this paper
• Protective Role of Diadzein in L-Arginine-Induced Acute pancreatitis in Rats

  2022cites this paper
• The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

  2022cites this paper
• Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced Osteoporosis in rats via the regulation of Wnt3a/β-catenin pathway

  2021cites this paper
• Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms.

  2021cites this paper
• Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner.

  2021cites this paper
• Phytoestrogens by inhibiting the non-classical oestrogen receptor, overcome the adverse effect of bisphenol A on hFOB 1.19 cells

  2020cites this paper
• Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies

  2020cites this paper
• Can increasing the prevalence of vegetable-based diets lower the risk of osteoporosis in postmenopausal subjects? A systematic review with meta-analysis of the literature.

  2019cites this paper
• DIET QUALITY AND BONE HEALTH

  2019cites this paper
• Die Rolle von RANK-Ligand und Osteoprotegerin bei Osteoporose

  2019influential citation
• Employing different types of phytoestrogens improve bone mineralization in bisphenol A stimulated osteoblast☆

  2018cites this paper
• Fruit and vegetable consumption and the risk of postmenopausal osteoporosis: a meta-analysis of observational studies.

  2018cites this paper
• Hormone responsive genes involved in osteoporosis in post-menopausal women

  2017cites this paper
• Daidzein stimulates osteogenesis facilitating proliferation, differentiation, and antiapoptosis in human osteoblast-like MG-63 cells via estrogen receptor-dependent MEK/ERK and PI3K/Akt activation.

  2017cites this paper
• The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism

  2017cites this paper
• (−)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro

  2017cites this paper
• Soybean Sprouts Inhibit Bone Turnover in Ovariectomized Rats

  2017cites this paper
• Molecular signaling mechanisms behind polyphenol-induced bone anabolism

  2017cites this paper
• Daidzein increases OPG/RANKL ratio and suppresses IL-6 in MG-63 osteoblast cells.

  2016cites this paper
• Anti-osteoporosis effect of Epimedium via an estrogen-like mechanism based on a system-level approach.

  2016cites this paper
• Comparison of maternal isocaloric high carbohydrate and high fat diets on osteogenic and adipogenic genes expression in adolescent mice offspring

  2016cites this paper
• Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition.

  2016cites this paper
• T HE MOLECULAR TRIAD SYSTEM INVOLVING RANK / RANKL / OPG AS THERAPEUTIC TARGETS FOR METABOLIC BONE DISEASES

  2016cites this paper
• Diet and the Bone Marrow Niche for Stem Cell Recruitment

  2014cites this paper
• Effect of combineduse of daidzein andraloxifene on osteoblast-like cells

  2014cites this paper
• Polimorfizm -643C/T genu RANKL i jego związek z osteoporozą u kobiet po menopauzie

  2014cites this paper
• Effect of dietary legumes on bone-specific gene expression in ovariectomized rats

  2013influential citation
• The prenyl group contributes to activities of phytoestrogen 8-prenynaringenin in enhancing bone formation and inhibiting bone resorption in vitro.

  2013cites this paper
• Isoflavonoids and Phytoestrogenic Activity 77

  2013cites this paper
• Role of Dietary Soybean Genistein in Osteoporosis Prevention

  2013cites this paper
• Dietary Phytoestrogens in Preventing Osteoporosis in Postmenopausal Women: Italian Aspects

  2013cites this paper
• Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling

  2013cites this paper
• Supplementation with Fish Oil and Genistein, Individually or in Combination, Protects Bone against the Adverse Effects of Methotrexate Chemotherapy in Rats

  2013cites this paper
• Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone

  2013cites this paper
• Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model

  2013cites this paper
• The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice.

  2012cites this paper
• The Effect of Phytoestrogens on Bone and T Cells Differentiation and Activity

  2012influential citation
• Role of RANK ligand and denosumab, a targeted RANK ligand inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data.

  2012cites this paper
• Clove (Syzygium aromaticum Linn) extract rich in eugenol and eugenol derivatives shows bone-preserving efficacy

  2012cites this paper
• Isoflavones suppress the expression of the FcεRI high-affinity immunoglobulin E receptor independent of the estrogen receptor.

  2012cites this paper
• Correlation between osteoporosis and degeneration of intervertebral discs in aging rats

  2012cites this paper
• Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiation in vitro.

  2012cites this paper
• Soybean Phytoestrogens – Friends or Foes?

  2011cites this paper
• The cellular and molecular properties of genistein against C. albicans infection

  2011cites this paper
• Effects of Sideritis euboea (Lamiaceae) Aqueous Extract on IL-6, OPG and RANKL Secretion by Osteoblasts

  2011cites this paper
• Diverse animal models to examine potential role(s) and mechanism of endocrine disrupting chemicals on the tumor progression and prevention: Do they have tumorigenic or anti-tumorigenic property?

  2011cites this paper
• Consumption of legumes improves certain bone markers in ovariectomized rats.

  2011cites this paper
• Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration

  2011cites this paper
• TAK-778 induces osteogenesis in ovariectomized rats via an estrogen receptor-dependent pathway

  2011cites this paper
• Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation.

  2010cites this paper
• Design and baseline characteristics of the soy phytoestrogens as replacement estrogen (SPARE) study--a clinical trial of the effects of soy isoflavones in menopausal women.

  2010cites this paper
• Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.

  2009cites this paper
• A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system.

  2009cites this paper
• When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols

  2009cites this paper
• Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

  2009cites this paper
• [Effects of sophoricoside and genistein on biological characteristics of osteoblasts].

  2009cites this paper
• Neither antioxidants nor genistein inhibit the progression of established atherosclerotic lesions in older apoE deficient mice.

  2009cites this paper
• Effect of combined use of daidzein and raloxifene on osteoblast-like cells

  2009cites this paper
• Efecto de las isoflavonas de soya en el control de los síntomas perimenopáusicos

  2009cites this paper
• Dietary Antioxidants and Genistein Do Not Inhibit the Progression of Established Atherosclerotic Lesions in Older Apo E Deficient Mice

  2009cites this paper
• Phyto-oestrogens and bone health

  2008cites this paper
• Unique ER Cistromes Control Cell Type-Specific Gene Regulation

  2008cites this paper
• Unique ERalpha cistromes control cell type-specific gene regulation.

  2008cites this paper
• Relationship between soy and isoflavone intake and periodontal disease: The Freshmen in Dietetic Courses Study II

  2008cites this paper
• Soy isoflavones in the management of postmenopausal osteoporosis

  2008cites this paper
• OPG and sRANKL Serum Concentrations in Osteopenic, Postmenopausal Women After 2‐Year Genistein Administration

  2008cites this paper
• PNS702 184..195

  2008cites this paper
• on ‘ Diet and bone health ’ Phyto-oestrogens and bone health

  2008cites this paper
• Avaliação de Matrizes Tridimensionais Colagênicas como Carreadores Celulares para a Bioengenharia Óssea

  2008cites this paper
• Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice.

  2008cites this paper
• Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action.

  2008cites this paper
• The complex role of estrogens in inflammation.

  2007cites this paper
• Biochemische Marker des Knochenstoffwechsels nach Osteotomie Das Schaf als Osteoporosemodell

  2007cites this paper
• Multiple Bio-imaging Modalities in Evaluation of Epimedium-Derived Phytoestrogenic Fraction for Prevention of Postmenopausal Osteoporosis

  2007cites this paper
• Estrogen signaling in stroke : genetic and experimental studies

  2007cites this paper
• Expression of osteoblast marker genes in rat calvarial osteoblast-like cells, and effects of the endocrine disrupters diphenylolpropane, benzophenone-3, resveratrol and silymarin.

  2006cites this paper
• La osteoporosis: Una epidemia silenciosa. Osteoporosis: A silent epidemic

  2006cites this paper
• Enhancing effect of daidzein on the differentiation and mineralization in mouse osteoblast-like MC3T3-E1 cells.

  2006cites this paper
• Los Fitoestrógenos como agentes moduladores del metabolismo óseo

  2006cites this paper
• Bedeutung von RANK-Ligand und Osteoprotegerin für den Knochenstoffwechsel

  2006cites this paper
• Soybean isoflavones preserve bone mass in hindlimb-unloaded mice

  2006cites this paper
• The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts.

  2006cites this paper
• Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption.

  2006cites this paper
• Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells.

  2006cites this paper
• Effects of genistein on angiotensin-converting enzyme in rats.

  2006cites this paper
• Protective Effects of Sodium Daidzein Sulfonate on Trabecular Bone in Ovariectomized Rats

  2006cites this paper
• Efectos moduladores de los fitoestrógenos sobre la diferenciación de osteoblastos humanos Modulatory effects of phytoestrogens on human osteoblast cell differentiation

  2005influential citation
• Chemistry and Mechanism of Action of Phytoestrogens

  2005cites this paper
• Age - Related Male Osteoporosis, and Soy, Its Alternative Therapy

  2005cites this paper
• Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile

  2005cites this paper
• Soy, isoflavones, and prevalence of allergic rhinitis in Japanese women: the Osaka Maternal and Child Health Study.

  2005cites this paper
• Cellular and physiological effects of soy flavonoids.

  2004cites this paper
• A low dose of daidzein acts as an ERβ‐selective agonist in trabecular osteoblasts of young female piglets

  2004cites this paper
• Die Rolle von RANK-Ligand und Osteoprotegerin bei Osteoporose

  2004cites this paper
• The OPG/RANKL/RANK system in metabolic bone diseases.

  2004influential citation
• Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine.

  2004cites this paper