Emerging Roles of γ Aminobutyric Acid (GABA) Gated Channels in Plant Stress Tolerance

The signaling role for γ-Aminobutyric acid (GABA) has been documented in animals for over seven decades. However, a signaling role for GABA in plants is just beginning to emerge with the discovery of putative GABA binding site/s and GABA regulation of anion channels. In this review, we explore the role of GABA in plant growth and development under abiotic stress, its interactions with other signaling molecules and the probability that there are other anion channels with important roles in stress tolerance that are gated by GABA.

• Publication year

  2021

• Venue

  Plants

• Publication date

  2021-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3390/plants10102178PMID 34685991PMCID 8540008
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ethylene in Plant Biology

  2022cited by this paper
• Exogenous Gamma-aminobutyric Acid Coordinates Active Oxygen and Amino Acid Homeostasis to Enhance Heat Tolerance in Wheat Seedlings

  2021cited by this paper
• Hypoxia-induced increase in GABA content is essential for restoration of membrane potential and preventing ROS-induced disturbance to ion homeostasis

  2021influential reference
• GABA signalling modulates stomatal opening to enhance plant water use efficiency and drought resilience

  2021influential reference
• The versatile GABA in plants

  2021cited by this paper
• Crosstalk between GABA and ALA to improve antioxidation and cell expansion of tomato seedling under cold stress

  2020cited by this paper
• Proteomic and metabolomic profilings reveal crucial function of γ-aminobutyric acid (GABA) on regulating ionic, water, and metabolic homeostasis in creeping bentgrass under salt stress.

  2020influential reference
• GORK Channel: A Master Switch of Plant Metabolism?

  2020cited by this paper
• Effects of nitric oxide on the GABA, polyamines, and proline in tea (Camellia sinensis) roots under cold stress

  2020cited by this paper
• γ-aminobutyric acid (GABA) mitigates drought and heat stress in sunflower (Helianthus annuus L.) by regulating its physiological, biochemical and molecular pathways.

  2020cited by this paper
• iTRAQ-based proteomics reveals key role of γ-aminobutyric acid (GABA) in regulating drought tolerance in perennial creeping bentgrass (Agrostis stolonifera).

  2019cited by this paper
• GABA-Alleviated Oxidative Injury Induced by Salinity, Osmotic Stress and their Combination by Regulating Cellular and Molecular Signals in Rice

  2019cited by this paper
• Cytosolic GABA inhibits anion transport by wheat ALMT1.

  2019cited by this paper
• The role of Arabidopsis ABA receptors from the PYR/PYL/RCAR family in stomatal acclimation and closure signal integration

  2019cited by this paper
• GABA operates upstream of H+-ATPase and improves salinity tolerance in Arabidopsis by enabling cytosolic K+ retention and Na+ exclusion

  2019cited by this paper
• GABA application improves the mitochondrial antioxidant system and reduces peel browning in 'Nanguo' pears after removal from cold storage.

  2019cited by this paper
• GABA (γ-aminobutyric acid), as a thermo-protectant, to improve the reproductive function of heat-stressed mungbean plants

  2019cited by this paper
• Phytohormones and polyamines regulate plant stress responses by altering GABA pathway.

  2019cited by this paper
• Mechanisms of cytosolic calcium elevation in plants: the role of ion channels, calcium extrusion systems and NADPH oxidase-mediated 'ROS-Ca2+ Hub'.

  2018cited by this paper
• Aluminum-Activated Malate Transporters Can Facilitate GABA Transport[OPEN]

  2018cited by this paper
• Aluminium-Activated Malate Transporters Can Facilitate GABA Transport

  2018cited by this paper
• γ-Aminobutyric Acid Imparts Partial Protection from Salt Stress Injury to Maize Seedlings by Improving Photosynthesis and Upregulating Osmoprotectants and Antioxidants

  2017cited by this paper
• Impact of postharvest exogenous γ-aminobutyric acid treatment on cucumber fruit in response to chilling tolerance

  2017cited by this paper
• Exogenous γ-aminobutyric acid treatment affects citrate and amino acid accumulation to improve fruit quality and storage performance of postharvest citrus fruit.

  2017cited by this paper
• GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic

  2017cited by this paper
• Exogenous GABA application transiently improves the tolerance to root hypoxia on a sensitive genotype of Prunus rootstock

  2016cited by this paper
• Plant GABA: Not Just a Metabolite.

  2016cited by this paper
• The varied functions of aluminium-activated malate transporters–much more than aluminium resistance

  2016cited by this paper
• Linking Metabolism to Membrane Signaling: The GABA-Malate Connection.

  2016cited by this paper
• Dual mechanisms regulating glutamate decarboxylases and accumulation of gamma-aminobutyric acid in tea (Camellia sinensis) leaves exposed to multiple stresses

  2016cited by this paper
• Gamma-aminobutyric acid depletion affects stomata closure and drought tolerance of Arabidopsis thaliana.

  2016cited by this paper
• γ-Aminobutyric acid (GABA) signalling in plants

  2016influential reference
• Cell-Type-Specific H+-ATPase Activity in Root Tissues Enables K+ Retention and Mediates Acclimation of Barley (Hordeum vulgare) to Salinity Stress1[OPEN]

  2016cited by this paper
• On a quest for stress tolerance genes: membrane transporters in sensing and adapting to hostile soils.

  2016cited by this paper
• GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

  2015influential reference
• GABAergic signalling in the immune system

  2015cited by this paper
• Maintaining the postharvest nutritional quality of peach fruits by γ-Aminobutyric acid

  2015cited by this paper
• Development and regulation of chloride homeostasis in the central nervous system

  2015cited by this paper
• Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined?

  2015cited by this paper
• Signal transduction: GABA receptor found in plants

  2015cited by this paper
• Effect of exogenous γ-aminobutyric acid (GABA) treatment on chilling injury and antioxidant capacity in banana peel

  2014cited by this paper
• The long-term effect of zinc soil contamination on selected free amino acids playing an important role in plant adaptation to stress and senescence.

  2014cited by this paper
• Transcriptional Evidence for Inferred Pattern of Pollen Tube-Stigma Metabolic Coupling during Pollination

  2014cited by this paper
• γ-Aminobutyric Acid (GABA) Imparts Partial Protection from Heat Stress Injury to Rice Seedlings by Improving Leaf Turgor and Upregulating Osmoprotectants and Antioxidants

  2014cited by this paper
• Clustering of the K+ channel GORK of Arabidopsis parallels its gating by extracellular K+

  2014cited by this paper
• Ethylene negatively regulates aluminium-induced malate efflux from wheat roots and tobacco cells transformed with TaALMT1

  2014influential reference
• OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis

  2014cited by this paper
• Characterization of the Complex Regulation of AtALMT1 Expression in Response to Phytohormones and Other Inducers1[W][OA]

  2013cited by this paper
• Calmodulin-dependent and calmodulin-independent glutamate decarboxylases in apple fruit

  2013cited by this paper
• Contribution of Gamma amino butyric acid (GABA) to salt stress responses of Nicotiana sylvestris CMSII mutant and wild type plants.

  2012cited by this paper
• Compartmentation of GABA metabolism raises intriguing questions.

  2012cited by this paper
• Accumulation of γ-aminobutyric acid in germinated soybean (Glycine max L.) in relation to glutamate decarboxylase and diamine oxidase activity induced by additives under hypoxia

  2012cited by this paper
• Hypothesis/review: contribution of putrescine to 4-aminobutyrate (GABA) production in response to abiotic stress.

  2012cited by this paper
• Hypoxia induces H2O2 production and activates antioxidant defence system in grapevine buds through mediation of H2O2 and ethylene

  2012cited by this paper
• Implications of paraquat and hydrogen peroxide-induced oxidative stress treatments on the GABA shunt pathway in Arabidopsis thaliana calmodulin mutants

  2011cited by this paper
• GABA accumulation causes cell elongation defects and a decrease in expression of genes encoding secreted and cell wall-related proteins in Arabidopsis thaliana.

  2011cited by this paper
• Dynamic metabonomic responses of tobacco (Nicotiana tabacum) plants to salt stress.

  2011cited by this paper
• Anion channels/transporters in plants: from molecular bases to regulatory networks.

  2011cited by this paper
• Does GABA increase the efficiency of symbiotic N2 fixation in legumes?

  2011cited by this paper
• Effects of exogenous GABA on gene expression of Caragana intermedia roots under NaCl stress: regulatory roles for H2O2 and ethylene production.

  2010cited by this paper
• AtALMT12 represents an R-type anion channel required for stomatal movement in Arabidopsis guard cells.

  2010cited by this paper
• Nitrate uptake and utilization is modulated by exogenous gamma-aminobutyric acid in Arabidopsis thaliana seedlings.

  2010cited by this paper
• The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance

  2010cited by this paper
• Metabolic responses to salt stress of barley (Hordeum vulgare L.) cultivars, Sahara and Clipper, which differ in salinity tolerance

  2009cited by this paper
• What makes a gate? The ins and outs of Kv-like K+ channels in plants.

  2009cited by this paper
• Comparative effects of drought, salt, heavy metal and heat stresses on gamma-aminobutryric acid levels of sesame (Sesamum indicum L.)

  2009cited by this paper
• The role and the mechanism of γ-aminobutyric acid during central nervous system development

  2008cited by this paper
• Novel Properties of the Wheat Aluminum Tolerance Organic Acid Transporter (TaALMT1) Revealed by Electrophysiological Characterization in Xenopus Oocytes: Functional and Structural Implications1[OA]

  2008cited by this paper
• Nitrogen Recycling and Remobilization Are Differentially Controlled by Leaf Senescence and Development Stage in Arabidopsis under Low Nitrogen Nutrition1

  2008cited by this paper
• The role and the mechanism of gamma-aminobutyric acid during central nervous system development.

  2008cited by this paper
• Characterization of the TaALMT1 protein as an Al3+-activated anion channel in transformed tobacco (Nicotiana tabacum L.) cells.

  2008cited by this paper
• Abscisic Acid and Abiotic Stress Signaling

  2007cited by this paper
• Not all ALMT1-type transporters mediate aluminum-activated organic acid responses: the case of ZmALMT1 - an anion-selective transporter.

  2007cited by this paper
• Higher accumulation of gamma-aminobutyric acid induced by salt stress through stimulating the activity of diamine oxidases in Glycine max (L.) Merr. roots.

  2007cited by this paper
• Does GABA Act as a Signal in Plants? Hints from Molecular Studies

  2007cited by this paper
• The Arabidopsis vacuolar malate channel is a member of the ALMT family.

  2007cited by this paper
• GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.

  2007cited by this paper
• Metabolism of γ-aminobutyric acid during cold acclimation and freezing and its relationship to frost tolerance in barley and wheat

  2006cited by this paper
• Regulation of Arabidopsis thaliana 14-3-3 gene expression by gamma-aminobutyric acid.

  2006cited by this paper
• The ectopic expression of the rice Osmyb4 gene in Arabidopsis increases tolerance to abiotic, environmental and biotic stresses

  2006cited by this paper
• Regulation of Arabidopsis thaliana 14‐3‐3 gene expression by γ‐aminobutyric acid

  2006influential reference
• Metabolism of gamma-aminobutyric acid during cold acclimation and freezing and its relationship to frost tolerance in barley and wheat.

  2006cited by this paper
• Fluctuations of γ-aminobutyrate, γ-hydroxybutyrate, and related amino acids in Arabidopsis leaves as a function of the light–dark cycle, leaf age, and N stressEditorial decisions for this paper were made by Robert Ireland, Associate Editor, Canadian Journal of Botany.

  2006cited by this paper
• Exogenous supply of glutamine and active cytokinin to the roots reduces NO3- uptake rates in poplar.

  2006cited by this paper
• GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens.

  2006cited by this paper
• pH regulation in anoxic plants.

  2005cited by this paper
• Putative role of γ ‐aminobutyric acid (GABA) as a long‐distance signal in up‐regulation of nitrate uptake in Brassica napus L.

  2004cited by this paper
• A wheat gene encoding an aluminum-activated malate transporter.

  2004cited by this paper
• The root-specific glutamate decarboxylase (GAD1) is essential for sustaining GABA levels in Arabidopsis

  2004cited by this paper
• GABA in plants: just a metabolite?

  2004cited by this paper
• Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels.

  2003cited by this paper
• Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants

  2003cited by this paper
• Cross-Talk between Reactive Oxygen Species and Calcium in Living Cells

  2003cited by this paper
• GABA signaling: a conserved and ubiquitous mechanism.

  2003cited by this paper
• Is there more to gaba than synaptic inhibition?

  2002cited by this paper
• Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus.

  2001cited by this paper
• FUNCTION AND MECHANISM OF ORGANIC ANION EXUDATION FROM PLANT ROOTS.

  2001cited by this paper
• Gamma Aminobutyric Acid (GABA) and Plant Responses to Stress

  2000cited by this paper
• GABA Increases the Rate of Nitrate Uptake and Utilization in Arabidopsis Roots

  2000cited by this paper
• Receptor modifiers indicate that 4-aminobutyric acid (GABA) is a potential modulator of ion transport in plants

  2000cited by this paper

• Overexpression of IbGAD4 enhances salt tolerance in sweetpotato by modulating the GABA pathway

  2026cites this paper
• Gamma-Aminobutyric Acid Application Methods for Sustainable Improvement of Plant Performance Under Abiotic Stress: A Review

  2026cites this paper
• Metabolomic profiling of ten cacao genotypes from Antioquia, Colombia reveals local effects on nutritional composition

  2025cites this paper
• Multi-Omics Analysis Reveals the Regulation of Amino Acid Biosynthesis in Cyclocarya paliurus Leaves Under Salt Stress

  2025cites this paper
• Regulatory Mechanisms of Microcystis in Response to Stress Following Gradual Transitions to Cold Temperatures

  2025cites this paper
• Multi-omics analysis reveals molecular and biochemical mechanisms underlying alkaline stress adaptation in Solanum lycopersicum L.

  2025cites this paper
• Transcriptome analysis reveals the role of E3 ubiquitin ligase MdPUB17 in apple fruit quality formation

  2025cites this paper
• Rootstock-specific bacterial microbiome and metabolome remodeling enhances glycine substitution efficacy for ammonium nitrate in watermelon

  2025cites this paper
• Growth and Mini-tuber Yield Breakthroughs in Agria Potatoes: Exploring the Roles of γ-Aminobutyric Acid (GABA), Melatonin, and Cycocel

  2025cites this paper
• Patch‐Clamp‐ and 15N Isotope Tracer‐Based Techniques Reveal the Transport Characteristics of SlGAT1 and the Metabolic Flow of Exogenous GABA Under Salt Stress

  2025cites this paper
• Molecular Mechanism of Exogenous GABA in Regulating Salt Tolerance in Tomato (Solanum lycopersicum L.)

  2025cites this paper
• Antioxidant Defense System in Plants: Reactive Oxygen Species Production, Signaling, and Scavenging During Abiotic Stress-Induced Oxidative Damage

  2025cites this paper
• Mechanistic understanding of GABA and trehalose in modulating plant response to drought stress

  2025cites this paper
• Effects of Gamma-Aminobutyric Acid (GABA) on Cadmium Accumulation in Rice Seedlings

  2025cites this paper
• Chemical application improves stress resilience in plants

  2025cites this paper
• Enhancing Horticultural Sustainability in the Face of Climate Change: Harnessing Biostimulants for Environmental Stress Alleviation in Crops

  2025cites this paper
• Effect of Exogenous γ-Aminobutyric Acid (GABA) on the Growth, Photosynthetic Pigment, Antioxidant and GABA Metabolism of Festuca arundinacea (Tall Fescues) Under Cadmium Stress

  2025cites this paper
• Functional analyses revealed Pinus radiata CHLOROPLAST SENSOR KINASE as a key component in UV-B stress and development

  2025cites this paper
• γ-aminobutyric acid mitigates manganese toxicity in soybean by regulating GmNAC022: Insights from biochemical and transcriptomic analyses.

  2025cites this paper
• Exogenous γ-Aminobutyric Acid (GABA) Regulates the Response of Sugar Beet Seedlings to Salt Stress Through GABA Branched Metabolism

  2024cites this paper
• γ-Aminobutyric acid (GABA) in N2-fixing-legume symbiosis: Metabolic flux and carbon/nitrogen homeostasis in responses to abiotic constraints.

  2024cites this paper
• Mitigating postharvest chilling injury in Orlando tangelo fruit: potential of melatonin and GABA in enhancing the antioxidant system

  2024cites this paper
• SlGAD2 is the target of SlTHM27, positively regulates cold tolerance by mediating anthocyanin biosynthesis in tomato

  2024cites this paper
• The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat

  2024cites this paper
• Emerging Trends in Non-Protein Amino Acids as Potential Priming Agents: Implications for Stress Management Strategies and Unveiling Their Regulatory Functions

  2024cites this paper
• Promoting γ-aminobutyric acid accumulation to enhances saline-alkali tolerance in tomato.

  2024cites this paper
• From Neurotransmitter to Plant Protector: The Intricate World of GABA Signaling and its Diverse Functions in Stress Mitigation

  2024cites this paper
• Exogenous γ-Aminobutyric Acid Enhanced Salt-alkaline Tolerance in Mulberry Trees Through Transcriptomic Sequencing Analysis

  2024cites this paper
• Role of Neurotransmitters (Biomediators) in Plant Responses to Stress

  2024cites this paper
• Harnessing GABA Pathways to Improve Plant Resilience Against Salt Stress

  2024cites this paper
• Characterization of triterpenoids as possible bitter-tasting compounds in teas infected with bird's eye spot disease.

  2023cites this paper
• Effects of Gamma Amino Butyric Acid (GABA) on Nutrient Uptake of Loquat [Eriobotrya japonica (Thunb.) Lindl.] Seedlings

  2023cites this paper
• Ultrasonic treatment to enhance seed germination and vigour of wheat (Triticum durum) in association with γ-aminobutyric acid (GABA) shunt pathway.

  2023cites this paper
• Enhancing crop resilience by harnessing the synergistic effects of biostimulants against abiotic stress

  2023cites this paper
• Metabolic pathways engineering for drought or/and heat tolerance in cereals

  2023influential citation
• Neodymium Nitrate Improves the Germination of Aged Wheat Seeds by Increasing Soluble Substances and Activating Antioxidative and Metabolic Enzymes in Seeds

  2023cites this paper
• Current understanding of unlocking the power of melatonin and other phytohormones to boost abiotic stress tolerance in solanaceous vegetable crops

  2023cites this paper
• Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

  2023cites this paper
• Synergistic effects of gamma-aminobutyric acid and melatonin on seed germination and cadmium tolerance in tomato

  2023cites this paper
• γ Aminobutyric Acid (GABA): A Key Player in Alleviating Abiotic Stress Resistance in Horticultural Crops: Current Insights and Future Directions

  2023cites this paper
• Global Metabolic Changes by Bacillus Cyclic Lipopeptide Extracts on Stress Responses of Para Rubber Leaf

  2023cites this paper
• The γ-Aminobutyric Acid (GABA) Synthesis Gene Regulates the Resistance to Water Core-Induced Hypoxia Stress for Pear Fruits

  2023cites this paper
• Phosphorus deficiency alters root length, acid phosphatase activity, organic acids, and metabolites in root exudates of soybean cultivars.

  2023cites this paper
• Role of Acetic Acid and Nitric Oxide against Salinity and Lithium Stress in Canola (Brassica napus L.)

  2023cites this paper
• Watercore Pear Fruit Respiration Changed and Accumulated γ-Aminobutyric Acid (GABA) in Response to Inner Hypoxia Stress

  2022cites this paper
• Time-course transcriptome and WGCNA analysis revealed the drought response mechanism of two sunflower inbred lines

  2022cites this paper
• Characterization of GABA-Transaminase Gene from Mulberry (Morus multicaulis) and Its Role in Salt Stress Tolerance

  2022cites this paper
• Regulation of salt tolerance in the roots of Zea mays by L-histidine through transcriptome analysis

  2022cites this paper
• Regulation of nutrient accumulation by γ-aminobutyric acid associated with GABA priming-enhanced heat tolerance in creeping bentgrass

  2022cites this paper
• Enrichment of gamma-aminobutyric acid in foods: From conventional methods to innovative technologies.

  2022cites this paper
• Effects of tetracycline, sulfonamide, fluoroquinolone, and lincosamide load in pig slurry on lettuce: Agricultural and human health implications.

  2022cites this paper
• Regulatory role of gamma-aminobutyric acid in cyanobacteria challenged with UV-B: the implication of nitric oxide

  2022cites this paper