p53-independent role of MDM2 in TGF-beta1 resistance.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Science

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 9856953
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Abnormal expression of MDM-2 in breast carcinomas

  2005cited by this paper
• Genomic analysis of essentiality within protein networks.

  2004cited by this paper
• Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma

  1998cited by this paper
• Smad3 mutant mice develop metastatic colorectal cancer.

  1998cited by this paper
• Aberrant responses of human lymphocytic neoplasms to cytokine regulation

  1998cited by this paper
• Transforming growth factor-beta in breast cancer: a working hypothesis.

  1997cited by this paper
• Mdm‐2: “big brother” of p53

  1997cited by this paper
• p53 gene mutations and expression of p53 and mdm2 proteins in invasive breast carcinoma

  1997cited by this paper
• Transforming growth factor-beta enhances adhesion of melanoma cells to the endothelium in vitro.

  1997cited by this paper
• p21/waf1/cip1 and mdm‐2 expression in breast carcinoma patients as related to prognosis

  1997cited by this paper
• Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cells.

  1996cited by this paper
• E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

  1996cited by this paper
• Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

  1996cited by this paper
• DPC4 gene in various tumor types.

  1996cited by this paper
• Overexpression of the MDM2 oncogene in leukemia and lymphoma.

  1996cited by this paper
• In situ analysis of transforming growth factor-beta s (TGF-beta 1, TGF-beta 2, TGF-beta 3), and TGF-beta type II receptor expression in malignant melanoma.

  1995cited by this paper
• Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

  1995cited by this paper
• Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression.

  1995cited by this paper
• Transcriptional control by E2F.

  1995cited by this paper
• Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

  1995cited by this paper
• p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

  1995cited by this paper
• Interaction between the retinoblastoma protein and the oncoprotein MDM2

  1995cited by this paper
• Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

  1995cited by this paper
• Mutant p53 proteins behave in a dominant, negative fashion in vivo.

  1994cited by this paper
• Paracrine and autocrine regulation of human melanocyte and melanoma cell growth by transforming growth factor beta in vitro.

  1994cited by this paper
• Development of resistance mechanisms to the growth‐inhibitory effects of transforming growth factor-β during tumor progression

  1993cited by this paper
• TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

  1990cited by this paper
• Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

  1990cited by this paper
• Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

  1990cited by this paper
• Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells.

  1988cited by this paper
• Carcinogenesis

  1961cited by this paper

• The CMG helicase and cancer: a tumor “engine” and weakness with missing mutations

  2022cites this paper
• Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb‐202 in gastric cancer

  2021cites this paper
• Stromal-MDM2 Promotes Lung Cancer Cell Invasion through Tumor–Host Feedback Signaling

  2020cites this paper
• Targeting MDM2 for novel molecular therapy: Beyond oncology

  2020cites this paper
• TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

  2020cites this paper
• TGF-b 1 – induced expression of human Mdm 2 correlates with late-stage metastatic breast cancer

  2019cites this paper
• CHD 1 L promotes cell cycle progression and cell motility by up-regulating MDM 2 in breast cancer

  2019cites this paper
• Anti-Müllerian Hormone Expression in Endometrial Cancer Tissue

  2019cites this paper
• Downregulation of AKT and MDM2, Melatonin Induces Apoptosis in AGS and MGC803 Cells

  2019cites this paper
• CHD1L promotes cell cycle progression and cell motility by up-regulating MDM2 in breast cancer.

  2019cites this paper
• miR-30 Disrupts Senescence and Promotes Cancer by Targeting both p16INK4A and DNA Damage Pathways

  2018cites this paper
• Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmospheric plasma-activated medium

  2017influential citation
• Dihydromyricetin Reduces TGF-β Via P53 Activation-dependent Mechanism in Hepatocellular Carcinoma HepG2 Cells.

  2017cites this paper
• The role of MDM2 and MDM4 in breast cancer development and prevention

  2017cites this paper
• Dihydromyricetin Induces Apoptosis by Reducing TGF-ò via P53 Activation inHepG2 Cells

  2016cites this paper
• Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner.

  2016cites this paper
• Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment.

  2016cites this paper
• A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity

  2015cites this paper
• Mdm2 Promotes Myogenesis through the Ubiquitination and Degradation of CCAAT/Enhancer-binding Protein β

  2015cites this paper
• Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA

  2015cites this paper
• TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.

  2014cites this paper
• A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1.

  2014cites this paper
• Targeting MDM2-p53 interaction for cancer therapy: are we there yet?

  2014cites this paper
• The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.

  2014cites this paper
• New insights into the role of NF1 in cancer.

  2013cites this paper
• New insights into the role of NF 1 in cancer

  2013cites this paper
• A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence.

  2013cites this paper
• Induction of p38δ Expression Plays an Essential Role in Oncogenic ras-Induced Senescence

  2013cites this paper
• Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis.

  2012cites this paper
• Natural product MDM2 inhibitors: anticancer activity and mechanisms of action.

  2012cites this paper
• Mdm2 and MdmX as Regulators of Gene Expression.

  2012cites this paper
• PRAK Suppresses Oncogenic ras-Induced Hematopoietic Cancer Development by Antagonizing the JNK Pathway

  2012cites this paper
• A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation

  2011cites this paper
• TGF-β signals the formation of a unique NF1/Smad4-dependent transcription repressor-complex in human diploid fibroblasts.

  2011cites this paper
• The role of Mdm2 in estrogen-mediated breast cancer cell proliferation

  2011cites this paper
• TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.

  2010cites this paper
• p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage

  2010cites this paper
• Mdm2 links genotoxic stress and metabolism to p53

  2010cites this paper
• A DNA Sequence Directed Mutual Transcription Regulation of HSF1 and NFIX Involves Novel Heat Sensitive Protein Interactions

  2009cites this paper
• Recent advances in validating MDM2 as a cancer target.

  2009cites this paper
• p38α and p38γ Mediate Oncogenic ras-induced Senescence through Differential Mechanisms*

  2009cites this paper
• Sodium Butyrate Alters Cell-Cell Interactions through Up-Regulation of E-Cadherin in Human Hepatocellular Carcinoma Cells

  2009cites this paper
• Association of v-ErbA with Smad4 disrupts TGF-beta signaling.

  2009cites this paper
• Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells

  2009cites this paper
• The c-myc promoter: still MysterY and challenge.

  2008cites this paper
• Crosstalk Between MDM2 and Akt Signaling Pathway in Oncogenesis.

  2008cites this paper
• Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex.

  2008cites this paper
• Small molecule inhibitors of the p53-MDM2.

  2008cites this paper
• MDM2 regulates dihydrofolate reductase activity through monoubiquitination.

  2008cites this paper
• Akt plays an important role in breast cancer cell chemotaxis to CXCL12

  2008cites this paper
• xCT expression reduces the early cell cycle requirement for calcium signaling.

  2008cites this paper
• miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism.

  2008cites this paper
• THE FUNCTIONAL SIGNIFICANCE OF AN ALTERNATELY SPLICED PRODUCT OF THE HDM2 GENE

  2007cites this paper
• PRAK is essential for ras-induced senescence and tumor suppression.

  2007cites this paper
• The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance.

  2007cites this paper
• Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

  2007cites this paper
• GammaD-crystallin associated protein aggregation and lens fiber cell denucleation.

  2007cites this paper
• A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition.

  2006cites this paper
• Regulation of the p14ARF-Mdm2-p53 pathway: an overview in breast cancer.

  2006cites this paper
• Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain.

  2006cites this paper
• MDM2 309T>G polymorphism and risk of lung cancer in a Korean population.

  2006cites this paper
• Immunohistochemical analysis for Mdm2 and p53 proteins in methylcholanthrene-induced mouse rhabdomyosarcomas.

  2006cites this paper
• Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia.

  2006cites this paper
• The retinoblastoma gene family in cell cycle regulation and suppression of tumorigenesis.

  2006cites this paper
• Immunohistochemical detection of Mdm2 and p53 in feline mammary gland tumors.

  2006cites this paper
• Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A (p21) gene by NFI in proliferating human cells

  2006cites this paper
• Human MDM2 Isoforms Translated Differentially on Constitutive versus p53-Regulated Transcripts Have Distinct Functions in the p53/MDM2 and TSG101/MDM2 Feedback Control Loops

  2006cites this paper
• Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1

  2006cites this paper
• Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009.

  2006cites this paper
• Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest

  2006cites this paper
• Oncogenes as Novel Targets for Cancer Therapy (Part IV)

  2005cites this paper
• Abrogation of transforming growth factor-beta signaling in pancreatic cancer.

  2005cites this paper
• Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

  2005cites this paper
• Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen‐induced rat mammary tumors

  2005cites this paper
• Mdm2 in growth signaling and cancer

  2005cites this paper
• Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms.

  2005cites this paper
• The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300/CBP and Rb family proteins.

  2005cites this paper
• HER-2 overexpression differentially alters transforming growth factor-β responses in luminal versus mesenchymal human breast cancer cells

  2005cites this paper
• MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

  2005cites this paper
• Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance.

  2005cites this paper
• p53-independent activities of MDM2 and their relevance to cancer therapy.

  2005cites this paper
• Migration via a Ras-MEK Kinase 1 Pathway Lysophosphatidic Acid Stimulates Ovarian Cancer Cell

  2004cites this paper
• Gene Expression in the Lung of p53 Mutant Mice Exposed to Cigarette Smoke

  2004cites this paper
• Cyclin-dependent Kinases Phosphorylate Human Cdt1 and Induce Its Degradation*

  2004cites this paper
• Radiosensitization by Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in in Vitro and in Vivo Human Cancer Models

  2004cites this paper
• TGF-β Signaling in Mammary Gland Development and Tumorigenesis

  2004cites this paper
• Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging.

  2004cites this paper
• Mdm2 mRNA expression in salivary gland tumour cell lines.

  2004cites this paper
• High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts*

  2004cites this paper
• Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor.

  2004cites this paper
• Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway

  2004cites this paper
• The Central Acidic Domain of MDM2 Is Critical in Inhibition of Retinoblastoma-mediated Suppression of E2F and Cell Growth*

  2004cites this paper
• A genetic screen to identify latent transforming growth factor beta activators.

  2004cites this paper
• Factors That Increase the Effective Concentration of CXCR4 Dictate Feline Immunodeficiency Virus Tropism and Kinetics of Replication

  2004cites this paper
• Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

  2004cites this paper
• The use of gene function to identify the rate-limiting steps controlling cell fate

  2004cites this paper
• The MDM2 RING finger is required for cell cycle‐dependent regulation of its protein expression

  2003cites this paper
• p 53-Independent Functions of MDM 2

  2003cites this paper
• Regulation of G1/S Cell Cycle Progression by Transforming Growth Factor-beta

  2003cites this paper
• Cell cycle regulatory functions of the human oncoprotein MDM2.

  2003cites this paper