DDX58/IFIH1-mediated induction of interferon-alpha/beta

HERC5/Ceb1 IFN-inducible ISG15-specific ligase. may play an important regulatory role in IFN-mediated antiviral responses. IFN induces ISG15 conjugation to DDX58 negatively regulating DDX58-me-diated antiviral signaling. ISGylated DDX58 becomes subject to an irreversible biochemical process, such as proteolysis or proteasomeal degradation. via The data suggest that HSP90 forms a in the cytosol and deliver the MAVS on the mitochondria.

• Publication year

  2022

• Venue

  Reactome

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  DOI 10.3180/r-hsa-168928.9
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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