Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular Biology of the Cell

• Publication date

  2005-12-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E05-09-0853PMID 16394098PMCID PMC1382332
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Herpes virus proteins ICP0 and BICP0 can activate NF-κB by catalyzing IκBα ubiquitination

  2005cited by this paper
• Herpes virus proteins ICP0 and BICP0 can activate NF-kappaB by catalyzing IkappaBalpha ubiquitination.

  2005cited by this paper
• HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

  2005cited by this paper
• A Central Role for the Hsp90·Cdc37 Molecular Chaperone Module in Interleukin-1 Receptor-associated-kinase-dependent Signaling by Toll-like Receptors*

  2005cited by this paper
• Analysis of Genes Induced by Sendai Virus Infection of Mutant Cell Lines Reveals Essential Roles of Interferon Regulatory Factor 3, NF-κB, and Interferon but Not Toll-Like Receptor 3

  2005influential reference
• The role of Toll-like receptors in the host response to viruses.

  2005cited by this paper
• Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection

  2004cited by this paper
• Innate Sensing of Viruses by Toll-Like Receptors

  2004cited by this paper
• Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

  2004cited by this paper
• Hsp90/p50cdc37 Is Required for Mixed-lineage Kinase (MLK) 3 Signaling*

  2004influential reference
• Geldanamycin, a heat shock protein 90‐binding agent, disrupts Stat5 activation in IL‐2‐stimulated cells

  2004cited by this paper
• Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication

  2004cited by this paper
• Direct Activation of HSP90A Transcription by c-Myc Contributes to c-Myc-induced Transformation*

  2004cited by this paper
• Toll-like receptor signalling

  2004influential reference
• Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

  2004cited by this paper
• Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

  2004cited by this paper
• Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

  2004cited by this paper
• Identification of Ser-386 of Interferon Regulatory Factor 3 as Critical Target for Inducible Phosphorylation That Determines Activation*

  2004cited by this paper
• IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

  2003influential reference
• IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

  2003influential reference
• Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity.

  2003cited by this paper
• Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-α (PPARα) and PPARβ activity

  2003cited by this paper
• Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

  2003cited by this paper
• IRF3 mediates a TLR3/TLR4-specific antiviral gene program.

  2002cited by this paper
• Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes

  2002cited by this paper
• Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function*

  2002cited by this paper
• Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

  2002cited by this paper
• Interactions of STAT3 with Caveolin-1 and Heat Shock Protein 90 in Plasma Membrane Raft and Cytosolic Complexes

  2002cited by this paper
• TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90.

  2002cited by this paper
• The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA‐dependent kinase PKR

  2001cited by this paper
• Toll-like receptors; their physiological role and signal transduction system.

  2001cited by this paper
• Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

  2001cited by this paper
• Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1

  2001cited by this paper
• Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways

  2001cited by this paper
• Viruses and interferons.

  2001cited by this paper
• Structure and in vivo function of Hsp90.

  2000cited by this paper
• Chaperones in progesterone receptor complexes.

  2000cited by this paper
• Getting Newly Synthesized Proteins Minireview into Shape

  2000cited by this paper
• Deficiency of T2K leads to apoptotic liver degeneration and impaired NF‐κB‐dependent gene transcription

  2000cited by this paper
• Roles of molecular chaperones in cytoplasmic protein folding.

  2000cited by this paper
• Induction of the human protein P56 by interferon, double-stranded RNA, or virus infection.

  2000influential reference
• Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation*

  2000influential reference
• NAK is an IkappaB kinase-activating kinase.

  2000cited by this paper
• Protein folding in vivo: the importance of molecular chaperones.

  2000cited by this paper
• Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

  1999cited by this paper
• Hsp90's secrets unfold: new insights from structural and functional studies.

  1999cited by this paper
• Interferon regulatory factors: the next generation.

  1999cited by this paper
• Hsp90 & Co. - a holding for folding.

  1999cited by this paper
• Molecular chaperones: the busy life of Hsp90.

  1999cited by this paper
• Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

  1999cited by this paper
• Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

  1998cited by this paper
• Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3*

  1998influential reference
• Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

  1998influential reference
• Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF‐3 and CBP/p300

  1998influential reference
• Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence.

  1998cited by this paper
• Innate immune recognition and control of adaptive immune responses.

  1998cited by this paper
• Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.

  1998influential reference
• Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.

  1997cited by this paper
• Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.

  1997influential reference
• Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.

  1996cited by this paper
• Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

  1995cited by this paper
• Herbimycin A Induces the 20 S Proteasome- and Ubiquitindependent Degradation of Receptor Tyrosine Kinases (*)

  1995cited by this paper
• Transient Interaction of Hsp90 with Early Unfolding Intermediates of Citrate Synthase

  1995cited by this paper
• Heat shock proteins: molecular chaperones of protein biogenesis

  1993cited by this paper
• Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state.

  1991cited by this paper
• The role of heat-shock proteins as molecular chaperones.

  1991cited by this paper
• The heat-shock proteins.

  1988cited by this paper
• Functional domains of the human glucocorticoid receptor.

  1986cited by this paper
• Purification of the major mammalian heat shock proteins.

  1982cited by this paper

• The IRF transcription factor family in type I interferon-mediated antiviral immunity and associated diseases

  2026cites this paper
• The efficacy of feed additives in alleviating heat stress and supporting gut health in poultry

  2025cites this paper
• Molecular mechanism by which SARS-CoV-2 Orf9b suppresses the Tom70-Hsp90 interaction to evade innate immunity

  2025cites this paper
• Betacoronavirus internal protein: role in immune evasion and viral pathogenesis

  2025cites this paper
• TBK1 is a signaling hub in coordinating stress-adaptive mechanisms in head and neck cancer progression

  2025cites this paper
• The multiple roles of interferon regulatory factor family in health and disease

  2024cites this paper
• Influence of heat shock protein 90 on the replication of spring viremia of carp virus

  2024cites this paper
• Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

  2024cites this paper
• A novel role of ETV6 as a pro-viral factor in host response by inhibiting TBK1 phosphorylation.

  2024cites this paper
• The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon-β activation.

  2023cites this paper
• Mode of Action of Heat Shock Protein (HSP) Inhibitors against Viruses through Host HSP and Virus Interactions

  2023cites this paper
• African swine fever virus protein p17 promotes mitophagy by facilitating the interaction of SQSTM1 with TOMM70

  2023cites this paper
• An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation

  2023cites this paper
• Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virus

  2023cites this paper
• DDX58/IFIH1-mediated induction of interferon-alpha/beta

  2022cites this paper
• Hsp90 Activity Is Necessary for the Maturation of Rabies Virus Polymerase

  2022cites this paper
• How RSV Proteins Join Forces to Overcome the Host Innate Immune Response

  2022cites this paper
• HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection

  2022cites this paper
• Pim1 promotes IFN-β production by interacting with IRF3

  2022cites this paper
• Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling

  2022influential citation
• Host protein, HSP90β, antagonizes IFN-β signaling pathway and facilitates the proliferation of encephalomyocarditis virus in vitro.

  2021cites this paper
• The Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1

  2020cites this paper
• Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections.

  2020cites this paper
• Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein Suppresses Type I IFN Expression by Impeding HSP70-Dependent Activation of IRF3 Kinase IKKε

  2020influential citation
• Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy

  2019cites this paper
• ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation

  2019cites this paper
• Chaperones in Sterile Inflammation and Injury

  2019cites this paper
• Molecular detection of Hsp90 inhibitor suppressing PCV2 replication in host cells.

  2019cites this paper
• Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex

  2018cites this paper
• Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV‐Induced Innate Immunity

  2018cites this paper
• Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview

  2017cites this paper
• Host proteostasis modulates influenza evolution

  2017influential citation
• Dexamethasone treatment decreases replication of viral hemorrhagic septicemia virus in Epithelioma papulosum cyprini cells

  2017cites this paper
• HSP90: a promising broad-spectrum antiviral drug target

  2017cites this paper
• Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity.

  2017cites this paper
• ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction

  2017cites this paper
• Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

  2016cites this paper
• HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis

  2016cites this paper
• The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes*

  2016influential citation
• Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4

  2016cites this paper
• Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology

  2015influential citation
• Tom70 Mediates Sendai Virus-Induced Apoptosis on Mitochondria

  2015cites this paper
• Gedunin Binds to Myeloid Differentiation Protein 2 and Impairs Lipopolysaccharide-Induced Toll-Like Receptor 4 Signaling in Macrophages

  2015cites this paper
• Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

  2015cites this paper
• Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses

  2015cites this paper
• Mitochondria–Nucleus Shuttling FK506-Binding Protein 51 Interacts with TRAF Proteins and Facilitates the RIG-I-Like Receptor-Mediated Expression of Type I IFN

  2014cites this paper
• HSPD1 Interacts with IRF3 to Facilitate Interferon-Beta Induction

  2014cites this paper
• Heat-Shock Protein 90 Promotes Nuclear Transport of Herpes Simplex Virus 1 Capsid Protein by Interacting with Acetylated Tubulin

  2014cites this paper
• Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease

  2014cites this paper
• University of Dundee DEAF 1 is a Pellino 1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

  2013cites this paper
• Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins.

  2013cites this paper
• The Negative Regulation of the Antiviral Signaling Pathway

  2013cites this paper
• Herpes Simplex Virus 1 ICP22 but Not US1.5 Is Required for Efficient Acute Replication in Mice and VICE Domain Formation

  2013cites this paper
• Role of C-terminal phosphorylation in the regulation of the tumour suppressor IRF-1

  2013influential citation
• DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA

  2013cites this paper
• GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

  2013cites this paper
• Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus

  2013cites this paper
• TRIM11 Negatively Regulates IFNβ Production and Antiviral Activity by Targeting TBK1

  2013cites this paper
• Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation

  2013cites this paper
• Mechanisms of MAVS regulation at the mitochondrial membrane.

  2013cites this paper
• HSP90 Protects the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Oncoprotein from Proteasomal Degradation To Support NF-κB Activation and HTLV-1 Replication

  2013cites this paper
• NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses

  2012cites this paper
• Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA*

  2012cites this paper
• Stochastic Expression of the Interferon-β Gene

  2012cites this paper
• Broad action of Hsp90 as a host chaperone required for viral replication.

  2012cites this paper
• Mitochondria: master regulators of danger signalling

  2012cites this paper
• Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll‐like receptor‐mediated autophagy

  2011influential citation
• HCV Infection and B-Cell Lymphomagenesis

  2011cites this paper
• Emerging roles for the non-canonical IKKs in cancer

  2011cites this paper
• IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1

  2011cites this paper
• Mitochondrion: an emerging platform critical for host antiviral signaling

  2011cites this paper
• Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action

  2011influential citation
• Negative Feedback Regulation of NF-κB Action by CITED2 in the Nucleus

  2011cites this paper
• Mitochondria in innate immune responses

  2011cites this paper
• Interactomics identifies novel regulators of the IRF-1 tumour suppressor protein

  2011influential citation
• Caractérisation de la voie d'activation des interférons de type I

  2011cites this paper
• The IKK-related kinases, unsuspected culprits in oncogenesis?

  2011cites this paper
• Peripheral B Cells May Serve as a Reservoir for Persistent Hepatitis C Virus Infection

  2010cites this paper
• Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

  2010cites this paper
• Varicella-Zoster Virus Immediate-Early Protein 62 Blocks Interferon Regulatory Factor 3 (IRF3) Phosphorylation at Key Serine Residues: a Novel Mechanism of IRF3 Inhibition among Herpesviruses

  2010cites this paper
• S1P1-mTOR axis directs the reciprocal differentiation of TH1 and regulatory T cells

  2010cites this paper
• Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

  2010cites this paper
• Tom70 imports antiviral immunity to the mitochondria

  2010cites this paper
• Poxvirus MC160 Protein Utilizes Multiple Mechanisms To Inhibit NF-κB Activation Mediated via Components of the Tumor Necrosis Factor Receptor 1 Signal Transduction Pathway

  2009cites this paper
• Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery*

  2009cites this paper
• Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling.

  2009cites this paper
• Interferon Regulatory Factors and the Atypical IKK-Related Kinases TBK1 and IKK-ε: Essential Players in the Innate Immune Response to RNA Virus Infection

  2009cites this paper
• Role of Heat Shock Proteins in Viral Infection

  2009cites this paper
• The TAK1-JNK cascade is required for IRF3 function in the innate immune response

  2009cites this paper
• IRF3 Inhibition by Rotavirus NSP1 Is Host Cell and Virus Strain Dependent but Independent of NSP1 Proteasomal Degradation

  2009cites this paper
• TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response1

  2009cites this paper
• The IKK-related kinases: from innate immunity to oncogenesis

  2008cites this paper
• Signal transduction in the type I interferon system and viral countermeasures

  2007cites this paper
• UXT is a novel and essential cofactor in the NF-κB transcriptional enhanceosome

  2007cites this paper
• The Induction and Inhibition of an Antiviral Response by Herpes Simplex Virus 1

  2006cites this paper
• Manipulation of the nuclear factor-κB pathway and the innate immune response by viruses

  2006cites this paper
• Regulation of IRF7 through cell type-specific protein stability.

  2006cites this paper
• MIT Open Access Articles Host proteostasis modulates influenza evolution

  year unknowninfluential citation