Role of Heat Shock Proteins in Viral Infection

One of the most intriguing and less known aspects of the interaction between viruses and their host is the impact of the viral infection on the heat shock response (HSR). While both a positive and a negative role of different heat shock proteins (HSP) in the control of virus replication has been hypothesized, HSP function during the virus replication cycle is still not well understood. This chapter describes different aspects of the interactions between viruses and heat shock proteins during infection of mammalian cells: the first part focuses on the modulation of the heat shock response by human viral pathogens; the second describes the interactions of HSP and other chaperones with viral components, and their function during different steps of the virus replication cycle; the last part summarizes our knowledge on the effect of hyperthermia and HSR modulators on virus replication.

• Publication year

  2009

• Venue

  Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease

• Publication date

  2009-10-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-90-481-2976-8_3PMCID 7121897
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Epstein–Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and co-chaperones

  2008influential reference
• Hsp90 inhibitors reduce influenza virus replication in cell culture.

  2008cited by this paper
• The dual immunoregulatory roles of stress proteins.

  2008cited by this paper
• A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction.

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• Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.

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• Anti-Vpr Activities of Heat Shock Protein 27

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• The Peptide-Binding and ATPase Domains of Recombinant hsc70 Are Required To Interact with Rotavirus and Reduce Its Infectivity

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• Functional association between viral and cellular transcription during influenza virus infection

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• Involvement of Hsp90 in Assembly and Nuclear Import of Influenza Virus RNA Polymerase Subunits

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• HSP90 and the chaperoning of cancer

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• Macromolecular synthesis at the early stage of herpes simplex virus type 2 (HSV-2) latency in a human neuroblastoma cell line IMR-32: repression of late viral polypeptide synthesis and accumulation of cellular heat-shock proteins

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• Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.

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• Recruitment of Hsp70 chaperones: a crucial part of viral survival strategies.

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• Binding site analysis of human HBV pol for molecular chaperonin, hsp60.

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• GRP78, a Coreceptor for Coxsackievirus A9, Interacts with Major Histocompatibility Complex Class I Molecules Which Mediate Virus Internalization

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• Molecular Chaperone Hsp90 Is Important for Vaccinia Virus Growth in Cells

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• Transcriptional activation by the human Hsp70-associating protein Hap50.

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• BAG-1M, an isoform of Bcl-2-interacting protein BAG-1, enhances gene expression driven by CMV promoter.

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• Heat Shock Proteins

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• Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

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• Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy.

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