Does clozapine work by blocking spikes and sparing bursts?

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Medical Hypotheses

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Mathematics, Psychology

• Identifiers
  DOI 10.1016/J.MEHY.2005.01.035PMID 15893121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aripiprazole for schizophrenia.

  2006cited by this paper
• Dose dependent occupancy of central dopamine D2 receptors by the novel neuroleptic CP-88,059-01: a study using positron emission tomography and11C-raclopride

  2005cited by this paper
• Prevalence of hyperprolactinemia in schizophrenia: association with typical and atypical antipsychotic treatment.

  2004cited by this paper
• Prolactin levels in schizophrenia and schizoaffective disorder patients treated with clozapine, olanzapine, risperidone, or haloperidol.

  2004cited by this paper
• Polypharmacy in patients with schizophrenia.

  2003cited by this paper
• New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis.

  2003influential reference
• Chlorpromazine equivalent doses for the newer atypical antipsychotics.

  2003cited by this paper
• A meta-analysis of the efficacy of second-generation antipsychotics.

  2003influential reference
• Amphetamine‐sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges

  2002cited by this paper
• Recent trends in antipsychotic combination therapy of schizophrenia and schizoaffective disorder: implications for state mental health policy.

  2002cited by this paper
• Classical approaches to the study of drug-receptor interactions

  2002cited by this paper
• The Effects of Atypical Antipsychotics on Serum Prolactin Levels

  2002cited by this paper
• The Effects of Antipsychotic-Induced Hyperprolactinaemia on the Hypothalamic-Pituitary-Gonadal Axis

  2002cited by this paper
• Dopamine D2 and D3 Receptor Occupancy in Normal Humans Treated with the Antipsychotic Drug Aripiprazole (OPC 14597): A Study Using Positron Emission Tomography and [11C]Raclopride

  2002cited by this paper
• Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade.

  2002cited by this paper
• "Hit-and-run" actions at dopamine receptors, part 1: Mechanism of action of atypical antipsychotics.

  2001cited by this paper
• Clozapine: diabetes mellitus, weight gain, and lipid abnormalities.

  2001cited by this paper
• Sex and psychopharmacology: is natural estrogen a psychotropic drug in women?

  2001cited by this paper
• Potentials and Pitfalls Using High Affinity Radioligands in PET and SPET Determinations on Regional Drug Induced D2 Receptor Occupancy - A Simulation Study Based on Experimental Data

  2001cited by this paper
• No support for regional selectivity in clozapine-treated patients: a PET study with [(11)C]raclopride and [(11)C]FLB 457.

  2001cited by this paper
• The handbook of brain theory and neural networks /

  2001cited by this paper
• D(2) and 5HT(2A) receptor occupancy of different doses of quetiapine in schizophrenia: a PET study.

  2001cited by this paper
• Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis.

  2001cited by this paper
• Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial.

  2001cited by this paper
• Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.

  2000cited by this paper
• Atypical antipsychotics in the treatment of drug‐induced psychosis in Parkinson's disease

  2000cited by this paper
• A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy.

  2000cited by this paper
• Review of incidence studies of tardive dyskinesia associated with typical antipsychotics.

  2000cited by this paper
• Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia.

  2000cited by this paper
• Review of Incidence Studies of Tardive Dyskinesia Associated With Typical Antipsychotics

  2000cited by this paper
• Tardive dyskinesia: pathophysiology and animal models.

  2000cited by this paper
• Heterogeneity of the mesotelencephalic dopamine fibers: physiology and pharmacology.

  2000cited by this paper
• Neurotransmitter Receptors in Actions of Antipsychotic Medications

  2000cited by this paper
• The effects of olanzapine, risperidone, and haloperidol on plasma prolactin levels in patients with schizophrenia.

  2000cited by this paper
• Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis

  2000influential reference
• Regulation of Neurotransmitter Receptors by Antipsychotic Drugs

  2000cited by this paper
• Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine.

  1999cited by this paper
• Evidence of clozapine's effectiveness in schizophrenia: a systematic review and meta-analysis of randomized trials.

  1999cited by this paper
• Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials.

  1999cited by this paper
• Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia.

  1999influential reference
• Cholinergic aspects of schizophrenia

  1999cited by this paper
• A history of antipsychotic drug development.

  1999cited by this paper
• Dopamine D2 receptor occupancy by olanzapine or risperidone in young patients with schizophrenia.

  1999cited by this paper
• Prolactin and antipsychotic medications: mechanism of action.

  1999cited by this paper
• Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson's disease.

  1999cited by this paper
• D2 and 5-HT2 receptor effects of antipsychotics: bridging basic and clinical findings using PET.

  1999cited by this paper
• Antipsychotic polypharmacy, Part 1: Therapeutic option or dirty little secret?

  1999cited by this paper
• Neuroleptic-induced hyperprolactinemia.

  1999cited by this paper
• Management of the adverse effects of clozapine.

  1998cited by this paper
• The relationship between compliance and neuroleptics of schizophrenic patients

  1998cited by this paper
• Single-cell models

  1998cited by this paper
• Novel antipsychotics, extrapyramidal side effects and tardive dyskinesia

  1998cited by this paper
• Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel®) in patients with schizophrenia

  1998cited by this paper
• Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors

  1998cited by this paper
• Do loxapine plus cyproheptadine make an atypical antipsychotic? PET analysis of their dopamine D2 and serotonin2 receptor occupancy.

  1998cited by this paper
• A new framework for investigating antipsychotic action in humans: lessons from PET imaging

  1998cited by this paper
• Do Loxapine Plus Cyproheptadine Make an Atypical Antipsychotic? PET Analysis of Their Dopamine D2 and Serotonin2 Receptor Occupancy

  1998cited by this paper
• 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine

  1998cited by this paper
• Serotonergic basis of antipsychotic drug effects in schizophrenia.

  1998cited by this paper
• A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.

  1997cited by this paper
• Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans

  1997cited by this paper
• Dose-response relationships for the antipsychotic effects and Parkinsonian side-effects of typical neuroleptic drugs: practical and theoretical implications.

  1997cited by this paper
• Limbic selectivity of clozapine.

  1997cited by this paper
• The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group.

  1997cited by this paper
• In vivo characteristics of dopamine D2 receptor occupancy by amisulpride in schizophrenia

  1996cited by this paper
• Mechanisms of action of atypical antipsychotic drugs: a critical analysis

  1996cited by this paper
• Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

  1996cited by this paper
• 5-HT2 antagonism and EPS benefits: is there a causal connection?

  1996cited by this paper
• The role of mesoprefrontal dopamine neurons in stress.

  1996cited by this paper
• Clozapine does not elevate serum prolactin levels in healthy men.

  1995cited by this paper
• New antipsychotics: the present status

  1995cited by this paper
• Positron emission tomography studies on D2 dopamine receptor occupancy and plasma antipsychotic drug levels in man

  1995cited by this paper
• Extrapyramidal side effects of clozapine and haloperidol

  1995cited by this paper
• Agonists and antagonists differentially regulate the high affinity state of the D2L receptor in human embryonic kidney 293 cells.

  1995cited by this paper
• Clozapine does not elevate serum prolactin levels in healthy men

  1995cited by this paper
• The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study.

  1995cited by this paper
• D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients.

  1995cited by this paper
• The effect of clozapine on Fos protein immunoreactivity in the rat forebrain is not mimicked by the addition of alpha 1-adrenergic or 5HT2 receptor blockade to haloperidol.

  1995cited by this paper
• Therapeutic receptor-blocking concentrations of neuroleptics

  1995cited by this paper
• The clinical impact of reported variance in potency of antipsychotic agents

  1995cited by this paper
• Lack of apparent antipsychotic effect of the D1-dopamine recepotr antagonist SCH39166 in acutely ill schizophrenic patients

  1995cited by this paper
• Risperidone in the treatment of schizophrenia.

  1994cited by this paper
• Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients.

  1993cited by this paper
• Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.

  1993cited by this paper
• Does clozapine cause tardive dyskinesia?

  1993cited by this paper
• A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients.

  1993cited by this paper
• Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.

  1992cited by this paper
• Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum.

  1992cited by this paper
• Extracellular dopamine and neurotensin in rat prefrontal cortex in vivo: effects of median forebrain bundle stimulation frequency, stimulation pattern, and dopamine autoreceptors

  1991cited by this paper
• Dopamine in schizophrenia: a review and reconceptualization.

  1991cited by this paper
• Synaptic Concentration of Dopamine in the Mouse Striatum in Relationship to the Kinetic Properties of the Dopamine Receptors and Uptake Mechanism

  1991cited by this paper
• Dopamine D-1 and D-2 receptors in relation to reward and performance: a case for the D-1 receptor as a primary site of therapeutic action of neuroleptic drugs.

  1990cited by this paper
• Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

  1989cited by this paper
• Dopamine-containing neurons in the mammalian central nervous system: electrophysiology and pharmacology.

  1988cited by this paper
• Firing patterns of midbrain dopamine neurons: differences between A9 and A10 cells.

  1988cited by this paper
• Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry.

  1988cited by this paper
• Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.

  1988cited by this paper
• A Pharmacologic Analysis of Drug-Receptor Interaction

  1987cited by this paper
• Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro.

  1984cited by this paper
• Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.

  1976cited by this paper

• Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study

  2021cites this paper
• Reiterate and integrate the adverse effect of antipsychotic agent and its attenuation by Ginkgo Biloba Extract on reproductive system and functions of rodents

  2017cites this paper
• The Role of Binding Kinetics in GPCR Drug Discovery.

  2015cites this paper
• The Effects of Chlorpromazine on Reproductive System and Function in Female Rats

  2015cites this paper
• Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism

  2012cites this paper
• The role of D1-D2 receptor hetero-dimerization in the mechanism of action of clozapine.

  2008cites this paper
• Mechanism of action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization--a working hypothesis.

  2008cites this paper