Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies

Based on the published animal studies, we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation. 74 animal studies were finally included, of which naturally derived biomaterials were applied the most widely (50.0%), rats were the most commonly used animal model (47.0%), and autologous tissue demonstrated the best outcomes in all animal models. The biomechanical properties of naturally derived biomaterials (maximum failure load: WMD 18.68 [95%CI 7.71–29.66]; P = 0.001, and stiffness: WMD 1.30 [95%CI 0.01–2.60]; P = 0.048) was statistically significant in the rabbit model. The rabbit model showed better outcomes even though the injury was severer compared with the rat model.

• Publication year

  2021

• Venue

  Bioactive Materials

• Publication date

  2021-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.bioactmat.2021.08.016PMID 34901561PMCID 8633530
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Localized delivery of ibuprofen via a bilayer delivery system (BiLDS) for supraspinatus tendon healing in a rat model

  2020cited by this paper
• Engineered Cell Sheets for the Effective Delivery of Adipose-Derived Stem Cells for Tendon-to-Bone Healing

  2020cited by this paper
• Possibilities and limitations of electrospun chitosan‐coated polycaprolactone grafts for rotator cuff tear repair

  2020cited by this paper
• Application of Autogenous Urine-Derived Stem Cell Sheet Enhances Rotator Cuff Healing in a Canine Model

  2020cited by this paper
• Can prospective systematic reviews of animal studies improve clinical translation?

  2020cited by this paper
• [Effect of microfracture combined with biomimetic hydrogel scaffold on rotator cuff tendon-to-bone healing in rabbits].

  2020cited by this paper
• Regeneration of the Rotator Cuff Tendon-to-Bone Interface using Umbilical Cord-Derived Mesenchymal Stem Cells and Gradient Extracellular Matrix Scaffolds from Adipose Tissue in a Rat Model.

  2020influential reference
• TGF–β3 Loaded Electrospun Polycaprolacton Fibre Scaffolds for Rotator Cuff Tear Repair: An in Vivo Study in Rats

  2020influential reference
• Effect of kartogenin-loaded gelatin methacryloyl hydrogel scaffold with bone marrow-stimulation for enthesis healing in rotator cuff repair.

  2020cited by this paper
• The Treatment of Muscle Atrophy After Rotator Cuff Tears Using Electroconductive Nanofibrous Matrices

  2020cited by this paper
• Tendon-Inspired Nanotopographic Scaffold for Tissue Regeneration in Rotator Cuff Injuries

  2020cited by this paper
• A Synthetic Graft With Multilayered Co-Electrospinning Nanoscaffolds for Bridging Massive Rotator Cuff Tear in a Rat Model

  2020cited by this paper
• The effect of autologous Achilles bursal tissue implants in tendon-to-bone healing of rotator cuff tears in rats.

  2020cited by this paper
• Midterm outcomes of arthroscopic rotator cuff repair in patients aged 75 years and older.

  2020cited by this paper
• Comparison of biologic scaffolds for augmentation of partial rotator cuff tears in a canine model.

  2020cited by this paper
• Reconstruction of large chronic rotator cuff tear can benefit from the bone–tendon composite autograft to restore the native bone–tendon interface

  2020cited by this paper
• Rotator Cuff Repair: Patch the Shoulder.

  2019cited by this paper
• Surgery for rotator cuff tears.

  2019cited by this paper
• In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells

  2019influential reference
• Use of a Novel, Reinforced, Low Immunogenic, Porcine Small Intestine Submucosa Patch to Repair a Supraspinatus Tendon Defect in a Rabbit Model

  2019cited by this paper
• Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane

  2019cited by this paper
• Overlay repair with a synthetic collagen scaffold improves the quality of healing in a rat rotator cuff repair model.

  2019cited by this paper
• A Collagen and Silk Scaffold for Improved Healing of the Tendon and Bone Interface in a Rabbit Model

  2019cited by this paper
• Mechanical Augmentation With Absorbable Alginate Sheet Enhances Healing of the Rotator Cuff.

  2019cited by this paper
• The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats.

  2019influential reference
• Engineered tendon-fibrocartilage-bone composite and bone marrow-derived mesenchymal stem cell sheet augmentation promotes rotator cuff healing in a non-weight-bearing canine model.

  2019influential reference
• Full publication of results initially presented in abstracts.

  2018cited by this paper
• Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo.

  2018influential reference
• Bridging Repair of Large Rotator Cuff Tears Using a Multilayer Decellularized Tendon Slices Graft in a Rabbit Model.

  2018cited by this paper
• Application of a Demineralized Cortical Bone Matrix and Bone Marrow–Derived Mesenchymal Stem Cells in a Model of Chronic Rotator Cuff Degeneration

  2018influential reference
• Rotator cuff tear healing process with graft augmentation of fascia lata in a rabbit model

  2018cited by this paper
• How to appraise quantitative research

  2018cited by this paper
• Meta-analysis and the science of research synthesis

  2018cited by this paper
• Current development of biodegradable polymeric materials for biomedical applications

  2018cited by this paper
• Mesenchymal Stem Cell Secretome Improves Tendon Cell Viability In Vitro and Tendon-Bone Healing In Vivo When a Tissue Engineering Strategy Is Used in a Rat Model of Chronic Massive Rotator Cuff Tear

  2018influential reference
• The effectiveness of demineralized cortical bone matrix in a chronic rotator cuff tear model.

  2017cited by this paper
• Autologous tendon‐derived cell‐seeded nanofibrous scaffolds improve rotator cuff repair in an age‐dependent fashion

  2017cited by this paper
• [Establishing the acupuncture-moxibustion clinical trial registry and improving the transparence of clinical trials of acupuncture and moxibustion].

  2017cited by this paper
• The biology of rotator cuff healing.

  2017cited by this paper
• Tissue-Engineered Tendon for Enthesis Regeneration in a Rat Rotator Cuff Model

  2017cited by this paper
• Repair of rotator cuff injuries using different composites.

  2017cited by this paper
• Rotator cuff repair using cell sheets derived from human rotator cuff in a rat model

  2017cited by this paper
• Tissue‐engineered tendon constructs for rotator cuff repair in sheep

  2017cited by this paper
• Osteogenic Differentiation of Periosteal Cells During Fracture Healing

  2017cited by this paper
• Poly-N-Acetyl Glucosamine (sNAG) Enhances Early Rotator Cuff Tendon Healing in a Rat Model

  2017cited by this paper
• Reparación de las lesiones crónicas del manguito rotador mediante diferentes compuestos

  2017cited by this paper
• Cell-based approaches for augmentation of tendon repair.

  2017cited by this paper
• Effective healing of chronic rotator cuff injury using recombinant bone morphogenetic protein-2 coated dermal patch in vivo.

  2017cited by this paper
• Enhancement of rotator cuff tendon-bone healing with fibroblast growth factor 2 impregnated in gelatin hydrogel sheets in a rabbit model.

  2017cited by this paper
• Rotator cuff repair augmentation in a rat model that combines a multilayer xenograft tendon scaffold with bone marrow stromal cells.

  2016influential reference
• Introduction to systematic reviews and meta‐analysis

  2016cited by this paper
• Outcomes After Patch Use in Rotator Cuff Repair.

  2016cited by this paper
• Platelet-derived growth factor-BB-immobilized asymmetrically porous membrane for enhanced rotator cuff tendon healing

  2016cited by this paper
• A synthetic bridging patch of modified co-electrospun dual nano-scaffolds for massive rotator cuff tear.

  2016cited by this paper
• Role of anti-adhesive barriers following rotator cuff repair surgery: an experimental study.

  2016cited by this paper
• Rotator cuff repair: a review of surgical techniques, animal models, and new technologies under development.

  2016cited by this paper
• Augmentation and repair of tendons using demineralised cortical bone

  2016cited by this paper
• Stimulation of Rotator Cuff Repair by Sustained Release of Bone Morphogenetic Protein-7 Using a Gelatin Hydrogel Sheet

  2015influential reference
• Animal models are essential to biological research: issues and perspectives

  2015cited by this paper
• In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-to-Bone Repair

  2015influential reference
• State of the art in rotator cuff repair

  2015cited by this paper
• Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model

  2015cited by this paper
• Using Qualitative Evidence in Decision Making for Health and Social Interventions: An Approach to Assess Confidence in Findings from Qualitative Evidence Syntheses (GRADE-CERQual)

  2015cited by this paper
• Rotator cuff repair using a decellularized tendon slices graft: an in vivo study in a rabbit model

  2015cited by this paper
• Clinical effectiveness and cost-effectiveness of open and arthroscopic rotator cuff repair [the UK Rotator Cuff Surgery (UKUFF) randomised trial].

  2015cited by this paper
• Local Application of Gelatin Hydrogel Sheets Impregnated With Platelet-Derived Growth Factor BB Promotes Tendon-to-Bone Healing After Rotator Cuff Repair in Rats.

  2015influential reference
• Healing improvement after rotator cuff repair using gelatin-grafted poly(L-lactide) electrospun fibrous membranes.

  2015cited by this paper
• Long-term follow-up after latissimus dorsi transfer for irreparable posterosuperior rotator cuff tears.

  2015cited by this paper
• rhPDGF-BB Promotes Early Healing in a Rat Rotator Cuff Repair Model

  2015influential reference
• Progress in cell-based therapies for tendon repair.

  2015cited by this paper
• Evaluation of a collagen-coated, resorbable fiber scaffold loaded with a peptide basic fibroblast growth factor mimetic in a sheep model of rotator cuff repair.

  2015cited by this paper
• Effect of Poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model

  2014cited by this paper
• Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

  2014influential reference
• Fascia lata allograft bridging of a rotator cuff tear in a rabbit animal model

  2014cited by this paper
• Porous membrane with reverse gradients of PDGF-BB and BMP-2 for tendon-to-bone repair: in vitro evaluation on adipose-derived stem cell differentiation.

  2014cited by this paper
• Rotator Cuff Biology and Biomechanics: a Review of Normal and Pathological Conditions

  2014cited by this paper
• SYRCLE’s risk of bias tool for animal studies

  2014cited by this paper
• Histological evaluation after arthroscopic reconstruction of the shoulder using a polytetrafluoroethylene patch for massive rotator cuff tears

  2013cited by this paper
• Cell‐based tissue engineering augments tendon‐to‐bone healing in a rat supraspinatus model

  2013cited by this paper
• Effect of Platelet-Rich Plasma and Porcine Dermal Collagen Graft Augmentation for Rotator Cuff Healing in a Rabbit Model

  2013cited by this paper
• Synthetic and degradable patches: an emerging solution for rotator cuff repair

  2013cited by this paper
• Regeneration of rotator cuff tear using electrospun poly(d,l-Lactide-Co-Glycolide) scaffolds in a rabbit model.

  2012cited by this paper
• Effects of lactic acid and glycolic acid on human osteoblasts: A way to understand PLGA involvement in PLGA/calcium phosphate composite failure

  2012cited by this paper
• Host response to xenograft ECM implantation is not different between the shoulder and body wall sites in the rat model

  2012cited by this paper
• Scaffold devices for rotator cuff repair.

  2012cited by this paper
• Does Augmentation with a Reinforced Fascia Patch Improve Rotator Cuff Repair Outcomes?

  2012cited by this paper
• National trends in rotator cuff repair.

  2012cited by this paper
• Tensile and shear mechanical properties of rotator cuff repair patches.

  2012cited by this paper
• Rotator cuff tears: what have we learned from animal models?

  2011cited by this paper
• GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables.

  2011cited by this paper
• Application of layered poly (L-lactic acid) cell free scaffold in a rabbit rotator cuff defect model

  2011cited by this paper
• Augmentation of a Rotator Cuff Suture Repair Using rhPDGF-BB and a Type I Bovine Collagen Matrix in an Ovine Model

  2011influential reference
• Adenoviral-Mediated Gene Transfer of Human Bone Morphogenetic Protein–13 Does Not Improve Rotator Cuff Healing in a Rat Model

  2011cited by this paper
• Systematic reviews and meta-analyses of preclinical studies: Publication bias in laboratory animal experiments

  2011cited by this paper
• Rehabilitation following arthroscopic rotator cuff repair.

  2010cited by this paper
• Cochrane Handbook for Systematic Reviews of Interventions

  2010cited by this paper
• Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed

  2010cited by this paper
• Biomechanical Analysis of an Ovine Rotator Cuff Repair via Porous Patch Augmentation in a Chronic Rupture Model

  2010cited by this paper
• Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines

  2010cited by this paper
• Extracellular matrix scaffold devices for rotator cuff repair.

  2010cited by this paper

• Exploring Patches for Rotator Cuff Repair: A Systematic Review

  2026cites this paper
• Biologic Augmentation in Rotator Cuff Repair: Current Evidence and Future Directions

  2026cites this paper
• [Advances of low-intensity pulsed ultrasound for treatment of musculoskeletal disorders in the past decade].

  2025cites this paper
• Decellularized tendon patch enhance biological and mechanical healing of large-to-massive rotator cuff tear in a rat chronic model: a comparison study of patch sterilization and storage methods

  2025cites this paper
• Augmentation Techniques for Rotator Cuff Repairs

  2025cites this paper
• A Quantitative Evaluation of the Efficacy of Endochondral Ossification-Based Grafts in Bone Defect Regeneration: An Analysis of Animal Studies.

  2025cites this paper
• Arthroscopic Superior Capsule Reconstruction With Combined Fascia Lata Autograft Augmented With Either LARS Ligament or Polypropylene Mesh Synthetic Scaffold Patch Graft: A Comparison of Techniques With a Minimum 2-Year Follow-up for the Treatment of Irreparable Rotator Cuff Tears

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• A twin-track therapeutic strategy for massive rotator cuff tears based on robust and piezoelectric nanocomposite hydrogel films

  2025cites this paper
• Bilayer book- like decellularized extracellular matrix scaffold with bioactive coatings for rotator cuff repair

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• Mesenchymal stem cell activity across a graded scaffold-hydrogel composite biomaterial for tendon-to-bone enthesis repair

  2025cites this paper
• The Effect of Vitamin D Deficiency on Post-operative Outcomes Following Rotator Cuff Repair: A Meta-Analysis

  2025cites this paper
• Preparation and evaluation of an injectable HAp/Col I composite for promoting tendon-to-bone healing in ACL reconstruction

  2025cites this paper
• Experimental methodology used for testing in vivo adhesion of composite meshes for incisional hernia repair: a scoping review

  2025cites this paper
• [Key role of biomechanical properties and material selection in rotator cuff repair].

  2025cites this paper
• Rotator cuff repair with all-suture anchor enhances biomechanical properties and tendon-bone integration in a rabbit model

  2024cites this paper
• Intrasynovial autograft for reconstruction of chronic large rotator cuff tears in a rabbit model: biomechanical, computed tomography, and histological results

  2024influential citation
• Patch Augmentation in Arthroscopic Rotator Cuff Surgery—Review of Current Evidence and Newest Trends

  2024cites this paper
• Biomechanical properties of various rat rotator cuff repair techniques.

  2024cites this paper
• Decellularized biological matrices for the repair of rotator cuff lesions: a systematic review of preclinical in vivo studies

  2024influential citation
• Repair of chronic and large rotator cuff tears using extra‐synovial autografts: An experimental study in rabbits

  2024cites this paper
• Design, Printing, and Engineering of Regenerative Biomaterials for Personalized Bone Healthcare

  2023cites this paper
• A Knitted PET Patch Enhances the Maturation of Regenerated Tendons in Bridging Reconstruction of Massive Rotator Cuff Tears in a Rabbit Model

  2023influential citation
• Surface Modification of Biodegradable Zinc Alloy for Biomedical Applications

  2023cites this paper
• Translation of biomaterials from bench to clinic

  2022cites this paper
• Biomaterials and regulatory science

  2022cites this paper
• Animal Models of Rotator Cuff Injury and Repair: A Systematic Review

  2022cites this paper