Profilin: emerging concepts and lingering misconceptions.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  TIBS -Trends in Biochemical Sciences. Regular ed

• Publication date

  2006-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TIBS.2006.02.006PMID 16542844
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mammalian CARMIL inhibits actin filament capping by capping protein.

  2005cited by this paper
• Real-time measurements of actin filament polymerization by total internal reflection fluorescence microscopy.

  2005cited by this paper
• Effects of Profilin and Thymosin β4 on the Critical Concentration of Actin Demonstrated in Vitro and in Cell Extracts with a Novel Direct Assay*

  2004cited by this paper
• A mechanistic model of the actin cycle.

  2004cited by this paper
• Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis.

  2004cited by this paper
• Structural basis of actin sequestration by thymosin‐β4: implications for WH2 proteins

  2004cited by this paper
• Processive capping by formin suggests a force-driven mechanism of actin polymerization

  2004cited by this paper
• The role of profilin complexes in cell motility and other cellular processes.

  2004cited by this paper
• Actin Polymerization-Driven Molecular Movement of mDia1 in Living Cells

  2004cited by this paper
• Actin binding proteins that change extent and rate of actin monomer-polymer distribution by different mechanisms

  2004cited by this paper
• Depolymerization of Actin Filaments by Profilin

  2003cited by this paper
• A Cross-linked Profilin-Actin Heterodimer Interferes with Elongation at the Fast-growing End of F-actin*

  2002cited by this paper
• An unexplained sequestration of latrunculin A is required in neutrophils for inhibition of actin polymerization.

  2002cited by this paper
• Actin filament barbed end elongation with nonmuscle MgATP-actin and MgADP-actin in the presence of profilin.

  2002cited by this paper
• Hydrolysis of ATP by polymerized actin depends on the bound divalent cation but not profilin.

  2002cited by this paper
• Microscopic analysis of polymerization dynamics with individual actin filaments

  2002cited by this paper
• A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.

  2002cited by this paper
• Formation and Implications of a Ternary Complex of Profilin, Thymosin β4, and Actin*

  2001cited by this paper
• Filament Assembly from Profilin-Actin*

  1999cited by this paper
• Profilin Promotes Barbed-end Actin Filament Assembly without Lowering the Critical Concentration*

  1999cited by this paper
• A Role for Polyproline Motifs in the Spinal Muscular Atrophy Protein SMN

  1999cited by this paper
• Impact of profilin on actin-bound nucleotide exchange and actin polymerization dynamics.

  1999cited by this paper
• Tropomodulin Increases the Critical Concentration of Barbed End-capped Actin Filaments by Converting ADP·Pi-actin to ADP-actin at All Pointed Filament Ends*

  1999cited by this paper
• The role of profilin in actin polymerization and nucleotide exchange.

  1998cited by this paper
• Plant profilin induces actin polymerization from actin:β‐thymosin complexes and competes directly with β‐thymosins and with negative co‐operativity with DNase I for binding to actin

  1998cited by this paper
• Interactions of drebrin and gephyrin with profilin.

  1998cited by this paper
• p140mDia, a mammalian homolog of Drosophila diaphanous,is a target protein for Rho small GTPase and is a ligand for profilin

  1997cited by this paper
• Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.

  1997cited by this paper
• Capping of the barbed ends of actin filaments by a high-affinity profilin-actin complex.

  1997cited by this paper
• Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.

  1996cited by this paper
• Role of Nucleotide Exchange and Hydrolysis in the Function of Profilin in Actin Assembly

  1996cited by this paper
• Regulation of Profilin Localization in Saccharomyces cerevisiae by Phosphoinositide Metabolism (*)

  1995cited by this paper
• The proline‐rich focal adhesion and microfilament protein VASP is a ligand for profilins.

  1995cited by this paper
• Crystallization and structure determination of bovine profilin at 2.0 A resolution.

  1994cited by this paper
• Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose

  1994cited by this paper
• Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development.

  1994cited by this paper
• How profilin promotes actin filament assembly in the presence of thymosin beta 4.

  1993cited by this paper
• Control of profilin and actin expression in muscle and nonmuscle cells.

  1993cited by this paper
• How profilin promotes actin filament assembly in the presence of thymosin β4

  1993cited by this paper
• The structure of crystalline profilin–β-actin

  1993cited by this paper
• The structure of crystalline profilin-beta-actin.

  1993cited by this paper
• Profilin-actin complexes directly elongate actin filaments at the barbed end.

  1992cited by this paper
• Microinjection of covalently cross-linked actin oligomers causes disruption of existing actin filament architecture in PtK2 cells.

  1990cited by this paper
• Exogenous nucleation sites fail to induce detectable polymerization of actin in living cells

  1990cited by this paper
• Specificity of the interaction between phosphatidylinositol 4,5‐bisphosphate and the profilin:actin complex

  1988cited by this paper
• Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments

  1986cited by this paper
• Mechanism of regulation of actin polymerization by Physarum profilin

  1984cited by this paper
• Quantitative analysis of the effect of Acanthamoeba profilin on actin filament nucleation and elongation.

  1984cited by this paper
• Actin from Thyone sperm assembles on only one end of an actin filament: a behavior regulated by profilin

  1983cited by this paper
• On the mechanism of actin monomer-polymer subunit exchange at steady state.

  1983cited by this paper
• Acanthamoeba profilin interacts with G-actin to increase the rate of exchange of actin-bound adenosine 5'-triphosphate.

  1980cited by this paper
• Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells.

  1977cited by this paper
• Head to tail polymerization of actin.

  1976cited by this paper
• Crystallization of a non-muscle actin.

  1976cited by this paper
• Thermodynamics of the polymerization of protein

  1975cited by this paper

• Hypoxia and the cytoskeleton.

  2025cites this paper
• Natural product drupacine acting on a novel herbicidal target shikimate dehydrogenase.

  2023cites this paper
• Actin polymerization and depolymerization in developing vertebrates

  2023cites this paper
• Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton

  2022cites this paper
• Actin depolymerizing factor ADF7 inhibits actin bundling protein VILLIN1 to regulate root hair formation in response to osmotic stress in Arabidopsis

  2022cites this paper
• The Actin Regulators Involved in the Function and Related Diseases of Lymphocytes

  2022cites this paper
• Pomacea canaliculata Ampullar Proteome: A Nematode-Based Bio-Pesticide Induces Changes in Metabolic and Stress-Related Pathways

  2021cites this paper
• Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation

  2021cites this paper
• Assessing the Precision and Recall of msTALI as Applied to an Active-Site Study on Fold Families

  2020cites this paper
• Evaluating Precisicon and Recall through the Utility of msTALI via an Active Site Study on Fold Families

  2019cites this paper
• Reconsidering an active role for G-actin in cytoskeletal regulation

  2018influential citation
• Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy.

  2018cites this paper
• Aktyna i miozyny w jądrze komórkowym

  2018cites this paper
• Primary immunodeficiencies caused by mutations in actin regulatory proteins

  2018cites this paper
• Arabidopsis FIM4 and FIM5 regulates the growth of root hairs in an auxin-insensitive way

  2018cites this paper
• Investigating Structural and Functional Defects in ALS-causing Profilin 1 Variants

  2017cites this paper
• Evolutionary expansion and structural functionalism of the ancient family of profilin proteins.

  2017cites this paper
• What We Know and Do Not Know About Actin.

  2017cites this paper
• Overexpression of GhPFN2 enhances protection against Verticillium dahliae invasion in cotton

  2017cites this paper
• Cofilin and drebrin mediated regulation of the neuronal cytoskeleton in development and disease

  2017cites this paper
• Biophysical analysis of three novel profilin-1 variants associated with amyotrophic lateral sclerosis indicates a correlation between their aggregation propensity and the structural features of their globular state

  2016influential citation
• Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility

  2016cites this paper
• Actin Assembly Dynamics and Its Regulation in Motile and Morphogenetic Processes

  2016cites this paper
• Rapid proteomic responses to a near-lethal heat stress in the salt marsh mussel Geukensia demissa

  2016cites this paper
• Arabidopsis plants deficient in constitutive class profilins reveal independent and quantitative genetic effects

  2015cites this paper
• Changes in thrombus composition and profilin-1 release in acute myocardial infarction.

  2015cites this paper
• The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis

  2015cites this paper
• Mutations of Profilin-1 Associated with Amyotrophic Lateral Sclerosis Promote Aggregation Due to Structural Changes of Its Native State.

  2015cites this paper
• The functional characterization of a root knot nematode effector Mi131 and an investigation of the role of jasmonic acid during the Arabidopsis-root knot nematode interaction

  2015cites this paper
• Acute coronary syndromes Changes in thrombus composition and profilin-1 release in acute myocardial infarction

  2015cites this paper
• Actin, actin-related proteins and profilin in diatoms: a comparative genomic analysis.

  2015cites this paper
• Controlling cell shape changes during salivary gland tube formation in Drosophila.

  2014cites this paper
• Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization

  2014cites this paper
• A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerization.

  2014cites this paper
• PKA-mediated regulation of Profilin-1 -- implication in sprouting angiogenesis

  2014cites this paper
• C-Terminus of Hsc70-interacting protein regulates profilin1 and breast cancer cell migration.

  2014cites this paper
• WIP: more than a WASp‐interacting protein

  2014cites this paper
• Polar Expansion Dynamics in the Plant Kingdom: A Diverse and Multifunctional Journey on the Path to Pollen Tubes

  2013cites this paper
• Dissecting the role and regulation of MRL function in Drosophila

  2013cites this paper
• Actin-binding Protein Drebrin Regulates HIV-1-triggered Actin Polymerization and Viral Infection*

  2013cites this paper
• Comparative Proteomic Analysis of Gallbladder Bile Proteins Related to Cholesterol Gallstones

  2013cites this paper
• ctin during Membrane Protrusion in Neuronal Motility

  2013cites this paper
• Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy

  2013cites this paper
• Regulation of actin by ion-linked equilibria.

  2013cites this paper
• Recombinant production, crystallization and preliminary structural characterization of Schistosoma japonicum profilin.

  2013cites this paper
• Molecular insights on context-specific role of profilin-1 in cell migration

  2012cites this paper
• Control of the actin cytoskeleton in root hair development.

  2012cites this paper
• Identification of cation-binding sites on actin that drive polymerization and modulate bending stiffness

  2012cites this paper
• α2-chimaerin and interacting proteins in axonal guidance signalling

  2012cites this paper
• Individual Actin Filaments in a Microfluidic Flow Reveal the Mechanism of ATP Hydrolysis and Give Insight Into the Properties of Profilin

  2011cites this paper
• Dissecting Regulatory Networks of Filopodia Formation in a Drosophila Growth Cone Model

  2011cites this paper
• Effect of ouabain on myocardial ultrastructure and cytoskeleton during the development of ventricular hypertrophy

  2011cites this paper
• The role of actin and myosin during spermatogenesis

  2011cites this paper
• Cell migration: an overview.

  2011cites this paper
• Active tension adaptation at a shortened arterial muscle length: inhibition by cytochalasin-D.

  2011influential citation
• Cordon-Bleu uses WH2 domains as multifunctional dynamizers of actin filament assembly.

  2011cites this paper
• Profilin-1 Is Expressed in Human Atherosclerotic Plaques and Induces Atherogenic Effects on Vascular Smooth Muscle Cells

  2010cites this paper
• The role of formins in filopodia formation.

  2010cites this paper
• Overexpression of a profilin (GhPFN2) promotes the progression of developmental phases in cotton fibers.

  2010cites this paper
• Watermelon Profilin: Characterization of a Major Allergen as a Model for Plant-Derived Food Profilins

  2010cites this paper
• Specific effects exerted by B‐lymphoproliferative diseases on peripheral T‐lymphocyte protein expression

  2010cites this paper
• Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia.

  2010cites this paper
• Mutational Analysis Reveals a Noncontractile but Interactive Role of Actin and Profilin in Viral RNA-Dependent RNA Synthesis

  2009cites this paper
• How depolymerization can promote polymerization: the case of actin and profilin

  2009cites this paper
• Models for actin polymerization motors

  2009cites this paper
• The biological functions of mouse twinfilin isoforms

  2009cites this paper
• Les rôles distincts des isoformes de myosine II non-musculaire dans des processus cellulaires impliquant le cytosquelette d'actine

  2009cites this paper
• Actin-Based Motility in Professional Phagocytes†

  2009cites this paper
• Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin.

  2009cites this paper
• Usual and unusual biochemical properties of ADF/cofilin-like protein Adf73p in ciliate Tetrahymena thermophila.

  2009cites this paper
• Bmc Cell Biology Testis-expressed Profilins 3 and 4 Show Distinct Functional Characteristics and Localize in the Acroplaxome-manchette Complex in Spermatids

  2009cites this paper
• The actin cytoskeleton in cancer cell motility

  2009cites this paper
• A Targeted Gain-of-Function Screen Identifies Genes Affecting Salivary Gland Morphogenesis/Tubulogenesis in Drosophila

  2009cites this paper
• Expression Analysis and Characteristics of Profilin Gene from Silkworm, Bombyx mori

  2009cites this paper
• The chloroplast outer membrane protein CHUP1 interacts with actin and profilin

  2008influential citation
• Central corticosteroid actions: Search for gene targets.

  2008cites this paper
• Effect of profilin on actin critical concentration: a theoretical analysis.

  2008cites this paper
• Latrunculin B facilitates Shiga toxin 1 transcellular transcytosis across T84 intestinal epithelial cells.

  2008cites this paper
• Chup1 - a chloroplast movement protein and its interactions

  2008cites this paper
• Flamingo/Starry Night in embryonic abdominal sensory axon development of Drosophila

  2008cites this paper
• Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation

  2008cites this paper
• Regulation of actin assembly associated with protrusion and adhesion in cell migration.

  2008cites this paper
• Moving the green

  2008cites this paper
• Liquid chromatography electrospray ionization and matrix-assisted laser desorption ionization tandem mass spectrometry for the analysis of lipid raft proteome of monocytes.

  2008cites this paper
• Actin motors that drive formation and disassembly of epithelial apical junctions.

  2008cites this paper
• Actin-Interacting Proteins in flagellated pathogenic Leishmania spp.: a genome-based bioinformatics report on profilins, formins and katanins

  2008influential citation
• Shiga toxin 1 transcellular transcytosis across T 84 intestinal epithelial cells

  2008cites this paper
• Analysis of the function of Spire in actin assembly and its synergy with formin and profilin.

  2007cites this paper
• Diverse roles of actin in C. elegans early embryogenesis

  2007cites this paper
• ARHGAP4 is a spatially regulated RhoGAP that inhibits NIH/3T3 cell migration and dentate granule cell axon outgrowth.

  2007cites this paper
• Structure, Function, and Evolution of the β‐Thymosin/WH2 (WASP‐Homology2) Actin‐Binding Module

  2007cites this paper
• Promiscuous stimulation of ParF protein polymerization by heterogeneous centromere binding factors.

  2007cites this paper
• Structural basis of cytoskeletal regulation by twinfilin

  2007cites this paper
• Regulation of actin filament assembly by Arp2/3 complex and formins.

  2007cites this paper
• Structural basis for the recruitment of profilin–actin complexes during filament elongation by Ena/VASP

  2007cites this paper
• How ATP Hydrolysis Controls Filament Assembly from Profilin-Actin

  2007cites this paper
• Addressing the role of the cytoskeletal molecules Diaphanous and Profilin in dendritic morphogenesis in Drosophila melanogaster

  2007cites this paper
• Glucocorticoid control of gene transcription in neural tissue

  2007cites this paper
• Capu and Spire Assemble a Cytoplasmic Actin Mesh that Maintains Microtubule Organization in the Drosophila Oocyte

  2007cites this paper
• An ectromelia virus profilin homolog interacts with cellular tropomyosin and viral A-type inclusion protein

  2007cites this paper