The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Anticancer Research

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 18630529
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells.

  2007cited by this paper
• 2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells.

  2007cited by this paper
• Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats.

  2006cited by this paper
• Role of Baicalein in the regulation of proliferation and apoptosis in human myeloma RPMI8226 cells.

  2006cited by this paper
• Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line.

  2006cited by this paper
• Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3.

  2006cited by this paper
• In vivo and in vitro effect of baicalein on human prostate cancer cells.

  2005cited by this paper
• Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells.

  2005cited by this paper
• Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.

  2005cited by this paper
• hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

  2004cited by this paper
• Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP

  2004cited by this paper
• 9-Hydroxypheophorbide alpha-induced apoptotic death of MCF-7 breast cancer cells is mediated by c-Jun N-terminal kinase activation.

  2004cited by this paper
• Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.

  2004cited by this paper
• The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions.

  2003cited by this paper
• The Bcl-2-regulated apoptotic pathway

  2003cited by this paper
• Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells.

  2003cited by this paper
• RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria.

  2003cited by this paper
• Apoptosis A Link between Cancer Genetics and Chemotherapy

  2002cited by this paper
• The Bcl2 family: regulators of the cellular life-or-death switch

  2002cited by this paper
• Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.

  2002cited by this paper
• Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.

  2002cited by this paper
• Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines.

  2002cited by this paper
• The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.

  2002cited by this paper
• Effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction.

  2002cited by this paper
• Nitric Oxide-induced Apoptosis in RAW 264.7 Macrophages Is Mediated by Endoplasmic Reticulum Stress Pathway Involving ATF6 and CHOP*

  2002cited by this paper
• Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity.

  2001cited by this paper
• Baicalein protects cortical neurons from β-amyloid (25-35) induced toxicity

  2001cited by this paper
• Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells.

  2001cited by this paper
• Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia.

  2001cited by this paper
• 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.

  2001cited by this paper
• Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms.

  2001cited by this paper
• Apoptosis in cancer.

  2000cited by this paper
• Inhibition of 12-lipoxygenase induced apoptosis in human gastric cancer cells

  2000cited by this paper
• Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin.

  2000cited by this paper
• Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery.

  1999cited by this paper
• Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

  1999cited by this paper
• Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi.

  1999cited by this paper
• Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.

  1998cited by this paper
• The Bcl-2 protein family: arbiters of cell survival.

  1998cited by this paper
• Apoptosis in cancer.

  1996cited by this paper
• The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin.

  1996cited by this paper
• Free radical scavenging action of baicalein.

  1993cited by this paper
• Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer.

  1987cited by this paper

• Phytoconstituents as emerging therapeutics for breast cancer: Mechanistic insights and clinical implications

  2025cites this paper
• Exploiting Nanostructured Lipid Carriers for Lamivudine Repurposing in Oncology Through Modulation of Key Molecular Pathways

  2025cites this paper
• Baicalein Sensitizes Triple Negative Breast Cancer Cells to Cisplatin by Activating Apoptosis

  2025cites this paper
• Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes [Retraction]

  2025cites this paper
• The Therapeutic Potential of Baicalin and Baicalein in Breast Cancer: A Systematic Review of Mechanisms and Efficacy

  2025cites this paper
• Antimicrobial Potential of Polyphenols: An Update on Alternative for Combating Antimicrobial Resistance.

  2024cites this paper
• Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel‐mediated oxidative stress

  2024cites this paper
• A review on endoplasmic reticulum-dependent anti-breast cancer activity of herbal drugs: possible challenges and opportunities

  2024cites this paper
• Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis

  2024cites this paper
• Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

  2023cites this paper
• Endoplasmic Reticulum Stress and Cancer: Could Unfolded Protein Response Be a Druggable Target for Cancer Therapy?

  2023cites this paper
• Baicalein—A review on its molecular mechanism against breast cancer and delivery strategies

  2023cites this paper
• Baicalein facilitates gastric cancer cell apoptosis by triggering endoplasmic reticulum stress via repression of the PI3K/AKT pathway

  2023cites this paper
• Calcium Homeostasis in the Development of Resistant Breast Tumors

  2023cites this paper
• Folate-Decorated Cross-Linked Cytochrome c Nanoparticles for Active Targeting of Non-Small Cell Lung Carcinoma (NSCLC)

  2022cites this paper
• An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

  2022cites this paper
• Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants

  2022cites this paper
• A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals

  2022cites this paper
• Assessment of the Biogenic Effects of Selenium Nanoparticles Prepared from Citrus paradise Peel Extract against Bisphenol A-Induced Liver Injury in Male Rats

  2022cites this paper
• Crosstalk between xanthine oxidase (XO) inhibiting and cancer chemotherapeutic properties of comestible flavonoids- a comprehensive update.

  2022cites this paper
• Effect of tetrahydroquinoline derivatives on the intracellular Ca2+ homeostasis in breast cancer cells (MCF-7) and its relationship with apoptosis.

  2022cites this paper
• Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer

  2022cites this paper
• Anticancer properties and mechanisms of botanical derivatives

  2022cites this paper
• Cellular Calcium Signals in Cancer Chemoprevention and Chemotherapy by Phytochemicals

  2022cites this paper
• Formulation and performance evaluation of polymeric mixed micelles encapsulated with baicalein for breast cancer treatment

  2021cites this paper
• Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review

  2021cites this paper
• Flavonoids as Inducers of Apoptosis and Autophagy in Breast Cancer

  2021cites this paper
• Encapsulation of Baicalein in Cinnamon Essential Oil Nanoemulsion for Enhanced Anticancer Efficacy Against MDA-MB-231 Cells

  2021cites this paper
• Baicalein: A metabolite with promising antineoplastic activity.

  2020cites this paper
• Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells.

  2020cites this paper
• Research Progress of Antitumor Activity by Baicalin and Baicalein

  2019cites this paper
• Baicalin Augments Hyperthermia-Induced Apoptosis in U937 Cells and Modulates the MAPK Pathway via ROS Generation

  2018cites this paper
• Liposome-delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation

  2018cites this paper
• Neurotherapeutic Effects of Bee Venom in a Rotenone-Induced Mouse Model of Parkinson’s Disease

  2018cites this paper
• Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment

  2018cites this paper
• Altering calcium influx for selective destruction of breast tumor

  2017cites this paper
• Increased Intracellular Reactive Oxygen Species Mediates the Anti‐Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells

  2017cites this paper
• Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors.

  2017cites this paper
• Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways

  2017cites this paper
• Anticancer Activity of Pterostilbene in Human Ovarian Cancer Cell Lines

  2017cites this paper
• Baicalein reduces endometriosis by suppressing the viability of human endometrial stromal cells through the nuclear factor-κB pathway in vitro

  2017cites this paper
• The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress

  2016cites this paper
• Stanniocalcin-1 Protects a Mouse Model from Renal Ischemia-Reperfusion Injury by Affecting ROS-Mediated Multiple Signaling Pathways

  2016cites this paper
• Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis.

  2016cites this paper
• The effect of Baicalein against lung cancer depends on GADD 45 a down-regulation

  2016cites this paper
• Anticancer properties of baicalein: a review

  2016cites this paper
• Baicalein antagonizes acute megakaryoblastic leukemia in vitro and in vivo by inducing cell cycle arrest

  2016cites this paper
• Synthesis and Biological Evaluation of Scutellaria Flavone Cyclaneaminol Mannich Base Derivatives as Novel CDK1 Inhibitors.

  2016cites this paper
• Baicalein increases keratin 1 and 10 expression in HaCaT keratinocytes via TRPV4 receptor activation

  2016cites this paper
• Suppression of the TNF‐alpha level is mediated by Gan‐Lu‐Yin (traditional Chinese medicine) in human oral cancer cells through the NF‐kappa B, AKT, and ERK‐dependent pathways

  2016cites this paper
• Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo.

  2016cites this paper
• Synthesis of novel flavone derivatives possessing substituted benzamides and their biological evaluation against human cancer cells.

  2016cites this paper
• Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis ( Review )

  2016influential citation
• Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression

  2015cites this paper
• Bisphenol A Induces Apoptosis in Liver Cells through Induction of ROS

  2015cites this paper
• Antitumor effects with apoptotic death in human promyelocytic leukemia HL‐60 cells and suppression of leukemia xenograft tumor growth by irinotecan HCl

  2015influential citation
• Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation.

  2015cites this paper
• Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes

  2015cites this paper
• The Mechanism of Ca(2+) Movement in the Involvement of Baicalein-Induced Cytotoxicity in ZR-75-1 Human Breast Cancer Cells.

  2015cites this paper
• Chloroform Extract of Solanum lyratum Induced G0/G1 Arrest via p21/p16 and Induced Apoptosis via Reactive Oxygen Species, Caspases and Mitochondrial Pathways in Human Oral Cancer Cell Lines.

  2015cites this paper
• The effects of baicalein on chloride transport and aqueous humour formation of porcine ciliary epithelium

  2015cites this paper
• Theranostic potentials of multifunctional chitosan–silver–phycoerythrin nanocomposites against triple negative breast cancer cells

  2015cites this paper
• Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.

  2015cites this paper
• BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS

  2015cites this paper
• Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells.

  2015cites this paper
• Baicalein Inhibits MCF-7 Cell Proliferation In Vitro, Induces Radiosensitivity, and Inhibits Hypoxia Inducible Factor.

  2015cites this paper
• The effects of baicalein on canine osteosarcoma cell proliferation and death.

  2014cites this paper
• Human gastric cancer cell line SGC-7901 apoptosis induced by SFPS-B2 via a mitochondrial-mediated pathway

  2014cites this paper
• The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin‐mediated cell death of human prostate cancer PC‐3 cells

  2014cites this paper
• Colorants and cancer: A review

  2014cites this paper
• Induction of cytotoxicity and apoptosis in human gastric cancer cell SGC-7901 by isovaltrate acetoxyhydrin isolated from Patrinia heterophylla bunge involves a mitochondrial pathway and G2/M phase cell cycle arrest.

  2013cites this paper
• Alpha-linolenic acid regulates the growth of breast and cervical cancer cell lines through regulation of NO release and induction of lipid peroxidation

  2013cites this paper
• Synthesis and Cytotoxic Effects of Sulfonamide-Substituted 5,6,7-Trimethoxyflavones on Human Cancer Cell Lines

  2013cites this paper
• Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress‐ and mitochondria‐dependent signaling pathways

  2013cites this paper
• The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death

  2013cites this paper
• Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer, Reactive Oxygen Species, and Antioxidants

  2012cites this paper
• Bee venom protects SH-SY5Y human neuroblastoma cells from 1-methyl-4-phenylpyridinium-induced apoptotic cell death.

  2012cites this paper
• CaMKKβ Is Involved in AMP-Activated Protein Kinase Activation by Baicalin in LKB1 Deficient Cell Lines

  2012cites this paper
• Investigation of the Role of Dietary Flavonoids on Cell Death: Evidence to Support a Non-Classical Apoptotic Mechanism

  2012cites this paper
• Bee venom induces apoptosis through intracellular Ca2+‐modulated intrinsic death pathway in human bladder cancer cells

  2012cites this paper
• Saponins isolated from Asparagus induce apoptosis in human hepatoma cell line HepG2 through a mitochondrial-mediated pathway.

  2012cites this paper
• Laminarin Induces Apoptosis of Human Colon Cancer LOVO Cells through a Mitochondrial Pathway

  2012cites this paper
• Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death

  2012cites this paper
• Danthron Triggers ROS and Mitochondria-Mediated Apoptotic Death in C6 Rat Glioma Cells Through Caspase Cascades, Apoptosis-Inducing Factor and Endonuclease G Multiple Signaling

  2012cites this paper
• Detecting Phenotype-Specific Interactions between Biological Processes from Microarray Data and Annotations

  2012cites this paper
• Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway.

  2011cites this paper
• Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences

  2011cites this paper
• Gallic Acid Induces G0/G1 Phase Arrest and Apoptosis in Human Leukemia HL-60 Cells through Inhibiting Cyclin

  2011cites this paper
• Antitumor activity of baicalein on the mice bearing U14 cervical cancer

  2011cites this paper
• Gallic acid induces G₀/G₁ phase arrest and apoptosis in human leukemia HL-60 cells through inhibiting cyclin D and E, and activating mitochondria-dependent pathway.

  2011cites this paper
• Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways.

  2010cites this paper
• Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.

  2010cites this paper
• Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells

  2010cites this paper
• Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells.

  2010cites this paper
• Bisphenol A Meningkatkan Malondialdehid dan Indeks Apoptosis Hati Tikus ( Rattus norvegicus ) Jantan (BISPHENOL A INCREASES MALONDIALDEHYDE AND APOPTOTIC INDEX IN THE LIVER OF MALE RATS ( RATTUS NORVEGICUS)

  2010cites this paper
• Anticancer Properties of Scutellaria baicalensis Root in Aspect of Innate Immunity Regulation Przeciwnowotworowa aktywność tarczycy bajkalskiej w świetle regulacji wrodzonej odporności

  2010cites this paper
• The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.

  2010cites this paper
• Danthron Induced Apoptosis Through Mitochondria- and Caspase-3-Dependent Pathways in Human Brain Glioblastoma Multiforms GBM 8401 Cells

  2010cites this paper
• Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9.

  2009cites this paper
• Curcumin-Induced DNA Damage and Inhibited DNA Repair Genes Expressions in Mouse–Rat Hybrid Retina Ganglion Cells (N18)

  2009cites this paper