Multi-faceted aspects of gamma-hydroxybutyric acid: a neurotransmitter, therapeutic agent and drug of abuse.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Mini-Reviews in Medical Chemistry

• Publication date

  2008-09-30

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.2174/138955708786141025PMID 18855733
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cloning and functional characterization of a gamma‐hydroxybutyrate receptor identified in the human brain

  2007cited by this paper
• Molecular diversity, trafficking and subcellular localization of GABAB receptors.

  2006cited by this paper
• GABAB receptor: a site of therapeutic benefit.

  2006cited by this paper
• Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons

  2006cited by this paper
• Unravelling the brain targets of gamma-hydroxybutyric acid.

  2006cited by this paper
• EFNS guidelines on management of narcolepsy

  2006cited by this paper
• Gamma‐hydroxybutyrate – a drug of abuse

  2006cited by this paper
• Clinical features of gamma-hydroxybutyrate and gamma-butyrolactone toxicity and concomitant drug and alcohol use.

  2006cited by this paper
• Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348.

  2006cited by this paper
• Novel γ-Hydroxybutyric Acid (GHB) Analogs Share Some, but Not All, of the Behavioral Effects of GHB and GABAB Receptor Agonists

  2005cited by this paper
• Gamma-hydroxybutyric acid.

  2005cited by this paper
• Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

  2005cited by this paper
• Animal models of drug craving

  2005cited by this paper
• Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons

  2005cited by this paper
• The GABAB-receptor antagonist, CGP 35348, antagonises γ-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice

  2005cited by this paper
• A double-blind, placebo-controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy.

  2005cited by this paper
• Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons

  2005cited by this paper
• Gamma-hydroxybutyric acid (GHB) and the mesoaccumbens reward circuit: evidence for GABA(B) receptor-mediated effects.

  2005cited by this paper
• Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice

  2005cited by this paper
• Discriminative Stimulus Effects of γ-Hydroxybutyrate (GHB) in Rats Discriminating GHB from Baclofen and Diazepam

  2005cited by this paper
• Presynaptic Modulation of Spontaneous Inhibitory Postsynaptic Currents by Gamma-hydroxybutyrate in the Substantia Nigra Pars Compacta

  2004cited by this paper
• Gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence.

  2004cited by this paper
• The Xyrem® Risk Management Program

  2004cited by this paper
• Gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of the substantia nigra.

  2004cited by this paper
• Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system

  2004cited by this paper
• A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor.

  2004cited by this paper
• Clinical features and management of gamma-hydroxybutyrate (GHB) withdrawal: a review.

  2004cited by this paper
• Narcolepsy and excessive daytime sleepiness

  2004cited by this paper
• 4-Hydroxy-trans-2-nonenoic acid is a gamma-hydroxybutyrate receptor ligand in the cerebral cortex and hippocampus.

  2004cited by this paper
• Molecular structure and physiological functions of GABA(B) receptors.

  2004cited by this paper
• Gamma-hydroxybutyric acid, unlike gamma-aminobutyric acid, does not stimulate Gi/Go proteins in rat brain membranes.

  2004cited by this paper
• Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid.

  2003cited by this paper
• The Role of GABAB Receptors in the Discriminative Stimulus Effects of γ-Hydroxybutyrate in Rats: Time Course and Antagonism Studies

  2003cited by this paper
• Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator γ‐hydroxybutyrate

  2003cited by this paper
• The neurobiology, diagnosis, and treatment of narcolepsy

  2003cited by this paper
• Pathway-Specific Action of γ-Hydroxybutyric Acid in Sensory Thalamus and Its Relevance to Absence Seizures

  2003cited by this paper
• Gamma-hydroxybutyrate reduces mitogen-activated protein kinase phosphorylation via GABA B receptor activation in mouse frontal cortex and hippocampus.

  2003cited by this paper
• A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand.

  2003cited by this paper
• Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.

  2003cited by this paper
• Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice

  2002cited by this paper
• GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid.

  2002cited by this paper
• Repeated Administration of Gamma‐Hydroxybutyric Acid (GHB) to Mice

  2002cited by this paper
• Gamma-hydroxybutyrate Reduces GABAA-mediated Inhibitory Postsynaptic Potentials in the CA1 Region of Hippocampus

  2002cited by this paper
• A randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy.

  2002cited by this paper
• Double-blind controlled trial of gamma-hydroxybutyrate and clomethiazole in the treatment of alcohol withdrawal.

  2002cited by this paper
• Evidence for a γ‐hydroxybutyrate (GHB) uptake by rat brain synaptic vesicles

  2002cited by this paper
• International Union of Pharmacology. XXXIII. Mammalian γ-Aminobutyric AcidB Receptors: Structure and Function

  2002cited by this paper
• gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors.

  2001cited by this paper
• GHB: a new and novel drug of abuse.

  2001cited by this paper
• Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid.

  2001cited by this paper
• gamma-Hydroxybutyrate modulation of glutamate levels in the hippocampus: an in vivo and in vitro study.

  2001cited by this paper
• Practice parameters for the treatment of narcolepsy: an update for 2000.

  2001cited by this paper
• GHB depresses fast excitatory and inhibitory synaptic transmission via GABA(B) receptors in mouse neocortical neurons.

  2001cited by this paper
• Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain.

  2001cited by this paper
• Mechanism of the antialcohol effect of gamma-hydroxybutyric acid.

  2000cited by this paper
• Gamma-hydroxybutyric acid in the treatment of alcohol and heroin dependence.

  2000cited by this paper
• Design and structure-activity relationship analysis of ligands of gamma-hydroxybutyric acid receptors.

  2000cited by this paper
• Gamma-hydroxybutyric acid efficacy, potential abuse, and dependence in the treatment of alcohol addiction.

  2000cited by this paper
• Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor.

  2000cited by this paper
• Gamma-hydroxybutyric acid and alcohol-related syndromes.

  2000cited by this paper
• Evaluation of the reinforcing and discriminative stimulus effects of gamma-hydroxybutyrate in rhesus monkeys.

  1999cited by this paper
• gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo.

  1999cited by this paper
• Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.

  1999cited by this paper
• Gamma-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices.

  1999cited by this paper
• Gamma-hydroxybutyric acid (GHB) in the treatment of alcohol withdrawal syndrome: a randomized comparative study versus benzodiazepine.

  1999cited by this paper
• Reduction of blood ethanol levels by the gamma-hydroxybutyric acid receptor antagonist, NCS-382.

  1999cited by this paper
• Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential?

  1999cited by this paper
• Gamma-hydroxybutyric acid reducing effect on ethanol intake: evidence in favour of a substitution mechanism.

  1998cited by this paper
• Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice.

  1998cited by this paper
• Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by γ-hydroxybutyric acid (GHBA) are specifically induced by activation of GABAB receptors

  1998cited by this paper
• A tale of novel intoxication: seven cases of gamma-hydroxybutyric acid overdose.

  1998cited by this paper
• Gamma-hydroxybutyric acid decreases intravenous cocaine self-administration in rats.

  1998cited by this paper
• The anxiolytic effect of gamma-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil.

  1998cited by this paper
• Gamma-hydroxybutyrate is a GABAB receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neurons.

  1998cited by this paper
• Maintaining abstinence from alcohol with gamma-hydroxybutyric acid.

  1998cited by this paper
• Involvement of GABA(A) and GABA(B) receptors in the mediation of discriminative stimulus effects of gamma-hydroxybutyric acid.

  1998cited by this paper
• GHB-induced delirium: a case report and review of the literature of gamma hydroxybutyric acid.

  1998cited by this paper
• Neurochemical and electrophysiological evidence for the existence of a functional gamma-hydroxybutyrate system in NCB-20 neurons.

  1998cited by this paper
• gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.

  1997cited by this paper
• Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist.

  1997cited by this paper
• Total intravenous anaesthesia using propofol, gamma-hydroxybutyrate or midazolam in combination with sufentanil for patients undergoing coronary artery bypass surgery.

  1997cited by this paper
• Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence.

  1997cited by this paper
• Rewarding properties of gamma-hydroxybutyric acid: an evaluation through place preference paradigm

  1997cited by this paper
• The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.

  1997cited by this paper
• ESBRA-Nordmann 1996 Award Lecture: ethanol drinking behaviour in Sardinian alcohol-preferring rats.

  1997cited by this paper
• Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain.

  1996cited by this paper
• Evaluation of the discriminative stimulus and reinforcing effects of gammahydroxybutyrate (GHB)

  1996cited by this paper
• An open multicentric study evaluating 4-hydroxybutyric acid sodium salt in the medium-term treatment of 179 alcohol dependent subjects. GHB Study Group.

  1996cited by this paper
• Does gamma-hydroxybutyrate inhibit or stimulate central DA release?

  1996cited by this paper
• Cross-tolerance to ethanol and gamma-hydroxybutyric acid.

  1995cited by this paper
• Blockade of the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB) by the GHB receptor antagonist NCS-382.

  1995cited by this paper
• Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat.

  1995cited by this paper
• Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: occurrence within narrow dose ranges.

  1995cited by this paper
• Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB (GABAB) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GHB.

  1995cited by this paper
• Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB, receptor-mediated hyperpolarization.

  1995cited by this paper
• Patterns of sleep and wakefulness in treated narcoleptic subjects.

  1994cited by this paper
• The ontogeny of [3H]gamma-hydroxybutyrate and [3H]GABAB binding sites: relation to the development of experimental absence seizures.

  1994cited by this paper
• γ-Hydroxybutyric acid (GHBA) induces pacemaker activity and inhibition of substantia nigra dopamine neurons by activating GABAB-receptors

  1993cited by this paper
• gamma-Hydroxybutyric acid in the treatment of alcohol dependence: a double-blind study.

  1992cited by this paper
• Pharmacokinetics of gamma-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses.

  1992cited by this paper

• International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain-beyond classic receptors.

  2025cites this paper
• γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

  2020cites this paper
• Anticonvulsant active inhibitor of GABA transporter subtype 1, tiagabine, with activity in mouse models of anxiety, pain and depression

  2015cites this paper
• γ-Hydroxybutyrate (Xyrem) ameliorates clinical symptoms and neuropathology in a mouse model of Alzheimer's disease.

  2015cites this paper
• Effect of intubation for gamma-hydroxybutyric acid overdose on emergency department length of stay and hospital admission.

  2014cites this paper
• GHB receptor targets in the CNS: focus on high-affinity binding sites.

  2014cites this paper
• Mise en évidence d’une soumission chimique au GBL au Centre d’accueil en urgence des victimes d’agression (CAUVA) du CHU de Bordeaux, à propos d’un cas

  2013cites this paper
• Date‐Rape Drugs with Emphasis on GHB

  2012cites this paper
• Enzymatic assay for GHB determination in forensic matrices.

  2012cites this paper
• Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems.

  2012cites this paper
• Analgesic and anticonvulsant activity of new derivatives of 2-substituted 4-hydroxybutanamides in mice

  2012cites this paper
• GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR_5

  2011influential citation
• Analysis of Electrical Brain Waves in Neurotoxicology: Gamma-Hydroxybutyrate

  2011cites this paper
• GABA transporters as targets for new drugs.

  2011cites this paper
• Determination of endogenous/exogenous γ-hydroxybutyric acid (GHB) in urine

  2011cites this paper
• A single acute pharmacological dose of γ-hydroxybutyrate modifies multiple gene expression patterns in rat hippocampus and frontal cortex.

  2010cites this paper
• Novel Radioiodinated γ-Hydroxybutyric Acid Analogues for Radiolabeling and Photolinking of High-Affinity γ-Hydroxybutyric Acid Binding Sites

  2010cites this paper
• Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sites.

  2010cites this paper
• Lack of γ-Hydroxybutyrate Prevalence Among An Urban Emergency Department Population

  2010cites this paper
• Lack of gamma-hydroxybutyrate prevalence among an urban emergency department population.

  2010cites this paper
• A review of tolerability and abuse liability of gamma-hydroxybutyric acid for insomnia in patients with schizophrenia.

  2009cites this paper
• Narcolepsy and depression and the neurobiology of gammahydroxybutyrate.

  2009cites this paper
• [Gamma-hydroxybutyric acid (GHB): more than a date rape drug, a potentially addictive drug].

  2009cites this paper