Cell Cycle Dysregulation by Human Cytomegalovirus: Influence of the Cell Cycle Phase at the Time of Infection and Effects on Cyclin Transcription

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Virology

• Publication date

  1998-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.72.5.3729-3741.1998PMID 9557655PMCID PMC109595
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996influential reference
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
• Mitosis in transition.

  1994influential reference
• Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts

  1994cited by this paper
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  1994cited by this paper
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