Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes

No abstract is available for this paper.

• Publication year

  2004

• Venue

  The Journal of pharmacy and pharmacology

• Publication date

  2004-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1211/0022357023060PMID 15005879
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
• Recent innovations in asthma therapy.

  1998cited by this paper
• Hepatic microsomal metabolism of montelukast, a potent leukotriene D4 receptor antagonist, in humans.

  1997influential reference
• Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.

  1997cited by this paper
• The use of adult human hepatocytes in primary culture and other in vitro systems to investigate drug metabolism in man

  1996cited by this paper
• Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.

  1994cited by this paper
• Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases.

  1993cited by this paper
• The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

  1993cited by this paper
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  1993cited by this paper
• Book Review: Computers in Biomedicine

  1993cited by this paper
• Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity.

  1990cited by this paper
• Rapid colorimetric assay for cell growth and survival in application of immunotoxicology

  1988influential reference
• Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.

  1986cited by this paper
• Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.

  1985cited by this paper
• Quantitative assay for albumin-producing liver cells after simian virus 40 transformation of rat hepatocytes maintained in chemically defined medium.

  1984cited by this paper
• Casarett and Doull's Toxicology: The Basic Science of Poisons

  1981cited by this paper
• A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.

  1978influential reference

• Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib

  2006cites this paper
• Formation of 4′-carboxyl acid metabolite of imrecoxib by rat liver microsomes

  2006cites this paper
• Pharmacokinetics of radiolabelled quinlukast in rats.

  2005cites this paper
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• HPLC-radiometric determination of quinlukast in biological fluids.

  2004cites this paper