IP3 Constricts Cerebral Arteries via IP3 Receptor–Mediated TRPC3 Channel Activation and Independently of Sarcoplasmic Reticulum Ca2+ Release

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Circulation Research

• Publication date

  2008-05-09

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/CIRCRESAHA.108.173948PMID 18388325PMCID PMC2430658
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endothelin‐1 activates a Ca2+‐permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes

  2007cited by this paper
• Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries.

  2007cited by this paper
• Multiple activation mechanisms of store‐operated TRPC channels in smooth muscle cells

  2007cited by this paper
• Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1

  2007cited by this paper
• Heteromultimeric TRPC6-TRPC7 Channels Contribute to Arginine Vasopressin-Induced Cation Current of A7r5 Vascular Smooth Muscle Cells

  2006cited by this paper
• E3-targeted anti-TRPC5 antibody inhibits store-operated calcium entry in freshly isolated pial arterioles.

  2006cited by this paper
• International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels

  2005cited by this paper
• Facilitatory effect of Ins(1,4,5)P3 on store‐operated Ca2+‐permeable cation channels in rabbit portal vein myocytes

  2005cited by this paper
• TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries.

  2005cited by this paper
• TRPV4 Forms a Novel Ca2+ Signaling Complex With Ryanodine Receptors and BKCa Channels

  2005cited by this paper
• Plasticity of TRPC expression in arterial smooth muscle: correlation with store-operated Ca2+ entry.

  2005cited by this paper
• Mitochondria-Derived Reactive Oxygen Species Dilate Cerebral Arteries by Activating Ca2+ Sparks

  2005cited by this paper
• The mammalian TRPC cation channels.

  2004cited by this paper
• Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of alpha-subunits.

  2004cited by this paper
• Ionic mechanisms mediating the myogenic response in newborn porcine cerebral arteries.

  2004cited by this paper
• Store-Operated Ca2+ Entry Activates the CREB Transcription Factor in Vascular Smooth Muscle

  2004cited by this paper
• Non‐selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP

  2004cited by this paper
• Conformational Coupling: A Physiological Calcium Entry Mechanism

  2004cited by this paper
• Agonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition.

  2004cited by this paper
• Historical review: Endothelin.

  2004cited by this paper
• Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation.

  2004cited by this paper
• Critical Role for Transient Receptor Potential Channel TRPM4 in Myogenic Constriction of Cerebral Arteries

  2004cited by this paper
• Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries

  2004cited by this paper
• Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor.

  2004cited by this paper
• International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

  2003cited by this paper
• Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries

  2002cited by this paper
• Discrete store‐operated calcium influx into an intracellular compartment in rabbit arteriolar smooth muscle

  2002cited by this paper
• RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

  2002cited by this paper
• Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone.

  2002cited by this paper
• Mechanisms of coronary artery depolarization by uridine triphosphate.

  2001cited by this paper
• Differential expression and alternative splicing of TRP channel genes in smooth muscles.

  2001cited by this paper
• Intravascular pressure regulates local and global Ca(2+) signaling in cerebral artery smooth muscle cells.

  2001cited by this paper
• myo-Inositol 1 , 4 , 5-Trisphosphate

  2001cited by this paper
• A simple method for the rapid generation of recombinant adenovirus vectors

  2000cited by this paper
• Calcium sparks in smooth muscle.

  2000cited by this paper
• Signaling mechanisms underlying the vascular myogenic response.

  1999cited by this paper
• The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels.

  1999cited by this paper
• Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+‐dependent K+ channels

  1998cited by this paper
• Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure

  1998cited by this paper
• Relaxation of Arterial Smooth Muscle by Calcium Sparks

  1995cited by this paper
• Reversible permeabilization. A novel technique for the intracellular introduction of antisense oligodeoxynucleotides into intact smooth muscle.

  1995cited by this paper
• Regulation of arterial tone by activation of calcium-dependent potassium channels.

  1992cited by this paper
• ‘Quanta’ Ca2+ release and the control of Ca2+ entry by inositol phosphates ‐ a possible mechanism

  1990cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper
• Smooth Muscle Cells : Dependence on Gab1 and Gab1-shp2 Association Treatment with Insulin Uncovers the Motogenic Capacity of Nitric Oxide in Aortic

  year unknowncited by this paper

• Docosahexaenoic acid protects against alcohol-induced constriction of cerebral arteries and inhibition of vascular smooth muscle BK channels.

  2025cites this paper
• Non-Ser36 phosphorylated p66Shc inhibits TRPC-dependent and TRPC-independent calcium influx in vascular smooth muscle cells.

  2025cites this paper
• Ca2+ microdomains in vascular smooth muscle cells: Roles in vascular tone regulation and hypertension.

  2025cites this paper
• Physiological functions and pharmacological targeting of transient receptor potential channels

  2025cites this paper
• Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes.

  2025cites this paper
• Nanomolar therapeutic concentrations of statins rapidly induce cerebral artery vasoconstriction by stimulating L-type calcium channels.

  2025cites this paper
• Electro-metabolic signaling

  2024cites this paper
• Role of transient receptor potential channels in the regulation of vascular tone.

  2024cites this paper
• Exploring the TRP channel superfamily: research hotspots and development trends from function to disease.

  2023cites this paper
• Progesterone activation of β1-containing BK channels involves two binding sites

  2023cites this paper
• Vascular Mechanotransduction.

  2023cites this paper
• Calcium handling coupled to the endothelin ETA and ETB receptor-mediated vasoconstriction in resistance arteries: Differential regulation by PI3K, PKC and RhoK.

  2023cites this paper
• IP3 receptor orchestrates maladaptive vascular responses in heart failure

  2022cites this paper
• Ion channel molecular complexes in vascular smooth muscle

  2022influential citation
• STIMulating blood pressure

  2022cites this paper
• Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects

  2022cites this paper
• TRPC6, a Therapeutic Target for Pulmonary Hypertension.

  2021cites this paper
• Role of TRP ion channels in cerebral circulation and neurovascular communication.

  2021cites this paper
• The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.

  2021cites this paper
• Mechanisms and Physiological Implications of Cooperative Gating of Ion Channels Clusters.

  2021cites this paper
• Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization

  2021cites this paper
• Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells.

  2020cites this paper
• Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2 + Entry for Angiogenesis, Arteriogenesis and Vasculogenesis

  2020cites this paper
• The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

  2020influential citation
• The structure of TRPC ion channels.

  2019cites this paper
• Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling.

  2019cites this paper
• Ion Channels and Their Regulation in Vascular Smooth Muscle

  2019cites this paper
• Calcium signals that determine vascular resistance

  2019influential citation
• Arterial Aging and Age-Associated Arterial Diseases

  2019cites this paper
• Structure–function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating

  2018cites this paper
• Inositol 1,4,5-Trisphosphate Receptors in Hypertension

  2018cites this paper
• Tyrosine 450 in the Voltage- and Calcium-Gated Potassium Channel of Large Conductance Channel Pore-Forming (slo1) Subunit Mediates Cholesterol Protection against Alcohol-Induced Constriction of Cerebral Arteries

  2018cites this paper
• Tyrosine 450 in the BK channel pore-forming ( slo 1 ) subunit mediates cholesterol protection against alcohol-induced constriction of cerebral arteries

  2018cites this paper
• Calcium Channels in Vascular Smooth Muscle.

  2017influential citation
• Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes.

  2017cites this paper
• Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

  2017cites this paper
• Regulation of transient receptor potential melastatin 4 channel by sarcoplasmic reticulum inositol trisphosphate receptors: Role in human detrusor smooth muscle function

  2017cites this paper
• Muscling in on TRP channels in vascular smooth muscle cells and cardiomyocytes.

  2017cites this paper
• Transient receptor potential canonical type 3 channels: Interactions, role and relevance - A vascular focus.

  2017cites this paper
• Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats

  2017influential citation
• TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling.

  2016cites this paper
• Ion channel networks in the control of cerebral blood flow

  2016cites this paper
• 9th International Symposium on Resistance Arteries (ISRA)

  2016cites this paper
• Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.

  2016cites this paper
• Heme Oxygenases in Cardiovascular Health and Disease.

  2016cites this paper
• Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells.

  2015cites this paper
• Ion Channels and Transporters in Lung Function and Disease Inositol 1 , 4 , 5-trisphosphate activates TRPC 3 channels to cause extracellular Ca 2 influx in airway smooth muscle cells

  2015cites this paper
• Increased Cerebrovascular Sensitivity to Endothelin-1 in a Rat Model of Obstructive Sleep Apnea: A Role for Endothelin Receptor B

  2015cites this paper
• Renal autoregulation in health and disease.

  2015cites this paper
• Transient receptor potential channels in the vasculature.

  2015cites this paper
• Connecting TRP Channels and Cerebrovascular Diseases

  2015cites this paper
• Transient Receptor Potential Channels in Hypertension and Metabolic Syndrome

  2015cites this paper
• CALL FOR PAPERS Ion Channels and Transporters in Lung Function and Disease Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca 2 (cid:2) influx in airway smooth muscle cells

  2015cites this paper
• Differences in Muscle Transcriptome among Pigs Phenotypically Extreme for Fatty Acid Composition

  2014cites this paper
• TRPC3: a multifunctional signaling molecule.

  2014cites this paper
• Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

  2014cites this paper
• Adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth

  2014cites this paper
• Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells.

  2014cites this paper
• Potential contribution of SOCC to cerebral vasospasm after experimental subarachnoid hemorrhage in rats.

  2013cites this paper
• Transient Receptor Potential Canonical Type 3 Channels—Their Evolving Role in Hypertension and Its Related Complications

  2013cites this paper
• Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.

  2013cites this paper
• Evolution of mechanisms of Ca2+-signalization. Role of Ca2+ in regulation of specialized cell functions

  2013cites this paper
• Endothelin receptor signaling: new insight into its regulatory mechanisms.

  2013cites this paper
• Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca2+ release in cardiomyoblast cells.

  2013cites this paper
• Inositol 1,4,5-Trisphosphate (IP3) Receptor Up-regulation in Hypertension Is Associated with Sensitization of Ca2+ Release and Vascular Smooth Muscle Contractility*

  2013cites this paper
• Expression of TRPC 1 and TRPC 4 in the basilar artery after experimental subarachnoid hemorrhage in rats

  2013cites this paper
• Inositol 1,4,5-Trisphosphate (IP 3 ) Receptor Up-regulation in Hypertension Is Associated with Sensitization of Ca 2

  2013cites this paper
• Ryanodine Receptors, Calcium Signaling, and Regulation of Vascular Tone in The Cerebral Parenchymal Microcirculation

  2013cites this paper
• What Role for Store‐Operated Ca2+ Entry in Muscle?

  2013cites this paper
• Pressor and renal regional hemodynamic effects of urotensin II in neonatal pigs

  2013cites this paper
• Emerging role of G protein-coupled receptors in microvascular myogenic tone.

  2012cites this paper
• Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells.

  2012cites this paper
• Pacemaking activity in normal rat kidney fibroblasts

  2012cites this paper
• Inositol trisphosphate receptors in smooth muscle cells.

  2012cites this paper
• An Elevation in Physical Coupling of Type 1 Inositol 1,4,5-Trisphosphate (IP3) Receptors to Transient Receptor Potential 3 (TRPC3) Channels Constricts Mesenteric Arteries in Genetic Hypertension

  2012cites this paper
• Ca(2+) signalling by IP(3) receptors.

  2012cites this paper
• TRPs to Cardiovascular Disease

  2012cites this paper
• Endothelial Ca2+ wavelets and the induction of myoendothelial feedback.

  2012cites this paper
• Size‐dependent heterogeneity of contractile Ca2+ sensitization in rat arterial smooth muscle

  2012cites this paper
• Activation of Transient Receptor Potential Canonical 3 (TRPC3)-mediated Ca2+ Entry by A1 Adenosine Receptor in Cardiomyocytes Disturbs Atrioventricular Conduction*

  2012cites this paper
• Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice

  2012cites this paper
• Endogenous cytosolic Ca(2+) buffering is necessary for TRPM4 activity in cerebral artery smooth muscle cells.

  2012influential citation
• Function and expression of ryanodine receptors and inositol 1,4,5‐trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles

  2012cites this paper
• entry by A1 adenosine receptor in cardiomyocytes disturbs atrio-ventricular conduction

  2012cites this paper
• Canonical Transient Receptor Potential Channel Expression, Regulation, and Function in Vascular and Airway Diseases

  2012cites this paper
• Funktionelle Charakterisierung der Kationenkanäle TRPM3 und Melastatin (TRPM1)

  2012cites this paper
• The Endothelium, Part I: Multiple Functions of the Endothelial Cells -- Focus on Endothelium-Derived Vasoactive Mediators

  2011cites this paper
• Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca2+ Influx and Ca2+ Release in Rat Aorta

  2011influential citation
• Interaction between IP3 receptors and BK channels in arterial smooth muscle: non-canonical IP3 signaling at work

  2011cites this paper
• The Endothelium, Part II: EDHF-Mediated Responses "The Classical Pathway"

  2011cites this paper
• Fluorescent Genetically Encoded Calcium Indicators and Their In Vivo Application

  2011cites this paper
• Einfluss der veränderten Transkript- und Protein- Exp ression der Transient Rezeptor Potential (TRP) Kationen Kanäle auf die Pathogenese der Hypertonie, des Diabetes mellitus und der chronischen Niereninsuffizienz

  2011cites this paper
• Function and regulation of endothelin type A receptor-operated transient receptor potential canonical channels.

  2011cites this paper
• Gating mechanisms of canonical transient receptor potential channel proteins: role of phosphoinositols and diacylglycerol.

  2011cites this paper
• Decreased Expression of Transient Receptor Potential Channels in Cerebral Vascular Tissue from Patients After Hypertensive Intracerebral Hemorrhage

  2011cites this paper
• Heart function in mouse models of muscular dystrophy

  2011cites this paper
• TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells.

  2011cites this paper
• Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes

  2010influential citation
• Exploring the Potential of Transient Receptor Potential: Troubleshooting Troublesome Calcium Thoroughfares in Biomedicine

  2010cites this paper
• Transient receptor potential channels and vascular function.

  2010cites this paper