Postinjury neutrophil priming and activation states: therapeutic challenges.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Shock

• Publication date

  1995-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/00024382-199503000-00001PMID 7773793
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The microcirculation and inflammation: modulation of leukocyte‐endothelial cell adhesion

  1994cited by this paper
• Superoxide production by neutrophils from trauma patients: regulation of NADPH oxidase activity.

  1994cited by this paper
• BN 52021: A Platelet Activating Factor Antagonist for Preventing Post-Transplant Renal Failure: A Double-Blind, Randomized Study

  1994cited by this paper
• Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury

  1994cited by this paper
• Platelet-activating factor-induced polymorphonuclear neutrophil priming independent of CD11b adhesion.

  1993cited by this paper
• Anticytokine strategies in the treatment of the systemic inflammatory response syndrome.

  1993cited by this paper
• Effects of accidental trauma on cytokine and endotoxin production

  1993cited by this paper
• Role of the neutrophil in adult respiratory distress syndrome

  1993cited by this paper
• Effects of accidental trauma on cytokine and endotoxin production.

  1993cited by this paper
• Gut ischemia mediates lung injury by a xanthine oxidase-dependent neutrophil mechanism.

  1993cited by this paper
• Platelet-activating factor: receptors and signal transduction.

  1993cited by this paper
• Effects of diacylglycerol on the activation and kinetics of the respiratory burst oxidase in a cell-free system from human neutrophils: evidence that diacylglycerol may regulate nucleotide uptake by a GTP-binding protein.

  1993cited by this paper
• Regulation of vascular integrins.

  1993cited by this paper
• Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559.

  1992cited by this paper
• The horror autotoxicus and multiple-organ failure.

  1992cited by this paper
• Detection of granulocyte reactive oxygen species formation in whole blood using flow cytometry.

  1992cited by this paper
• Protein kinase C isoforms in human neutrophil cytoplasts

  1992cited by this paper
• Inhibition of neutrophil respiratory burst and degranulation responses to platelet-activating factor by antagonists WEB 2086, CV 6209 and CV 3988.

  1992cited by this paper
• Inflammatory mediators, infection, sepsis, and multiple organ failure after severe trauma.

  1992cited by this paper
• Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

  1991cited by this paper
• Separation of Leucocytes: Improved Cell Purity by Fine Adjustments of Gradient Medium Density and Osmolality

  1991cited by this paper
• Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma.

  1991cited by this paper
• Acceleration of Superoxide Production from Leukocytes in Trauma Patients

  1991cited by this paper
• Superoxide production by stimulated neutrophils: temperature effect.

  1991cited by this paper
• Clinical applications of chemiluminescence of granulocytes.

  1991cited by this paper
• Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins.

  1991cited by this paper
• Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

  1991cited by this paper
• Kinetics of superoxide production by stimulated neutrophils.

  1991cited by this paper
• Primed neutrophils injure rat lung through a platelet-activating factor-dependent mechanism.

  1991cited by this paper
• Effects of granulocyte-macrophage colony-stimulating factor in burn patients.

  1991cited by this paper
• Superoxide anion production from human neutrophils measured with an improved kinetic and endpoint microassay.

  1991cited by this paper
• Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol

  1990cited by this paper
• The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil.

  1990cited by this paper
• Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate.

  1990cited by this paper
• Priming of neutrophil oxidative responses by platelet-activating factor.

  1990cited by this paper
• A comparison of the priming effect of phorbol myristate acetate and phorbol dibutyrate on fMet-Leu-Phe-induced oxidative burst in human neutrophils.

  1990cited by this paper
• Inadequate granulopoiesis after major torso trauma: a hematopoietic regulatory paradox.

  1990cited by this paper
• Kinetic microplate assay for superoxide production by neutrophils and other phagocytic cells.

  1990cited by this paper
• The human neutrophil respiratory burst oxidase.

  1990cited by this paper
• Granulocyte/macrophage colony‐stimulating factor primes human neutrophils for increased diacylglycerol generation in response to chemoattractant

  1989cited by this paper
• Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway.

  1989cited by this paper
• Tissue destruction by neutrophils.

  1989cited by this paper
• Roles of the neutrophil and other mediators in adult respiratory distress syndrome.

  1989cited by this paper
• Simultaneous measurement by flow cytometry of phagocytosis and hydrogen peroxide production of neutrophils in whole blood.

  1989cited by this paper
• Whole-body inflammation in trauma patients. An autopsy study.

  1988cited by this paper
• Multisample photometric biochemical analysis using Vmax and SOFTmax.

  1988cited by this paper
• Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

  1988cited by this paper
• Effect of surgery on neutrophil functions, superoxide and leukotriene production

  1988cited by this paper
• Evaluation and improvement of a rapid microassay for measuring superoxide anion production by phagocytes. 1. Spectrophotometric aspects.

  1987cited by this paper
• Perspectives in platelet-activating factor research.

  1987cited by this paper
• Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

  1987cited by this paper
• A simultaneous flow cytometric measurement of neutrophil phagocytosis and oxidative burst in whole blood.

  1987cited by this paper
• Platelet-activating factor as a stimulus of exocytosis in human neutrophils.

  1986cited by this paper
• Subpopulations of neutrophils with increased oxidative product formation in blood of patients with infection.

  1986cited by this paper
• Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis.

  1986cited by this paper
• Posttraumatic complications and inflammatory mediators.

  1986cited by this paper
• Gamma interferon is able to enhance the oxidative metabolism of human neutrophils.

  1986cited by this paper
• Granulocyte stem cells are decreased in humans with fatal burns.

  1985cited by this paper
• Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4.

  1985cited by this paper
• Multiple-organ failure. Generalized autodestructive inflammation?

  1985cited by this paper
• In vivo neutrophil delivery to inflammatory sites in surgical patients. Correlation with in vitro neutrophil chemotaxis and adherence.

  1985cited by this paper
• A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: its use in the simultaneous fluorimetric assay of cellular activation processes.

  1984cited by this paper
• Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

  1983cited by this paper
• Depression of cellular immunity after multiple trauma in the absence of sepsis.

  1983cited by this paper
• Polymorphonuclear Leukocyte Migration Abnormalities and Their Significance in Seriously Traumatized Patients

  1983cited by this paper
• Multiple organ failure in polytrauma patients.

  1983cited by this paper
• Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader.

  1981cited by this paper
• Multiple system organ failure. The role of uncontrolled infection.

  1980cited by this paper
• Role of secretory events in modulating human neutrophil chemotaxis.

  1978cited by this paper
• The cause of post-traumatic pulmonary insufficiency in man.

  1975cited by this paper
• Biological defense mechanisms. The effect of bacteria and serum on superoxide production by granulocytes.

  1974cited by this paper
• Impaired function of polymorphonuclear leukocytes in patients with burns and other trauma.

  1973cited by this paper
• Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.

  1973cited by this paper
• Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

  1969cited by this paper
• Quantitative nitroblue tetrazolium test in chronic granulomatous disease.

  1968cited by this paper

• EFFECT OF PLURONIC F68 AND PHOSPHOLIPIDS LIPOSOMES MODIFIED WITH PLURONIC F68 ON THE HUMAN NEUTROPHILS FUNCTIONAL ACTIVITY.

  2025cites this paper
• Neutrophil kinetics and function after major trauma: A systematic review

  2021cites this paper
• Ethyl Pyruvate Reduces Systemic Leukocyte Activation via Caspase-1 and NF-κB After Blunt Chest Trauma and Haemorrhagic Shock

  2020cites this paper
• Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model

  2019cites this paper
• Experimental Hemorrhagic Shock Protocol in Swine Models: The Effects of 21-Aminosteroid on the Small Intestine

  2018cites this paper
• TNF-α release capacity is suppressed immediately after hemorrhage and resuscitation

  2017cites this paper
• The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.

  2017cites this paper
• Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-κB and HMGB 1 Running head : Ethyl pyruvate and lung injury after trauma / hemorrhage

  2017cites this paper
• Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-κB and HMGB1.

  2017cites this paper
• Postinjury Inflammation and Organ Dysfunction.

  2017cites this paper
• Dimerization of complement C5a receptors in inflammatory responses

  2017cites this paper
• Prognostic significance of C5a2 on polymorphonuclear neutrophil and C5a2intra/C5a2 ratio level for early sepsis in an ED.

  2016cites this paper
• Proteomic Analysis of Neutrophil Priming by PAF.

  2016cites this paper
• Demystifying damage control in musculoskeletal trauma.

  2016cites this paper
• ANÁLISE DA CONCENTRAÇÃO DE SICAM-1 EM CRIANÇAS E ADOLESCENTES COM PROCESSO INFLAMATÓRIO COM DESVIO NUCLEAR À ESQUERDA

  2015cites this paper
• Specific miRNA and its target in neutrophils after traumatic injury.

  2015cites this paper
• Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new phenotype of multiple organ failure.

  2015cites this paper
• Evolving paradigms in the nutritional support of critically ill surgical patients.

  2015cites this paper
• The Neutrophil Nucleus and Its Role in Neutrophilic Function

  2015cites this paper
• Efeito da hidroxiureia na adesão in vitro de neutrófilos, sob condições inflamatórias = : Effect of hydroxyurea on the adhesion of neutrophil under in vitro inflammatory conditions

  2015cites this paper
• Neutrophil oxidative burst capacity for peri-operative immune monitoring in trauma patients.

  2014cites this paper
• Ativação in vitro de neutrófilos expostos a stents carotídeos de nitinol e cobalto-cromo

  2014influential citation
• Multiple Organ Failure

  2013cites this paper
• Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans

  2013cites this paper
• Comparison of the Neutrophil Proteome in Trauma Patients and Normal Controls

  2012cites this paper
• Regulation of the Inflammatory Response: Enhancing Neutrophil Infiltration under Chronic Inflammatory Conditions

  2012cites this paper
• Effects of hypertonic saline on macrophage migration inhibitory factor in traumatic conditions

  2012cites this paper
• The 5-Lipoxygenase Pathway Is Required for Acute Lung Injury Following Hemorrhagic Shock

  2012cites this paper
• Effect of Apocynin on Acute Lung Injury in Rats Given Interleukin-1α Intratracheally

  2011cites this paper
• Chronic Inflammatory Conditions Enhancing Neutrophil Infiltration under Regulation of the Inflammatory Response:

  2011cites this paper
• Refractory postinjury thrombocytopenia is associated with multiple organ failure and adverse outcomes.

  2011cites this paper
• The perioperative granulocyte/lymphocyte ratio is a clinically relevant marker of surgical stress in patients with colorectal cancer.

  2011cites this paper
• iii) An update on the systemic response to trauma

  2010cites this paper
• Role of the PLA 2-Activated Neutrophilic Oxidative Stress in Oleic Acid-Induced Acute Lung Injury

  2010cites this paper
• Blood Still Kills: Six Strategies to Further Reduce Allogeneic Blood Transfusion-Related Mortality

  2010cites this paper
• Claude H. Organ, Jr. memorial lecture: splanchnic hypoperfusion provokes acute lung injury via a 5-lipoxygenase-dependent mechanism.

  2010cites this paper
• Rutin Ameliorates Neutrophilic Oxidative Stress-Induced Acute Lung Injury by Intratracheal IL-1 Insufflation in Rats

  2010cites this paper
• Role of the PLA2-Activated Neutrophilic Oxidative Stress in Oleic Acid-Induced Acute Lung Injury

  2010cites this paper
• Moxifloxacin Alleviates Oleic Acid-provoked Neutrophilic Respiratory Burst in the Rat Lung through the Inhibition of Cytosolic Phospholipase A2

  2010cites this paper
• AWARD NUMBER: W81XWH-06-1-0570 TITLE: Poloxamer 188 (P188) as an Adjunct in Prolonged Hypotensive Resuscitation PRINCIPAL INVESTIGATOR: Robert Hunter CONTRACTING ORGANIZATION: University of Texas-Houston

  2009cites this paper
• The evolving rationale for early enteral nutrition based on paradigms of multiple organ failure: a personal journey.

  2009cites this paper
• Systemic not just mesenteric lymph causes neutrophil priming after hemorrhagic shock.

  2009cites this paper
• Immunomodulatory Effects of Hypertonic Saline-The Effects on Nuclear Translocation of NF-κ B and TNF-α Synthesis in Stimulated PMNs

  2009cites this paper
• Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow‐derived cells and parenchymal cells

  2008cites this paper
• Effects of poloxamer 188 on human PMN cells.

  2008cites this paper
• Neutrophil proteome: lessons from different standpoints.

  2008cites this paper
• Compensatory anti-inflammatory response syndrome

  2008cites this paper
• NEUTROPHIL-DERIVED CIRCULATING FREE DNA (cf-DNA/NETs): A POTENTIAL PROGNOSTIC MARKER FOR POSTTRAUMATIC DEVELOPMENT OF INFLAMMATORY SECOND HIT AND SEPSIS

  2008cites this paper
• Cytosolic Phospholipase A2 Activity in Neutrophilic Oxidative Stress of Platelet-activating Factor-induced Acute Lung Injury

  2008cites this paper
• CHAPTER 51 – Economics of Ventilator Care

  2008cites this paper
• Hyperbaric oxygen pretreatment attenuates hepatic reperfusion injury.

  2008cites this paper
• Transfusion-related immunomodulation (TRIM): an update.

  2007cites this paper
• Systemic inflammation after trauma.

  2007cites this paper
• Application of proteomics and cytomics in human neutrophils functional studies

  2007cites this paper
• Isolated head injury in children affects the neutrophil function and lymphocyte count.

  2007cites this paper
• SODIUM CHLORIDE INHIBITS CYTOKINE PRODUCTION BY LIPOPOLYSACCHARIDE-STIMULATED HUMAN NEUTROPHILS AND MONONUCLEAR CELLS

  2007cites this paper
• Chapter 13 – Surgical Hemorrhage

  2006cites this paper
• LEUKOCYTE-ENDOTHELIUM INTERACTIONS AFTER HEMORRHAGIC SHOCK/REPERFUSION AND CECAL LIGATION/PUNCTURE: AN INTRAVITAL MICROSCOPIC STUDY IN RAT MESENTERY

  2006cites this paper
• Deleterious Clinical Effects of Allogeneic Blood Transfusion–Related Immunomodulation

  2006cites this paper
• Alteration of polymorphonuclear neutrophil surface receptor expression and migratory activity after isolation: comparison of whole blood and isolated PMN preparations from normal and postfracture trauma patients.

  2006cites this paper
• Neutrophil priming for elastase release in adult blunt trauma patients.

  2006cites this paper
• Intestinal ischemia/reperfusion induces bronchial hyperreactivity and increases serum TNF-alpha in rats.

  2006cites this paper
• SIVELESTAT, A NEUTROPHIL ELASTASE INHIBITOR, ATTENUATES NEUTROPHIL PRIMING AFTER HEPATOENTERIC ISCHEMIA IN RABBITS

  2005cites this paper
• Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injury.

  2005cites this paper
• Smoke inhalation enhances early alveolar leukocyte responsiveness to endotoxin.

  2005cites this paper
• The role of the lung in postinjury multiple organ failure.

  2005cites this paper
• Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans1

  2005cites this paper
• Intestinal epithelial cells modulate PMN activation and apoptosis following bacterial and hypoxic challenges.

  2005cites this paper
• Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation.

  2005cites this paper
• THE TWO-EVENT CONSTRUCT OF POSTINJURY MULTIPLE ORGAN FAILURE

  2005cites this paper
• Putative mechanism of hemorrhage-induced leukocyte hyporesponsiveness: induction of suppressor of cytokine signaling-3.

  2004cites this paper
• Toxicities of hemoglobin solutions: in search of in‐vitro and in‐vivo model systems

  2004cites this paper
• Peripheral Polymorphonuclear Leukocyte Priming Contributes to Oxidative Stress in Early Pregnancy

  2004cites this paper
• Chemiluminescence: comparison of whole blood with isolated polymorphonuclear leukocytes after major trauma.

  2004cites this paper
• Sepsis in Humans (C5L2), during Experimental Sepsis and Changes in the Novel Orphan, C5a Receptor

  2004cites this paper
• The next generation in shock resuscitation.

  2004cites this paper
• Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance

  2003cites this paper
• Neutrophil C5a receptor and the outcome in a rat model of sepsis

  2003cites this paper
• Blood substitutes: the future is now.

  2003cites this paper
• The Abdominal Compartment Syndrome as a Second Insult During Systemic Neutrophil Priming Provokes Multiple Organ Injury

  2003cites this paper
• WBC‐containing allogeneic blood transfusion and mortality: a meta‐analysis of randomized controlled trials

  2003cites this paper
• The neural and humoral response to acute neurological illness is the mechanism of consequent new organ failures

  2003cites this paper
• Systemic neutrophil activation in COPD : Analysis of gene expression profiles and intracellular signaling

  2003cites this paper
• Chapter 3 Exacerbations of COPD correlate with down-regulation of cytokine-inducible genes in peripheral blood neutrophils

  2003cites this paper
• The neural and humoral response to acute neurological illness

  2002cites this paper
• Acute Hypoxemia in Humans Enhances the Neutrophil Inflammatory Response

  2002cites this paper
• Immunity During Sepsis Complement-Induced Impairment of Innate Erickson and

  2002influential citation
• Complement-Induced Impairment of Innate Immunity During Sepsis1

  2002influential citation
• Diabetic hyperglycemia: a facilitating factor in systemic capillary leak.

  2002cites this paper
• Sepsis and Organ Dysfunction — Basics, Controversies, Rationale

  2002cites this paper
• Protection of innate immunity by C5aR antagonist in septic mice

  2002cites this paper
• Growth hormone increases circulating neutrophil activation and provokes lung microvascular injury in septic peritonitis rats.

  2002cites this paper
• Early immunological defects in comatose patients after acute brain injury.

  2001cites this paper
• CXCR2 regulation of tumor necrosis factor-alpha adherence-dependent peroxide production is significantly diminished after severe injury in human neutrophils.

  2001cites this paper
• G-protein receptor responses in trauma neutrophils.

  2000cites this paper
• Hypertonic saline attenuation of polymorphonuclear neutrophil cytotoxicity: timing is everything.

  2000cites this paper
• Enhanced responsiveness of circulatory neutrophils after cardiopulmonary bypass: increased aggregability and superoxide producing capacity.

  2000cites this paper
• Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling.

  2000cites this paper
• Monitoring of neutrophil priming in whole blood by antibodies isolated from a synthetic phage antibody library

  2000cites this paper
• Inflammatory responses and mediators.

  2000cites this paper