Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1993-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.90.11.4922PMID 8389457PMCID PMC46625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis

  1993cited by this paper
• Processing of adrenocorticotropin by two proteases in bovine intermediate lobe secretory vesicle membranes. A distinct acidic, tetrabasic residue-specific calcium-activated serine protease and a PC2-like enzyme.

  1992cited by this paper
• Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives.

  1992cited by this paper
• Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary.

  1992cited by this paper
• The prohormone and proprotein processing enzymes PC1 and PC2: structure, selective cleavage of mouse POMC and human renin at pairs of basic residues, cellular expression, tissue distribution, and mRNA regulation.

  1992cited by this paper
• The cDNA structure of the porcine pro‐hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N‐terminal glycopeptide segment of porcine POMC

  1992cited by this paper
• Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

  1992cited by this paper
• PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

  1991cited by this paper
• Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

  1991cited by this paper
• Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

  1991cited by this paper
• Plasticity of peptide biosynthesis in corticotropes: independent regulation of different steps in processing.

  1991cited by this paper
• Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

  1991cited by this paper
• Ontogenesis of proopiomelanocortin gene expression and regulation in the rat pituitary intermediate lobe.

  1990cited by this paper
• The tissue-specific processing of Pro-ACTH/Endorphin recent advances and unsolved problems.

  1990cited by this paper
• Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

  1990cited by this paper
• cDNA Sequence of Two Distinct Pituitary Proteins Homologous to Kex2 and Furin Gene Products: Tissue-Specific mRNAs Encoding Candidates for Pro-Hormone Processing Proteinases

  1990cited by this paper
• Analysis of proopiomelanocortin gene expression during prenatal development of the rat pituitary gland.

  1989cited by this paper
• Prenatal ontogenesis of pro-opiomelanocortin in the mouse central nervous system and pituitary gland: an in situ hybridization and immunocytochemical study.

  1989cited by this paper
• Functional diversity of bioactive peptides in the nervous system itself: “How the brain may understand”

  1989cited by this paper
• Plasticity in the adrenocorticotropin-related peptides produced by primary cultures of neonatal rat pituitary.

  1988cited by this paper
• Proopiomelanocortin Gene Expression, Prohormone Processing, and Secretion during Rat Pituitary Development a

  1987cited by this paper
• The Synthesis and Processing of Pro‐ACTH/Endorphin in the Developing Rat Pituitary

  1987cited by this paper
• The pituitary polypetide “7B2” is associated with LH/FSH and TSH cells and is localized within secretory vesicles

  1987cited by this paper
• Differential subcellular localization of ACTH and alpha-MSH in corticotropes of the rat anterior pituitary.

  1986cited by this paper
• Long-term trophic action of alpha-melanocyte-stimulating hormone on the zona glomerulosa of the rat adrenal cortex.

  1986cited by this paper
• Biosynthesis and processing of pro-opiomelanocortin-derived peptides during fetal pituitary development.

  1984cited by this paper
• Ontogeny of opioid and related peptides in the rat cns and pituitary: an immunocytochemical study.

  1983cited by this paper
• An efficient method of antibody elution for the successive or simultaneous localization of two antigens by immunocytochemistry.

  1978cited by this paper
• The fetal brain and intrauterine growth.

  1978cited by this paper
• [Demonstration by immunofluorescence of corticotropic cells and melanotropic cells in the anterior pituitary gland of the golden hamster (Mesocricetus auratus Waterh)].

  1974cited by this paper

• Journey through the spectacular landscape of melanocortin 1 receptor

  2024cites this paper
• Furin is involved in uterine activation for labor

  2021cites this paper
• Transcription factor Creb3l1 regulates the synthesis of prohormone convertase enzyme PC1/3 in endocrine cells

  2020cites this paper
• Melanocortin Regulation of Inflammation

  2019cites this paper
• Pituitary Transcription Factor Mutations Leading to Hypopituitarism.

  2019cites this paper
• Molecular Cloning and Expression of Prohormone Convertases PC 1 and PC 2 in the Pituitary Gland of the Bullfrog , Rana catesbeiana

  2019cites this paper
• Seeing the light to change colour: An evolutionary perspective on the role of melanopsin in neuroendocrine circuits regulating light‐mediated skin pigmentation

  2018cites this paper
• An investigation of interaction between Neuroserpin and its putative targets PC1/3, PC2 and Furin with a YFP-protein complementation assay

  2016cites this paper
• Insulin-like growth factor 2 rescues aging-related memory loss in rats.

  2016cites this paper
• Establishment of proprotein convertase, furinA knocked-out lines in medaka, Oryzias latipes, and unique form of medaka furin-like prorprotein convertase (mflPC).

  2015cites this paper
• Effects of chronic psychosocial stress on HPA axis functionality in male C57BL/6 mice and the impact of trait anxiety on the individual stress vulnerability

  2015cites this paper
• Proprotein Convertase Enzymes FURIN and PCSK7 in Immune Regulation

  2015cites this paper
• Haplotype combination of the caprine PC1 gene sequence variants and association with growth traits in Chinese Haimen breed

  2014cites this paper
• Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention.

  2014cites this paper
• Proprotein Convertase 2

  2013cites this paper
• Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) Is Essential for the Zebrafish Development and Bioavailability of Transforming Growth Factor β1a (TGFβ1a)*

  2013cites this paper
• CRH CRH CRH CRH CRH CRH CRH CRH CRH POMC POMC POMC LIMBIC HYPOTHALAMUS PITUITARY ACTH

  2013cites this paper
• Proprotein Convertase 1/3

  2013cites this paper
• Addiction and the adrenal cortex

  2013cites this paper
• TGF of Transforming Growth Factor Beta 1 a Zebrafish Development and Bioavailability Type 7 ( PCSK 7 ) Is Essential for the Proprotein Convertase Subtilisin / Kexin Developmental

  2013cites this paper
• Proprotein Convertases: Discovery, Characteristics, and Link to Tumor Progression and Metastasis

  2013cites this paper
• Regulation of the β-endorphin precursor proopiomelanocortin in lymphocytes in a rat model of inflammatory pain

  2013cites this paper
• Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2.

  2013cites this paper
• Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis

  2013cites this paper
• The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions*

  2013cites this paper
• α-TC1.9 cells--a model system for analyzing the endoproteolytic processing of POMC.

  2011cites this paper
• Dégradation des membres de la famille du LDLRpar la convertase PCSK9 : troisième locus de l'hypercholestérolémie familiale

  2011cites this paper
• The polymorphisms of bovine PCSK1 gene and their associations with growth traits

  2011cites this paper
• Novel Single Nucleotide Polymorphisms of the Caprine PC1 Gene and Association with Growth Traits

  2010cites this paper
• A Postnatal Pax7 Progenitor Gives Rise to Pituitary Adenomas.

  2010cites this paper
• Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2.

  2009cites this paper
• The Regulation of Expression of Hemokinin-1

  2009influential citation
• Impact of environmental factors on the development of corticotroph subpopulations in the fetal sheep pituitary.

  2008influential citation
• Autoimmune hypophysitis of SJL mice: clinical insights from a new animal model.

  2008cites this paper
• Proteomic analysis of neuroendocrine peptidergic system disruption using the AtT20 pituitary cell line as a model.

  2008cites this paper
• Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice.

  2008influential citation
• Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.

  2007cites this paper
• Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development.

  2007influential citation
• The melanocortin system in leukocyte biology

  2007cites this paper
• Du mécanisme moléculaire de la résistance hormonale à la tumorigénèse dans la maladie de Cushing

  2007cites this paper
• A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

  2007cites this paper
• PC1/3 and PC2 Gene Expression and Post‐Translational Endoproteolytic Pro‐Opiomelanocortin Processing is Regulated by Photoperiod in the Seasonal Siberian Hamster (Phodopus sungorus)

  2006cites this paper
• Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins.

  2006cites this paper
• Proopiomelanocortin gene expression and β‐endorphin localization in the pituitary, testis, and epididymis of stallion

  2006cites this paper
• The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.

  2005cites this paper
• Molecular and Neuroendocrine Determinants of Seasonal Body Weight Regulation

  2005cites this paper
• Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels

  2005cites this paper
• Manserin, a novel peptide from secretogranin II in the neuroendocrine system

  2004cites this paper
• Evolution and function of melanocortin and melanin-concentrating hormone receptors

  2004cites this paper
• Proopiomelanocortin production by epidermal cells: evidence for an immune neuroendocrine network in the epidermis

  2004cites this paper
• Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain.

  2004cites this paper
• Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

  2004cites this paper
• Subcellular Pathways of β-Endorphin Synthesis, Processing, and Release from Immunocytes in Inflammatory Pain

  2004cites this paper
• Intrapituitary Regulatory System of Proliferation of Mammotrophs in the Pituitary Gland

  2004cites this paper
• Gene Expression Patterns of Pro-opiomelanocortin-processing Enzymes PC1 and PC2 During Postnatal Development of Rat Corticotrophs

  2004cites this paper
• Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase.

  2003cites this paper
• Targeted mutagenesis of processing enzymes and regulators: Implications for development and physiology

  2003cites this paper
• Molecular cloning of proopiomelanocortin (POMC) cDNA from mud turtle, Pelodiscus sinensis.

  2003cites this paper
• α-Melanocyte-Stimulating Hormone Stimulates Prolactin Secretion through Melanocortin-3 Receptors Expressed in Mammotropes in the Mouse Pituitary

  2003cites this paper
• Expression and Localization of Prohormone Convertase PC1 in the Calcitonin-producing Cells of the Bullfrog Ultimobranchial Gland

  2003cites this paper
• The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease.

  2003cites this paper
• Comparative Aspects of Intracellular Proteolytic Processing of Peptide Hormone Precursors: Studies of Proopiomelanocortin Processing

  2003cites this paper
• Menkes Protein Contributes to the Function of Peptidylglycine α-Amidating Monooxygenase

  2003cites this paper
• Molecular Cloning and Expression of Prohormone Convertases PC1 and PC2 in the Pituitary Gland of the Bullfrog, Rana catesbeiana

  2003cites this paper
• Chromogranin A processing in human pituitary adenomas and carcinomas: Analysis with region-specific antibodies

  2003cites this paper
• Ontogeny of a novel decapeptide derived from POMC-A in the brain and pituitary of the rainbow trout.

  2003cites this paper
• Biochemical Characterization and Immunocytochemical Localization of EM66, a Novel Peptide Derived from Secretogranin II, in the Rat Pituitary and Adrenal Glands

  2003cites this paper
• Ectopic hormone syndromes

  2002cites this paper
• Neuropeptides and Chromogranins

  2002cites this paper
• Localization and characterization of evolutionarily conserved chromogranin A-derived peptides in the rat and human pituitary and adrenal glands

  2002cites this paper
• Dynamic processing of neuropeptides: sequential conformation shaping of neurohypophysial preprohormones during intraneuronal secretory transport.

  2002cites this paper
• Neuropeptides and chromogranins: session overview.

  2002cites this paper
• Immunocytochemical Localization of Prohormone Convertases PC1 and PC2 in the Mouse Thyroid Gland and Respiratory Tract

  2002cites this paper
• Role of Pituitary POMC-Peptides and Insulin-Like Growth Factor II in the Developmental Biology of the Adrenal Gland

  2002cites this paper
• Dynamic processing of neuropeptides

  2002cites this paper
• Differential localization of prohormone convertases PC1 and PC2 in two distinct types of secretory granules in rat pituitary gonadotrophs

  2001influential citation
• PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

  2001cites this paper
• Altered Processing of Pro-Orphanin FQ/Nociceptin and Pro-Opiomelanocortin-Derived Peptides in the Brains of Mice Expressing Defective Prohormone Convertase 2

  2001cites this paper
• Cell type-specific metabolism of peptidylglycine alpha-amidating monooxygenase in anterior pituitary.

  2000cites this paper
• Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain

  2000cites this paper
• Differential onset of expression of mRNAs encoding proopiomelanocortin, prohormone convertases 1 and 2, and granin family members during Xenopus laevis development.

  2000cites this paper
• Insulin and glucagon mRNA expression and prohormone convertase immunoreactivity in normal and neoplastic pancreatic endocrine tissue

  2000cites this paper
• Proopiomelanocortin and the Melanocortin Peptides

  2000cites this paper
• Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system

  2000influential citation
• Expression of proopiomelanocortin peptides in human dermal microvascular endothelial cells: evidence for a regulation by ultraviolet light and interleukin-1.

  2000cites this paper
• Proopiomelanocortin Synthesis and Cell‐Specific Processing

  2000cites this paper
• Immunohistochemical evidence for the implication of PCI in the processing of proneurotensin in rat brain

  2000cites this paper
• Crosstalk between nervous and immune systems through the animal kingdom: focus on opioids

  2000cites this paper
• Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro‐neurotensin in rat brain

  2000cites this paper
• Cell Type-Specific Metabolism of Peptidylglycineα -Amidating Monooxygenase in Anterior Pituitary.

  2000cites this paper
• Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.

  2000cites this paper
• Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-derived Peptides in Murine Skin

  2000cites this paper
• Hypothalamic Neurons: Regulation and Gene Expression

  2000cites this paper
• Ontogenesis of Proopiomelanocortin and Its Processing to β-Endorphin by the Fetal and Neonatal Rat Brain

  2000cites this paper
• Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: Their presence in Schwann cells, macrophages, and smooth muscle cells

  1999cites this paper
• Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.

  1999cites this paper
• Cellular Localization and Role of Prohormone Convertases in the Processing of Pro-melanin Concentrating Hormone in Mammals*

  1999cites this paper
• Distribution and Regulation of Proconvertases PC1 and PC2 in Human Pituitary Adenomas

  1999cites this paper
• Furin-independent Pathway of Membrane Type 1-Matrix Metalloproteinase Activation in Rabbit Dermal Fibroblasts*

  1999cites this paper
• The Subtilisin/Kexin Family of Precursor Convertases: Emphasis on PC1, PC2/7B2, POMC and the Novel Enzyme SKI‐1

  1999cites this paper