Early-life stress and HPA axis trigger recurrent adulthood depression.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Epilepsy & Behavior

• Publication date

  2014-09-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.yebeh.2013.10.020PMID 24269030
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of Early Life Stress in Adult Psychiatric Disorders: A Systematic Review According to Childhood Trauma Subtypes

  2013influential reference
• Diagnostic and Statistical Manual of Mental Disorders

  2013cited by this paper
• The role of mineralocorticoid receptor function in treatment-resistant depression

  2013cited by this paper
• Assessment of the hypothalamic–pituitary–adrenal axis activity: glucocorticoid receptor and mineralocorticoid receptor function in depression with early life stress – a systematic review

  2012influential reference
• Hypothalamic–pituitary–adrenal axis dysfunction in chronic fatigue syndrome

  2012cited by this paper
• Early life stress, HPA axis, and depression

  2011cited by this paper
• An integrative science approach: neuroscience in the DSM-V and ICD-11

  2011cited by this paper
• Analysis of the occurrence of early life stress in adult psychiatric patients: A systematic review.

  2011influential reference
• Melancholia in Latin American studies: a distinct mood disorder for the ICD-11.

  2011cited by this paper
• The prednisolone suppression test in depression: dose-response and changes with antidepressant treatment.

  2010cited by this paper
• Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case series

  2009cited by this paper
• Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double-blind, placebo-controlled proof-of-concept study.

  2009cited by this paper
• Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study.

  2009cited by this paper
• [Childhood maltreatment and adult psychopathology: pathways to hypothalamic-pituitary-adrenal axis dysfunction].

  2009cited by this paper
• Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology.

  2009cited by this paper
• Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls.

  2009cited by this paper
• Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance.

  2009influential reference
• The link between childhood trauma and depression: insights from HPA axis studies in humans.

  2008influential reference
• Childhood parental loss and adult hypothalamic-pituitary-adrenal function.

  2008cited by this paper
• The coming out of the brain mineralocorticoid receptor.

  2008cited by this paper
• Measuring cortisol in human psychobiological studies.

  2007cited by this paper
• [Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome].

  2007cited by this paper
• [Depression and stress: is there an endophenotype?].

  2007cited by this paper
• Different responses to dexamethasone and prednisolone in the same depressed patients

  2006influential reference
• Do Corticosteroids Damage the Brain?

  2006cited by this paper
• Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review.

  2006influential reference
• The dex/CRH test--is it better than the DST?

  2006cited by this paper
• Treatment-resistant depression.

  2006cited by this paper
• Assessment of subtle changes in glucocorticoid negative feedback using prednisolone: comparison of salivary free cortisol and urinary cortisol metabolites as endpoints.

  2006cited by this paper
• Disruption of mineralocorticoid receptor function increases corticosterone responding to a mild, but not moderate, psychological stressor.

  2005cited by this paper
• Stress and the brain: from adaptation to disease

  2005influential reference
• Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation

  2005cited by this paper
• Erratum: Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma (Proceedings of the National Academy of Sciences of the United States of America (November 25, 2003) 100, 24 (14293-14296))

  2005cited by this paper
• Defining the boundaries of atypical depression: evidence from the HPA axis supports course of illness distinctions.

  2005cited by this paper
• Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation.

  2004cited by this paper
• O eixo hipotálamo-pituitária-adrenal, a função dos receptores de glicocorticóides e sua importância na depressão

  2004cited by this paper
• Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder.

  2004cited by this paper
• Do antidepressants regulate how cortisol affects the brain?

  2004cited by this paper
• Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers

  2004cited by this paper
• Puberty, Ovarian Steroids, and Stress

  2004influential reference
• Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder

  2004cited by this paper
• Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties.

  2004influential reference
• Corticosteroid-serotonin interactions in depression: a review of the human evidence

  2004cited by this paper
• [The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression].

  2004cited by this paper
• Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse.

  2004cited by this paper
• Altered glucocorticoid immunoregulation in treatment resistant depression.

  2003cited by this paper
• Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma

  2003influential reference
• The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).

  2003cited by this paper
• Mineralocorticoid receptor function in major depression.

  2003cited by this paper
• Molecular mechanisms of glucocorticoid receptor sensitivity and relevance to affective disorders

  2003influential reference
• Development and validation of a brief screening version of the Childhood Trauma Questionnaire.

  2003cited by this paper
• Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders

  2002cited by this paper
• Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.

  2002cited by this paper
• Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

  2002cited by this paper
• A novel prednisolone suppression test for the hypothalamic-pituitary-adrenal axis.

  2002influential reference
• Dexamethasone-induced effects on lymphocyte distribution and expression of adhesion molecules in treatment-resistant depression.

  2002cited by this paper
• Cortisol, serotonin and depression: All stressed out?

  2002cited by this paper
• Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress.

  2002cited by this paper
• Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy.

  2001cited by this paper
• Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice.

  2001cited by this paper
• Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment.

  2001cited by this paper
• Prevalence of Psychopathology in Dutch Epilepsy Inpatients: A Comparative Study.

  2001cited by this paper
• The Corticosteroid Receptor Hypothesis of Depression

  2000cited by this paper
• Future therapeutic targets in mood disorders: the glucocorticoid receptor

  2000cited by this paper
• Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.

  2000cited by this paper
• Allostasis and Allostatic Load: Implications for Neuropsychopharmacology

  2000cited by this paper
• Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primates.

  2000cited by this paper
• Effect of an oral contraceptive on the plasma levels of budesonide and prednisolone and the influence on plasma cortisol

  2000cited by this paper
• Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis.

  2000cited by this paper
• Protective and Damaging Effects of Mediators of Stress: Elaborating and Testing the Concepts of Allostasis and Allostatic Load

  1999cited by this paper
• Effects of dexamethasone on neuroendocrine and psychological responses to L-tryptophan infusion

  1999cited by this paper
• The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.

  1999cited by this paper
• Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.

  1998cited by this paper
• Brain corticosteroid receptor balance in health and disease.

  1998influential reference
• Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective Disorders

  1998cited by this paper
• Reproducibility of the low dose dexamethasone suppression test: comparison between direct plasma and salivary cortisol assays

  1998cited by this paper
• The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans.

  1998cited by this paper
• Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists.

  1998cited by this paper
• Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis.

  1998cited by this paper
• 5-Hydroxytryptamine receptor function in humans is reduced by acute administration of hydrocortisone

  1998cited by this paper
• Corticosteroid receptor function is decreased in depressed patients.

  1997cited by this paper
• DST studies in psychotic depression: a meta-analysis.

  1997cited by this paper
• Lipocortin 1: a second messenger of glucocorticoid action in the hypothalamo-pituitary-adrenocortical axis.

  1997cited by this paper
• The Ernst Schering Poster Award. Intracellular traffic of steroid hormone receptors.

  1996cited by this paper
• Intracellular traffic of steroid hormone receptors

  1996cited by this paper
• Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy.

  1996cited by this paper
• The dexamethasone suppression test in patients with mood disorders.

  1996cited by this paper
• Relationship of site of seizure focus to psychiatric morbidity

  1995cited by this paper
• Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression.

  1995cited by this paper
• Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I.

  1995cited by this paper
• The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.

  1995cited by this paper
• Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis.

  1995cited by this paper
• The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders.

  1994cited by this paper
• Melancholic symptom features and DSM-IV.

  1994cited by this paper
• Salivary cortisol in psychoneuroendocrine research: recent developments and applications.

  1994cited by this paper
• Similar Age Related Increase of Vasopressin Colocalization in Paraventricular Corticotropin‐Releasing Hormone Neurons in Controls and Alzheimer Patients

  1994cited by this paper
• Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression.

  1993cited by this paper
• Social rearing effects on HPA axis activity over early development and in response to stress in rhesus monkeys.

  1993cited by this paper
• The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

  1993cited by this paper
• Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.

  1993cited by this paper

• The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

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