Mechanism of HIV-1 Neutralization by Antibodies Targeting a Membrane-Proximal Region of gp41

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Virology

• Publication date

  2013-11-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02664-13PMID 24227838PMCID PMC3911647
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• HIV‐1 neutralizing antibodies: understanding nature's pathways

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• Generation of HIV-1 potent and broad neutralizing antibodies by immunization with postfusion HR1/HR2 complex

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• B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

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• HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120

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• Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

  2012influential reference
• Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41

  2011cited by this paper
• MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1

  2011cited by this paper
• Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

  2011cited by this paper
• Acute HIV-1 Infection.

  2011cited by this paper
• Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions

  2010cited by this paper
• Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies

  2010cited by this paper
• Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody.

  2010cited by this paper
• Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

  2010cited by this paper
• Role of HIV membrane in neutralization by two broadly neutralizing antibodies

  2009cited by this paper
• Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?

  2009cited by this paper
• Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity

  2009cited by this paper
• A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

  2008cited by this paper
• Viral membrane fusion

  2008cited by this paper
• HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane.

  2008cited by this paper
• The Membrane-Proximal External Region of the Human Immunodeficiency Virus Type 1 Envelope: Dominant Site of Antibody Neutralization and Target for Vaccine Design

  2008cited by this paper
• The Role of Antibody Polyspecificity and Lipid Reactivity in Binding of Broadly Neutralizing Anti-HIV-1 Envelope Human Monoclonal Antibodies 2F5 and 4E10 to Glycoprotein 41 Membrane Proximal Envelope Epitopes1

  2007cited by this paper
• Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion.

  2007cited by this paper
• The HIV lipidome: a raft with an unusual composition.

  2006cited by this paper
• Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies

  2005cited by this paper
• Recommendations for the Design and Use of Standard Virus Panels To Assess Neutralizing Antibody Responses Elicited by Candidate Human Immunodeficiency Virus Type 1 Vaccines

  2005cited by this paper
• Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies

  2005cited by this paper
• Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.

  2005cited by this paper
• Antibody neutralization and escape by HIV-1

  2003cited by this paper
• Rapid evolution of the neutralizing antibody response to HIV type 1 infection

  2003cited by this paper
• Novel therapies based on mechanisms of HIV-1 cell entry.

  2003cited by this paper
• Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization

  2002cited by this paper
• HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

  2002cited by this paper
• A Potent Cross-Clade Neutralizing Human Monoclonal Antibody against a Novel Epitope on gp41 of Human Immunodeficiency Virus Type 1

  2001cited by this paper
• Plasma membrane rafts play a critical role in HIV-1 assembly and release

  2001cited by this paper
• HIV entry and its inhibition.

  1998cited by this paper
• A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

  1993cited by this paper
• Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes.

  1993cited by this paper

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• Conformational Variability of HIV-1 Env Trimer and Viral Vulnerability

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• Heterologous immunization modulates B-cell epitope competition between helper peptides and the MPER segment in MPER/liposome vaccines

  2025cites this paper
• Potent broadly neutralizing antibodies mediate efficient antibody-dependent phagocytosis of HIV-infected cells

  2024cites this paper
• Affinity gaps among B cells in germinal centers drive the selection of MPER precursors

  2024cites this paper
• In vivo affinity maturation of the CD4 domains of an HIV-1-entry inhibitor

  2024cites this paper
• In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

  2024cites this paper
• Ab initio prediction of specific phospholipid complexes and membrane association of HIV-1 MPER antibodies by multi-scale simulations

  2024cites this paper
• Neutralizing antibodies to block viral entry and for identification of entry inhibitors.

  2024cites this paper
• In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

  2024cites this paper
• Antibody-dependent cellular cytotoxicity, infected cell binding and neutralization by antibodies to the SIV envelope glycoprotein

  2023cites this paper
• Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

  2023cites this paper
• Biochemical and biophysical characterization of natural polyreactivity in antibodies

  2023cites this paper
• Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

  2023cites this paper
• Current ARTs, Virologic Failure, and Implications for AIDS Management: A Systematic Review

  2023cites this paper
• Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies

  2022influential citation
• Peptide Triazole Inhibitors of HIV-1: Hijackers of Env Metastability.

  2022cites this paper
• Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent

  2022cites this paper
• Small-molecule HIV-1 entry inhibitors targeting the epitopes of broadly neutralizing antibodies.

  2022cites this paper
• Detecting and Characterizing Virus Neutralizing Antibodies in Real Time Using Cellular Impedance and Live Cell Imaging

  2021cites this paper
• HIV-1 Entry and Membrane Fusion Inhibitors

  2021cites this paper
• The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8

  2020cites this paper
• HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes

  2020cites this paper
• Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

  2020cites this paper
• Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses

  2020cites this paper
• Neutralizing Antibodies Targeting HIV-1 gp41

  2020cites this paper
• HIV‐1 Envelope Spike MPER: From a Vaccine Target to a New Druggable Pocket for Novel and Effective Fusion Inhibitors

  2020cites this paper
• Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

  2020cites this paper
• Selection and immune recognition of HIV-1 MPER mimotopes.

  2020cites this paper
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• Unidirectional Presentation of Membrane Proteins in Nanoparticle-Supported Liposomes.

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• Broadly Neutralizing Antibodies against HIV: Back to Blood.

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• Viral Vectors for the Induction of Broadly Neutralizing Antibodies against HIV

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Potential HIV-1 fusion inhibitors mimicking gp41-specific broadly neutralizing antibody 10E8: In silico discovery and prediction of antiviral potency

  2018cites this paper
• Induction of broadly neutralizing antibodies in Germinal Centre simulations.

  2018cites this paper
• Functional Optimization of Broadly Neutralizing HIV-1 Antibody 10E8 by Promotion of Membrane Interactions

  2018cites this paper
• The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

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• HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins

  2018cites this paper
• Structure of the membrane proximal external region of HIV-1 envelope glycoprotein

  2018cites this paper
• Stabilization of HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies

  2017cites this paper
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  2017cites this paper
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• Optimization of the EC26-2A4 Epitope in the gp41 Membrane Proximal External Region Targeted by Neutralizing Antibodies from an Elite Controller

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• Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike

  2017cites this paper
• Development of a DNA vaccine expressing a secreted HIV-1 gp41 ectodomain that includes the membrane-proximal external region.

  2017cites this paper
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  2017cites this paper
• Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target

  2017cites this paper
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• Antigp41 membrane proximal external region antibodies and the art of using the membrane for neutralization.

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• Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

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