Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Cell

• Publication date

  1991-09-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(91)90037-YPMID 1913805
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biosynthesis of the secretory core protein of duck hepatitis B virus: intracellular transport, proteolytic processing, and membrane expression of the precore protein

  1991cited by this paper
• Redistribution of critical major histocompatibility complex and T cell receptor‐binding functions of residues in an antigenic sequence after biterminal substitution

  1991cited by this paper
• Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope

  1991cited by this paper
• Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

  1991cited by this paper
• The binary logic of antigen processing and presentation to T cells.

  1990cited by this paper
• Cellular peptide composition governed by major histocompatibility complex class I molecules

  1990cited by this paper
• Transporters of delight

  1990cited by this paper
• Antigen processing. Transporters of delight.

  1990cited by this paper
• Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y.

  1990cited by this paper
• Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

  1990cited by this paper
• Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

  1990cited by this paper
• The secretory core protein of human hepatitis B virus is expressed on the cell surface

  1989cited by this paper
• A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes

  1989cited by this paper
• Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase.

  1989cited by this paper
• Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen

  1989cited by this paper
• Association of class I major histocompatibility heavy and light chains induced by viral peptides

  1989cited by this paper
• Antigen recognition by class I-restricted T lymphocytes.

  1989cited by this paper
• Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen

  1988cited by this paper
• A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection

  1988cited by this paper
• A sequence pattern common to T cell epitopes.

  1988cited by this paper
• Total chemical synthesis of a gene for hepatitis B virus core protein and its functional characterization.

  1988cited by this paper
• Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89

  1988cited by this paper
• Expression and replication of the hepatitis B virus genome under foreign promoter control.

  1987cited by this paper
• On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes

  1987cited by this paper
• Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus [published erratum appears in J Exp Med 1987 Nov 1;166(5):following 1608]

  1987cited by this paper
• Sequence and structural organization of murine cytomegalovirus immediate-early gene 1

  1987cited by this paper
• The molecular biology of the hepatitis B viruses.

  1987cited by this paper
• Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence

  1986cited by this paper
• Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen.

  1986cited by this paper
• The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.

  1986cited by this paper
• T-cell antigenic sites tend to be amphipathic structures.

  1985cited by this paper
• Hormonal regulation of cell surface expression of the major histocompatibility antigen H‐2Ld in transfected cells.

  1985cited by this paper
• A new dominant hybrid selective marker for higher eukaryotic cells.

  1981cited by this paper

• ERAP1-dependent extreme antigen processing efficacy can govern MHC class I expression hierarchy.

  2025cites this paper
• Oligonucleotide library screening for identification of virus‐specific T‐cell receptors

  2024cites this paper
• The molecular mechanisms of CD8+ T cell responses to SARS-CoV-2 infection mediated by TCR-pMHC interactions

  2024cites this paper
• Physicochemical effects of emerging exchanges on the spike protein's RBM of the SARS-CoV-2 Omicron subvariants BA.1-BA.5 and its influence on the biological properties and attributes developed by these subvariants.

  2023cites this paper
• SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses

  2023cites this paper
• Early protective effect of a (“pan”) coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration

  2023cites this paper
• The SARS-CoV-2 Omicron BA.1 spike G446S potentiates HLA-A*24:02-restricted T cell immunity

  2022cites this paper
• Adenovirus-Inspired Virus-like-Particles Displaying Melanoma Tumor Antigen Specifically Target Human DC Subsets and Trigger Antigen-Specific Immune Responses

  2022cites this paper
• Stimulation of the immune system by a tumor antigen-bearing adenovirus-inspired VLP allows control of melanoma growth

  2022cites this paper
• The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition

  2022cites this paper
• FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8+ T Cells During Ischemic Stroke

  2020cites this paper
• Antigen processing and presentation in HIV infection.

  2019cites this paper
• Vaccine Vectors Harnessing the Power of Cytomegaloviruses

  2019cites this paper
• Vaccine vectors: the bright side of cytomegalovirus

  2019cites this paper
• Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation

  2019cites this paper
• pMell7 is recognised by monoclonal antibodies NKI-beteb, HMB-45 and HMB-50 and by anti-melanoma CTL

  2019cites this paper
• The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors

  2019cites this paper
• A SIINFEKL-Based System to Measure MHC Class I Antigen Presentation Efficiency and Kinetics.

  2019cites this paper
• This information is current as Low-Avidity Epitope Vaccine Vector Expressing a Single Immune Protection by a Cytomegalovirus

  2017cites this paper
• Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

  2017cites this paper
• Engineering Virus-like Particles for Antigen and Drug Delivery.

  2017cites this paper
• Prediction of cleavage fragments generated by the proteasome

  2016cites this paper
• Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation Events Generate a Common Peptide from Influenza A Virus M2 and M1 mRNAs

  2016cites this paper
• Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.

  2016cites this paper
• Refining human T-cell immunotherapy of cytomegalovirus disease: a mouse model with ‘humanized’ antigen presentation as a new preclinical study tool

  2016cites this paper
• Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma

  2016cites this paper
• Influenza Virus-specific CD8+ T Cells : -longevity, cross-reactivity and viral evasion-

  2016cites this paper
• Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

  2016cites this paper
• Peptide from Influenza A Virus M 2 and M 1 Initiation Events Generate a Common Standard and Alternative Translation Defining Viral Defective Ribosomal Products :

  2016cites this paper
• The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing*

  2015cites this paper
• Understanding influenza CD8+ T cell immune escape from pre-existing immunity and T cell receptor cross-strain recognition

  2015cites this paper
• Differential Recognition of Influenza A Viruses by M158–66 Epitope-Specific CD8+ T Cells Is Determined by Extraepitopic Amino Acid Residues

  2015cites this paper
• The presence of prolines in the flanking region of an immunodominant HIV‐2 gag epitope influences the quality and quantity of the epitope generated

  2015cites this paper
• Novel approaches in polyepitope T-cell vaccine development against HIV-1

  2014cites this paper
• Viruswith the Newly Emerging H7N9 to Seasonal Influenza A Viruses Human Cytotoxic T Lymphocytes Directed

  2014cites this paper
• Mapping of CD8 T Cell Epitopes in Human Respiratory Syncytial Virus L Protein

  2014cites this paper
• 0304 Alleles W Epitopes Restricted by HLA-A0207 and -C Lymphocytes and Definition of Degenerate Subtype-Specific CD8 Cytotoxic T Immunodeficiency Virus Type 1 Comprehensive Screening for Human

  2014cites this paper
• T-cell immunity to influenza A viruses.

  2014cites this paper
• The Effect of Adjuvanting Cancer Vaccines with Herpes Simplex Virus Glycoprotein D on Melanoma-Driven CD8+ T Cell Exhaustion

  2014cites this paper
• Immunogenicity Evaluation of a Rationally Designed Polytope Construct Encoding HLA-A*0201 Restricted Epitopes Derived from Leishmania major Related Proteins in HLA-A2/DR1 Transgenic Mice: Steps toward Polytope Vaccine

  2014cites this paper
• Exhaustion T Cell + on Melanoma-Driven CD 8 with Herpes Simplex Virus Glycoprotein D The Effect of Adjuvanting Cancer Vaccines

  2014cites this paper
• Human Cytotoxic T Lymphocytes Directed to Seasonal Influenza A Viruses Cross-React with the Newly Emerging H7N9 Virus

  2013cites this paper
• HLA-B51 associated HIV-1 viral control

  2013cites this paper
• Immunodomination during Peripheral Vaccinia Virus Infection

  2013cites this paper
• Repertoire in Inbred and F1 Mice after Vaccinia Virus Infection and the Naive Altered CD8+ T Cell Immunodominance

  2013cites this paper
• Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

  2012cites this paper
• Enhancement of DNA vaccine efficacy by targeting the xenogeneic human chorionic gonadotropin, survivin and vascular endothelial growth factor receptor 2 combined tumor antigen to the major histocompatibility complex class II pathway

  2012cites this paper
• Induction of Protective Anti-CTL Epitope Responses against HER-2-Positive Breast Cancer Based on Multivalent T7 Phage Nanoparticles

  2012cites this paper
• IndividualsImmune Escape Patterns in HIV-Infected HIV Epitope Presentation and Predicts Aminopeptidase Substrate Preference Affects

  2012cites this paper
• Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals

  2012cites this paper
• Vaccinated HLA-A*0201 Transgenic Mice Critically Depends on CD4 T Cell Help in Epitope 503 - 495 Phosphoprotein pp65 to the Human Cytomegalovirus Tegument The Immunodominant CD8 T Cell Response

  2011cites this paper
• Epitope-Specific CD8 (cid:1) T Lymphocytes Cross-Recognize Mutant Simian Immunodeficiency Virus (SIV) Sequences but Fail To Contain Very Early Evolution and Eventual Fixation of Epitope Escape Mutations during SIV Infection (cid:1) †

  2011cites this paper
• Entwicklung einer Multi-Epitop-Vakzine auf Basis exponierter Peptiddomänen verschiedener Virulenz-assoziierter Außenmembranproteine uropathogener Escherichia coli

  2011cites this paper
• The Immunodominant CD8 T Cell Response to the Human Cytomegalovirus Tegument Phosphoprotein pp65495–503 Epitope Critically Depends on CD4 T Cell Help in Vaccinated HLA-A*0201 Transgenic Mice

  2011cites this paper
• Epitope-Specific CD8+ T Lymphocytes Cross-Recognize Mutant Simian Immunodeficiency Virus (SIV) Sequences but Fail To Contain Very Early Evolution and Eventual Fixation of Epitope Escape Mutations during SIV Infection

  2011cites this paper
• Generation of MHC class I ligands in the secretory and vesicular pathways

  2011cites this paper
• Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

  2011cites this paper
• Caspases in Virus-Infected Cells Contribute to Recognition by CD8+ T Lymphocytes

  2010cites this paper
• Processing of HIV-1 Nef Mutations Disrupt Proteasomal T Cell Epitope-Flanking + CD8

  2010cites this paper
• Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches

  2010cites this paper
• Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties.

  2010cites this paper
• Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens.

  2010cites this paper
• MHC-I-restricted HIV epitope processing, immune control and immunogen design

  2010cites this paper
• TAA Polyepitope DNA-Based Vaccines: A Potential Tool for Cancer Therapy

  2010cites this paper
• Lymphocytes T + Contribute to Recognition by CD8 Caspases in Virus-Infected Cells

  2010cites this paper
• Construction of HCV-polytope vaccine candidates harbouring immune-enhancer sequences and primary evaluation of their immunogenicity in BALB/c mice

  2010cites this paper
• A novel mouse model for immunogenic evaluation of human HBV vaccines.

  2009cites this paper
• Das 20S Proteasom in Astrozyten und seine Rolle bei Entzündungsprozessen im Zentralnervensystem

  2009cites this paper
• Mice 1 Repertoire in Inbred and F after Vaccinia Virus Infection and the Naive T Cell Immunodominance + Altered CD8

  2009cites this paper
• The Efficacy of Antigen Processing Is Critical for Protection against Cytomegalovirus Disease in the Presence of Viral Immune Evasion Proteins

  2009cites this paper
• Altered CD8+ T Cell Immunodominance after Vaccinia Virus Infection and the Naive Repertoire in Inbred and F1 Mice

  2009cites this paper
• HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice

  2009cites this paper
• Dissection of the antiviral NK cell response by MCMV mutants.

  2008cites this paper
• for Cross-Presentation Targeting Antigen to Human Dendritic Cells over Receptor-Specific Antibodies in No Advantage of Cell-Penetrating Peptides

  2008cites this paper
• Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans.

  2008cites this paper
• Cellular and Humoral Immunogenicity of Hamster Polyomavirus-Derived Virus-Like Particles Harboring a Mucin 1 Cytotoxic T-Cell Epitope

  2008cites this paper
• No Advantage of Cell-Penetrating Peptides over Receptor-Specific Antibodies in Targeting Antigen to Human Dendritic Cells for Cross-Presentation1

  2008cites this paper
• of CD8 T Cell Responses in Antigen Presentation and the Generation Analysis of the Role of Bleomycin Hydrolase

  2007cites this paper
• Protective immunization against murine cytomegalovirus infection using adenoviruses and poxviruses expressing hepatitis B virus chimeras.

  2007influential citation
• Analysis of the Role of Bleomycin Hydrolase in Antigen Presentation and the Generation of CD8 T Cell Responses1

  2007cites this paper
• Explorer pMel 17 is recognised by monoclonal antibodies NKI-beteb , HMB-45 and HMB-50 and by anti-melanoma CTL

  2007cites this paper
• Mechanistic studies on long peptide-based vaccines for the use in cancer therapy

  2007cites this paper
• Diversity of escape variant mutations in Simian virus 40 large tumor antigen (SV40 Tag) epitopes selected by cytotoxic T lymphocyte (CTL) clones.

  2007influential citation
• Structural engineering of pMHC reagents for T cell vaccines and diagnostics.

  2007cites this paper
• Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease

  2007cites this paper
• Portable flanking sequences modulate CTL epitope processing.

  2007cites this paper
• Design and development of synthetic peptide vaccines: past, present and future

  2007cites this paper
• Funktionelle Charakterisierung des 26S Proteasoms unter Nutzung in vitro generierter Ubiquitin-konjugierter Substrate

  2007cites this paper
• The immunoinformatics of cancer immunotherapy.

  2007cites this paper
• Protective Immune Responses to a Recombinant Adenovirus Type 35 Tuberculosis Vaccine in Two Mouse Strains: CD4 and CD8 T-Cell Epitope Mapping and Role of Gamma Interferon

  2007cites this paper
• The role of T-lymphocytes in the pathogenesis of dengue haemorrhagic fever

  2007cites this paper
• Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O.

  2006cites this paper
• Funktionelle Charakterisierung des 26S Proteasoms unter Nutzung in vitro generierter Ubiquitin-konjugierter Substrate

  2006cites this paper
• A Long N-terminal-extended Nested Set of Abundant and Antigenic Major Histocompatibility Complex Class I Natural Ligands from HIV Envelope Protein*

  2006cites this paper
• Analysis of the Role of Cytosolic Aminopeptidases in the Generation of MHC-Class I Presented Peptides: a Dissertation

  2006cites this paper
• Inmunodominancia y procesamiento de epítopos de la glicoproteína F del virus respiratorio sincitial humano reconocidos por linfocitos T citotóxicos CD8+ murinos

  2006cites this paper
• Impact of Gag Sequence Variability on Level, Phenotype, and Function of Anti-HIV Gag-Specific CD8+ Cytotoxic T Lymphocytes in Untreated Chronically HIV-Infected Patients

  2006cites this paper
• Spontaneous in vivo retrovirus-infected T and B cells, but not dendritic cells, mediate antigen-specific Fas ligand/Fas-dependent apoptosis of anti-retroviral CTL.

  2006cites this paper
• A polytope DNA vaccine elicits multiple effector and memory CTL responses and protects against human papillomavirus 16 E7-expressing tumour

  2005cites this paper
• Recognition of endogenously synthesized HLA-DR4 restricted HCV epitopes presented by autologous EBV transformed B-lymphoblastoid cell line.

  2005cites this paper