Selected scientific topics of the 11th International Isotope Symposium on the Synthesis and Applications of Isotopes and Isotopically Labeled Compounds.

Palladium-Catalyzed Hydroxycarbonylation of Aryl Halides with Substoichiometric Carbon Monoxide
2013cited by this paper
Alkyne metathesis on the rise.
2013cited by this paper
A convenient method to produce [(14) C]carbon monoxide and its application to the radiosynthesis of [carboxyl-(14) C]celivarone, [carboxyl-(14) C]SSR149744.
2013cited by this paper
Pd-catalyzed thiocarbonylation with stoichiometric carbon monoxide: scope and applications.
2013cited by this paper
Why do metabolites circulate?
2012cited by this paper
Ruthenium-catalyzed selective α,β-deuteration of bioactive amines.
2012cited by this paper
Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38
2012cited by this paper
Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1.
2012cited by this paper
Pharmacokinetics and Metabolism in Drug Design: SMITH:PHARMACOKINETICS 3E O-BK
2012cited by this paper
14Carbon monoxide made simple – novel approach to the generation, utilization, and scrubbing of 14carbon monoxide
2012cited by this paper
Multiple labeling of a potent CX3CR1 antagonist for the treatment of multiple sclerosis
2012cited by this paper
Metabolic activation in drug-induced liver injury
2012cited by this paper
A Novel Relay Method for Determining Low-Clearance Values
2012cited by this paper
Deuteration of molecules for neutron reflectometry on organic light-emitting diode thin films
2012cited by this paper
Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: expedient access to substituted 13C2-labeled phenethylamines.
2012cited by this paper
Total synthesis of neurymenolide A based on a gold-catalyzed synthesis of 4-hydroxy-2-pyrones.
2012cited by this paper
Tritium labelling of PACAP-38 using a synthetic diiodinated precursor peptide
2012cited by this paper
Quantitation by MS imaging: needs and challenges in pharmaceuticals.
2012cited by this paper
An efficient method for the preparation of tertiary esters by palladium-catalyzed alkoxycarbonylation of aryl bromides.
2012cited by this paper
Stereoselective benzylic hydroxylation of alkylbenzenes and epoxidation of styrene derivatives catalyzed by the peroxygenase of Agrocybe aegerita
2012cited by this paper
Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies.
2012cited by this paper
HPLC/ICP-MS in combination with "reverse" online isotope dilution in drug metabolism studies.
2012cited by this paper
Best Practice in the Use of Physiologically Based Pharmacokinetic Modeling and Simulation to Address Clinical Pharmacology Regulatory Questions
2012cited by this paper
Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry
2012cited by this paper
Palladium-catalyzed carbonylative α-arylation for accessing 1,3-diketones.
2012cited by this paper
Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?
2012cited by this paper
Microdosing: a critical assessment of human data.
2012cited by this paper
Managing the challenge of chemically reactive metabolites in drug development
2011cited by this paper
Catalysis-based and protecting-group-free total syntheses of the marine oxylipins hybridalactone and the ecklonialactones A, B, and C.
2011cited by this paper
Doubly labeled water analysis using cavity ring-down spectroscopy.
2011cited by this paper
Molecular gas sensing below parts per trillion: radiocarbon-dioxide optical detection.
2011cited by this paper
Palladium-catalyzed approach to primary amides using nongaseous precursors.
2011cited by this paper
Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
2011cited by this paper
Selective hydroxylation of alkanes by an extracellular fungal peroxygenase
2011cited by this paper
Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals.
2011cited by this paper
Carbonylative Heck reactions using CO generated ex situ in a two-chamber system.
2011cited by this paper
Total synthesis of tulearin C.
2011cited by this paper
Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.
2011cited by this paper
The debate is over: accelerator MS provides the route to better drug-development paradigms/protocols.
2011cited by this paper
Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction.
2011cited by this paper
Preparation of human drug metabolites using fungal peroxygenases.
2011cited by this paper
Highly enantioselective synthesis of α-amino acid derivatives by an NHC-catalyzed intermolecular Stetter reaction.
2011cited by this paper
Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes.
2011cited by this paper
Synthesis of isotopically labelled [14C]ZT‐1 (Debio‐9902), [d3]ZT‐1 and (−)‐[d3]huperzine A, a new generation of acetylcholinesterase inhibitors
2011cited by this paper
Investigating Morphology and Stability of Fac‐tris (2‐phenylpyridyl)iridium(III) Films for OLEDs
2011cited by this paper
Synthesis of potential drug metabolites by a modified Udenfriend reaction
2011cited by this paper
Synthesis of triphenylsilyl[14C2]acetylene for use in a Sonogashira reaction
2011cited by this paper
Second-generation total synthesis of spirastrellolide F methyl ester: the alkyne route.
2011cited by this paper
Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution
2011cited by this paper
Ex situ generation of stoichiometric and substoichiometric 12CO and 13CO and its efficient incorporation in palladium catalyzed aminocarbonylations.
2011cited by this paper
Stereoselective synthesis of E,Z-configured 1,3-dienes by ring-closing metathesis. Application to the total synthesis of lactimidomycin.
2011cited by this paper
Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development
2010cited by this paper
N-heterocyclic carbene-catalyzed cascade reaction involving the hydroacylation of unactivated alkynes.
2010cited by this paper
Metabolites: have we MIST out the importance of structure and physicochemistry?
2010cited by this paper
Hydrogen isotope labelling using iridium(I) dionates
2010cited by this paper
Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective
2010cited by this paper
Microdosing: current and the future.
2010cited by this paper
Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes.
2010cited by this paper
New and classic families of secreted fungal heme peroxidases
2010cited by this paper
Addressing metabolite safety during first-in-man studies using ¹⁴C-labeled drug and accelerator mass spectrometry.
2010cited by this paper
Das Maß aller Ringe – N‐heterocyclische Carbene
2010cited by this paper
The development and use of novel iridium complexes as catalysts for ortho‐directed hydrogen isotope exchange reactions
2010cited by this paper
Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform.
2010cited by this paper
The efficiency of solvent‐free catalyst systems in the synthesis of tritium‐labelled biologically active compounds
2010cited by this paper
On-tissue protein identification and imaging by MALDI-Ion mobility mass spectrometry
2010cited by this paper
Interview: Interview with Professor Malcolm Rowland.
2010cited by this paper
Microdosing in early lead discovery.
2010cited by this paper
Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation
2010cited by this paper
Practical experience of using human microdosing with AMS analysis to obtain early human drug metabolism and PK data.
2010cited by this paper
Stepwise oxygenations of toluene and 4-nitrotoluene by a fungal peroxygenase.
2010cited by this paper
The development and use of iridium(I) phosphine systems for ortho‐directed hydrogen‐isotope exchange
2010cited by this paper
Intermolecular N-heterocyclic carbene catalyzed hydroacylation of arynes.
2010cited by this paper
Oxidation of N-Nitrosoalkylamines by Human Cytochrome P450 2A6
2010cited by this paper
Rhodium‐ and ruthenium‐catalysed hydrogen isotope exchange
2010cited by this paper
Trends in microdosing and other exploratory human pharmacokinetic studies for early drug development.
2010cited by this paper
Early human ADME using microdoses and microtracers: bioanalytical considerations.
2010cited by this paper
Concise total synthesis of the potent translation and cell migration inhibitor lactimidomycin.
2010cited by this paper
C-H hydroxylation using a heterocyclic catalyst and aqueous H2O2.
2009cited by this paper
A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide.
2009cited by this paper
Application of a liquid extraction based sealing surface sampling probe for mass spectrometric analysis of dried blood spots and mouse whole-body thin tissue sections.
2009cited by this paper
Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins
2009cited by this paper
Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase.
2009cited by this paper
High-precision optical measurements of 13C/12C isotope ratios in organic compounds at natural abundance
2009cited by this paper
N-heterocyclic carbene-catalyzed hydroacylation of unactivated double bonds.
2009cited by this paper
Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment.
2009cited by this paper
Oxidative Cleavage of Diverse Ethers by an Extracellular Fungal Peroxygenase*
2009cited by this paper
Does human pharmacokinetic prediction add significant value to compound selection in drug discovery research?
2009cited by this paper
Microdose Pharmacokinetics of IDX899 and IDX989, Candidate HIV‐1 Non‐Nucleoside Reverse Transcriptase Inhibitors, Following Oral and Intravenous Administration in Healthy Male Subjects
2009cited by this paper
Intracavity optogalvanic spectroscopy. An analytical technique for 14C analysis with subattomole sensitivity.
2008cited by this paper
Ruthenium catalyzed biomimetic oxidation in organic synthesis inspired by cytochrome P-450.
2008cited by this paper
Palladium-catalyzed C-allylation of benzoins and an NHC-catalyzed three component coupling derived thereof: compatibility of NHC- and Pd-catalysts.
2008cited by this paper
Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development
2008cited by this paper
Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita
2008cited by this paper
Regioselective preparation of (R)-2-(4-hydroxyphenoxy)propionic acid with a fungal peroxygenase
2008cited by this paper
The utility of microdosing over the past 5 years
2008cited by this paper
Organocatalysis by N-heterocyclic carbenes.
2007cited by this paper
The renaissance of H/D exchange.
2007cited by this paper
The use of biocatalysis in the synthesis of labelled compounds
2007cited by this paper
Enzymatic hydroxylation of aromatic compounds
2007cited by this paper
A Predictably Selective Aliphatic C–H Oxidation Reaction for Complex Molecule Synthesis
2007cited by this paper

Selected scientific topics of the 11th International Isotope Symposium on the Synthesis and Applications of Isotopes and Isotopically Labeled Compounds.

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