Inhibition of MDA‐MB‐231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation‐mediated p21WAF1/CIP1 expression

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Environmental Toxicology

• Publication date

  2017-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/tox.22247PMID 26872304
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Natural Products as Zinc‐Dependent Histone Deacetylase Inhibitors

  2015cited by this paper
• Phytochemicals potently inhibit migration of metastatic breast cancer cells.

  2015cited by this paper
• The natural anticancer compound rocaglamide selectively inhibits the G1‐S‐phase transition in cancer cells through the ATM/ATR‐mediated Chk1/2 cell cycle checkpoints

  2014cited by this paper
• Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells.

  2013cited by this paper
• Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat

  2012cited by this paper
• The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3

  2012cited by this paper
• Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells

  2012cited by this paper
• Triple-negative breast cancer: an unmet medical need.

  2011cited by this paper
• The histone deacetylase inhibitor panobinostat demonstrates marked synergy with conventional chemotherapeutic agents in human ovarian cancer cell lines

  2011cited by this paper
• Progesterone Receptor Isoform-Specific Promoter Methylation: Association of PRA Promoter Methylation with Worse Outcome in Breast Cancer Patients

  2011cited by this paper
• Treatment and care of patients with metastatic breast cancer.

  2011cited by this paper
• Epigenetics in cancer.

  2010cited by this paper
• Triple-Negative Breast Cancer: A Short Review

  2010cited by this paper
• Apigenin: A Promising Molecule for Cancer Prevention

  2010cited by this paper
• Three-dimensional cell growth confers radioresistance by chromatin density modification.

  2010cited by this paper
• Epigenetics in cancer: Targeting chromatin modifications

  2009cited by this paper
• Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.

  2009cited by this paper
• Cell cycle control as a basis for cancer chemoprevention through dietary agents.

  2008cited by this paper
• Dietary components impact histone modifications and cancer risk.

  2008cited by this paper
• Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells.

  2008cited by this paper
• Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells.

  2008cited by this paper
• Epigenetics in cancer.

  2008cited by this paper
• Focus on acetylation: the role of histone deacetylase inhibitors in cancer therapy and beyond

  2007cited by this paper
• Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence

  2007cited by this paper
• Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts

  2007influential reference
• Apigenin and cancer chemoprevention: progress, potential and promise (review).

  2007cited by this paper
• Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation

  2007cited by this paper
• Apigenin-induced Cell Cycle Arrest is Mediated by Modulation of MAPK, PI3K-Akt, and Loss of Cyclin D1 Associated Retinoblastoma Dephosphorylation in Human Prostate Cancer Cells

  2007cited by this paper
• Molecular profiling of breast cancer

  2006cited by this paper
• Targeting histone deacetylase in cancer therapy

  2006cited by this paper
• Anticancer activities of histone deacetylase inhibitors

  2006cited by this paper
• Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

  2006cited by this paper
• Histone deacetylase inhibitors: multifunctional anticancer agents.

  2006cited by this paper
• Participation of histones, histone modifying enzymes and histone chaperones in vertebrate cell functions.

  2006cited by this paper
• A Novel Histone Deacetylase Inhibitor, Scriptaid, Enhances Expression of Functional Estrogen Receptor α (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine

  2003cited by this paper
• Molecular Profiling of Breast Cancer

  2003cited by this paper
• Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

  2002cited by this paper
• Dietary agents in cancer prevention: flavonoids and isoflavonoids.

  2001cited by this paper
• The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

  2000cited by this paper
• Cell cycle control as a basis for cancer drug development (Review).

  2000cited by this paper
• p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

  1998cited by this paper
• Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol.

  1986cited by this paper

• Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

  2026cites this paper
• Apigenin modulates cell survival pathways and restores olaparib sensitivity in high-grade serous ovarian cancer cells.

  2026cites this paper
• Preclinical Study of Cannflavins A and B Action Against Glioblastoma Cells

  2026cites this paper
• Unveiling the influence of polyphenols on histone modifications in human diseases.

  2025cites this paper
• Apigenin and Its Derivatives in Breast Cancer Prevention and Therapy: A Review on Bioavailability and Recent Development

  2025cites this paper
• Harnessing apigenin for breast cancer treatment: Current insights

  2025cites this paper
• Potential anticancer effects and toxicity of flavones luteolin and apigenin in vivo

  2025cites this paper
• Flavonoids as epigenetic modulators: A new frontier in disease prevention and therapy

  2025cites this paper
• Phytochemical profiling and in vitro bioactivity of Pyrus calleryana extracts via UPLC-MS/MS and GNPS molecular networking

  2025cites this paper
• Apigenin Induces Apoptosis and Inhibits Migration in Human Cholangiocarcinoma Cells

  2025cites this paper
• Molecular insights into the antineoplastic potential of apigenin and its derivatives: paving the way for nanotherapeutic innovations

  2025cites this paper
• Molecular Insights into Phytochemicals Mediated Epigenetic Regulation in Preclinical Models of Breast Cancer

  2025cites this paper
• Effects of polyphenols on cancer cell progression mediated by inhibition of cyclin-dependent kinases (CDKs): the emerging drug targets in cancer

  2025cites this paper
• Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma

  2024cites this paper
• Phytochemical strategies in glioblastoma therapy: Mechanisms, efficacy, and future perspectives.

  2024cites this paper
• Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer

  2024cites this paper
• A systems biology-based study to assess the effects of TNF-alpha ± apigenin in triple-negative breast cancer cell line

  2024cites this paper
• A comprehensive review of apigenin a dietary flavonoid: biological sources, nutraceutical prospects, chemistry and pharmacological insights and health benefits

  2024cites this paper
• Comparative Analysis of Acetylated Flavonoids’ Chemopreventive Effects in Different Cancer Cell Lines

  2024cites this paper
• Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone

  2024cites this paper
• Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading

  2024cites this paper
• Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review

  2024cites this paper
• Phytocompounds targeting epigenetic modulations: an assessment in cancer

  2024cites this paper
• GPER binding site detection and description: a flavonoid-based docking and molecular dynamics simulations study.

  2024cites this paper
• Microbiota derived d-malate inhibits skeletal muscle growth and angiogenesis during aging via acetylation of Cyclin A

  2024cites this paper
• Natural Flavonoid Apigenin, an Effective Agent Against Nervous System Cancers

  2024cites this paper
• Crocin suppresses breast cancer cell proliferation by down‐regulating tumor promoter miR‐122‐5p and up‐regulating tumor suppressors FOXP2 and SPRY2

  2023cites this paper
• Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction

  2023cites this paper
• Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer

  2023cites this paper
• Plant-Derived Epi-Nutraceuticals as Potential Broad-Spectrum Anti-Viral Agents

  2023cites this paper
• N-Heterocycle based Degraders (PROTACs) Manifesting Anticancer Efficacy: Recent Advances.

  2023cites this paper
• The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC).

  2023cites this paper
• Antineoplastic activity of plant-derived compounds mediated through inhibition of histone deacetylase: a review

  2023cites this paper
• Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing

  2023cites this paper
• Insights into Pharmacological Potential of Apigenin through various Pathways on a Nanoplatform in Multitude of Diseases.

  2023cites this paper
• Antiproliferative Activity and Mechanisms of Action of Plant-Derived Flavonoids on Breast Cancer.

  2023cites this paper
• An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

  2023cites this paper
• Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition

  2023cites this paper
• The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions

  2022cites this paper
• Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

  2022cites this paper
• Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: a mini-review

  2022cites this paper
• Agri-Food By-Products in Cancer: New Targets and Strategies

  2022cites this paper
• Flavonoids for the treatment of breast cancer, present status and future prospective.

  2022cites this paper
• Recent updates on anticancer mechanisms of polyphenols

  2022cites this paper
• The Potential Role of Apigenin in Cancer Prevention and Treatment

  2022cites this paper
• Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

  2022cites this paper
• Research of the process of biocatalysis of plant raw materials for the intensification of the extraction of biologically active substances

  2022cites this paper
• Apigenin in cancer therapy: From mechanism of action to nano-therapeutic agent.

  2022cites this paper
• Apigenin Targets MicroRNA-155, Enhances SHIP-1 Expression, and Augments Anti-Tumor Responses in Pancreatic Cancer

  2022cites this paper
• An update of Nrf2 activators and inhibitors in cancer prevention/promotion

  2022cites this paper
• Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress

  2022cites this paper
• Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells

  2022cites this paper
• The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53

  2022cites this paper
• Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma

  2022cites this paper
• Chemotherapeutic Role of Polyphenols Present in Ocimum Sanctum.

  2022cites this paper
• Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates

  2022cites this paper
• Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins

  2022cites this paper
• Anticancer Effects and Molecular Mechanisms of Apigenin in Cervical Cancer Cells

  2022cites this paper
• Effects of propolis and its bioactive components on breast cancer cell pathways and the molecular mechanisms involved

  2021cites this paper
• Flavonoids overcome drug resistance to cancer chemotherapy by epigenetically modulating multiple mechanisms.

  2021cites this paper
• Natural products in the reprogramming of Cancer epigenetics.

  2021cites this paper
• Potential Impacts of Interleukin-17A Promoter Polymorphisms on the EGFR Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan

  2021cites this paper
• Cadmium-Associated Molecular Signatures in Cancer Cell Models

  2021cites this paper
• Remodeling the Epigenetic Landscape of Cancer—Application Potential of Flavonoids in the Prevention and Treatment of Cancer

  2021cites this paper
• Apigenin inhibits the growth of colorectal cancer through down-regulation of E2F1/3 by miRNA-215-5p.

  2021cites this paper
• An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line

  2021cites this paper
• Potential of Flavonoids as Anticancer Drugs

  2021cites this paper
• Nutrients and phytonutrients as promising epigenetic nutraceuticals

  2021cites this paper
• Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy

  2021cites this paper
• Molecular Mechanisms of Biologically Active Compounds from Propolis in Breast Cancer: State of the Art and Future Directions

  2021cites this paper
• Apigenin as an anticancer agent.

  2020cites this paper
• miR‐16 enhances miR‐302/367‐induced reprogramming and tumor suppression in breast cancer cells

  2020cites this paper
• Investigation Of Possible Effects Of Apigenin, Sorafenib and Combined Applications On Apoptosis And Cell Cycle In Hepatocellular Cancer Cells.

  2020cites this paper
• Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention

  2020cites this paper
• Flavonoids in cancer therapy: current and future trends

  2020cites this paper
• Dietary Phytochemicals as Epigenetic Modulators in Cancer Prevention: Emerging Research Trends, Gaps, and Future Perspectives

  2020cites this paper
• Bioactive Polyphenols as Promising Natural Medicinal Agents Against Cancer: The Emerging Trends and Prospective Goals

  2020cites this paper
• Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM

  2020cites this paper
• The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells

  2020cites this paper
• Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

  2020cites this paper
• Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals

  2020cites this paper
• Pharmacotherapeutic Botanicals for Cancer Chemoprevention

  2020cites this paper
• SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma

  2020cites this paper
• Rationalizing the therapeutic potential of apigenin against cancer.

  2020cites this paper
• Targeting epigenetics in cancer: therapeutic potential of flavonoids

  2020cites this paper
• Breast Tumor Microenvironment: Emerging target of therapeutic phytochemicals.

  2020cites this paper
• Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent

  2019cites this paper
• Nuclear Receptors and Epigenetic Regulation

  2019cites this paper
• Extra Virgin Olive Oil and Corn Oil and Epigenetic Patterns in Breast Cancer

  2019cites this paper
• Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe.

  2019cites this paper
• Knockout of the Placenta Specific 8 Gene Affects the Proliferation and Migration of Human Embryonic Kidney 293T Cell

  2019cites this paper
• Cytotoxicity and Anti-inflammatory Properties of Apigenin-Derived Isolaxifolin.

  2019cites this paper
• Structure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study.

  2019cites this paper
• Natural Anticancer Agents

  2019cites this paper
• Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action

  2019cites this paper
• Roles of polyphenols as dietary epigenetic modulators

  2019cites this paper
• Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review

  2019cites this paper
• Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer

  2019cites this paper
• Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis

  2019cites this paper
• Influence of DNA-binding compounds with cancer preventive activity on the mechanisms of gene expression regulation

  2019cites this paper