Functional Consequences of Radiation-Induced Oxidative Stress in Cultured Neural Stem Cells and the Brain Exposed to Charged Particle Irradiation

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2014-02-27

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1089/ars.2012.5134PMID 23802883PMCID PMC3936501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterizing low dose and dose rate effects in rodent and human neural stem cells exposed to proton and gamma irradiation☆

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  2013influential reference
• Early Effects of Whole-Body 56Fe Irradiation on Hippocampal Function in C57BL/6J Mice

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  2012influential reference
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• Mitochondrial Complex II Dysfunction Can Contribute Significantly to Genomic Instability after Exposure to Ionizing Radiation

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• Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis.

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• Redox changes induced in hippocampal precursor cells by heavy ion irradiation

  2007influential reference
• Technical developments at the NASA Space Radiation Laboratory

  2007cited by this paper
• Radiation response of neural precursor cells.

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  2004influential reference
• Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

  2003cited by this paper
• Retrograde and anterograde object recognition in rats with hippocampal lesions

  2003cited by this paper
• Cognitive deficits induced by 56Fe radiation exposure.

  2003cited by this paper
• Heavy Ion Track-Structure Calculations for Radial Dose in Arbitrary Materials

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  2002cited by this paper
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  2002cited by this paper
• Brain Signaling and Behavioral Responses Induced by Exposure to 56Fe-Particle Radiation

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• Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen.

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  2000cited by this paper
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• Impaired Recognition Memory in Rats after Damage to the Hippocampus

  2000cited by this paper
• Neurocognitive dysfunction in cancer patients.

  2000cited by this paper
• Glucose Deprivation‐Induced Oxidative Stress in Human Tumor Cells: A Fundamental Defect in Metabolism?

  2000cited by this paper
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  1997cited by this paper
• Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells.

  1996influential reference
• Computer simulation of initial events in the biochemical mechanisms of DNA damage.

  1993cited by this paper
• Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?

  1990cited by this paper
• Galactic cosmic rays and cell-hit frequencies outside the magnetosphere.

  1989cited by this paper
• Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.

  1980cited by this paper
• Microdosimetric structure of heavy ion tracks in tissue

  1976cited by this paper

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