Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Gut

• Publication date

  2004-12-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1136/gut.2004.046706PMID 15591514PMCID PMC1774384
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer.

  2004cited by this paper
• Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

  2003cited by this paper
• c-Fos expression as endogenous marker of lumbosacral spinal neuron activity in response to vaginocervical-stimulation.

  2002cited by this paper
• Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.

  2002cited by this paper
• Molecular prognostic markers in pancreatic cancer.

  2002cited by this paper
• Stable suppression of tumorigenicity by virus-mediated RNA interference.

  2002cited by this paper
• Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.

  2000cited by this paper
• The Dominant Negative Ras Mutant, N17Ras, Can Inhibit Signaling Independently of Blocking Ras Activation*

  2000cited by this paper
• Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.

  2000cited by this paper
• Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression*

  1999cited by this paper
• Heart 6-Phosphofructo-2-kinase Activation by Insulin Results from Ser-466 and Ser-483 Phosphorylation and Requires 3-Phosphoinositide-dependent Kinase-1, but Not Protein Kinase B*

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Growth Factors and Cytokines in Pancreatic Carcinogenesis

  1999cited by this paper
• Cell cycle progression: new therapeutic target for vascular proliferative disease.

  1998cited by this paper
• Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.

  1998cited by this paper
• Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

  1998cited by this paper
• A simplified system for generating recombinant adenoviruses.

  1998influential reference
• Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade

  1998cited by this paper
• Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen Synthase Kinase 3 Inactivation

  1998cited by this paper
• Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.

  1997cited by this paper
• Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

  1997cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

  1996cited by this paper
• Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

  1996cited by this paper
• Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity.

  1995cited by this paper
• Phosphatidylinositol-3-OH kinase direct target of Ras

  1994cited by this paper
• Ki-ras oncogene activation in preinvasive pancreatic cancer.

  1992cited by this paper
• Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.

  1991cited by this paper
• Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras

  1991cited by this paper
• Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.

  1988cited by this paper

• Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer

  2023cites this paper
• Rare germline variants in pancreatic cancer and multiple primary cancers: an autopsy study

  2023influential citation
• Genome-Wide Characterization of Fennel (Anethum foeniculum) MiRNome and Identification of its Potential Targets in Homo sapiens and Arabidopsis thaliana: An Inter and Intra-species Computational Scrutiny

  2023cites this paper
• Genetics and Molecular Biology

  2022cites this paper
• Girdin interaction with vimentin induces EMT and promotes the growth and metastasis of pancreatic ductal adenocarcinoma

  2020cites this paper
• A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population

  2019cites this paper
• Integrated transcriptomic analysis reveals hub genes involved in diagnosis and prognosis of pancreatic cancer

  2019cites this paper
• Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191

  2018cites this paper
• WAVE3 promotes proliferation, migration and invasion via the AKT pathway in pancreatic cancer

  2018cites this paper
• Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.

  2018cites this paper
• Metabolic regulation of the plasma membrane calcium pump in pancreatic ductal adenocarcinoma

  2015cites this paper
• LY294002 enhances inhibitory effect of gemcitabine on proliferation of human pancreatic carcinoma PANC-1 cells

  2013cites this paper
• Direct binding of p 85 to sst 2 somatostatin receptor reveals a novel mechanism for inhibiting PI 3 K pathway

  2013cites this paper
• Therapeutic targeting of apoptotic pathways: novel aspects in pancreatic cancer.

  2012cites this paper
• A Targeted siRNA Screen Identifies Regulators of Cdc42 Activity at the Natural Killer Cell Immunological Synapse

  2011cites this paper
• Activation of the PI3K/Akt Pathway Mediates Bone Morphogenetic Protein 2-Induced Invasion of Pancreatic Cancer Cells Panc-1

  2011cites this paper
• The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer

  2011cites this paper
• High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer.

  2011cites this paper
• Over-expression of PTEN Involved in Troglitazone- induced Apoptosis in Human Osteosarcoma Cells

  2011cites this paper
• Pancreatic Cancer Gene Therapy: From Molecular Targets to Delivery Systems

  2011cites this paper
• Structure of the dominant negative S17N mutant of Ras.

  2010cites this paper
• Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation.

  2009cites this paper
• Molecular changes in pancreatic cancer

  2009cites this paper
• Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved

  2009cites this paper
• Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival

  2008cites this paper
• Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer

  2008cites this paper
• Molecular Diagnosis of Pancreatic Cancer : Review Series

  2008cites this paper
• 1 Gene Therapy for Pancreatic Cancer

  2008cites this paper
• Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells

  2008cites this paper
• Lupeol: connotations for chemoprevention.

  2008cites this paper
• 1 Gene Therapy for Pancreatic

  2008cites this paper
• Targeting signal transduction in pancreatic cancer treatment

  2007cites this paper
• Kombinierte Inhibition von Raf-Kinase und IGF-IR blockiert multiple pro-angiogenetische Signalwege und steigert die Chemosensitivität humaner Pankreaskarzinomzellen

  2007cites this paper
• Pankreatik Kanserin Moleküler Patogenezi

  2007cites this paper
• Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility

  2007cites this paper
• Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the β4 integrin and the PI3k pathway

  2007cites this paper
• NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases.

  2007cites this paper
• SPECT/CT imaging of oncolytic adenovirus propagation in tumours in vivo using the Na/I symporter as a reporter gene

  2007cites this paper
• Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells

  2007cites this paper
• Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

  2006cites this paper
• Gene therapy developments for pancreatic cancer.

  2006cites this paper
• Expression of PTEN, p27, p21 and AKT mRNA and protein in human BEL‐7402 hepatocarcinoma cells in transplanted tumors of nude mice treated with the tripeptide tyroservatide (YSV)

  2006cites this paper
• Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors.

  2006cites this paper
• An overview of apoptosis and the prevention of colorectal cancer.

  2006cites this paper
• Assessment of endostatin gene therapy for familial adenomatous polyposis-related desmoid tumors.

  2006cites this paper
• Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.

  2005cites this paper
• Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway.

  2005cites this paper
• Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.

  2005cites this paper
• Mechanisms of Disease: PI3K/AKT Signaling in Gastrointestinal Cancers

  2005cites this paper