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The first report of the most important sequential differences between COVID-19 and MERS viruses by attribute weighting models, the importance of Nucleocapsid (N) protein

M. Ebrahimi,B. Novikov,E. Ebrahimie,Alexey Spilman,Reza Ahsan,M. Tahsili,M. Najafi,Samaneh Navvabi,F. Shariaty

Published 2020 in Unknown venue

ABSTRACT

COVID-19 and the Middle East respiratory syndrome-related coronavirus (MERS) viruses are from coronaviridae family; the former became a pandemic while the latter confined to a limited region. Their pathogenicity and infection rates are also different; the high mortality rate for MERS with low spreading capability. To investigate the possible structural changes at RNA sequences of both virus, 1621 and 125 sequences of COVID-19 and MERS downloaded and converted to polynomial datasets and seven attribute weighting (feature selection) approaches have been used for the analysis of genomic sequences of COVID-19 and MERS viruses. The end nucleotide sequences (from 29288 to the end genome positions) selected by the most attribute weighting models to be significantly different between two virus classes followed by smaller piece at 5700 and 1750 and 7600 nucleotide positions. These parts encode Nucleocapsid (N), Papin-like protease (NSP3) and NSP4 proteins of COVID-19. The finding for the first time reports the structural differences between two important viruses at the sequential level and paves the road to decipher new emerging COVID-19 virus high pathogenicity.

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