Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2004-09-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.0405499101PMID 15347805PMCID PMC518804
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid transformation of white adipocytes into fat-oxidizing machines

  2004cited by this paper
• Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

  2004cited by this paper
• Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging

  2003cited by this paper
• Leptin Activates Cardiac Fatty Acid Oxidation Independent of Changes in the AMP-activated Protein Kinase-Acetyl-CoA Carboxylase-Malonyl-CoA Axis*

  2002cited by this paper
• Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

  2002cited by this paper
• Leptin-replacement therapy for lipodystrophy.

  2002cited by this paper
• Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

  2002cited by this paper
• Liporegulation in Diet-induced Obesity

  2001cited by this paper
• A novel mouse model of lipotoxic cardiomyopathy.

  2001cited by this paper
• Lipotoxic heart disease in obese rats: implications for human obesity.

  2000cited by this paper
• Novel Form of Lipolysis Induced by Leptin*

  1999cited by this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cited by this paper
• Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.

  1998cited by this paper
• OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.

  1998cited by this paper
• Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.

  1998cited by this paper
• The AMP-activated protein kinase--fuel gauge of the mammalian cell?

  1997cited by this paper
• Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

  1997cited by this paper
• Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy.

  1996cited by this paper
• Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.

  1996cited by this paper
• Weight-reducing effects of the plasma protein encoded by the obese gene.

  1995cited by this paper
• Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

  1994cited by this paper
• Positional cloning of the mouse obese gene and its human homologue

  1994cited by this paper
• Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.

  1978cited by this paper

• Prophylactic administration of kanli granule maintains fatty acid oxidation in the myocardium to prevent heart failure via activating AMPK/PPARα/CPT1A pathway: A network pharmacology-based study.

  2025cites this paper
• Molecular and Cellular Mechanisms Underlying the Cardiac Hypertrophic and Pro-Remodelling Effects of Leptin

  2024cites this paper
• The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis

  2023cites this paper
• Adiposity-associated atrial fibrillation: molecular determinants, mechanisms and clinical significance.

  2022cites this paper
• The Acute Effects of Leptin on the Contractility of Isolated Rat Atrial and Ventricular Cardiomyocytes

  2022cites this paper
• Microvesicular Steatosis and Severe Cardiac Allograft Dysfunction

  2022cites this paper
• Adipokines in obesity and metabolic diseases

  2021cites this paper
• Ghrelin and adipokines: An overview of their physiological role, antimicrobial activity and impact on cardiovascular conditions.

  2021cites this paper
• THE SIGNIFICANCE OF THE QUALITY OF CONSUMED FATS AND HYPOTHERMAL STIMULATION IN ANTI-INFLAMMATORY MECHANISMS AND IN THE PREVENTION OF OBESITY

  2021cites this paper
• Adiponectin, Leptin and Cardiovascular Disorders.

  2021cites this paper
• Strawberry fruit (Fragaria x ananassa cv. Romina) extenuates iron-induced cardiac oxidative injury via effects on redox balance, angiotensin-converting enzyme, purinergic activities, and metabolic pathways.

  2020cites this paper
• Role of Leptin in Cardiovascular Diseases

  2020cites this paper
• DMSO_A_233667 107..115

  2020cites this paper
• Early Left Ventricular Systolic Dysfunction Detected by Two-Dimensional Speckle-Tracking Echocardiography in Young Patients with Congenital Generalized Lipodystrophy

  2020cites this paper
• Cardiomyocyte-specific ACSL1 Deficiency Prevents Cardiac Lipotoxicity and Alleviates Heart Dysfunction in the ob/ob Model of Obesity

  2020cites this paper
• Molecular and histopathological identification of ovine neosporosis (Neospora caninum) in aborted ewes in Iraq

  2020cites this paper
• Death by lipids: The role of small nucleolar RNAs in metabolic stress

  2020cites this paper
• Caffeic Acid Protects against Iron-Induced Cardiotoxicity by Suppressing Angiotensin-Converting Enzyme Activity and Modulating Lipid Spectrum, Gluconeogenesis and Nucleotide Hydrolyzing Enzyme Activities

  2020cites this paper
• Buddleja saligna Willd (Loganiaceae) inhibits angiotensin-converting enzyme activity in oxidative cardiopathy with concomitant modulation of nucleotide hydrolyzing enzymatic activities and dysregulated lipid metabolic pathways.

  2020cites this paper
• Potential Role of Leptin in Cardiac Steatosis Induced by Highly Saturated Fat Intake During Adolescence.

  2019cites this paper
• Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction

  2018cites this paper
• Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

  2018cites this paper
• The role of stearoyl-CoA desaturase in the regulation of cardiac metabolism

  2018cites this paper
• Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression.

  2018cites this paper
• An Obesity Paradox: Increased Body Mass Index Is Associated with Decreased Aortic Atherosclerosis

  2017cites this paper
• The relative contribution of metabolic and structural abnormalities to diastolic dysfunction in obesity

  2017cites this paper
• Fat Hormones, Adipokines

  2017cites this paper
• Are targeted therapies for diabetic cardiomyopathy on the horizon?

  2017cites this paper
• Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

  2017cites this paper
• Cardiac Lipids by 1H MRS

  2016cites this paper
• Trans-Fatty Acids Aggravate Obesity, Insulin Resistance and Hepatic Steatosis in C57BL/6 Mice, Possibly by Suppressing the IRS1 Dependent Pathway

  2016cites this paper
• Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

  2016cites this paper
• Lipid metabolism and signaling in cardiac lipotoxicity.

  2016cites this paper
• dysfunctionand does not exacerbate left ventricular High-fat diet postinfarction enhances mitochondrial

  2016cites this paper
• Nutrient sensing and utilization: Getting to the heart of metabolic flexibility.

  2016cites this paper
• Metabolic reprogramming of the heart through stearoyl-CoA desaturase.

  2015cites this paper
• Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens.

  2015cites this paper
• Lean heart: Role of leptin in cardiac hypertrophy and metabolism.

  2015cites this paper
• Dose apolipoprotein AV has influence on the regulation of fatty acids and triglyceride metabolism in cardiomyocyte in case of obesity.

  2015cites this paper
• Adiponectin-mediated antilipotoxic effects in regenerating pancreatic islets.

  2015cites this paper
• A new biology of diabetes revealed by leptin.

  2015cites this paper
• Therapeutic Effects of Selective Androgen Receptor Modulation in the Treatment of Cardiac, Metabolic and Bone Pathologies Associated with Androgen Decline and Obesity

  2015cites this paper
• To eat or not to eat – Anti‐ageing effects of energy restriction

  2015cites this paper
• Myocardial Metabolic Abnormalities and Cardiac Dysfunction

  2015cites this paper
• Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects

  2015cites this paper
• Regulation of Zhiyixiao on the Expression of Visfatin in NAFLD Rats

  2015cites this paper
• AMPK: a cellular metabolic and redox sensor. A minireview.

  2014cites this paper
• Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation.

  2014cites this paper
• Molecular mechanisms of diabetic cardiomyopathy

  2014cites this paper
• Is There a Paradox in Obesity?

  2014cites this paper
• Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity.

  2014cites this paper
• Myocardial Steatosis and Necrosis in Atria and Ventricles of Rats Given Pyruvate Dehydrogenase Kinase Inhibitors

  2014influential citation
• Impact of N-acetylcysteine and etodolac treatment on systolic and diastolic function in a rat model of myocardial steatosis induced by high-fat-diet.

  2014cites this paper
• Investigating the CaMKKβ signalling pathway and its role in the regulation of blood pressure

  2014cites this paper
• Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy

  2013cites this paper
• The role of leptin in the control of insulin-glucose axis

  2013cites this paper
• Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue.

  2013cites this paper
• Relation of leptin to left ventricular hypertrophy (from the Multi-Ethnic Study of Atherosclerosis).

  2013cites this paper
• Stearoyl-CoA Desaturase in the Control of Heart Metabolism

  2013cites this paper
• Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals.

  2013cites this paper
• Fish Oil Selectively Improves Heart Function in a Mouse Model of Lipid-induced Cardiomyopathy

  2013cites this paper
• Obesity reduces left ventricular strains, torsion, and synchrony in mouse models: a cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance study

  2013cites this paper
• Role of adipokines in cardiovascular disease.

  2013cites this paper
• Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine

  2013cites this paper
• Modulation of the cardiovascular system by leptin.

  2012cites this paper
• Myocardial Insulin Resistance: An Overview of Its Causes, Effects, and Potential Therapy

  2012cites this paper
• Mechanisms of Lipotoxicity in the Cardiovascular System

  2012cites this paper
• Adipose tissue: friend or foe?

  2012cites this paper
• Lipid metabolism and toxicity in the heart.

  2012cites this paper
• Nature Reviews UNCORRECTED PROOF

  2012cites this paper
• AMP-activated protein kinase pathway and bone metabolism.

  2012cites this paper
• The effects of a very low calorie diet and exercise in obese type 2 diabetes mellitus patients

  2011cites this paper
• Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity.

  2011cites this paper
• Adipocytokines, cardiovascular pathophysiology and myocardial protection.

  2011cites this paper
• Leptin and cardiovascular function in African and Caucasian men and women : the SABPA study

  2011cites this paper
• Fatty heart, cardiac damage, and inflammation.

  2011cites this paper
• Adiponectin, leptin, and resistin in patients with aortic stenosis without concomitant atherosclerotic vascular disease.

  2011cites this paper
• Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling

  2011cites this paper
• Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction

  2011cites this paper
• ACCIONES LIPOSTÁTICAS DE LA LEPTINA ACTUANDO VÍA SISTEMA NERVIOSO CENTRAL: MECANISMOS MOLECULARES EN EL HÍGADO Y EN EL TEJIDO ADIPOSO

  2011cites this paper
• Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling.

  2011cites this paper
• Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial

  2011cites this paper
• Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction

  2011cites this paper
• Lipotoxicity in the heart.

  2010cites this paper
• Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice

  2010cites this paper
• Étude de la fonction vasculaire et du remodelage cardiaque avant l’établissement de l’obésité et de la dyslipidémie chez les rats femelles Sprague-Dawley recevant une diète riche en gras

  2010cites this paper
• Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy: A Clinical Assessment

  2010cites this paper
• The efficacy of Diavite tm (Prosopis glandulosa) as anti-diabetic treatment in rat models of streptozotocin-induced type 1 diabetes and diet-induced-obese insulin resistance

  2010cites this paper
• Myocardial fatty acid metabolism in health and disease.

  2010cites this paper
• AMPK as a mediator of hormonal signalling.

  2010cites this paper
• Improved ejection fraction after exercise training in obesity is accompanied by reduced cardiac lipid content.

  2010cites this paper
• Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle.

  2010cites this paper
• Diabetic cardiomyopathy: signaling defects and therapeutic approaches

  2010cites this paper
• The effects of aerobic interval training on the left ventricular morphology and function of VLCAD-deficient mice

  2010cites this paper
• Contemporary Reviews in Cardiovascular Medicine

  2010cites this paper
• Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.

  2010cites this paper
• Cardiac Expression of Microsomal Triglyceride Transfer Protein Is Increased in Obesity and Serves to Attenuate Cardiac Triglyceride Accumulation

  2009cites this paper
• Clinical characteristics and pathophysiologic features of growth restriction, insulin resistance and tumour development

  2009cites this paper
• Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue.

  2009cites this paper
• Dyslipidemia, C-reactive protein and leptin levels in non diabetic obese subjects

  2009cites this paper