Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II).

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1997-06-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1006/BBRC.1997.6786PMID 9199184
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of a 55-KDA endonuclease in rat liver mitochondria with nucleolytic properties similar to endonuclease G.

  1996cited by this paper
• Endonuclease G from mammalian nuclei is identical to the major endonuclease of mitochondria

  1995cited by this paper
• Oxidative damage to mitochondrial DNA and its relationship to ageing.

  1995cited by this paper
• Repair of mitochondrial DNA damage induced by bleomycin in human cells.

  1995cited by this paper
• The development of mitochondrial medicine.

  1994cited by this paper
• Levels of the mitochondrial endonuclease during rat cardiac development implicate a role for the enzyme in repair of oxidative damage in mitochondrial DNA.

  1994cited by this paper
• Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.

  1993cited by this paper
• Primers for mitochondrial DNA replication generated by endonuclease G.

  1993cited by this paper
• DNA damage by peplomycin and its repair in an in vitro system.

  1991cited by this paper
• DNA damage by peplomycin and its repair in an in vitro system.

  1991cited by this paper
• Mitochondrial endonuclease activity in the rat varies markedly among tissues in relation to the rate of tissue metabolism.

  1991cited by this paper
• Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases.

  1989cited by this paper
• The preference of the mitochondrial endonuclease for a conserved sequence block in mitochondrial DNA is highly conserved during mammalian evolution.

  1988cited by this paper
• Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo.

  1988cited by this paper
• Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

  1988cited by this paper
• Structural aspects of platinum anticancer drug interactions with DNA

  1987cited by this paper
• Purification and characterization of the potent endonuclease in extracts of bovine heart mitochondria.

  1987cited by this paper
• Endonuclease G: a (dG)n X (dC)n‐specific DNase from higher eukaryotes.

  1987cited by this paper
• Reevaluation of interaction of cis-dichloro(ethylenediamine)platinum(II) with DNA.

  1986cited by this paper
• S1 nuclease sensitivity to cis- and trans-diamminedichloroplatinum(II) modified DNAS: influence of (G+C) content and nucleotide sequence.

  1984cited by this paper
• Nuclease detection in SDS-polyacrylamide gel electrophoresis.

  1977cited by this paper
• The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase.

  1976cited by this paper
• In vitro recognition of carcinogen-induced local denaturation sites in native DNA by S1 endonuclease from Aspergillus oryzae

  1975cited by this paper

• Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways

  2024cites this paper
• Oxidized mitochondrial DNA: a protective signal gone awry.

  2023cites this paper
• Mitochondrial Genome Maintenance: Damage and Repair Pathways

  2019cites this paper
• Mitochondrial DNA in liver inflammation and oxidative stress.

  2019cites this paper
• Review article: drug‐induced liver injury in the context of nonalcoholic fatty liver disease – a physiopathological and clinical integrated view

  2018cites this paper
• Endonuclease G promotes mitochondrial genome cleavage and replication

  2018cites this paper
• Molecular signature pathway of gene protein interaction in human mitochondrial DNA (mtDNA) metabolism linked disease

  2018cites this paper
• Mitochondrial DNA repair and damage tolerance.

  2017cites this paper
• Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer

  2016cites this paper
• Mechanisms of DNA repair in mitochondria

  2016cites this paper
• Programmed Cell Death is Intrinsic to Yeast Gametogenesis

  2015cites this paper
• Alterations of Mitochondrial DNA in Liver Diseases

  2015cites this paper
• Modulation of rabbit mitochondrial nuclease activity by S-adenosyl-L-methionine

  2013cites this paper
• Investigating the role of apoptosis regulator EndoG on exogenous DNA uptake, stability, replication and recombination

  2013cites this paper
• Minimizing the damage: repair pathways keep mitochondrial DNA intact

  2012cites this paper
• Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans

  2012cites this paper
• Mitochondrial DNA Repair

  2011cites this paper
• Cytotoxic Endonucleases: New Targets for Prostate Cancer Chemotherapy

  2011cites this paper
• Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

  2011cites this paper
• Mitochondrial DNA alterations and reduced mitochondrial function in aging.

  2010cites this paper
• DNA repair in mammalian mitochondria: Much more than we thought?

  2010cites this paper
• Estudio de la nucleasa EndoG en el protozoo "Leishmania infantum": caracterización e implicaciones en la supervivencia y muerte del parásito

  2010cites this paper
• Purification, crystallization and data collection of the apoptotic nuclease endonuclease G.

  2009cites this paper
• Oxidative stress induces degradation of mitochondrial DNA

  2009cites this paper
• Role of apoptosis in cardiovascular disease

  2009influential citation
• Is there more to aging than mitochondrial DNA and reactive oxygen species?

  2009cites this paper
• Expression der Caspase-unabhängigen Apoptosefaktoren Apoptosis-Inducing-Factor (AIF) und Endonuklease G im Vergleich zu aktivierter Caspase-3 in humanen Astrozytomen unterschiedlichen WHO-Grads und deren Assoziation mit dem Überleben

  2008cites this paper
• Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.

  2008cites this paper
• The essential role of the mitochondria and reactive oxygen species in Cisplatin-mediated enhancement of fas ligand-induced apoptosis in malignant pleural mesothelioma.

  2007cites this paper
• Induction of renal endonuclease G by cisplatin is reduced in DNase I-deficient mice.

  2007cites this paper
• EndoG is dispensable in embryogenesis and apoptosis

  2006cites this paper
• Endonuclease G: a role for the enzyme in recombination and cellular proliferation.

  2006cites this paper
• Regulation of the human apoptotic DNase/RNase Endonuclease G: involvement of Hsp70 and ATP

  2005cites this paper
• Mitochondrial Endonuclease G function in apoptosis and mtDNA metabolism: a historical perspective.

  2003cites this paper
• Affinity purification of antibodies by using Ni2+-resins on which inclusion body-forming proteins are immobilized.

  2003cites this paper
• DNA Fragmentation in Mammalian Apoptosis and Tissue Homeostasis

  2003cites this paper
• Endonuclease G is required for early embryogenesis and normal apoptosis in mice

  2003cites this paper
• A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing within the mitochondrial matrix.

  2003cites this paper
• Molecular Mechanisms of Programmed Cell Death

  2003cites this paper
• Mammalian mitochondrial endonuclease G. Digestion of R-loops and localization in intermembrane space.

  2002cites this paper
• Maintenance of mitochondrial DNA integrity: repair and degradation

  2002cites this paper
• Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion.

  2002cites this paper
• Apoptotic DNA fragmentation and tissue homeostasis.

  2002cites this paper
• 23 Endonuclease G Isolation and Assays

  2002cites this paper
• Isolation and characterization of the Schizosaccharomyces pombe cDNA encoding the mitochondrial endonuclease(1).

  2001cites this paper
• Action of Recombinant Human Apoptotic Endonuclease G on Naked DNA and Chromatin Substrates

  2001cites this paper
• Peplomycin-induced apoptosis in oral squamous carcinoma cells depends on bleomycin sensitivity.

  2001cites this paper
• Endonuclease G is an apoptotic DNase when released from mitochondria

  2001cites this paper
• Binding of human mitochondrial transcription factor A, an HMG box protein, to a four-way DNA junction.

  2000cites this paper
• Mitochondria, oxidative DNA damage, and aging

  2000cites this paper
• Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration.

  1999cites this paper
• Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria.

  1999cites this paper
• Repair of DNA damage in mitochondria.

  1999cites this paper
• Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats

  1999cites this paper
• An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice.

  1999cites this paper
• Rapid report Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration 1

  1999cites this paper