Mitochondria, oxidative DNA damage, and aging

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of the American Aging Association

• Publication date

  2000-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11357-000-0020-yPMID 23604866PMCID PMC3455271
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

  2005cited by this paper
• European Standards Committee on Oxidative DNA Damage (ESCODD). Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage

  2000cited by this paper
• Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage

  2000cited by this paper
• Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice.

  2000cited by this paper
• Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

  2000cited by this paper
• Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy.

  2000cited by this paper
• Mitochondrial endogenous oxidative damage has been overestimated

  2000cited by this paper
• The Roles of Dopamine Oxidative Stress and Dopamine Receptor Signaling in Aging and Age-Related Neurodegeneration

  2000cited by this paper
• Polynucleotide degradation during early stage response to oxidative stress is specific to mitochondria.

  2000cited by this paper
• Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage. ESCODD (European Standards Committee on Oxidative DNA Damage).

  2000cited by this paper
• Linkage disequilibrium and recombination in hominid mitochondrial DNA.

  1999cited by this paper
• Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages.

  1999cited by this paper
• 8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging

  1999cited by this paper
• The mitochondrial theory of aging: do damaged mitochondria accumulate by delayed degradation?

  1999cited by this paper
• Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria.

  1999cited by this paper
• Oxidative DNA damage, antioxidants, and cancer

  1999cited by this paper
• Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients

  1999cited by this paper
• Endogenous oxidative damage of mtDNA.

  1999cited by this paper
• The mitochondrial theory of aging: is the culprit a faulty disposal system rather than indigenous mitochondrial alterations?

  1999cited by this paper
• Fragmented mitochondrial DNA is the predominant carrier of oxidized DNA bases.

  1999cited by this paper
• Evidence for mitochondrial DNA recombination in a human population of island Melanesia

  1999cited by this paper
• Mitochondrial DNA influences radiation sensitivity and induction of apoptosis in human fibroblasts.

  1999cited by this paper
• Comparison of oxidative base damage in mitochondrial and nuclear DNA.

  1998cited by this paper
• A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

  1998cited by this paper
• The free radical theory of aging matures.

  1998cited by this paper
• Hashimoto thyroiditis is associated with defects of cytochrome-c oxidase in oxyphil Askanazy cells and with the common deletion (4,977) of mitochondrial DNA.

  1998cited by this paper
• Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice*

  1998cited by this paper
• Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damage.

  1998cited by this paper
• A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

  1998cited by this paper
• Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage.

  1998cited by this paper
• Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells.

  1998cited by this paper
• Independent occurrence of somatic mutations in mitochondrial DNA of human skin from subjects of various ages

  1998cited by this paper
• Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging

  1998cited by this paper
• Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy.

  1998cited by this paper
• Age-associated change in mitochondrial DNA damage.

  1998cited by this paper
• DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria.

  1998cited by this paper
• Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA.

  1998cited by this paper
• Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage.

  1998cited by this paper
• Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria.

  1998cited by this paper
• DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine.

  1998cited by this paper
• The Role of 3′-5′ Exonucleolytic Proofreading and Mismatch Repair in Yeast Mitochondrial DNA Error Avoidance*

  1998cited by this paper
• An Oxidative Damage-specific Endonuclease from Rat Liver Mitochondria*

  1997cited by this paper
• Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997.

  1997cited by this paper
• Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II).

  1997cited by this paper
• Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.

  1997cited by this paper
• Induction of a particular deletion in mitochondrial DNA by X rays depends on the inherent radiosensitivity of the cells.

  1997cited by this paper
• Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.

  1997cited by this paper
• Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs.

  1997cited by this paper
• Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.

  1997cited by this paper
• Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

  1997cited by this paper
• Copyright © 1998, American Society for Microbiology Efficient Repair of Abasic Sites in DNA by

  1997cited by this paper
• Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle.

  1997cited by this paper
• Reduction of CuZn-Superoxide Dismutase Activity Exacerbates Neuronal Cell Injury and Edema Formation after Transient Focal Cerebral Ischemia

  1997cited by this paper
• A proposed refinement of the mitochondrial free radical theory of aging

  1997cited by this paper
• Down-regulation of mammalian mitochondrial RNAs during oxidative stress.

  1997cited by this paper
• Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

  1997cited by this paper
• Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease.

  1997cited by this paper
• Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA.

  1997cited by this paper
• Oxidative Decay of DNA*

  1997cited by this paper
• A proposed refinement of the mitochondrial free radical theory of aging.

  1997cited by this paper
• The rate of mitochondrial mutagenesis is faster in mice than humans.

  1997cited by this paper
• Insulin-induced Activation of NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by Gαi2*

  1997cited by this paper
• Mitochondrial DNA maintenance in vertebrates.

  1997cited by this paper
• DNA repair of UV photoproducts and mutagenesis in human mitochondrial DNA.

  1997cited by this paper
• In situ localization of mitochondrial DNA replication in intact mammalian cells

  1996cited by this paper
• Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum group A cell line.

  1996cited by this paper
• Detection and analysis of mitochondrial DNA deletions by whole genome PCR.

  1996cited by this paper
• Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

  1996cited by this paper
• Repair of DNA damage in a mitochondrial lysate of Xenopus laevis oocytes.

  1996cited by this paper
• Detection and quantification of oxidative adducts of mitochondrial DNA.

  1996cited by this paper
• Clonal expansion of mitochondrial DNA with multiple deletions in autosomal dominant progressive external ophthalmoplegia

  1996cited by this paper
• Mitochondrial electron transport chain activities and DNA deletions in regions of the rat brain.

  1996cited by this paper
• Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases.

  1996cited by this paper
• Tandem Duplications and Large‐Scale Deletions of Mitochondrial DNA Are Early Molecular Events of Human Aging Process a

  1996cited by this paper
• Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome.

  1996cited by this paper
• Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells.

  1996cited by this paper
• Mammalian Mitochondria Possess Homologous DNA Recombination Activity*

  1996cited by this paper
• Simultaneous Increase of Mitochondrial DNA Deletions and Lipid Peroxidation in Human Aging a

  1996cited by this paper
• Presence of a DNA-4236 bp deletion and 8-hydroxy-deoxyguanosine in mouse cardiac mitochondrial DNA during aging

  1996cited by this paper
• Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle.

  1995cited by this paper
• High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys.

  1995cited by this paper
• Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

  1995cited by this paper
• Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism.

  1995cited by this paper
• DNA damage, mutation and fine structure DNA repair in aging.

  1995cited by this paper
• Action of Mitochondrial DNA Polymerase at Sites of Base Loss or Oxidative Damage (*)

  1995cited by this paper
• Mapping of Copper/Hydrogen Peroxide-induced DNA Damage at Nucleotide Resolution in Human Genomic DNA by Ligation-mediated Polymerase Chain Reaction (*)

  1995cited by this paper
• Dietary restriction.

  1995cited by this paper
• Accumulation of deletions in MtDNA during tissue aging: analysis by long PCR.

  1995cited by this paper
• Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

  1995cited by this paper
• Purification of All Forms of HeLa Cell Mitochondrial DNA and Assessment of Damage to It Caused by Hydrogen Peroxide Treatment of Mitochondria or Cells (*)

  1995cited by this paper
• Repair of mitochondrial DNA damage induced by bleomycin in human cells.

  1995cited by this paper
• Nitric oxide: an overview.

  1995cited by this paper
• Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs.

  1994cited by this paper
• Ageing‐associated tandem duplications in the D‐loop of mitochondrial DNA of human muscle

  1994cited by this paper
• Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds.

  1994cited by this paper
• Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice.

  1994cited by this paper
• Chemical determination of oxidative DNA damage by gas chromatography-mass spectrometry.

  1994cited by this paper
• Major oxidative products of cytosine, 5-hydroxycytosine and 5- hydroxyuracil, exhibit sequence context-dependent mispairing in vitro

  1994cited by this paper
• Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria.

  1994cited by this paper
• Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing.

  1994cited by this paper

• Strawberry Fragaria x ananassa Duchesne (cv. Romina) methanolic extract attenuates hydrogen peroxide induced DNA damage in human peripheral blood mononuclear cells in vitro

  2026cites this paper
• Mitochondria in Corneal Physiology and Pathology: A Mechanistic Perspective.

  2025cites this paper
• Influence of sex, age, ethnicity/race, and body mass index on the cerumen volatilome using two data analysis approaches: binary and semiquantitative.

  2024cites this paper
• Dihydroquercetin and biochaga reduce H2O2 induced DNA damage in peripheral blood mononuclear cells of obese women in vitro-a pilot study.

  2024cites this paper
• Dysregulation of the Acrosome Formation Network by 8-oxoguanine (8-oxoG) in Infertile Sperm: A Case Report with Advanced Techniques

  2021cites this paper
• Lactoferrin Ameliorates Dry Eye Disease Potentially through Enhancement of Short-Chain Fatty Acid Production by Gut Microbiota in Mice

  2021cites this paper
• Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease.

  2021cites this paper
• ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

  2020cites this paper
• Traumatic brain injury-induced cerebral microbleeds in the elderly

  2020cites this paper
• MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men

  2020cites this paper
• Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species‐mediated mitochondrial injury

  2020cites this paper
• 8-OxoG in GC-rich Sp1 binding sites enhances gene transcription during adipose tissue development in juvenile mice

  2019cites this paper
• Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population.

  2019cites this paper
• 8-OxoG in GC-rich Sp1 binding sites enhances gene transcription in adipose tissue of juvenile mice

  2019cites this paper
• Antigenotoxic Effects of Biochaga and Dihydroquercetin (Taxifolin) on H2O2-Induced DNA Damage in Human Whole Blood Cells

  2019cites this paper
• Healthy Ageing

  2019cites this paper
• Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro.

  2018cites this paper
• Mitochondria and mitochondria-induced signalling molecules as longevity determinants.

  2017cites this paper
• Genetic Factors Associated with Longevity in Humans

  2017cites this paper
• Mitochondrial determinants of cancer health disparities.

  2017cites this paper
• Aging asymmetry: systematic survey of changes in age-related biomarkers in the annual fish Nothobranchius guentheri

  2017cites this paper
• Mitochondrial structure and function are not different between nonfailing donor and end‐stage failing human hearts

  2016cites this paper
• Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle

  2016cites this paper
• Natural Compounds Modulating Mitochondrial Functions

  2015cites this paper
• Endogenous ROS levels in C. elegans under exogenous stress support revision of oxidative stress theory of life-history tradeoffs

  2014cites this paper
• Exploring the Role of Genetic Variability and Lifestyle in Oxidative Stress Response for Healthy Aging and Longevity

  2013cites this paper
• Within- and between-species study of extreme longevity--comments, commonalities, and goals.

  2012cites this paper
• Effects of Reactive Oxygen Species on Life History Traits of Caenorhabditis elegans

  2012cites this paper
• Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria.

  2003cites this paper
• Metallothionein provides ubiquinone-mediated neuroprotection in Parkinson's disease.

  2002cites this paper
• DNA Repair in Mammalian Mitochondria

  2002cites this paper
• Suicide inactivation of peroxidases and the challenge of engineering more robust enzymes.

  2002cites this paper