The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Neurochemistry

• Publication date

  2004-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.2003.02297.xPMID 15030387
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of Protein Kinase CK2 Phosphorylation in the Molecular Chaperone Activity of Nucleolar Protein B23*

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• Expression of the Cystathionine β Synthase (CBS) Gene During Mouse Development and Immunolocalization in Adult Brain

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• Altered Gene Expression in Liver from a Murine Model of Hyperhomocysteinemia*

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• l-Homocysteine Sulfinic Acid and Other Acidic Homocysteine Derivatives Are Potent and Selective Metabotropic Glutamate Receptor Agonists

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• Regulation of c‐Jun N‐terminal kinase, p38 kinase and AP‐1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

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• Elevated plasma von Willebrand factor in a murine model of severe hyperhomocysteinemia

  2003cited by this paper
• Memantine in moderate-to-severe Alzheimer's disease.

  2003influential reference
• Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism.

  2003influential reference
• UV Stimulation of Nucleophosmin/B23 Expression Is an Immediate-early Gene Response Induced by Damaged DNA*

  2002cited by this paper
• Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.

  2002cited by this paper
• Hydrogen Sulfide Is Produced in Response to Neuronal Excitation

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• In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific.

  2002cited by this paper
• Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage

  2002cited by this paper
• Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

  2002cited by this paper
• Elevated homocysteine levels in young male patients with schizophrenia.

  2002cited by this paper
• Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals

  2002cited by this paper
• Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue.

  2002cited by this paper
• Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins.

  2002cited by this paper
• Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals

  2002cited by this paper
• Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

  2001cited by this paper
• Evidence for Existence of a Nuclear Pore Complex-mediated, Cytosol-independent Pathway of Nuclear Translocation of ERK MAP Kinase in Permeabilized Cells*

  2001cited by this paper
• Identification and expression of a mouse ortholog of A2BP1

  2001cited by this paper
• Kainate Receptor Activation Induces Mixed Lineage Kinase-mediated Cellular Signaling Cascades via Post-synaptic Density Protein 95*

  2001cited by this paper
• Endothelial Dysfunction and Elevation of S-Adenosylhomocysteine in Cystathionine &bgr;-Synthase–Deficient Mice

  2001influential reference
• Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia.

  2000cited by this paper
• Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

  2000cited by this paper
• Plasma homocysteine is a predictor of alcohol withdrawal seizures

  2000cited by this paper
• c-Jun and the transcriptional control of neuronal apoptosis.

  2000cited by this paper
• Molecular mechanisms associated with long-term consolidation of the NMDA signals.

  2000cited by this paper
• Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures.

  2000cited by this paper
• Learning enhances adult neurogenesis in the hippocampal formation

  1999cited by this paper
• Ratio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures.

  1999cited by this paper
• Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice.

  1999cited by this paper
• Hypoxia Induces Selective SAPK/JNK‐2‐AP‐1 Pathway Activation in the Nucleus Tractus Solitarii of the Conscious Rat

  1999cited by this paper
• Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

  1999cited by this paper
• Homocysteine and Alzheimer's disease.

  1999cited by this paper
• Hyperhomocysteinemia, Atherosclerosis and Thrombosis

  1999cited by this paper
• Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells.

  1999cited by this paper
• Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons

  1998cited by this paper
• Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure

  1998cited by this paper
• Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development.

  1998cited by this paper
• [Signal transductions by the MAP kinase cascades].

  1998cited by this paper
• Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury

  1998cited by this paper
• In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines.

  1998cited by this paper
• Characterization of the stress-inducing effects of homocysteine.

  1998cited by this paper
• Overexpression of the Nucleoporin CAN/NUP214 Induces Growth Arrest, Nucleocytoplasmic Transport Defects, and Apoptosis

  1998influential reference
• Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.

  1997cited by this paper
• Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli.

  1997cited by this paper
• Selective interaction of JNK protein kinase isoforms with transcription factors.

  1996cited by this paper
• Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture.

  1996cited by this paper
• The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells

  1996cited by this paper
• Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia.

  1995influential reference
• Sulfate and cysteine levels in the plasma of patients with Parkinson's disease.

  1995cited by this paper
• Hyperhomocysteinaemia; with reference to its neuroradiological aspects

  1995cited by this paper
• An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses.

  1994cited by this paper
• A synaptic model of memory: long-term potentiation in the hippocampus

  1993cited by this paper
• Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis.

  1990cited by this paper
• IL-2 mRNA expression in Tac-positive malignant lymphomas.

  1990cited by this paper
• Excitatory Amino Acid Receptor Potency and Subclass Specificity of Sulfur‐Containing Amino Acids

  1987cited by this paper
• The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

  1985cited by this paper
• Excitatory actions of homocysteic acid on hippocampal neurons.

  1982cited by this paper
• Homocystinuria: pathogenetic mechanisms.

  1977cited by this paper
• INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY

  1976cited by this paper
• JCB Article The

  year unknowncited by this paper

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  2021cites this paper
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  2021cites this paper
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  2018cites this paper
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  2018cites this paper
• H2S biosynthesis and catabolism: new insights from molecular studies

  2016cites this paper
• Molecular Rescue of DYRK1A Overexpression in Cystathionine Beta Synthase-Deficient Mouse Brain by Enriched Environment Combined with Voluntary Exercise

  2014cites this paper
• Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain

  2013cites this paper
• Dyrk1A, a Serine/Threonine Kinase, is Involved in ERK and Akt Activation in the Brain of Hyperhomocysteinemic Mice

  2012cites this paper
• Hiperhomocisteinemia. Panorama actual y contribución del ratón a su estudio

  2010cites this paper
• LA HOMOCISTEÍNA: UN AMINOÁCIDO NEUROTÓXICO*

  2009cites this paper
• Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice.

  2008cites this paper
• Endoplasmic Reticulum Stress Increases the Expression of Methylenetetrahydrofolate Reductase through the IRE1 Transducer*

  2008cites this paper
• Homocysteine activates calcium‐mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus

  2008cites this paper
• The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?

  2008cites this paper
• Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats.

  2007cites this paper
• Diet-induced hyperhomocysteinemia does not lead to large gene-expression differences in rat aorta.

  2007cites this paper
• Homocysteine and Cognitive Function in a Population‐Based Study of Older Adults

  2005cites this paper
• Ferric cycle activity and Alzheimer disease.

  2005cites this paper
• Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus.

  2005cites this paper
• Activation of catechol‐O‐methyltransferase in astrocytes stimulates homocysteine synthesis and export to neurons

  2005cites this paper
• The central nervous system in animal models of hyperhomocysteinemia.

  2005cites this paper
• Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects.

  2005cites this paper